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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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lib:1352
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{FRG
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}
{RED
iid:1354
eid:1506843772
seq:
GAATTTCTGGCTACTCTTCTTGCTCTACGGATCGTGTCTTCCACTCACGGTCCTCCATCC
TCTAACCGAAGCCTAGCAACAGAAAATTTCGGCAGCACCTCCCCTGCACAGGGAGGTTTC
GAAATCCTGCAAATAAAACTATCAGCACGATGGCTGACATACACGCATAATTCAACGGCA
CGATGGCCGGCAATCACACACACACACACACACACACACACACACACACACACATATATA
TATATATATATATATATATATATATATTCTCTCTGTGAGTCTATTCTACACATAATTTCG
CGGGGTGATATATATATTTCTCACACAAATTCTCAGCGAGTCTATCGCCTCACACATGTG
ATATATATATTCTCTCTCACACATATACACGCGATATATATACTCTCTCCTATACTAAAA
AAAAAAAAAAAGACACACATCAAACGCACATATCGCGCGCGGGTGCGACTCTCGCGCGCG
CGGCGCGCGCGCGCGAATATAGACACACGCGTGGAGTCTCTCTCGCGCGATAGAGTGTCG
CGCGCGCGTTCTGCG
.
qlt:
54547:554478486876S665678>F?C::6K9;E=B9KFD9>=RHPG>?OCM?P<OIO
=?=<KM>9SCEELI?G?B?MFI@=>>=>HPJMRFUHACJHPaaPQ[UOLHIACMXPJPPX
OUU[JOIMMGaaaU[bUUSKSUSWSSV[S]]_HUW]TPSS[POSKOHOLQ[bXb[bb[eb
b_[b_QL_bWW]d]b]]b]bbbb]___X]V]V]XbW_Q[X_[__d]_[_X]KHMDKNN[S
_]b[_]]W[]_e___bdbde^U]SG>@:<:<?=:A>B98:8@8<88=:=>@C>A::9:;8
:>D9?:>8:A=HDHH:C:?::;<?@=H:BAE:88;=:FCG<=IAC8;<<:88=?<A<9=:
=CACKQTMD=7=>>DH>F:B;<97=D@CE@7=?=@MEA<::5>@=C<@:::8;578<5:>
:::88=<8K7;7::;::<>:55:<8?<<<<7;=B:<@;G5=5799887575;77:??<97
5:77;77;9;65547654:=9:<77:9:<867;976445785478>C:435555777787
77=:8<843444343
.
frg:1332
clr:18,459
}
{RED
iid:1355
eid:1506843835
seq:
GAACGGTAGTACTCGTAATCTCGCGTCGTACCTCGTGGGACGATCTACTGATCCCCCGGG
GAGAGCTAGAGACTAACATAAAATGTGAAAATTATAAGCAGAATGAACATAACTCTTGTT
ATGATGAGACCGACTAATAATTTTCCTGAGACCCTTAACGCGTGCTTCCTTTGAGGACTA
CCAGAAATACGCGCGTTTCCTTTCTCCTTGTTGAGAATGGGAGCCTTTTGGCTTGTTAAG
TTCTTGGGTCCCTTTCGAAAACCAAGACCATCCTTAATCGAGGGGTGTCTACCAATAGTG
TAGGCATCCCTTGGGTACTTTAATGTAACAAAATCAATTTTGCAAGTCTTAGGTTGAGCG
TTAGGACTTGCCACCTCAGCATTCAGCTGAGTAATAGAGATAAGATGTTCTTCACATGCA
TCGACATCCAAGTATTTACATCTATAACAAATACTGACATGCTCTACGCATGAACTTGTG
TTGCTAGCTTCCACTGACTGAGCATATAAATCTTTATTTATATGCTTTATCTAGAGATGG
ATGCATGGCAGGCAGATAACTTATAAGATAGCATTTCATTTCTCTTAGTTTCTAAAGCAA
GAGACTTTTGTAACTAACATCTTGTCATGTTCCTGAAACAGATGTACTCTTGCATTTGCG
AGTGGCGATCGGTATCAGTAGAGGATGCATTAGGTCTTAATTTTCGGCTACTGAGCGTCA
GTCTAACCCGTCCCTTAAACTAGAGTATGCTACTTCAGCATCGGAGGTATGCGTCTTACT
TGCAGAGGAGTCTTGAGGGGTATCCTAAGGTACCTCCTG
.
qlt:
74484:<775765>?6::984887@6<>78768A:;@8<D98:>::998@88E[SE?CH?
F=8GSBHRK@D><@<>;8C=<;DIL<;?=<=:9:=<<9:=;:<D>===;CO?GF;G=C??
?C;@?=LLC<C@L<??;=<<=HD>:<:;=<:==<F==<<><CCL=<BL===BB>CGLMKH
?:?HA::<<;M;?C;?BCC==<<;;;;<BS:=?:=@<CL?EGLG?B>B=N=C=CTC==FK
=BGHL[S<E:KL?PCT@?A@K@;@CL<UEAHAEHGGLILLD<?=C;E;FBIHCHC>PP<a
ACKA?9>D>CK>E=::?<9;99>B::>8;=BJC<CEEHHFHM>9@IB;>C;>AA>G;FBC
@H=:=HM?EA7==899?9A9:8::6=>@=OAE=HCKK7<677D<M:@A:@::=LH8AC>=
9H>D>H<@9:=D:8877@?>KK:?;<=:8E<@=DI>;>FJ@=DB>9H9I;@<:888@AC9
<6;>9>:AG9>N<@775<VQQ>CLE8AC<DTQ?@KPMAKG>KN9K>=7@:=EH:9>>E>8
;D9=:CL<8AFCF:=M;::CE>@<A<MN=MMQNA=HT?CG<NUP9:>9?L=QACFC>=?<
FA<IGI9:<A55C?<HJT=8=>@ME;OMB5=>DVA58:F=5K?N?>K:?>B=?8MF:8:7
:M6;:>87>E9<;5;ED8;=F;?GEH?>;;@>5:CJ5L7:<9D>@6:C>@<<79L8A7;7
9>@95?AAN8757555=MEKJ99:G9M65=;?S?O89559?==79BO:8M8N6:66<:::
6P5J<GK>;85:7=A9>\\G5MD79=<E46I5?6B5556
.
frg:1334
clr:33,815
}
{RED
iid:1356
eid:1539600373
seq:
CGCTGCGATGGCTGAATACACGCATAATTCAACGGCACGATGGCCGGCAATCACACACAC
ACACACACACACACACACACACACACACACACATATATATATATATATATATATATATAT
ATATTCTCTCTGTGAGACTATAACACACATAATTTAGGGGTGTGATATATATATTTCTCT
CACATATTTTGAGAGAGTGTATAGTCTCACACACATGATATATATATCCTCTCTCTCACA
TATACACACGATATATACTCTCTCTCATCAAAAAAAAAAAATAAAAAAAGAGACACAAAA
AGAGCACACATCTCGCGTGGGGGAAAAAAGCACACGCGCGGGGGGCGCGGGAGAATAGAG
AGGCACGCGAGGGGGCCCCCCCGCGCGGGGGAGGGTGGGCGCGCGAGGGGGTCTCTCAAA
GTGTGAGATGGACGCCCCCCGCTAATTAAAAGAGAAATAAAAAAAAAAAACCCTCTACTA
.
qlt:
321445?658658;67@CLIRLMGXKJK^HCI_iPQMUXQUdENdiGESR^_^^TdY[YT
NTOTUUPRSXXUPRUZWYTUVXPWUVT[TKK>KLNee_Z_VVN[[WOSKWSb_[W]VPWX
D>8;:?>?E:8::A9>>9=<>;;=CA>>DAG<=:=98:AA8A=>>@C>EFA>=O8===@<
ME=A8=CH<A;:A<H>==9G:>9:9<:=@=D<=8:>>ACCHHQRTAA9@FFHHAD:H>D:
8:D=@CH<K=CDMFA:==8>?OQ?=A::::?A=C:CCC=:?8C8?@F?A;@;A@F:C>?@
788:9?::;88?9@=;V:V=?7::::::D>88A;DE=I:CC;P:D8::9967:@:8<=::
B89A:@<:<>@<:?@>:JBH:>:=?E?7A>H>:77886<A;?>D:>9;887:=8;8?78>
698788:;:88:<:?8<<87469:867577;8>888;>C8G:@><?BB8854;6875546
.
frg:1336
clr:16,468
}
{RED
iid:1357
eid:1539600374
seq:
ACGCTGCTGCACAGAATTTCGGCAGCACCTCCCCTGCACAGGGAGGTTCGAAATCCTGCA
AATAAAACTATCAGCACGATGGCTGACATACACGCATAATTCAACGGCACGATGGCCGGC
AATCACACACACACACACACACACACACACACACACACACACACATATATATATATATAT
ATATATATATATATATACAATCGGTGAGTCGATTCCGCGCACATTCGAACGGGGAGTGAT
ATATTTCTCACTCATATAATTTCCGCGAGTCTCGCGCCATATACAAGTGACATATGTCCG
CTCTCTCTCGCACATAAACACGATACATATATTCTATAATCAAAAAAATAAAAAAAAAAA
AGGCACACAAAACGTGTGTACCCCGCGCGGGGGGGAATGTCGTGCGCGCGTGGGGCGTAA
AAGACAGATTAGTTCGCGGGGGGGCGCGCCCGGAGCAGAGACGGGCGTGCGCGCTATAAC
CACCAACAATACCTTGGTCGCCGTGCCCTAAGATTGGCAGAGCGATAATAAGGTAAGGAC
GCTGGTGTTTGGTTGGTAGGGAGGTTGGACCGGATGCAGAGGGGCGTTTAACAGAGTTAG
ATTAATCTAGCCGACATCGGGGGAGAACATAGGTGTCAACCTTATTCTTTTTTTT
.
qlt:
4546545787:9@<86568QR@:;Z<9BQLWLKML[JDG>UOFGVUBLMHNOVOVLVdUQ
PWWW[[ddaadVV[JMTUd]k[[dkT?HLGKKdd]NWPVNT[[[[kaTKJHG=K=<FMG?
?HHJMSKNKNPSUNKNLVG[S[[WLPIUIUINKTKUGOGOBNBBIHIGNKOWGWKGBFBK
CGBJMKNKPLFPLLBI<8;9<;:<:G<=<::<<<;B@CC==<==<;=B=<<B<NGF<:@F
KBGM9I8?>:<<BBAD@H>G<<<;<<T=FJ??:<DB<C=:=89<?>G:KIC@GBK<B<;8
=B=F?;K=L@IC=BC<:GG=F:<<:;H=:<<:<F;:?:GBF<?J<?G?88E;F?KBKKU<
GC>=>CA:B88=D8:C99<<965::<F<H:?<A<:<9<;==::8;;I<PI;?D<B48=<;
;;;;<==:::;<<=G:<G:<<<:;@9;59=9<<;::;<8<8:=:C=9=?HDB;<<=<=:A
6B=<;:89::99<?==;?:F=K=<:8<=7=<B<=9;;8>F<;<9?<K<<86=?;8<59:H
<=::<8;;:8758B;;F;::=;<:=>;:9?<J9;98;:9@N<=8:BB;;:;<>B9:?:<9
6:==:;<?K<:;;:8:74:<B=:BE=@9><L:787:;LKE7=U;K78=;;EBB<9
.
frg:1337
clr:19,653
}
{RED
iid:1358
eid:1544855188
seq:
GTGTTATCTAGTATCGCTTAGATGATAGAATGTATAAATCGTGTAAATTGGTGAATGATA
GGATATATAAATCATGTAAGTTAGGCTATAGTCTCGTTGAAAATTTGTGAATGAAATATG
TAAATCATGCCGTTAAATTATGCGTAGTATAGTCTCATGGATTGAATATATATATATATA
TATATATATATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGAT
TCCCCCCCCCGCACGGTCCCTTAAATGTATCTCTGTCTACACACGTCGGTGCCATATATA
TATTTGGGGGGTATCGCTCACTCTGCGTTTGGGGGGGGTGCTCGAAAAAATTTTCTGTCC
CGACGTATGAGAGAGAAGAACGCTACAGAGCGAGCGTATGACCCCGCCCCAGAGACAAAG
ACGCACTCACCACTCTGTATATAAGAGAGAGAGCTCTTTTCTTTTGGTAAGCGTATGGCC
TCCCAACACAGCCGTCACGAGATTGGAGGGAGAGCCCTGGATCAA
.
qlt:
3634444479557?7749;AM?;A;=B>>FBA:NNGNKPWJBUABDLQVZ@BLLKDTPOZ
R[BH[SOWHSO[UUb_V[W_[T[gUggg[V[V[[[a[bbUOJUUYdaV[d[adgdgaggg
d[dadaadkkkkWkdkkkkkkkkdVkkak]kkdkkkkkkTb\\aakkkbaa]Sa]kdkdd
kkkkkkkk[kdH=?<BBDCKQNBKCBBCWWFICLKH:EGHN[DK??FE<BHCGC=?==B<
H==8;=C<<==C<G<<;B@BG<C===<C;;:<:;=C??@=;;D=B@BG=C>:=HHJ=GMG
LCM=B>C=B=<GKB9=>>?<UCB=A;8:;<>=?C=BAE=CA?;;><<=<;;B;=<<?==<
A8I::::CCC?OD:@=C=<:<<9D=<B<=B=G:J?<=8=<<<@=G;FG=CD8C?<B=BB8
B:;A:?GB:G=GQ@=<C<C:<;;:=I<:9<<>@C@<F=<<9:<<<=::<=C876I@7@99
9==:=?K<C9;:<;<;:>=G<;I<>@<;=::>8<DKP==BH;G:;
.
frg:1339
clr:18,524
}
{RED
iid:1359
eid:1544855189
seq:
GGAGCGAGTGCTGTCACTGCACTCGGCACAGATGTTTGCCGAGTGCCTGCGATCTGGCAC
TCGGCAAAGACTATTTTTAAATTAAAAAAATCTTTGCCGAATGCCCGCGATCTGGCACTC
GGCAAAGCTTAAAACATAACGTATACTGAGACCCTTTTCTTGTCCTTCTCACTCTCACTA
ACTGAACGCCGCGCGCCACTCACCGCCGTCGCGCCACCCCGCCGCGCGCCACCACCTCCC
CGCGGGAGGCCGCCTCCTCGCGTGCCGCCATCCTCGCCCGGCCACACCACCCGGACCATC
GTCGCCCCCACGCTAGGTATGAACTTGATAGGCGTCTTTTTTAAAATTATTACTGCCCAG
CGGAAGGAACGAAAAAATCGTGAAAATTCGCCGACTGATACGATTTTTTTTTTCATTTTT
TCTAATGCTGTCGGTGATCTAATTTTTGGTGGCTGATACTTCTTACTCCTGGCCCCTCAC
TT
.
qlt:
434455779D7=I:9578875BbVU>6K49EE6G;eWHAOHVbXH7eNN@DON]SbAIVW
ed[[MSbHSWSSVRaVUVO[[RXPHUJV[U[[agdaaYdaddgaddaaadddddV[Tadd
YHTT[a[[ddkadkadd[adaVadadddW[[[akkkkkdddka[dadaYVVT[k[XVkkk
l]][[V[QLkkPUDHHKOS]OVV[TKTOIkkPTO[QQ[C[NPkd][LNKBEKNFKBSKBK
OKLB<=BBF<DF:BS[VWSP=K==;<;;HA=H<<BB<G<;L;;@H:=B=@==<:L[VQV[
C:F==C=C;DCCH>C:B=DDKHCHOTH@>?>FF@=E@;8B=@?B<=>;B?8<:;H?<;99
;<<<<9<=EE?9<;>CG<B=CK9<=;=A>S:?;;;<>:;=<<:FCH>==C==FG=CB@CA
=<=;;<99C<;==;<<??8B;<49G@HS<;=<<:9<;=C;C<B;?HHE:CA=C<C<;=;;
>M
.
frg:1340
clr:9,481
}
{RED
iid:1360
eid:1544855190
seq:
TTCATTCGCCGGCCTGCTAGCCTAGGTGAGCACAAGCTCACTTTTGTTCCAAACTAGTGC
GCAGAAGCCTAGCCAGCTTCCTCCTATGCCTCTCCTTCTACCTTGCAGCAAAAATTCAAA
AACGACAAAGAAAGTAGTGCCGCCGTTGAGCGAAAAAAAATTTGGTGCAGCCGGCTGCAA
ACCAGAATGTTTGCAGCCCCTCTCACAAAAAGGAGGAACGCCCCACCTGCAGGTCTTCAG
GTACGTTTTACTTGTGTTGTTCTTTTGCGGTTGGGTCTATCCTCCTTTTTTTAGAGCTAC
AACATTTAAGTTTACCTCGGTTCCACCAATTTTTTCTCGTTCAGCCGCCGGCACCTCATC
GACAGAGCACCCCTCCGGATCCTCCACATCTTCTTGTACC
.
qlt:
7445445568755858:C<;8A9C9=:HP98:;8<K@C:67>B>AL;6L<:K=VHV[COC
LG@KMKN?M@[HH?D<DJBWWWLCB:<C:KKI<BGG=HCHSK=GSHFJI\L<87:=B<KT
SNG>PI=BK<KJPMGFB=PDHGJNLPPTRK??GFbQPUQPPQHQGBPG=:AJDIGT[Y<=
889;<HCAH88:><=BBBBG?<==7B:;:=:==:9:<688B=B?:B>>BHBK=;<77<<:
B<@<88:<<<;@B779:8=;86;D8;;86:59856<7:987:66<7::7869=<7<68:?
79><D876;<<:7<A<8@=;;998;;85===7:::::7877:>8;D<?6;:66:;:9:=<
:<77BLA@=BA:?A67;?:DH8FEA:GB<<B<=;8:<::C
.
frg:1341
clr:16,399
}
{RED
iid:1361
eid:1544855191
seq:
TACACACACACACATATATATATATATATATATATATATATATATGCTCCCTATGAGTGT
ATCACACACCTACTTTACGGGCTTGTTTTATATATTTTTTTCAAATATTTTCGGCGAGTC
TATACTCTCATATACAAAATTTATATATTCTCTCTCACACATATATACACTATATATATT
CTCTCTCATATAATAAAAAAAAAAAAAAAAGTGACACAAAACACTTTCATCTCGCGCGGG
GGCGAGAAAAGGGCGCGCGGGGGGGGGGCGCGCGACAAGGGGGACGCGCGGAGAGGCCGT
CTCGCGCGGGGGGGGGGGCGCGCGAGGGGGGGTGTCGAATAAGATTTGTCGCGCGCGCTC
TCTGTAGAGAGAGAGAGATAAATAAAAAAGTTGCTA
.
qlt:
57;57:87578788;7?7G@KKPSPPXKTVYST[a[gaada[[CN<EG[LC=C=I;F@=J
=K=<;:<<D=LA?>?C;<<B;==G=<=DGCBBLLSA?;;;:<=;B9GLO<=>AB;B<=>C
HDI?H<K>=<<<;@<<<;==:B=Bd]KG8@@==<C?8IA8><I??BKB<B=HHKJFB==<
<BFN=CBBLB<<B<BBF=CI>H=KKKKQCKB=B=GIGC=B==@A?=<B;===B?BE;P=M
<F:B=<==<G<<<?AGH=S=TPBJ=QBGEA:G:GC::B<==?<<E=IBBF;8<AH>@<:8
D<H<PQEL<DC=<B<BHF>:?<JB8;<:8<?<=<<=:;;;;:;8<86:9;887?:B:;=<
<>;:69::=6=8A88<8;<;<:7J=QDC=9;8<:B>
.
frg:1342
clr:16,395
}
{RED
iid:1362
eid:1506843773
seq:
GCGTTTTACCGCTCGAGCTGTGTAACTGTCATATTATCCGCGCCGAGTGGTTATATCATC
CTATGTGTTTCCCAGCTAGGCTCCTTCTTTGAATCCTTCTTTGAGTTTTGGGTTGAGATC
TCGTGTAAAGCCCACCCCTAAAGCGCTTTTTTTTGTTTGCCGCACCATGCCGAGCTATGC
ATTTATTTTGTTTGGTTGAGATTGTGGAAATCACTCATCTAAAATTGAAGAAAAGGAAAA
CCTTTTCCTCTCTCCCCTCCCCTCCTTCCCCAATTACGCCCGAACAAGTCATTAGTGTGT
GAAGAGGAGAATAGGCAGCGCCGCCTGATGAATTTGGGGTATTGGCAGGACATCCCCGGC
GACTCTAGTCGCCAGATGAACCAAATCGTCCAGCTCACGCGCTATGTCTTATTCGTTGAG
GAAAAAGAACACGAATTGATATGTCAACTACAGGACTGACCAGATTTGGCCTCTGGGTCA
GTGTTAAGTTATCTCGGTGGTATTATAATAGTGGAGATTGATGAAGGGATGCAAGCATTC
GAATAAGAAGAACAGATGATAACAGATACGGGGCGCTCCGTCTACTACTATGGAGCGGAA
TCTATCGCAGTAGGGGTCTCGAGGGACTATCACGTGCTCTTCGGTCTGAATTTTCTCCGG
TGACTCGTGGTAAAATTTGGTCTGCAGGAGTTGGTGA
.
qlt:
8447976:577:D9:8<8;;>89@@CCAA@D?AG?9AF<8::D9=D99878;<D;;99;9
:<AD;C>A<;:?C=;<?<:;ABEKB7:C<<[B==<G?C??=GY;POBMLLC;?A<==CBH
=H?=G==ABHL=?G@C?HVLHH===C=BK=KLOFI<BJNdaUOVLULLUPFBK[kGOLGQ
=W[[[[[QGUHCLTD>DKLCSHGLHLHHJLLPYdTG:<I=CTUU?[[TO[TULTUNT[[[
HGBGGMU[UTUULLLIHHTYPUOTYUV[ULFA;;?99:<<<;B@==<=<>;9;<>>H=?C
C;;8:89:7=B9;E7ECCIC=K@B;;<88<98;;;@9B848>78FB9A=B9HE<788=M9
:9:>>9>=<<;8A<;;<;98879F==<=;:=H:?<=>87::89=9<;==7;::>8::88F
:>><<@86F@>;C9?:87:>=<B6<>BC88>C@8A>:68><=;6<LH@:?:?IE>AJHCA
89G<>D8<:D9E8:>D9DGH<:7ABH<@<<BA7::A99<69;88;8=8:><C8=;5CA?:
<G?8;<8598A:=>C:J?G@7<7B?<:A:F=>=588:C@<=A687AA:?FA@=L5:?7=>
B=<5B6>@6==94=8A8BMM7=>::KF;A7;<?:I>>94:;C>LEH4?<;5775C8:7;;
58@=5@>H8@8>:>9>:7:9A7BED8<:?:488H<69
.
frg:1333
clr:11,694
}
{RED
iid:1363
eid:1506843836
seq:
AAGAGTTTAGCTGCTAGTGCTTCTTCAGCGGGTCGCTCTTGCTTTTGAGATCCTCGATGC
GTCGGTCTTTTCGCGCTCCAAAGCTGATGCCGCTTTTTCTGGAATACTGATATTGCAATG
TTTCTTTTGTCGCCATTCTTGAGCGCGCGTGAACGAGCTTCTCCGGATCTTGAAAAGACC
TTAGATTTCTTGAGACGCAACTTCTACCAGCTAAGGCTTGTCTTTGAGAGTTTTGAACTT
GATATATCCCACACCCGCTATGGGTTTTCCTTTGTTTCTGTGGTGTCTGATTTCCCGGAT
TTCTCCGCTGAATGAATATTGACGGAGAGGAGATGGGGATTCCGACCCAGCCTCCTTAAA
TTCAACAAGGACAACTTGATAATAAGAGCAGGCAAAACGACGTATCATAGATAATCTCTC
ATGTATATTGATAAGATGTGAGAAACAGCAAAAAGTTAAACAATAATAATCCAACTCAGA
TTGAAATCAAGGACATGGATAACAAAAGCTGGGTCAATCCTTAAGGGCTACAGGTGTAAA
GCGAGATGGGAATTAAAGAATCATAATTACTGAGGTAGGGAAAGGACCATGAATCCACCA
GCGAGTGCTGCTTAGGGGCTGCTCCTGCGAATACTTTCGGGGTCTTCAACTGCATCTTCC
GCTATGATGAGAGGCAACATTCATTCCATCCATCCGGCTGGAATTAGGCAAGCACCAAGC
TCCCGTATCTGAGTAAGTAGTAGTTTGAATCGTGCTTAGCAGGATGACAAGTGATAATT
.
qlt:
6433455=77=<D>;?88M>8<@7877777:7FBB9>A>;C979<D9<=9:<A=F:9CL>
:;F>G;=HK>;:;;BHVH;:<::<@=?<<;;?<>=BB=B;9;?A=D<=>;?;@=;E:?=@
==B=C=CGC=<<=H;<P=DJHA??<O=H==?LCT<B<=<=:?<=G<;:<<?<<B<?C<<:
8<5<<=BBGC<?<=FF=;8:G<=:?;<<:<<;?B<9:888===C=BJB?:;76<;B<;88
:>;=?<=99:E<G8B4=86B:;<99<H?9;;?H<<:5;;D;AGBB?G;;:=;F<;B<=;;
<7=<;B8;<?QW8;;=<:<@=HC=KD;CD:8<?C==F<C?>?=B=<?><:==8B=BB<:B
<:=<IJ>?H?<BLKDC=9<?;GB[=T=<:;<=?<H=BA4D:M=B<;<CK=BG=<<:=8E:
;8;<=BD9?B;?7B9C<<<<CC85F;F?<B8::BG<C=<GC9E:GGA:=KJC79>:8;<G
?:75@@:C<<A;A:9;9;<:;?<NLLC@;@??K><=:;<;9;<?HJC@>C?9C=;;=C;:
C6>9F@7>;>;:;;;;?=>>C;=?A97::;;:I9>=GEB:B9>;<<886:;978::>77:
89BC<F<H>OF=9H<>=A>H>=;F;=@:>;9887:?:989C;;=88@:8:=:9ON<>89?
999<:AC>=KF;D8:A<8?8H?:OE@?9KFC:H??D?>>C=K<:>>::8>:6?D79<:78
G8DE7CG<><A89=<96:>O;6B:8<B:<E=96<:8Q;7<G8>88G96>9O7@C69856
.
frg:1335
clr:10,774
}
{RED
iid:1364
eid:1539600375
seq:
ATAGTGTGCAGACCATGCCGAGCTATGCTTTATTTTGTTTGGTTGAGATTGTGGAAATCA
CTCATCTAAAATTGAAGAAAAGGAAAACCTTTTCCTCTCTCCCCTCCCCTCCTTCCCCAT
TTCGGCGCTGCCCCCCAGCCGGTGGCCAAGCTATTACGTGTGAACAAGGTGAAAGGATAT
GAGGACTCGGCGGCAAGGTCTTTACGACTAAGAGCAGCTGGATTGAATAATGTTTGATAA
CCGAGGATCAGCCCCGGAAGAGCCAAATAGGACTTGAACTCGTTAGCGTAAGTCCTGTTC
CTGGCGGTTTTATGCCTCAGGCTTCGTCATATCATCTCGCTTGGTCTTTCTAATCCCTCT
ATGAACGTAGGGAATGTCATCCTCGACGGAAGATACTATACCTTTTCAACCTAATGGGCT
CTTCCGGGTTCGGCCATTCGGTGCAACGGTTCAACGAGAGGCGCTACCCCTTCTCCTCCC
CCACCCACAGAAGGAGCTGAAAGAACCGCCGGCGATATCCATGAGCGCCGTGGAGTGAAG
GAGTCAAGCGTCTTCATGCCGTTGTGCAATGAGATTGATTGGCACAACCCGTCTAGCTTT
CACCTGCCGACCACGCGTGTAACCAGAAGTGTTAGCTGCTTCATTGGTCGGTCTGTTCCG
TTACCCAATTGGGAAGAGGGATTTGGTTTGCTAAAGGCTGATCCACGACTATAATAGTCA
TCTCGGAAGATTTTTTTCACTCTGACTTACCATGTGTATTGTACTGACTTGTACCTTCGC
TTTCGAGAGCTTCCAGGTCCTTGTCTATGGATTACTCTCTGACAAACATGCGGATGAGTG
ACACTG
.
qlt:
443554:7;5<78:8<QM=:9;6AIA;<@D=HNKJHU@>ELNDSMLG@=EHB>;;B;KP@
EO[DSOM<;>JDFFCIJA;??=:E<B?=CCG=B=<GBK@FBN<;9;<=;KGJNdkS=B?<
GCHLCH=H<=<9@B9<8<=<B?BL:7B<:L;=<>;::<;?8:D:9<<9=;;::9D;?::;
><9=;?;:<;C?>?;;:=G:B:9;888=<=D=:889G:=9=C;;L===N<=L:8459:=:
:9EB=:@;UH<;;<:4:;=<:8:::;;:=@<=<88>;H;@;:;=C?98;CLQ<;<C=>=B
?;:<C;9;:;=?=BFCH<=:<MGK;GE9:;CD:88<:;99>>:LCNGT:B;;<>>>C;;<
<<;59<<<;:A?;:?:=<==<;<=?=@>>;:9=>;99=<>;9>:?=<:::I>HB><>9;>
OH;;?E89<<<FA<<;?=<=;9G>;:>:9BBK:9<<?=99759:99;F9898A7><<:9=
9D?>7<F=?;8>88>=B999A>@C>>A7E@@C:877988?:;><;::85:>BC9:7C8<?
<:@@@8:E?B<9>:CK=R7:;=K:=:<H87BF?:@E:<;BAEDS8>7?79:DP9A;68<8
:8<?D955:8>A:95A99<::@:<<:977::7:CB@;><AB9>;A@<5:886555566><
;:>G<<DA6:858878MDNB955596:6;85ABG;79:D>IG>::;:M:@5B=<BB=799
7>E@FHH::7<;<B5@E=75:=I9=D9F9>=6D556AC>I==7875687;G76A>55585
9:97>5<>777>::85>55;=<9A=55B:977;6;:F<7A7664<5<:=A8::9967955
757574
.
frg:1338
clr:15,761
}
{RED
iid:1365
eid:1544855192
seq:
CTTTCCCCGAGATCACTTTACCTGAGAGACACGAGTACTCATGCAGATTCACTAAGGTAC
CAGCTCTTACACTTCCGGGGAATAAAGTTTAGTCTATGTCACATCGAATATTTAAGTAAC
AAATACGAGTATTAAATATAATCTAATTACAAAACTAACTACATAGATGAAGACTAAATG
ACAAGAAAGGGAATCCAGACCATCG
.
qlt:
:745::7655757:679<:?:=??7=9999<=9K<9F>AO@H@?G@==BKGU=P@H=>@?
99<>BH?DGLGHC==<=A=<=;BB?:<=<;<B=L??CK=GDLPQTT[WQ]PLHHHQHHa[
KTVTWWCKMBONHKGOOTLHQLkka[][[kP[dadd[adkkkTkUNMPNMGgggda[[dg
dd[[g<<=;775::LI:NSU[=564
.
frg:1343
clr:17,201
}
{RED
iid:1366
eid:1544855193
seq:
GATTTCACGATAATATTTACCTGGATTGCACTTGCACTCTTGCAGGATCACAATGTATAC
ATGCTCTTACACTTCCAGGGAATAAAGTTTAGTCTATGTCACATCGAATATTTAAGTAAC
AAATACGAGTATTAAATATAATCTAATTACAAAACTAACTACATAGATGAAGACTAAATG
ACAAGAAAGGGAATCCAGACCA
.
qlt:
65544544555556;GHE:[SKLPC:@B?AULTGKGPTdTdaCXXNI;kVk[a[aQVdaV
GW[[VaTUTaL[[[d[Ikk[dkddd[[VTSUVR[LT[T[[[[aaaT[dadd[UU[d[[a[
dPd[a[HaUHPSBGP[KYEUa[ggaU[VU[Oll[[[T][[WUPb[[TQWZQle_U[QQVb
VWd_lLKKWH5467GMHWWJK?
.
frg:1344
clr:14,201
}
{RED
iid:1367
eid:1544855194
seq:
AGCTCGATATTGTTGCCGCACCATGCCGAGCTATGAGTTATTTTGTTTGGCGAGATTGTG
GAAAACACTCATCTGAATTGCTGAGCGGTACACAAGTTCCTAATACCCCCCTGGCCTGCC
CCTGTGGGTGGTTTTGATGACATGACACTGATTTAAGCGGAACCAATTTATCTTTTTAGT
TCTGTCTTCTAATAGAATCCAAATTTTGTATCATTTTAAAGAAAAATCAATAATTACATA
TTATATTTGCCCTAGTTTTCCCAAAATTTTTGGAGTAAAATATTAATTCCTAAAAATATA
AAATTACATAAAAAACATAATATTTTTGTATCTTATTCATTTCTTATCTTGTGAGGCTAA
AACTTTTACTAGAGCTAAATAATGCTACAAATAAACTACTTAATTTATTGTTGATTTTAT
TAAAGAAGTTGAGTTATCTTTCTTCTATTAGTAACCAAATCAATTTTACATTTGTTGTAT
TTAGAACACATATCAAACAGTACTAACACGATATCCCATTCTTTATGTAGAGCCTCTATT
AGATAAACAACA
.
qlt:
@6575577487>8;:SFA>HJX:NI>=9FNCO=<EBBBHB>I>LPKaVJ?:<F@PB?P<G
H?CG<L?CC;=?<==;B<<88==D=9:==K<F<;=<:===::<==;EB<=6=B::F;;==
=;:B=N?B=R[CC=CKIBKBRIFC<B:?LLLKPK@CPLG?;GGC?CCGL<B<KW[[PFGF
=HFBCK<GK=C<?@CRDWTDC?LRL=KN@NUBT=KLH<G;IQCKGP?LIMTKENWRPLTM
T[WHLRROKNKWHHB<HCYLV;>BBVPUHKHTGKG<<?H:9=;9:CGD<RAVTUV[B??;
B<D<CBK?IGGGKK?=:<<<<HI==CCG9L=LK;G?QM=;7;KBDK=S=BM<<:?B;GBB
GLVVTG@MGJE?PKK<:=F??B<AG<;E=::?;L?H@LRA?::?<:?<AGCBO>=?;C@?
:;9>TRGRIAC??>?BgU:A9EGUT@?LESE?BFM89F:=K>CCHBB>V<>8:97COD><
H>:>D@9==79C<:98HSSN>H9A8=C7=8LFLHCK@A?B7=>CA9:<97H>AD8D9=@@
>8=@A98I=IKC
.
frg:1345
clr:11,551
}
{RED
iid:1368
eid:1544855195
seq:
TAGTCGCTAACATTGATCTTTTGCAAGTTTAGCTACTTTTGGCTTTACATCTCGTGTAAA
GCAAAACCATAAAATGCTTTATTTTGTTTGCCGCACCATGCCGAGCTATATATCTATTTT
GATCGCCTTACATTGGGGAAATTACTCATCTAAAATTGAAGAAAACCTACCTTCTTTCCT
TTTTGCCCCTCCTTACTTTCATATTCTTGTATCCTTCCTACCAAACCCGTCCAGTTGTCA
ACGAATGGTTCGTCCAATTCTATTGTAGCACTCTCATTCCCTCCATTGAACAATTTGTTG
AAGTACTCCTTCCATCTGTATCTTGATCTCTTCACTCTTCACTAATAGTCGGTTTGCTTC
GTCCTTTGATGCATTTGACTTGGTTGACATCCCCTTGTCTTCCTTTCACGAATCTAGTCC
ATCTCTATAGATTTCCTTTTTCTCCCTGCTTTGTGTACAGCCGTTGATACAGGTCGTCAT
AGACTTGACCACGGGCTCTACTAACCGCTCGAATTTGCAGACTCTTCGCTATCCTGTACT
TCTCTATGTTTCTGCC
.
qlt:
44445774:756SQRD?>==87788;>877>=888<B;8;;@CK<<;=JIJ>;@:@K?F?
G;B;BB?@:=DCLLLM;@;:?<BBBH==K>?C<LO=PD<CDH8G?C;LL;?AH:AB==<=
@?CH?=;<CR<CC<F:;;C@?;;CH<BCA?:;=<G=<===<>=<:<=;C9;<;B?Q;G>N
=M=:DJ<L?BTR=P;:<O<B:DaTTK<GTGCTKICCB<;<G>H?G<C=9;<96=9<B<<<
9<;B<BK<=<GK=LLBJ;VKN>C=K;<SCL@[UIHVV[VOSV[KBSMNTNTMBS[[I:@K
GMMK?UWML;<<6:AE@?<;<C?<LJAPJLHHL9ISSFDP=<=C=@J?<@C:9?BJGFFU
F=IS?I:KE:CC;FHPSPEH>C98BOHKLLH:<<@KWOG>BB?;HMP:>AHQCDL>E5:C
EKG;9EOC>:MD;><A=GLLSQNRNAEK@C=@HCCA:>8H>@9?=HICG>L;=79=:C>>
:69:8>@9==5H:>8<FI9<?>IN=G=:@A>89><>H8DGO7:?A9>L6?>788>BD:;@
C]VIVFEA:78;9755
.
frg:1346
clr:12,548
}
{RED
iid:1369
eid:1559463944
seq:
GGATCGTATCTGTGCAGTGTGTCAATGGCACATGACAAGAAGGAGCCTTAGCTGGTGTAA
CGCCCTGAATTTGGGGGTAGAATTTTTTCTTCTTTTCTCTCACCAAATTTAGGCGTTACC
CTTTCCTTTTCCCTTTCCCCCTCGCTAAACCTTGATCTTTTCCAAAGTTATAGCGGGTTT
TGGCTTTAGATCTCGTGTAAAGCAAAACCCTAAAATGCTTTATTTTGTTTGCCGCACCAT
GCCGAGCTATGCATTTATTTTGTTTGGTTGAGATTGTGGAAATCACTCATCTAAAATTGA
AGAAAAGGAAAACCTTTTCCTCTCTCCCCTCCCCTCCTTCCCCATTTCGGCGCAGCCGCG
CCCCCCCTTGGCGCGCGACCCAGCCGGCTGGCCCAGCCGCCCCCTCCCCTTCCGGCGAGG
GCCCCGCGGAAGCCCAGCCGCCCCTCCCCCACCGTGGGCCGTCCTGGCGGCCCAAGCCGC
GCCCCCCCCTCCCCCCTTTGGGCCCAGCCGGACCAACTGCCCTGTCCCCTTATCTTTTTC
CAAAAATCCTCCCCGCGGGGCCCGCCCGACATCCACTCTCACTCTACCTCCCCCATAACC
CTAACCGCCGCGACTCCTCTAACGCAAGCGCAGACCCCCGCCGCTCCCTGGCGCCCTTCG
CCTAGCTCAACAACCTCCTTGGTGGAGGCTTCTCCCGCCTCTTACCTCCTCTGAACCTAC
CCGGCTTTTTTGCATCAACTGAAGGTCAGCCATGAACACCGCGATTTA
.
qlt:
434466548:@=IAD888:;5747:DB=9EH=@<H?<9:C?FQWA:DNFNGMOOM8E<8E
D>;C>CGS[WEJJCECKBJFPJCABF>JHHFLLLE[LOLOE?;;<CQCODLLOTTKNS==
CQKH=CKKTUOOLLLTGFHLVLGMCDFLHCVLLLBGH@HVLLLHTOTLVO[L[LYSTHV[
[dVOTLHLKUaaLKVKRKVVR[V[[dk[[[YTT[a[_YaaT[[YTTUOTaaUPHT[LMRl
ga[Wa[QUT[TTWd[YYTOOLTHLLUMCLLPAUKLTBUPJUJUOHHUPF[UKSTPUPaab
[RaUUbURUOU[QVa[U[UOURRJRKMOOURILOVOKOSOGEMO[bR[SbEHHG??FLE>
ICDKKFZZW[LKSDH@C<:>8A<>A:D:]Z]=C=NB?RO?DA@AAF@A?C@:799:9APA
A:=><C<A::>::::]]WC?C8>BTHNJE@HDFKDV=PNDM=]PbZSFNVAESPK]KVL[
_BXbP]RZRMS@>::8@;:F>F;H:<H>FKH<E;>B;8C>E>98MKTRXIE8=:AH>DH>
=<:D::?;6;8888@IWSN6@WNI;BNA:BFR=>9<;7>59<CGA<:>@GLGNS8>VH8A
HGKL8C=9D7C?>A<HNBTGA<867:;9:;9HM6KM:5?E889>D9M7467:75<558B7
8<8:<@:@5@=<6BG>@559I@H?=6E>7?H=<ALL8RLAS<@;M=LALDK=@>99;5D;
<@97:A7>:;E=97L;;?::<GGBE<F8>AGA6695D89897=A<LG;
.
frg:1347
clr:9,767
}
{RED
iid:1370
eid:1559464015
seq:
GGGAACTGCTCCGTTAACTACGGCCGTGATTCCCTTTCTGCCTGGAGATCATGACTCTCC
ATTGATCACTACCAAGGTGACCCAGCAGGGCATCACTACGTAGCCTTTACAAAGATTCCC
CGGGGTTGTAGCCGCCCGTTAGGTTTCCTAAATGCGCCGCACTCCTCCCCAAGGGGCGAA
CCCAAACTTGGCAGAGCGAGCCGCATACACCGAGCCCCATTGACGGCACAACGGCTAAGC
GAACTACACCCCAGATCCTCTAATTATTCAGCTTAGGACATCCCATTTCACCCACATGGT
TGCACTGTTTTCCCGGCCGGTCATCCATAGAACAGGTCCTTACGGAGAGGCACTCGAGAA
ACCGCTCGAGCCCCCTTAAAGGCAACAAGTACAACTTCATAATAAGAGAAGGGAAAACAA
CGTATCATAGATAATCTCATCATGTTTATTGATTAGAGTTGAGCAATAGCATAAAGCTAA
ACAATAATAATCCAACCCAAATAGGTAAACAAGGACATGGATAACAAAAGCTAGTCAATC
CTTAGGTATACATGTGTAAAGCGGGAGGTGAATTAAAGAATGAATAGGACAGAGATAGGT
CAAAGGACACTTGCCTCCACCAACCGACTGCTGCTCAGGGGCTTCTCCTGCGAATACTTC
AGGCTCTTCAACCGGATCGTCCTCTATGCGAGTGCAAACATACATACATCCATCCGTTGA
AATTAGGAAACCAACAGTACACCATACAGAGACAGTAGATTAAACATGCATAGAATATGA
CATGCGATAATGAATTTACCTTGTTAGAAGAGGTGGGGGGAAAGGTCTCGCGGAGGGTTA
AAGCTTAAGCCCGAGACGCCACTACGGGTAGGCGGAGACTT
.
qlt:
8744557:5<8:6?:7554589:<AL=HDA>:88BNIDEEDBKKH<QBFHA>A?BECMGD
;CECIF>?ID>JFIEKT=LTKLK?<JGGTCTJOUAOPLVPGC@CVCGPBPDJCHLOKQLV
UTaRB?LOBLaHKGGHHH<;=GG=<>BGGHGBFQC@VLQQTKKNGLRVQVV[[[OaOWV[
SKLCHJRY[dYCL[[LAHLQY[[KTOTTQTLQSQLST[T[T[R[DL=<T?BJFLTILUAO
EKOLJJ;:KLIHO<JBA<<;;<=AJGC<?BH<F<?<J>=CKICHMO;;>B>@<?IO;gbg
gllUllllllUbllllblllRlellllllelllle_bblbellble[llllelllbeele
l_llllllllee_Z_lellllldb_]VV_Viieeeieeeieiiieiede^_ebeee^ede
eedeeee_e]ee]eeeiebieeiiib_bd^id[ddeei[ii__ee___^eiee^iieddi
^ee^ei^^ei^idViii[VeieeiRSei_eb^YiZbXdiePVe_W_QSV^U]YieWYdee
deU_ZdTQePeXddT^`eiN[Q^iYSS\KYXOSeTi]VPSQ`LSUO^\UIX``LHLP^_K
_`c\T`MHOP]\\K_RMMKIRLMR_SONM\MMTIMMLDc^IQMNM\MOMTHLMHDJMJYL
QLO@MKDFLBINYNMJLMMHMQMNLLMLLDMJMKHJT:FGMMMEMHMATID;NFYNRJMC
TB?MKXMGT@@M;?Q@MLC<7=I<MG>@78;?:<5;?KNFG>N7D;RNOCKCA;759CKG
@:JQC8B?58AQE=6OG>@=8;;6:E?OF8B8I?@\ZTQ>DN?7G678@F>A66AZL<8>
B6?EGCAC@AEFB@99>5479?NHFETGHHI@867@5=595
.
frg:1348
clr:22,876
}
{RED
iid:1371
eid:1638845626
seq:
TTACGTAGCTGACGACCTGCCGCCGAACGGCGGGTCGAACGCGAGGGGTCCACCCCATAA
AACACCAGTTTTAACCACCCAGATTACCAAGTTTTAAAACCCAGTTCACCAATTTGTTCT
CACCCATTTCAACCATGTTTAATAACTCACCGTTATCCACCAGCTTCGGATCCGTCTCTC
TGCTCATCTGATTTCCGTTGAGAGAAAGTCTCTCAGATCTATCGGCCACATACCTCCATG
GTAGGGCTCGCTCGCTTAGGCCGTTTTGTCAGGACGTTTCTCCTCTTGCAGCTCGTGCGC
GCGTGGCTCGGGAGACCGCCATGTGGGGCTGGGTGTCGGGACGTCCCTTTCCCCGCGGAT
CTCGCGTTCCTCCCATCGATTTTCCCCAAATCGGCGCTGAACTCGGAATCCGAGTTTTTT
TTTTGCACAAACTTCGCGAGGGGTGGGTTGCGGGGCGCCATGGGACGGATTCCTCGGGGC
TATAAAGTCGTAGGGCTAGGGACCGGTTCTCCTCTATTCCTCGTAACCCACCACCATTTA
CCGTAGAACCGGGTGGATTGCGCCGGCCGTCGGTGGCACTTCGCGGGTTGCTCGCGCGCT
GCTTTCGAAAGGTGAGAGCTGTGGGTTCGTTTGGTTTCTGTGACTTTAATGGTGACTGTT
CCAGTGACGATTCTCCCCGGGGAGCTATCGCAATTGCTCTCGAACGGTCCGTTTCCCGTT
GGCCGCAGGATGTCATGGTCAGGGGGTCCGTGCGGTTCTTTCAGGTAATAACCCCTTTAT
CGGTTCCCTGGTGCTTCCTTCTTCACAACACCAGTTAAAGGTAGTAGGGCACCTGGGGAT
TTGATCGTTC
.
qlt:
4465545<98665:7787556?66A:89<9:8:8:78657:9799@;98746695:::6<
<;787<<:4B8B647796B:P;<88:4=LG::@FH44;65=@N<75<74<a=5FN575:4
;9=C<@64458<<PT@95<5?<:665;=6<<<:;<PGQ;58HL5F58:9;:B<;45>ESN
kKHB:5\GkkklldNJP@GKUGPU[WH[EEB=F=W[k\PTaddaUWaa[LdRWTTSTKkk
k[kV\TS[LTDNU[L]U[[N<DX==GGJ:F:DS@8HOD<==;BI;4BB=GK?KG[KUBLJ
CHOMNFE[LQGdT[[EMTQSIYgYgTRaYTPA7?K>;E@FAC;>?;AKOO<F>@ECPBD=
?F;O>?::::><:9=>;=CB>C;<;;GCCJUMJDHPS[?ME>KB@8::7;:9E99@8888
8:89:K?G:=:><D>:9AHHZbQEHA=AHHA:=>@@EHHCGNO=IGK=>7H>>8<CFPNK
VPXMPFN@CACLHNA98D8@<C;CACPNLKP<?@LZC?ADLA=8DAEGCEA>>:AD9KDG
E;EAYPP<;FGLJ6MBO8EZ<=CB:7FA:::8?9RQ9<<>>9A<GKM9;887BMC>8<=K
H>C?;:8=PFD=5;LAC<LLQ8HTC>E=8<H<D58:765@:F>6>::8<<LA68;><B5D
?F=HBPH>;M5??D<:89?I\EG;5675:9@;6P?E879=7?8A9:::;=;7::57<CBJ
=E8977IHHCAH:7?ALE77:>KCT:;887579D>>@5:;777:K9>=5:69M>>@565:
6668::?;:NE67;G9P6545954494:547=@AE=<>DJD9@<8>9N9;;;8<;F:775
:554;75553
.
frg:1351
clr:78,836
}
{RED
iid:1372
eid:1609117485
seq:
CTGTGGTCTACGGTGAAGAGTGGTGACGAGCCTTTAAGAATGTCAGGCCAGCACGCCCTC
GGTAAAGGGAGCTCTAATGGGCCCCAACGCAGTTTCTGTGCCAAGTGTTTAAAATGGCAC
ACGACAAAGAAGGAGCCTTAGCTGGTGTAACGCCCTGAATTTGGGGGTAGAATTTTTTCT
TCTTTTCTCTCACCAAATTTAGGCGTTACCCTTTCCTTTTCCCTTTCCCCCTCGCTAAAC
CTTGATCTTTTCCAAAGTTATAGCGGGTTTTGGCTTTAGATCTCGTGTAAAGCAAAACCC
TAAAATGCTTTATTTTGTTTGCCGCACCATGCCGAGCTATGCATTTATTTTGTTTGGTTG
AGATTGTGGAAATCACTCATCTAAAATTGAAGAAAAGGAAAACCTTTTCCTCTCTCCCCT
CCCCTCCTTCCCCATTTCGGCGCAGCCGCGCCCCCCCTTGGCGCGCGGCCCAGCCGGCTG
GCCCAGCCGCCCCCTCCCCTTTCCGCGTGGGCCCCGCGGCAGCCCAGCCGCCCCTCCCCC
ACCGTGGGCCGTCCTGGCGGCCCAAGCCGCGCCCTCTCCTTCCCCCTTTTGGGCCAGCCG
GCCCAACCGCCCCCTCCCCTTTTTCTTTTTCCAAAAATTCTTCCCGGGGGCCCGCCCGTC
ATCCCCTTTTTTTTTCCTTCCCCAACCCTAACCGCCGCCGCCTTCCCTTACCCTAAGGGA
AGCCGCCGCCTTCCCCGGGGCCCCCGCCGCGCCGTCCTTCCCTTTGGGGGGGTTTCTCCC
CCCCTTCCTCCTCCTCTCCTCCCTCCTTCTTCTTTTCCTTCCGGGGGGCCTCTCCCCC
.
qlt:
2334333646CG=44767869>@GU<;BV>@?WiX_NK><HJDDEUeNDFePPZdbe_dZ
VRHVJ@A<@@PGbS_OVel_QZelSLd]bGW]lllMe[]b[KG[bS[blbTdbbblgUUO
Uag_aallalgllOg[Sgg[b[gblOgaa[[bbgbgV__glllg\gga[blabgggglPb
\KblllIgJlJSbYSgbgggYggagglbblggllabggggUM[gllRggggg[V[gagbU
bgggPYObbggPa[gbggb[bVgalbbbggggbOlglUgUgOlOlUg[bg[gKgggbUba
gaglg_gUggbabllggRlldPbbSb[bSl[[b[bbMeOeb[TlllQdllebSlllbQbZ
SPWNeROblZlPbDWMbGHG@SGOlbblbWZ[bZZ[dd[ll_Kl_l_^ZOeOdC_<FC8;
EF_ZWSW_eAl_AP__eNXSJM<H:?D:CHLZVPME@VPTB7=;P:_HTJNH>CAJL<ZP
_=Z@SMKNFM]UUKL8HWDOK8?@A:@9PHVKPIBK?MC>KLPWGSKJGEKNH;D:@<PD
OFJP>ee]OHR>CNPJH:GF?GAN@A7889@G955:6798@98866:NP@HA87:8<9>7
78MF9EFK:LSNQB;5A=;9TTQE8DPT\>5:?GKD>87>:C>DN<;NU>;JHF;?EJ?7
=N89:7;;>@T<J<IBAA5>:<77:5G=GFD<:9E;:=G9@?7;::A:5<7@8MC<<799
<9=7:@57:<9I7H?D=C7<875>77>;C9J8?;<85C7;:><WC9:7:7=5:YC5D7Wc
ccT<;<B5;HB;5==5?=78<K;98:7877:8<VVM::<:8;?<:D::8>658:9C=6
.
frg:1349
clr:21,829
}
{RED
iid:1373
eid:1609117486
seq:
AAGCAGTGTGCCTTTACCACAGCCGTGATTCCTTTCTGCCTGGAGATCATGACTCTCCAT
TGATCACTACCAAGGTGACCCAGCAGGGCATCACTACGTAGCCTTTACAAAGATTCCCCG
GGGTTGTAGCCGCCCGTTAGGTTTCCTAAATGCACCGCACTCCTCCCCAAGGTGCGAACC
CAAACTTGGCAGAGTGAGTCGAAAACACCGAGTCCCACAGACGGCACAACGGCTAAGCGA
ACTACACCCCAGATCCTCTAATTATTCAGCTAAGGGCATCCCATTCCACCCTCATGGTTG
CACTGTTTTCCCGGCCGGTCATCCATAGAACAGGTCCTTACGGAGAGGCACTCGAGAAAC
CGCTCGAGCCCCCTTAAAGGCAACAAGTACAACTTCATAATAAGAGAAGGGAAAACAACG
TATCATAGATAATCTCATCATGTTTATTGATTAGAGTTGAGCAATAGCATAAAGCTAAAC
AATAATAATCCAACCCAAATAGGTAAACAAGGACATGGATAACAAAAGCTAGTCAATCCT
TAGGTATACATGTGTAAAGCGGGAGGTGAATTAAAGAATGAATAGGACAGAGATAGGTCA
AAGGACACTTGCCTCCACCAACCGACTGCTGCTCAGGGGCTTCTCCTGCGAATACTTCAG
GCTCTTAAACGGATCGTCCTCTATGCGAGTGCAAACATACATACATCCATCCTGTTGAAA
TTAGGAAACCACCAGTACATCATACAAGAGAACAAGTAGATTAAACATGCATAGAATATG
ACATGCGATAATGAATTTACCTTTGTTAGAAAGAAGGTGGGGGGAAAGG
.
qlt:
616445675C:769B8:?8BCG86S?Q9J?NMWXQKWPOEQSCNQ@ACE][QLWVWP=>R
JQBLJHNTHZAIPQPJQPQPFFVTIV[ZNX]VMPTKWGIKLO[]VTRP?KLVQWPVNR]X
I7<FHVVKVORONPVRHFOOHHVVRNKRSHLZLGKHPELPPW@EF?:@FCNT7@JJLZSS
L?ZZJLVK@BNNV@8H9?>>H=D9BC8=:8>>9IA87:8888]PFR]PO[[BHLLREEGL
LHVFJCLKONFHJVRPSN]KRNSeZePUQR]MSObPZWZSN[Pb_TFPVbb]Z]b[T_e_
HLS]SEK[_RS]bLL]_HNLSURVQ[]]YRUOHSPKVSLLEACTPJOTQQddSLKTXNNF
QGGVQNFCGLLLIJR<VXVZHURLDJbCINGELVLO?TEBKHObXVTLNPVNUQJRCHNF
ILVVEKH>HHDOTRXEMUA;DULTDLQBOMMX\SQJ>UHQOOUTX`THPLH_dVMUNXRQ
NOJHeWOHMML>TUXUTeWLOUYKJUKSKTUXHXHQNCQYOJKN\e\XDPQ_QQLIDDYN
\H@`NLVINAPNLRTP^_`FONNMWM>_M=;[ITWJMDBOLMMMMWBILM`HKLMTLOFM
DCKBIHEM`PMAERBL8;N=MHNGLGLHKJGIMJD<HK<EMIFMRLDKHLMM=ELJCAK>
Q;MAC7676P<D9JMMELBCBG>LFCGQI7>A@TGJAG<8:M@KAQ?J>D9F7?GLN?MB
>E>I=7=<7?95;5>F7;65H:M>;;77<58DF;KC<7MD@;:FB86JJD9><:??9@?:
C;8:F:7?66>BOC=CNJ7?95=K747858QH45569ADFD:@9>8446
.
frg:1350
clr:9,824
}
{RED
iid:1374
eid:1127298131
seq:
TACTCTGATGAATCAGCTTGATTCGTTATTTAAATCATACCTGACCTCCATAGCAGAAAG
TCAAAAGCCTCCGACCGGAGGCTTTTGACTTGATCGGCACGTAAGAGGTTCCAACTTTCA
CCATAATGAAATAAGATCACTACCGGGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGC
TAAGGAAGCTAAAATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAA
TTCCAACATGGATGCTGATTTATATGGGTATAAATGGGCTCGCGATAATGTCGGGCAATC
AGGTGCGACAATCTATCGATTGTATGGGAAGCCCGATGCGCCAGAGTTGTTTCTGAAACA
TGGACATGGTAGCGGTGCCAATGAAGATACACATGAGATGGTGAGCGATTCTGAAGAATG
AAATAATGAAACTTCCGACAGACATAAAAAAATGCAAACCCCTGATGATGGAACGTTACG
AACAATTACTACATTAGTTAAGTTTAAGGCCCGCTTTGACGAAAAGTCAAGAAGTCAGAG
CGATTAGCTAGATTAGGATCTACCCTGCGTAGGAAGATTATGATTTTTGTTACAGGTGTG
TGGATGCGACTTGCAGGTAATAGAGACTTA
.
qlt:
131358<T@B977967GY\iiKiiY[PbSiN_iiiRDiiiii_HdiiiZTellZllllll
ll<<;8<<:97=<?JVll_lllgllllglllllllllkdkVOUI=G;:BB=FFJJSUkkk
kkkkkkklllkkkkdlllklllllkka\k]lllllllllkkkkkkakdlklkdkWOkWCL
HBCWkkd]klllkklgkaklkkkkklakkkkakdkkddkkkldkkWkYkdlklklkllkd
kkkk[dkaklkkklkkklkkkdkkkllddkkdk]aldTTUUGLNSGI[dl]dWdWLGEGW
C=K=KBBKd=ROUBHCK;CLTWKTL[R=WK?=G=<<<B:9KTO;a==BK;<=J=KB:66:
<H@65=;BD;<===9=C<=<:=H=>H;;CH;;N6<?9:@==88:854;56::B:G<<B9;
<=79?8;>I=<9@D=;B=;::?<=>:F7<=?L==<::K==<<:<9:;LAC=B=;I<B<H9
8<:<>==?:;G;K:>;;:;;EB::=<:9:I;:<9=<G:I@:?<=<;68<:><:49;G<E<
<=:98:;<;<:<9985;::8?=9:=?<;=<I;;<;:<><998888;A:G;::9:8:<G9<
IB8<:B==?8:=9=<;;:G:<=9;9?;<:C
.
frg:1
clr:406,628
}
{RED
iid:1375
eid:1128922814
seq:
CAACTTTGTACTAATTCGTCAGCCTTGCACGATTAGACAATGGGAGACGCTAGTAACCCG
CAAAGGAGGGGAGCGGAACCTTGTTCGGGATAAGCTTGGGAAGAAAACGAAGGGTCCCTA
AATCAATGGTGTCGGTTCTTTTACTTATTAAGAATTTCAACATGTTCTGCCCAGGAATTG
CACTTGTTTGCTACTTCTGATTTAACATATCAATCTGTGTTGACCCTTTGCACCTACAAA
TGGTTGTGAGACAAGTGTATATTTCTGAAGAAAGCATTTCCTTTATCTTAACTTCTTACG
TAGCCGATTTTTGTGCCTCAATAGATTTATCATGCTCTTCTCCCACAAATCCTCTTGCAT
TTCTACCGTATAGTCTTTTAATTCAAGGCTTCGGGAATTCATTAATTATGGCCATCTTAG
ATCTCTCCTGCCCTTGAACGAACATGAGAATCTACTTCATCCTCATCATTAGACTCGACA
TCACTTGAAGAAGCATGTGCACAGTTGCGAGTACATAACGTCTTCTCCCTCCGCATAACG
CATGTGTGACTCTCGTCGGGGAATAGGGTTGATTTGCTGAAGGCGGTGCCGATAGTCCTT
TCATTGTCAGAGTCGGGAGTACGATCAATCCGAGTCCCCCTCCTAGCCAAGATGCCGCCT
CCGCACTTTGTCTTCATATAAGGCTTCTCCTTTCCGCCAGGATAACCTATTCTTGTGCCT
TCAATTGCAGGGAAAGTTAGCAATAACTTGCCTAACTTAACTCTGTGAAGATGTATCTTT
CCCAATGAAGTAATCTTCCCGAAAGTCCTCGGCCTCATCAACATACGATATGGACGTAGT
T
.
qlt:
4444444466457975:77>7776<C@=>A85888:97578<8>97968<67>7=C8;75
76444647:E>::7999;=MI;:CC@:=::=;<;:8:?987875;==;;?=<;G=:85KT
B:=989:;=8G<:=996=<<::=;<C?:;G>B:NGONHD=H=HQL?BCB?=;AA;E<DC>
:88;?<===FB;H?;<:>?9BFG?:;<<:B==H:K;<;<;;=F==L?BG:;@=<@C9HD;
<G<<@AB@=LSB;H>OLGCCG@C<==>;GBGL<S?9?GB?@AG==HLCC98@=<=<==:K
8:<?:<H;====LFHFLEJ<A=;:C<@DH@L><<=;99;CG;B?:9C;:;<=D@?;?999
<<RBD;8>9?D=;:9:C;=>:>:;9:;>EAIM;<9888<@@GAH<CE9>E=E=>KOE>B<
?>:=>G>8:7CAH::A:9<999=7A>:<8:DB@>;9>ALIXKI@CMKC=:=7:7:@ADKH
EG8><>F?>DMB;@AFN;@<A6J>88<A:99DVQFBLHA668:>@6><D><:DE9GDA87
8<7LENKLF?:NND7@:8<9:>G9?:A<FCGK88<F@F<A:8>::87D6;<7585=<<9;
>C;A@A;:C>KQ8G>NGO6;D>G;6>9>=G>QW56H>86?FD?:=C<BAC8H>8:L=?G9
5:>=><>M9D;EGE<5B8=?7=MCA6>D;8AAMMD:795:<8>B;97:@C=>6:<AB6IM
<876=9<<8:57:669HEMEEA8S>>677=8K>65>@B857:<75C6AV>::<A55<>H7
H7A57:>5557@BC:9767<B=6:AAGA88;>6>:T7C6:Q685<<78>;59575<5967
5
.
frg:1
clr:68,820
}
{RED
iid:1376
eid:1127298132
seq:
GCCTGCCTCATTAAAAAACATGCTTGATTTCGTTATCTCCGTATATTTGCATTAGGTGAA
AACAGTTCCCCTCCATGAGCTCCGACCCGATGGTAATAAGACGTCGAACCTCGGTACTTG
ACTAGATTTTTTGGATTGAGACTTATTCTTGTCTGTAGCCCCCCGCCATCCTTCCCTTGT
CGGTGTTAAGGTTATTACAGACGGCCGCCGAGGGCAATAGATGGATGATGTCTGCCCATC
CGGAGCCGACGGGAAGGAGGGCTTCATCAAGACGGACATGGATCCCACGGGCGTGGCTAA
TTATGGCCTGGCGGTCCTCCGTTGGCCCATACAAGCCTTGCCATAAATCGTTCGGGAGAA
GGGCTCCGGGTGATGTGTTATTGACTGAAACCCCCCAGTGTATTTCTTGCATCTGATCCC
TAACATGGGCTGTCTAGACTCATCGCCGGAGGATAATAGATGGCCTCCCATAACAATTTT
CCTCTTCATCTGCCAACAAAAGGAACCACTTGACTGCGTCCCGATACCCGCCGAGCCTCC
ACTTTTTCGAGGAGTATCCTCTTCTCCGGAAACATACTGAAGAGGTCGTGGACTGGCTAT
CTCGGTTCTGGCGTCGACCCGCTCTGCTTTTTGTCCTATTTCCAGTGCCTCTCCCTCGCG
CGCGCATGGGACCTCCCTCATGAACAATCGGAATGTCGAACTGATTGATAGGATCACTCA
GAGTTTAAGCAGAGAGTGCATAGGCCTCCCGGAACGAACATCGATCTTGTACAAAATGGT
TCAAG
.
qlt:
54475:6576777657:7775B78<=67@::6;87:::E?G:>8:9<:78787:8:<@>8
;CCF;;;?:9968998;?H<FG:@P<H;<;<?==<IHCD:?9:?B=9<B==B:<G<;<<9
;;>;:<::==<<BG<<;=F<EEH;<<=G@GGDA=TC;T;M=GKCM;E=<B:=B<B[=<O;
;<:=;9=A<;B:<:=<<<;==<<=:<=<<<<9=>;KB:;:E?;?>B=@BKBHBOB<<I9J
E=TUJHKKGW=K]:<;<>=THIB<=>H:<<L:;<;8=;<<8:<=;:=9<=<98<==;:==
:8<;=;<G=B;==;85<;9:;<G=B=K?<@<8I<;:F=GGI@<8?<IBK==G<F;<T@:<
<;>=KHB?<==C<<<GFB<?=<?FG<9B<:=C==@6O>=G==AGHC?HB=869=<<LA=<
9G=::F=<<<8;<:8G<L<9==?C@;9:7H<=M=8<;;;V<L;88<9B:E>G;==:8:8:
BB8<AGL=BE<?==<<@;<;K<:QD?:HB;L;?868<:=?9<<4>;DGH<HV;UEJNPP:
?=;99=C@9:<8I:<<=9BE<=;<<@<CECPP:SCCBJP::9><>9;G><R:;<EHKC9<
E>?7>;=;9<E=9>99:>>EC>F><999999:=AMDEF<;>;E>F>@>:VN;9=I=;88=
8:<:8H?=>I<=D>E@75FD8>9>A699<<89:;HB9=68C=MC68=8?E?9:7859@D>
D879:>>>8:9:HAAA85>87:=989LI9@>A8>A@>AH68E@E<:<::6>8?><M=H87
B8<8;
.
frg:2
clr:35,781
}
{RED
iid:1377
eid:1128922815
seq:
CATACGATTCTATAGCATTCGTCTGTACCAGGATGAGCAGCTCACTGAGGAGCGGCACAT
TGACCACGAGGAGCACAATGAGGCTGAGCAGCACAATGAGGAGGTGGAGCACAATGAGGA
GGTGGACCACGTGACATGGGACCAGGCCGCACAGCATCACCAGCCATGGGACCAGTGGGA
CCACCAGAGAGAGCAGCAACAAGCGTGGGACCATTGGGGCCAACAGGGCGAACCGGCTGA
CAACCCGATGGATGATGGCTCGGGAGGCTCTTCAGCGACACGCACACGTCGCTCAAGAAA
AAGCCACTCAGTAAAGCCTCGTCACGCGATAGAGCGAGAGGCTGATAGGACTTTAATCAT
GCCACATGGAGATCGGTGAGTGTAATATATTAACTTATCTAATATAACTATTATGTGTAT
TGTTAATGTTTTTGTGTACTGCAGGAATTGGGAGGACCTGTCCTTTGATGGCAAGGGACA
CCACACTCAGGTTAACCTTACGTTGGGTTCTCTTTGCCGCCTTCACTACCCTGGTATAGT
GAAGGTGTCAAACGGTGATACCGAGGATGATGTGCTCGTCAGTACCTGGGATGAGTACAA
GTTTAAAAGGAACGAAACCACACCGACAGACAGGGACTTGTGCGTAATGACTTTTGGGTA
TGAATTCTTTATTATTTTTGTTATGTTTCTTAATATTGTAAATCTATGACTTATACCATT
GTATTTGTATTCTTTATGTGTAGCTTCGATATCGGTTGCCTGACGGAGAGGATTACTGGG
GCACGCTGAACGTGGTCTTGCAAAACAATGCAAGATCTGGCGAAGATGCATATACTATGG
GAGAATTCCGGCTAACAAACCC
.
qlt:
4010100200300<004002042D100600026312090010B08E000<5065000K00
000010200012423600BG00J0H0=0B00N0D00=000060A000100122=?20130
0@400=050=0500K03200>0806?0E000E0070I00D007?60H0000060D06003
000G000L0I0J0<00D00H060D0::005030B00005060400080=0>00:000Y00
0025510A=000;=00000E000G0030E0;0A00@0>00;0005070N009C0040M02
0909708:0005?0A076300900;0207@00[0?0700090D0F000A80=0000@00B
0000?0B0070E30000:;0E000840<0100004090000860B0?010;00<00600B
000:041101507000;0870000=?06;000F0600@2000310203;07003280@00
<;0<02E000I50000709000B00001?=000000270687000E=00C3:00B0500A
0050;5<2000:A00504;0500D0@F0000=4809009200>4519000@0000<0308
6<01001<08;0>0@050;090>=0000=@00B000C320002220<9100F060:00>0
70140800L00592026009090?04000070940K0007?06040094057060470O0
00>0>0091H0<0G00700103023060I00?00050A0072707040681709003668
00800370H000B040<0@1003D080;5:0350D01:0:001C0107802<006038:0
0C0D0600080030800>0000
.
frg:2
clr:22,845
}
{RED
iid:1378
eid:1127298133
seq:
TGGTTCTGATGAATCAGCTTGAATTCGTTGAACCATTTGGGTCAAAAGGACCGGCCATGA
TGGCTCACGGATTCCCTTGGGTGGTGTCCATGGCCTCATCGAGGGATTCAGATGAGTAAT
CCATCGATGATTGCTCGCCAGTGTTGGGTCACGACCGTGTGGCCACGGAGCACCGTGGCT
AGGAAAATTTGTGCCACAAAACCTGGTAAGAACCCTCCTCACATGTTCATTGTTGGATGA
TCATCATTTGGCATCGTTTTGATTAGAGTTTGGCCGTCGGGTCGCGGTGCCGGTGGCCTA
TGCCGCCGTGGTCTGGGCACTGTTGCCCTGTTGTTCGGCAAAGTGGAGGAAGCAGCACCG
TGGCACGTCAGATGTGTGGCCAACGGTATAGATTGGGGGGAGGTTAATACCTCGGGTGGA
CCATCGAGGACTGTTGATCCACTTTCCAAGGGTGGAGTCTCGCTCATCGTTATTTCAAAT
CCGGCACATTGAATCTGGATCGGGGGAATGGAGACGCATACCAATTCAGTGAGTAAATTT
TCTAATCCTATCCGTGGATCTCAGATCCTAAGATTCAAGCAGTGATCGGTTTACTACTGT
CTAATGACTCAATTCTGCTTTGAAATTGTATCTTCTTGAACAATCTTCCTTATCCCCCCC
TCTCGCCTGTCTCTCGAAAGAAGACCCCGTTGGGTTTTTTTTATGACCCTCAATCCAAAC
CGCAAAGGCCCGCCATTTCAAATCCTACTGAATTATCAATCATCCCTATC
.
qlt:
12213845:AD<7;=77\^^Y?8@iiMRiYG8PPGiiii__]XLeii__MWilllWKll[
[lb_779<97459:;?gggggglgglglaallggggPkll[lkk=H:=:59CJLUJTlll
lgglllllllllllllllllllllllllllllllllllllllllllllklllllllllll
lllllggllllllllllllllllllllllllllllllllllllllllllllllllkklll
llllkllllllllllllllllllllklllllllllllllllllkllkkllllllllklll
llllllllkllklllglllllllllllggllllkllklkkkkllllkklllklkdlklll
llkkkllklkkllllllllklkllllklll[kkkk\klkklkk?D=BTIGGTK@KGWdUT
NGB<KCCOBHBKT<KLTKKE:==9?GCJ?GU==QJC=?ECN;SEG=TOB?ELHH?H<KBC
H;<;:<:<<A<;<CK:B;<;;:C<9;=66@9B=?PL[BK:D;:<?BC<<FFB;9AC?BHO
GCF;B:<=D=;CH;=B9DH<=G==V<;=<T?<K<=<<;;<:8;<?;=GC;?;=<<<;9CK
;<799@=686:8?=<<@;:<;<?=?<??A=A:;9>@;>99<<;CC<?<:9;CK@<<<UID
SMI>:>9<><<=<>;9>B;9><:::=;;9BC?I9GF>B;;9A;<BS9?:IBB8;<<7899
88?;7M>97:9@989AA;88A=99:F<:98:8997:88:577:7:D@8:8
.
frg:3
clr:8,746
}
{RED
iid:1379
eid:1128922816
seq:
CCATGACGATCTAGAGATTCGTCAGGCCGCACGCACACGCCGCGAACTAGCCGTGCGCAC
GTCGGGGAGACACTAGCCGAGCTCAAAGCCGCGCGCCATAGGCACACAGGGCCGAGCTCG
AGGCCACGCAGGGGCCGACACGACGTGAGCAAGGCGTGGCGGGGCGAGGACTGCTTCCGT
TACCAAGTTCGCGCGACGCCGGGGCTCGAGTCTATGCACCTAGAGCCTCTGCTTGGTCTC
CGAGTACCTGTTTTCCAAAAATTGTTCTCTCTCTAGCACCTCCTGAACTGCACTAGTTAA
CCTTTTTTACACTTTTTGCCAGGCTCTTACATTCCTCTCTCATTCTTGAGTTAAACGGCC
TCTTGCCATAATAATATATCTGTTGACTCAAAAAACTTTACAAATATTCTTTAAGGTAGT
TTCTTCTTGAATATTGTTAAATTCCGGGACGACGAATACCTGTAAATAATTAACAGATCA
ATACCGTGACGGGACTAATAATTCCCTTTATTTCCCATATTAATCTCAAATCTTTAATTT
AGAACAAAAATAAAAAAGAGCTTCACCTTAACCTCCCGGAGAAAAGCTTTCATTATTAAC
CTTCTCAACTTGACAATTTTTTTATGATCGGTTTTTAGGGGTCTCACTGGGGGGTATAAA
ACCACTCAAAAAAAATCGCCCCACCCAAGGCCCTCCATAGGGAGATTCGGAAGACATGCC
CACCCCCCAAAACTCTTTTAGGGTTTTAGAAAC
.
qlt:
745?46:7:::===K@A;@UHZN<bi=__R?S]XH[=b@KA87;>JHKFKOaUUbVbTOd
U@l=A?6594444<;KFTKkWQkVQ[d]klkkkllkkVVVGL589699;:=;;==B=\[P
gTkdTM]K\KLSYaTQBSH=W?aWENWQVSGKK\FHN]TKUKKC==HCBGG:<;:9:<<B
B<==@=976=;;::8=<<B:B;=:85:<?B<9;78;4;<<;<9;:9:F=8<<76;8F;:;
<?;?=<:8=H5:7<=?<<F6:9;<;<998859:H>:888<89?:;957;88<FD=:<9::
8B=99<;?<<:;=:7;B<@6?6=8BBB9986<8A<:;:7<===<9<86668<;;<<:<9=
<<=9<::86;;;=C99<==:<9;85759;<;::=:<999<<=A=<:<:==8<8<<<?<;:
B=89:<<9=:=<89<@?:8;:<>:67:9;:6;8<88<:89=8=:>:=:<<<B<<<:<;:8
:;=<<==::578:=:B89BD?<<8<9;::<<9=<?:>6;;8=F88;<;=:?<9:<=:<:<
:<;;<=F?<99BB=;?;67:9==<:9=86;<<;99:8:74:;88<:9<8:<;:=<@=:55
9::?;?=><N=;:<;;;;8;<9?<;;;<?=;;:9?<9:?<><@:;CCB;?FF<<<=<;B<
<<;;9K<DE=M<>G;;A:>>:;>B>>A<GE8:9>;9:>:8;>AB<>=8;;8D99@:>88:
==K>GL;;:AA><8;:E=:F8B=B:=8:=68:8
.
frg:3
clr:8,748
}
{RED
iid:1380
eid:1127298134
seq:
TGCTTCTGATGATATCAGCTTGATTCGTGTTGGCATCAATCACCAAAAAGGGGGAGATTG
AAAGGGAATTAGGCTTACACCTAGTTCCTAAATAATTTTGGTGGTTGAATTGCCCAACAC
AAATCTTTGGACTAACTTGTTTGCCCAAGTGTATAGTATACAGGTGTAAAAGGTTCACAC
TCAGCCAATAAAAAGACCAAGTTTTGGATTCAATAAAAGAGCAAAGGGGCAACCGAAGGC
ACCCCTGGTCTGGCGCACCGGACTGTCCGGTGTGCCACCGGACAGTGAATAGTACTTGTC
CGGTGCACCAGGGGACTCAGACTCAAACTCGCCACCTTCGGGAATTTCCAAGGCGACTCG
GCTATAATTCACCGGACTGTCCGGTGTACACCGGACAGTGTCCGGTGCGCCAAGGAAGGT
CGGCCTCGGGTTCGCGCGGCAGCCGCTCCGCTAAAATTCACCGGACTGTCCGGTGTGCAC
CGGACTGTCCGGTGTGCCAGCGGAGCAACGGCTCCCTGCGGCGCCAACGGCTCCCTGCGG
TGCATTTAATGCGCGCGTAGCGCGCGCAGACGTCAGGCACACCCATACCGGTGCACCGGA
CATCAAACAGTACATGTCCGGTGTGCACCGGACACCCAGGCGGGCCCACAAGTCAGAAGC
TCCAACGGCTAGAATCCAACGGCAGTGATGACGTGGCAGGGGGCACCGGACTGTCCGGTG
.
qlt:
44444;78@>A@89;966ll<@:9>B_lllllad[lllllkllkkllllllkkkkkkVll
lllkkTYOV\K=]llkllkllkllllllkglllllllllkllllllllllkgllllllll
llllllllkkllllllllllllllkllllklllllllllllllkklllllllllllllll
lllllllllllllllllllllkkkkllllllllkkkllllllllllllllllllkllkll
kklllllllllllllllllllllllllllllllllllllllllllllllllkllllllll
llllllllllllllkllllkllllllllllllllllllllllllllllllllllllllll
llklllllllllllllllllllllllllllllllllllllllllllllllllllkkkkll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llggllllllllgllllllgllllbllblellllbllllllllllblllllllllllllN
DledZlllleedeeiiieibi__iieeebi[eiieeiieeeieeeeediiieiiedidid
Xeed]YieedeeeXXiieeidbieeZZW_R_RKX_eXeWdeeiQUWXTXSeS`XO:ceEe
ee\NKYN_O_XI\OL\ONWNEHMNW][;9C8<MT]^MUO`^_TMMM[HEM9BKMMHCJ>?
.
frg:4
clr:8,718
}
{RED
iid:1381
eid:1128922817
seq:
CGATCTAGAGATTCGTCCACCCTTGCTCTACACACCAAACCCCCCCCCCAGGTTGTCAGC
ATCAGCAACCACTGCTCAGGCGAAGATGAAGCTGTGGAAGGAGACTTCCAGGAGTTCCAA
GACTACGACGAGTTCTAGGTGTGGGTTAGCGGCAACCCCCCAGTCGGCTGCCTGTGAAGG
CCGCGTTATCTACGTTTCTTTTCCGCACTTTGATTTATTGTAAGAACTATATGGACGTCT
TAGACGTATGATGTAATCGACTATTTCCCTTATTAATACTATTTTGAGCACTGTGTGATG
ATGTCCATATTATGTAACTGCTGTGTACGTGAATAACTGATCCTGGCACGTACATGGTTC
GCATTCGGTTTGCCTTCTAAAACCGGGTGTGACAGGGCGTCTTGCCGCAGCCGAAGCACC
AGATCGCCCACCTGGAGGTCTTGGGACCGGACCCCTCGGGCGTGGTAGCGTCGCAGGGAC
TGCTGGTACCGCGCCGAGTGTAGTAAGGCCCTGTCCCGAGCCTCCTCCAGCTGGTCCAGC
GATTCTTCTCGGCTAGCTTGGTTGCTTTGATCGGTGTAGGCCCTCGTCCTCGGGGAGCCG
TATTCCAGGTCAGTGGGCAAGATAGCTTCAGCCCCGTAGACCAAGAAAAACGGCGTGAAA
ACCGTGGCACGACTCGGCGTCGTCCTTAGCTCCAGACCACCGAGGGGAGTTCCTTCTTCA
CCGCTTGCCGACTTGTTAGAGGACGATGAATGCGAGCTGAGCCTTGAAAAACATGCCGTG
GACCTCCTGATGGCCTTCACAGTGACCACGAGT
.
qlt:
7458@;J@?78<Q`JQQD8Kii^iiUi_WNN<PDiB>iillZZ_llllUKlllll[_>7;
89756697956UMOMlVUlglgll\g_gllllllgglll[gTCRH[[lkkklllllkkal
llllllllllllllllklllllllllllllllllkkllgklllllllllllkllllllll
lllllllllllllllllllgllllllllgglllllgllgglllgllllllllllllllgl
llgllllllggllllllllllllllllgglllllllllllllggllllllllllllllll
llllllgllllllllllllllllllllllllgglllllllllKbllllllllllllllll
llllllllelllWllllllllllllllllbllblllllllllllbllllblllllWlell
eblle_VU_Wblllll_VZee_ieeeRieee_Z___e^__ee]_i]e_iebeQ]]LiidN
ei__idZd]e]b]__GiBWiNeLReNdeA[[_i]]^_]iK^^bd]]b]OTZei^J^ONVe
]YR^WZibbXeeSUeBRiLd87YdEei^YUXXXdOeFX9RHVYQUHFNXUXJYVX_>FQH
>>9AOMKAHGE?AFXWSNNOEWIPF`NNK?KLNNPAKW5]@MAEGUOO]5:@A>@MSA\M
6=I>><>BHGGYCME>MLILL>BMHJF<97M@J=6@;J?@AMT<NLAN<AI:A9N<7;JD
EEN?D>B;>ETECBP5@68<5L57559<8445756<<K=655=55<:77N695>H9:=65
:56399<766BF79C4>@;5544874:7<G<75
.
frg:4
clr:4,741
}
{RED
iid:1382
eid:1127298135
seq:
CACGTCTGATGAATCAGCTTGATTCGTTGCCAGTTATCTAACGCTTTAAACGGCTTTTAC
TGCATCGGCGATGCGGTGTGCAAATTCAGTCACCTGCGCTTCGTCTTCGCCTTCCACCAT
CACGCGAATTAACGGTTCGGTGCCGGATTTACGCAGCAACACGCGTCCACGGTTGCCCAG
CGCAGCTTCAACCTCTGCGGTCACGGCTTTAACTGACTCATGCTCAAGTGGATCGCCGCT
ACCTGCGGTGTAACGTACGTTAACCAGAATCTGCGGGAACATTTTCATGCCGCTGCAAAG
GTCGTGCAGGCTCATATGGTTACGTGCCATCGCCGCCAGCACCTGCAAGCCAGCAACGAT
GCCGTCACCGGTAGTAGTTTTATCCAGCAGGATCACATGACCGGAATTCTCTGCACCGAT
ACGCCAGCCTTTCTCCTGCATTTTTTCCAGTACGTAGCGGTCACCCACTTTCGCGCGCGC
AAATGGAATTCCTAACTGTTTCAGCGCCAGTTCAAGCCCCATGTTGCTCATCAATGTACC
CACAGCGCCACCACGCAGCTGGCCCTGACGAAGACCTTCACGCGCGATGATATACATGAT
CTGATCGCCATCGACTTTATTGCCTTCATGGTCAACCATAATCACGCGATCGCCATCGCC
GTCGAAGGCAATACCGAGATCCGCTTTTTCAGC
.
qlt:
31344979]=?:89:66bi:<:7:=U_el]NAlbVbQbUSb[b_llSalllllbllgSdg
lla>;=;;897;KGHSklllklllllkkllkllllllklGHFL<B<=G=<<<LSTV]lkl
lllg\gg\glllllllllllllllllllllllllllllllkkag\[kkdlllgklllllk
llllkllklllllllllllllllllllllllllllllllllllglllllllllllllllg
lllllllllllllllllllllllllllllllllllllbllllllllllllllllllllll
llllllllllllllliiiii__eiiiieeiiiiieie^ii___U__eiiieeieiiiiie
iiiiiibdiiieie^ieeii^e[iVS^iiNiVO^eeWiiiUieiY_UieiieibbUieid
_eWdXTeeieiie`ieeiSTYiYYii[YQeW_Xe\eUei]T\]UieSeiiieeee`c_`_
Nc_O]]PPO[JUNM]NPc>^]OLP^\M`LWM^MKMQMccNMK[BXUK\QQMWENM^JMLc
UMNLQ[[S[@MQQVKMOIVRMNGcJIVQDC^W<XC[LNMIOS[KMGT?MS>NJMLIMQIC
MGMHNLCCIOQRCMHO\GMB:T;D?GHAKGI:LBC?FELFNCMORLNBMOC;;DKQM9@=
@@N?ME<>9R?AQLV987CFRPLHO\\\FEH>G
.
frg:5
clr:8,691
}
{RED
iid:1383
eid:1128922818
seq:
GGGGATCTAGAGATTCGTCGATTATCGGTCGCCTGGTGCCGGAACACGATCCGGTGCACA
AAGAGACGATTATCCCACGCGGTCGTGCGCTGGGTGTGACTTTCTTCTTGCCTGAGGGCG
ACGCAATCAGCGCCAGCCGTCAGAAACTGGAAAGCCAGATTTCTACGCTGTACGGTGGTC
GTCTGGCAGAAGAGATCATCTACGGGCCGGAACATGTATCTACCGGTGCGTCCAACGATA
TTAAAGTTGCGACCAACCTGGCACGTAACATGGTGACTCAGTGGGGCTTCTCTGAGAAAT
TGGGTCCACTGCTGTACGCGGAAGAAGAAGGTGAAGTGTTCCTCGGCCGTAGCGTAGCGA
AAGCGAAACATATGTCCGATGAAACTGCACGTATCATCGACCAGGAAGTGAAAGCACTGA
TTGAGCGTAACTATAATCGTGCGCGTCAGCTTCTGACCGACAATATGGATATTCTGCATG
CGATGAAAGATGCTCTCATGAAATATGAGACTATCGACGCACCGCAGATTGATGACCTGA
TGGCACGTCGCGATGTACGTCCGCCAGCGGGCTGGGAAGAACCAGGCGCTTCTAACAATT
CTGGCGACAATGGTAGTCCAAAGGCTCCTCGTCCGGTTGATGAACCGCGTACGCCGAACC
CGGGTAACACCATGTCAGAGCAGTTAGGCGACAAGTAAGTTCCCGCATCAGATGACTGTA
TTTGTACCGAAACCCCGGGGCGTGCTCCGGGGTTTTTTCTATCAATTCATACCAGGGATA
CATCATGAAACTCTTTGCCCAGGGTACTTCACTGGACCTTAGCCATCT
.
qlt:
6556677==B?<=:T]IVeTK>KECllOEl_PlllllllllggKWIllllllllllVOQ?
9974799gkkkklllk[lllllllllllllllllllllll\NY\\d]lllllllllklll
lllllkllklllllllllllllllllllllllllllkllllkklllllllllllllllll
llllllllllllllllllkklllllllllllllllllllllllllllllllkllllllkg
ggllllllllllllllklllllllllllllllllllllllllllllllllglllllllll
llllllllllllllllllllllllllllglllllllllllg\gllllgllllllllglll
lgllllllllllllllbllllllllllllllllllllllllllllllllllbllllllll
lbllllllllllllllllllllllllleeliiiiiiW_iieWiiiiiie_eeiiiiieii
ieeiiiiiii_iiiiii]iiiieeeYiieibeiiiieeeib^ieeiRdYiidYi_IQiid
dYS_Viieibiiebibbdeeei^YVSeeiiide^YVeeQiOQ]UeieeeX\_YK\SKQXi
\Y^UMV`NP\N^]N^MOTPH^^MWK`W`MMMLMT``L\MMEQOONMMXYLQLMY[M[PMW
TN[WMNMNLMNGLYMOI>^8MOQRWH?<JK[BDGMSKOLRONVBLKMTQD6N>QJGLV?L
DTIH=C@DLVVVFPJD?VTK@JDNBQDEB\M66\\\TC777?O?8:BE<JMCDC=Z@<5?
7:JE<@CCZ=<NCBZ??=L@CGZH=L=C@;==?>B;:=?BD7F=;@K5
.
frg:5
clr:7,826
}
{RED
iid:1384
eid:1127298136
seq:
TGTGTCTGATGAATCAGCTTGATTCGTTTTCATCCCTATGGAATGAGCGCTGCCCCGTAC
ACATGTTGGCCCGTGTTTGTTATCCCAATCAATCTCCCCCCTGGTGTGTGCTTTCAAAGG
CAGAATATATTCGTGTCGTTGATAATTACCGGACACCCGGGGAATAAAATGGGCGTGTAC
ATGGAGCCTTTGATCAATGAATTGGTACGTGCCTGGGAGGAAGGGGTATGGACGTATGAC
CGAGCTACGAAGACAAACTTCAGAATGCATGTTTGGTACTAGTACTCCATGCATGACTTA
CTGGCGTATGGGCTATTCTGCGCCTGGTGTGTTCACGGTAAGTTCCCATGCCTAGTTTGC
AAGGAAGCTCTCAGGTTCATTTGGTTGAAAAAGGGTGGCAAATATTCGTCATTCGATAAA
CATCGACAATTTCTCCCTGCTGACCATCCATTCCGCCTAGACATCAAGAACTTTACGAAA
GGTGTCGTAGTGACAGACTGCCCACCTGCAACGATGACTGGTGCCGAAATTCGTCAATAG
ATAGATGGGCTCGTGGCCAATACAGAAGGTGGTTTTGTGGGATATGGTGAGCAGCATATG
TGGACACATAAGTCTGGCTTAGCTCGGCTCCCCTATTATGACGACCTGCTCCTTCCACAC
AACATTGACGTGATGCACACTGAAAAGAATGTTGCTGAGGCACTGTGGGCAACAATTATG
GACATTCCTGATAAGTCAAAGGATAACGTGAAGG
.
qlt:
31345>7;P<B:7:;77^_ii_LiiWZlDED9HUlllllll_aVllllallllllllklk
kl>?<;;77:MKLHlklllllllkkkklkkkllllkgkllllkW=HGGGGBJ\gkdkk\k
klkgkllllllgkllllllllllllllllllllllllllllkklllllllllllllllll
llllllllklllklllllllllllllllllllllllkkllllllllllklklllllllll
lllkllllklldllkklllllkdgglllllllgllllllllllllkklllllllllllll
llllllllllllllllllllllllklllllllllllllllllllllllllllllklllll
llllllllllllllllkklllllllllkkllllklllllllkllllllllllllllllll
llllllllllllllllgkllllllllllllllllllllllllllllllglllllllglll
lllllllllllllllglllllllllllllllllllllllllllllllllllllllll[ll
ldllllllllllllllllWlllllliiii]iZ_iiic_iiiZPd_i^Viiieieebieei
eiieebieieieiiiidbideLiiie[bieiiieedUeY^VTVeVeeieeeeVeedVddd
Ii``d^^RXXeeQQeUUdi^ei^iiiHQ]L[GeiUeX\>^N]Y_cNNJcYUcQRO_QSM]
UMNKX_PYM_`DHPMWYIcYBJMDDGMQSTPN=;
.
frg:6
clr:5,752
}
{RED
iid:1385
eid:1128922819
seq:
TGACGATCTAGAGATTCGTCTATGTCGTGTGATTGGAGATCCTCAGCTGAGTATAATCGA
TTCGGATCGGCGTACCTTCGCGGTTATGAAGACTTGGTCACTGCCCTACACGTAGCATTC
CACTAAAGACAATGGGCTTTTGTAAAAAAATTGGCTAGTGCAGGACCAGTGATTGAACTA
GGGTAGAAAGAACTCTAGTGCAGGTAATTTTACTTAACTTGACAAATTAAAACTGGATTT
TTAAGGATCCACTTTAGTAAGCATTTCTGCAAAATAGAGTCTTTGAATATTGAAAAGCCT
TACCTTGACTCCCATATAACCAGCATACCCTTGAGAGTCTTTTCTTTAGTCGGGTAAGAC
TTGCTGAGTATTCCATACTCAGGGTTTATCCCTTCGTTGTTTTTAGGTGCGGAAGTAGCA
GACTTTTGCTGCTTCTGTGCCAAGGTGGTTCCAAAAGAAGAAAATCAAGACTGATGTGCG
GGAGGACTCGGTCCTCCACCTAGGATCTTTTGCTTTTGTCTTCTCGGGAGGAGTTTGTGC
CTCCCTGGTTTGTATTATATTAGTTCTATGCACTCACTTTTAGTTTGGTCTGTAATAACA
TAACTCAAGCTTGCTTTTGAAATAAATGTAAGATTATGTAATTCGCTTCCGCATTTCTTT
ATCTCCGATGTTCTGTAATGTCTACAGATGGGTGAGACGTTCCTGGTGAGGTAAGGAAAG
ATACCGAACTTGTCAGTAGTTCAGGGCACCTAAAGGGTTGTCTGATGTCATGACAGACAC
TGTAGTGGACTATACTTGGGAGTTCTGTCACATCGACTGACGAAATACTTCATACTCTCG
TCGC
.
qlt:
845776:8;A886:;RRELMCFAITZAIdNWI?JWMSKKIWMHH;;AP][EVSKLB<>9:
7897789<IDJKAC?@DAgTdgdaXYTO[GD[daakU[[KUTaFIIKFPQ]Y][LV[add
UV[[TUkdl]Ud]k]aTddddkaYWaa[a]kkTPQa]QLk[]]kk][POVaUYad]Wd[[
Qkk]kTk]]Ykaakl][QYk]V]kS[]aTTdaddkaTd[[[V[OSY[[[OaakkkT[[dk
ggdd[lggdgddddRTGaddUdaddaa[lgdgddddRgUababgb_aabbabbaVbS[bg
ggbgggl_bbggV[gbbaabbS[S[]][S[[[[[Ib[[b[bbbbKIVSAPbSSMSWWLlb
bPbMOQbVXb]Z_]S]b]ZVOHbWRZV]]ZZZ][]PN[_VZ]__dS_]_PJI_PLXRHde
]e]]]]Ueee[[]W]VdN]NTDPV_Ze_K_bYCUURZ[SFi;>[YbTQOeZ[edVdXbX\
bN^Jb_LUUPZZebZYXLW^\Y:SRQTOdXWdZZQNUePSX\\U`HWUeUYeFNQPXRPO
KNO`_O\[Y_N[:XNLVWOON]>OM`NMMYNMT^MUUM_\MT>MTPWHEWBR9MFISMM>
MMMOMB:A@MKKXMLYTNKMOGD>?BA^CJL8^@FMLG>TMIMJGEFIEOM@@YOCE=YC
BG@?AY?R?LJ?F@NCLCCP6H:=A@5C=GVFDJO7H>?ECBG@LO8DDCQ>LDG=DSB9
87=DE6IEHQ?F><N6;G=;=846>;:7;E87434A9>7:56<EB7EIH8M636;356=6
?:5;36:425:GC5669GA43;6544:?>8:7;:F?;DHA5:@K9?:3A694594;569:
7694
.
frg:6
clr:8,825
}
{RED
iid:1386
eid:1363736519
seq:
ACCATTCGGGAATGGACGGAATTAATTCATAACTCTCGTCTTTCCTGGGAACGACGGGAA
ATAATAAAAACACCCCTCAGCCAGCAACACCGACGGGAGTTAGCCTTAACAAACAGGGGG
CCACCTTCTAGCCGACGAGAATTAATTATTCCCGTCAACCGCCGACGGGGATAAACTTAT
CCCCTCCCTGGAGACGCCTGGGGGCCAGAAACCGACGGGAATAAGCCCTAAACCGACGGG
AATTACTTATTCTCGTCTGTTTAGGCTTATTCTCGTCTGTTTAGGCTTATTCCCGTCGGT
TTCTGGCCTAGGGGAATTATTTGAATTCCTGTAGTGAAAGAGGCGGTTTTTCTTTGAGGC
AG
.
qlt:
1111134334566876448;:?O?54=57C<57<<GP97:998476EITE?;AM?TN=99
HMC98654454445546H9DH=7<:::8R^YiidiebPYdNUeR7675545555685:?:
8@CPRZ__OYe_____diZ__d__O_ll_ZbWVbPQHCVZbHLbLIHbLaSQUMggllg?
=9757689576=RHHWTgllllllklklkkkkkllkkkSkkk]VVVUKX]S\dHLKB:D<
\Ykkk[]T\kd\dTP;HFUGQQkkkkkkd\EBBB66:=J@6KMP\dkd\]]KMKPBH[KJ
U<=9J<BMNH8KPDK7?J76<FPF9?KHF=UBG==E6<<?;LB::I@8BK=P?G;=5=B<
86
.
frg:6
clr:19,359
}
{RED
iid:1387
eid:1127298137
seq:
TGGTCTGATGAATCAGCTTGATTCGTTCAACTTTGATCAAACTCTAGAGGATATGGTCCC
AGAGGATTTGTTATCAGAGCCTGTGGATGTTGATGCAACAGAGATCTGCGCTGCCGTGCC
TGATGCTGGGTTGAGGTCATCCCGTGCCTCGTCGACCTTAGAGCGCGATCTCGAGGGTCA
GGATGCTGACTTGGATTGTCCTGGTCCCATGGAAGTGGCTGAAGGCTTGTCAACCTTAGA
GGTGGTTACTGCAGAAAGCCTAGGCCCCAAGAATGGTGCTGACACATGTCCAGCCCCCGA
GGATGTCGCCAGGAATGACTTAGCTCGGGCGAAGAGTGTAAGTCACTGCCCAGTGAAAGG
GAAATGTGCCTTTGGGCCATTTCTAAGTATTTTGGTGATTGAGTGCAAACACAAGTGCTT
AAATGTGAAAATATGCCCAAGGATGAACAAAGTGTAAATCACAAGTTAAGGTATGTTTCT
AAGCCTTAGTACATTGGTTTTGTGTACTAATGTATTTGTCTAAGTGTTAGAAACAGATAG
AAGAAGAGAAGAGAAGACTTGGCTGTGTAAAGCCAAGGGGCTGCTTCGGTCTGGGGCACC
GGACTGTCCGGTGGTGCACCGGACAGTGTCCCGGTGGTGCACCGGACAGTGTCCGGTGCG
CCAAGCTGCCTCGGCCGAAGAGGGCCGCTCTCGGGTTTTTCTCCGGCGGCTTCGGCTAAG
ATTCACCGGGACTGTCCGGTGTGCACCGGACTG
.
qlt:
43448==Q@G969:79WilllUllV_lT;ElllllaaaLlllllllllllkLlkllllll
klkRTHXkSPTallkkllllllllllkklllllklllllkllkkkdSSYUdlllllllll
llkklllllllllllllllllllllllllllllllllllllllllllllllllllgklll
llkkllllllllllkllllkkllllllllllllkllllllllllllllllllllllllkl
llllllllllllllllllllllllllllllllllllllllllllllllllkkllllllll
llklllllllllklllllllllkllllllllllkllllllllllllllllllllllllkg
klllallllllllllgllllllllllglllllllllllglllllllllllllllllllll
lllllllllllll_llllllgl__lllllllllllllllllllll[lllb_el[llllll
llllllllWlllbllleeiiic_eeieeZiieddZiiibiieieie]ei]iieeddieie
iiZiiViTiiWiUiiZiNdiiieiibieeiiX_iRebii^ieROedXM[QediiiiRXSi
WUOD_eXUQMiOc]O\KNNQUX^LVLI^NE]M@J?Q[N`CMMTGD[IMSL^LLUHQHNMQ
WPMP;EMNHMJMM9:M=I=:O9W<ENLNXMNMMcMW[YYQI?BNF688576:DJHMMN:7
A=MC;<<=>55>FP?LIB?7:7;76FAI9IB>;
.
frg:7
clr:5,751
}
{RED
iid:1388
eid:1128922820
seq:
AGATCTAGAGATTCGTCCTTGCAATTTTAGCTTATCGAATTCATTCTTGCTAGTCTTAAG
TTGAGCATTAAGACTAGCCAGTTCATCATTAAGCTTGGAAATTGAAACTAGGTGTTCACT
ACAAGCATTAATGTCAAAGTCTTTACACCTAGTACAAATTTCAACATGTTCTACACAAGA
ATTGGATTTGTTTGCTACTTCTAATTTAGCATTTAAATCATTGTTGACACCTTTCAAAGT
AGAAATGGTTTCATGACAAGTAGATAGTTCAAAAGAAAGCATTTCATTTCTCTTAACTTC
TAAAGCATAGGATTTTTGTGCCTCAACAAATTTATCATGCTCTTCATACAACAAATCCTC
TTGCTTTTCTAAAAGTATATTCTTTTCATTCAAGGCATCAATTAATTCATTAATTTTGTC
TATCTTAGATCTATCTAAGCCCTTGAACAAACATGAATAATCTACTTCATCCTCATCACT
AGATTCGTCCTCACTTGAAGAAGCATGGGTAGAGTTGCGAGTACATACCTTCTTCTCCCT
TGCCATAAGGCATGTGTGACGCTCGTTGGGGAATAGGGTTGATTTGTTGAAGGCGGTGGC
GGCGAGTCCTTCATTGTCGGAGTCGGACGAGGAGCAATCCGAGTCCCACTCCTTGCCTAG
ATGCGCCTCGCCCTTTGCCTTCTATATGCTTCTCTTTCCCTCTGTTTCCCTTTTCCTGTC
ACTTTCATATCAGACAGTAGCATAAAATGACAGCTACGCATTTGAGCATGATCGCTCCCT
GTCTAGTCTGCTCGCTGTCATGCGCCCTTTAGCACGTCTGAGCGCTTATG
.
qlt:
445669>=:767NOQQQDR_iIDSJiiDLQeiL_QiNRUViK>cllllllVPllllUbKM
bl_H_bll_lllllg[llVVlllLPl_Wl_llllllllllllllllllgallllllg[la
laglllllllglllaallllllllllalllllalggllllladlllllllllllllglll
lllllllllllllllllggllllllllllllllllllllllllllllllllllllgllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllbllllll[WlllllellUlllllelllllllllllllllllllll_lieiii_J_i
ii_iiiiiieiiiiieieiciiiiiieVeieS_Ziieiibiiieiiiedeeiieiiiibi
eiiiidi]i_ieiiideiei___iiiiddiieeii[SVi[[ibie[YdY^[YeeWeddbb
dWdTee[e^Viedei^eR^OieLeXViYYVeUiWUd^TUiVU\NSe\QINXeJUeYU\JU
UeLXHUQT;^ENRcI]__[HPX^V_F\\^]OKMM\DcTIWYI6^PH;NMN><@>TW@[[M
Q[MEY>IJSLMMLMMYGMHLY9JMOOQ>CPG=^?MKLOLOBYBIJT@DLMEKAAM>IFM=
MDH?>GJBMELcLFcENDHECB::688V>C?:9@E\MFcAA79=5R=EW@;ZRC>I=E4:
A:D\ED:WNGL6><>E<MEC?M>BTR<<L>C;8;M=J<<>7T:BJ5AD?H?@C74=5<79
814KG;87:87C7E59D8I9F:44;MB7M>A::5F=<9E?B359;E6A65
.
frg:7
clr:12,827
}
{RED
iid:1389
eid:1127298138
seq:
ACATCTGATGAATCAGCTTGATTCGTTGGTTGCCGGTGGCGTCATTATGGCGGGCAGCCT
GAAAATTGGTCGTTACGACGAATTCTCTAGATATCGCTCAATACTGACCATTTAAATCAT
ACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTGACTTGATCGGC
ACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGGCGTATTTTTTG
AGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTCAACGGGAAACGT
CTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGGTATAAATGGG
CTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCCCGATG
CGCCAGAGTTGTTTCTGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGA
TGGTCAGGCTAAACTGGCTGACGGAATTTATGCCTCTTCCGACCATCAAGCATTTTATCC
GTACTCCTGATGATGCATGGTTACTCACCACTGCGATCCCAGGGAAAACAGCATTCCAGG
TATTAGAAGAATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGC
GCCGGTTGCATTCGATTCCTGTTTGTAATTGTCCTTTTAACGGCGATCGCGTATTTCGTC
TCGCTCACGCGCAATCACGAATGAATAACGGTTTGGTTGGTGCGAGTGATTTT
.
qlt:
4754?89O8D;9<@89We<D:8=?S_ll_[l_Olllg_lglllaaggklllllkllllll
l<@>;;C<8=]]\kkldlkklllklllllklllkllaL<=;;:=>LGFIHHLgkkklkll
llllkkllllllllkllkgllllllllllllllllllllkl\k\\glklllllllllllk
kkkkkkdlklllklllllllS\lllllllllllllllllllllllllllkllllklllll
lllllllklgSgllllkklllllllkllllllllklllllllllllllllllllllllll
llllllllllllllllllllllllgllllllllalllllllllllllllllllllglgll
lllllllllllllllllllllllg\\llllllllllllllllllllllllllllllllll
lglllglllllllllllllllllllllllglllllllllllbllll_llllllblellVl
lll[lllllllllllllellldellldlllZlllllliiiei_ibieZe_iediiie__i
ebieiieeeeXeeTYdbiiibieebiXidViiii]dbei^QeeiiiiedSdeb[iedNei
UbS_dLiiNiYOdXidViULidHM^UeYLGLX\SiNGe\XBiUXeeY^KSW`Y=PPcN_P
N__T`KP_MK[`NHTU`U`McE`^[GIGG[[BMSNccVGOMM^MMOLLNXMLVMcTQRQY
MNMOVM84<IGNIMMRDMATMLYEMMKQH?DHcNC><@CSBPCVMIBOE>R75
.
frg:8
clr:4,76
}
{RED
iid:1390
eid:1128922821
seq:
CGATCTAGAGATTCGTCGTACGACCAATTTTCAGGCTGCCCGCCATAATGACGCCACCGG
CAACCAACGAATTCAAGCTTGATATCATTCAGGACGAGCCTCAAACTCCAGCGTAACTGG
ACTGCAATCAACTCACTGGCTCACCTTCACGGGTGGGCCTTTCTTCGGTAGAAAATCAAA
GGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCA
CCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAGGTAA
CTGGCTTCAGCAGAACGCAAATACCAAATACTGTTCTTCTAGTGTACCCGTACTTAGGGC
ACCGCTTCCAGAAATCGGTGGCACCGCCGAGATGCCATTTTTCTGCTAGGCCGGATACCG
GTGGCTGCTGAGAGAGGAGAGAAAACCTGTCTTACCGAACTGGACGAACGACGGGGATCC
GGGTAATAGGGGACGAAATAGAAGAAGGAGATGAATAGCGAAGGCAAACAAAAGAGTCAC
CGATCGGAAATAGGAAGTGGGAAGGTGTAGATGATCAGACGATCGATATGAAGACTAGGA
AGAGGACCAGAAAGGGGAAAGAGGGATCTAAGTTCCCAGAGGCTGTAACTCGCAATAGAG
GAGTACGACGTAGATTTGATAGTCGGAGGGGGGTGGACTACGGGAACACCATCCATCCCC
AACCTACGGACATTGAATAGAGACCATCATACAGTCCCGGCACAGCAGCGTAA
.
qlt:
5349C<D;=87:M_EPcPPWQGdQ@9IiiiiD6_YbdY_i^eeT<eee^^ee[lV88746
68:8678:>BL[b[9Mlllllllll_Hll[Plb[OETG:C<?68M=DD<<ARgNllllll
llllldllldlllaglllllgNYlllla[lllllllglllllllllllllkkda[gk[kl
kklllllllllllllllllllllllklkkllklkllllkllglllgTbllgllllllllg
lllllgggX[dbaUgYggddUBCCAB<d_aLUL=aA[YURL?@HUTLYd[[E<:I=<@JT
I[aF:F>F>=?;:N:HHCCAGB><;;:CICCBJ<;E;GIOO::I=B;@O;:=9;<>899;
=CH;>CDE=F;@98=Q<??:>HDW>V9EBE9=F<<99;988>OOPOA<::9:@NH<EDK=
9=C;>OO@H>;<9=78DH:BAA8;:7;>K@D:>89=8;9;;C9;6>986C996C>H@87:
:86D988868<?D?9<676957A:<=D9<<889E86=99<A7;AG6:78<88B8:89>86
7?@7:<>A:>5798BB@:;58987B;?AE>B8EAAHKHC;7A:87A8L58989C67;<?8
<M=B>S88D:>@4;<@<8?;=8H:<85;:>B>8<C>:LG9K8:9@5>N>9AC7D;6:9C8
@>B6D@;85>8?B888:<D79E@D:<98G88896:8>55H:PA88D4>45<54465>>95
9776:I9R97597;C:<5>E76;785;:H:@76I59;6<>5MGM;>N;7@<<6
.
frg:8
clr:4,65
}
{RED
iid:1391
eid:1127298139
seq:
GCTCTGATGATATCAGCTTGATTCGTTCCATTGATGATGGTTATTTTTGATTCCATTTGA
TGATCGATTACATTCGATTCCATTTGATCATAATTCCATTCAATTCCACTCGATGACGAA
TTCTCTAGATATCGCTCAATACTGACCATTTAAATCATACCTGACCTCCATAGCAGAAAG
TCAAAAGCCTCCGACCGGAGGCTTTTGACTTGATCGGCACGTAAGAGGTTCCAACTTTCA
CCATAATGAAATAAGATCACTACCGGGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGC
TAAGGAAGCTAAAATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAA
TTCCAACATGGATGCTGATTTATATGGGTATAAATGGGCTCGCGATAATGGCCGGCAATC
AGGTGCGACAATCTATCGATTGTATGGGAAGCCCGATGCGCCAGAGTTGTTTCCTGAAAC
ATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCACGCTAAAATGGGCTG
ACGGAATTTTATGCCTCCTCCGACCATCAAGCAATTTTATCCGTACTCCTGATGATGCAT
GGGTAATCACCCCCTGCGATCCAGCGAAAACAGCATTCCTGTATTATGAAGAAATATCCC
GCAGCTCGTGAGAAAATGTTGAGCGCGGCGCGTGTCCCTGTGCCGATGCATTCCATATCT
GTGTATAGTCCACTTAAACGCGATCGCGTATTCGTCTCGCTCTAGGAGA
.
qlt:
23146;E?=86745457>DJJ>TT;@=96:<KcI?[P>WNHNMK^^^^NTMiUMCiiieX
QM86=77SI6?GLGA6____I8QQQ_e^WQie____ZE88655:<@>98;8:??IHH>bb
lllbIL_Sleelllllllgllgbg_a_WgggaddgldllddY[GPa[lgdgkaddalklk
klkllkkakdkkWkdkklkVlkgggklkdkkk[kkkkdakkdkKB\F]LddlWlllllk]
kk\ddaWkaYLTdWCk][Lkkkkkkkk\d]kdkklkkllkkkdddWdRdW]]]]Q=aSBL
PGKDllkgkkddYkdkdHOVLTUSYS=KK[dggbRddYdaER;>C<OG[H[FIC[ESTgg
glb[GSVO[bVMDSHKMU>bIZb][d_O@KH@PLL^WL_eeV[]PHA==G:>9JPDEUZ]
K@YPbPFbHGNCbINNRENFVU=Pbe^UNIKKGSDN?LLGFI:9M78C?=U`@:<JRTN=
GQU[HQTX8N=\LWVCVQEI6ROYLGO>MHGA?]>MO<M>MHCR=4:;M98:7;>H=>MR
SAEHHL9<IG<=D>H>C5?:@<JBE6?C<FFK?9[YW<E@KTKCDIEEND[M@MI9FCDE
MA58:7:;6CKD7P7:88;?<K555F>VVA<A9A>AA=C565FCD:>8LN6?S=7F=?:6
8555>7895?<5:?A6665EJ@45=;6;8E59657<595:59M;:98=5@>M96;54477
6;=9<3:DF;:6D9><66:865:546657?9?C95B796:5;5@54343
.
frg:9
clr:17,114
}
{RED
iid:1392
eid:1128922822
seq:
GCGATCTAGAGATTCGTCATCGAGTGGATCGAATGGAATTATGATCAAATGGAATCGAAT
GTAATCATCATCAAATGGAATCAAAAATAACCATCATCAATTGGAACGAATTCAAGCTTG
ATATCATTCAGGACGAGCCTCAGACTCCAGCGTAACTGGACTGCAATCAACTCACTGGCT
CACCTTCACGGGTGGGCCTTTCTTCGGTAGAAAATCAAAGGATCTTCTTGAGATCCTTTT
TTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGT
TTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAGGTAACTGGCTTCAGCAGAGCGCAGA
TACCAAATACTGTTCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAG
CACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATA
AGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGG
GCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGA
GATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACA
GGTATCCGGTAAGCGGCAGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAA
CGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCACTTCTGACTGAGCATCGATTTTGTG
ATGCTCGTCAGGGGGGCGGAGCTATGGAAAACGCAGCACGCAAAGTCACCCGAGGGGAGC
AGGTGATACATTTGGGCCCTCAGAAAAACTCCATCGAGCATTCA
.
qlt:
574587:>9666:NSFME:SeU^]_iW_NeXOHOi[OKLUNTWbVDLl]llllbWl<EE9
754456<O>COHO[ablllll_Sllllllll_[l_ag_PLKDC:B==gggllaWllllll
llllkkllkklkklkllklllkklllllkkllklklllllklllllllkkdkdUTkl[Tl
lklllllklllllllkkllllllllklllglllgllggllllllllllllldllggllll
lllllllgllllllllllllllllgdglllllllllllllllllllllglllllllllll
lllglgllllllblbglgllggblgggllleebllllllllllllllbbllbllllllbl
dlllebllllllllllllllbllllddl^ZlSlllZld___ldelllbb_l_^eieideL
^e_eddee_ebieieiee^ieeieee_^_Z_iiddd_eebiieiiiii]VVdeiddeiXi
ibid_bi_eiee_iiiieeieiVeeQUQeSJiXe_eedU^^edQeeH^I_^bTde^Oddi
^]eeiNeTiY^V^U]XdUiTUYYeU`[eOSTV\Xc<i>eQN]KQ`H\OVRRO]MRQNW]U
DNFMCWNPNM\``U`YLQMMMM]=^_NMMRK_LMQQK?JYWET?8Q@TAYcMKNBJEL?K
QQKLMLPMTILN?MLLK;:<6CBIHPEHI?H>WCI@DLHE^AT<I8MVTKIOLTcVCVVG
FKIF@FG8<IRKcIC@EH@LFGM@NGSDDOBQ8;7H655>ON9O9E8B=NOCQV\TB=5<
D>O@GG>AN5BTTQR>:A:Q9M>B@@ABTMF75@6H@D39@4H432259=<762445<5D
8=;9<<J;74:K=<I8<?9>?66KMMHD<=6549=7=7876;55
.
frg:9
clr:12,104
}
{RED
iid:1393
eid:1127298140
seq:
GTCTTACTTCTGATGATTCAGCTTGATTCGTTACCAACTTTGGGTTGAAATGATTAAGCT
GAGACCGGGCGGGTGACTTGCACGAGAAGAGAGTCTCGGTGTAGTGTCTCCGTCTGAGTC
GATTAAGGACCGTCTCGATGTAGGCTTGATGATCGACGACCCTTAAACTGGTCACATGCC
TCGTCATGGGTAAGCCTTGCCTCGGGCAGACTAAGGCCGGAATAAGATAACACGAAATGG
GCGTGGAGCGGTGGCGAGAGTACCGTGTACCCTCCGTGGCAAGAGGCTGGACGGTGGTGT
AGCTGTGCTCTCGGTTTGCGTGAACCTGATCCGGTCTTAAGAACCCCGGTGGCGGGTTGA
CATATGCAAGGGTTAAGTGCTACATATGTCGTGTGATTGGAGATCCTCAGCTGAGTATAA
TCGATTCGGATCGCCGTACCTTCGCGGTTATGAAGACTTGGTCACTGCCCTACACGTAGC
ATTCCACTAAAGACAATGGGCTTTTGTAAAAAAATTGGCTAGTGCAGGACCAGTGATTGA
ACTAGGGTAGAAAGAACTCTAGTGCAGGTAATTTTACTTAACTTGACAAATTAAAACTGG
ATTTTTAAGGATCCACTTTAGTAAGCATTTCTGCAAAACAGAGTCTTTGAATATTGAAAA
GCCTTACCTTGACTCCCATATAACCAGCATACCCTTGAGAGTCTTTTCTTTAGTCGGGTA
AGACTTGTTGAGTATTCCATACTCAGGGTTTATCCCTTCGTTGTTTTTAGGTGCG
.
qlt:
414455554:8;M>K@588<A_i>B:8@AblZHNQO]_lll_lllll_gl_l_aadadgl
llkkkkkL<<?;9;;=8GBP=<OKdHV]Uldkka][Wd]dkd\;<K==ADB;B;<<<KJB
CTSWLH=k[CCL=CC]W][a][C]BLHK<HGKEK<KBJNGLKB=?=>=GUICH=GBHFIG
CO=<QCMT<=IBG<=B=BN=TGUBBFBOLkaBCB=UFRHLWHITM<kPKOLBFBUCCN\K
DJGTdKXK]TGOaPCBW=TKBK;F??WCL[ddWkkdakaOL]MkKaNTaYaWWkNk]Wk]
kWk][SYTYbWaWWVaUaVKWaTLRWR[]][[RWNka]dN;dN]]]]JMBdTUFHFBNGT
K<GCVWdBGBS?E[kWGTdaUYkCQHKOGdLOkL[[PQYLT=[RV[adK<UYYgGOUOLQ
OT;WPUd<RgVPJEO<=[[VRU[<bUPHMUPPb[>bUUUaHCTOUUaM[ggbb[bS[b?b
]Ub[[[[_S[MKd]SW_lVZVbb]eeW[bb]b]]_eeOO]ZKOl]ZOee[_WRVeOWiie
_eidVe_Zedi_ZZe^dee^^Ziiee[eeeb[d]W__bdd]bbiie_U]dYedZeeeiid
dYeeeRdedddVddU_ei^UZZbbTbQU_bdeebHVeWUZ`iGeeeeeWiQTUXeeXUS\
QOi\\UMQY[^XO\XeUN_P\\_O^MNVNQXMUDP`_^H[LMMMc^^\N^MKLM_Tc_MM
cF[BMM[L^P[LKMEWMHCMTMVOFQc^MYPPYGYMMQMGTDQQc^^MMAPJY>9
.
frg:10
clr:11,773
}
{RED
iid:1394
eid:1128922823
seq:
CGGACGGAAACTAGAGATTCATCAGTAAACGCGGTCTTCGGTATATCCTCGGGCCGAATA
CGGATTTTATGATAGCCCGACCTGAGATCAATTTGGGAAAATACCCTCGCCCCAGTCAGT
TGATCAAATAAGATGTCGATCCTGGGAAGGGGGTACTTATTCTTGATAGTGACCTCATTT
AGGGGTCGATAATCCACGCACATTCTCAAGGTTTGATCCTTCTTCTTAACAAAAATGGCG
GGACAACCCCAAGGGGACGAGCTTGGCCGGATGAATCCCTTATTCAGTAGATCTTGTAAT
TGAATCTTCAGTTCCGCTAATTCATTAGGGGGCATGCGGTACGATCTTCGGGAGATGGGA
GCCGTATCGGGCTTTAGCTCAATTACGAATTCTACATCTCTTTCAGGGGGCAGTCCAGGC
AAATCTTCCGGAAATACATCTGGAAACTCACGTACTACCGGAATGTTCTTGATCTCCGGT
ACAATGGCTTCATAGACTCTACCAGAAGTTTTGGCCGGATTGGTTGCGGGGAGAGTCAAA
AGAATCTCTTCTTGGTTATAGCTCAACCTGACGGTTCTGAGTTCAGTGTTGAGGATTGCC
TTGTGTTGGGTTAACCAATTCATACCCAAGATTACATCTATATCCTGACCTTTCAGACAA
TCAATATTAGCAAGAAAGTTCCGTCCGGGCATTGATACTGCCACTCCATAGGCCACTTCT
TTAGTAAAAATGTGTCCCCCAAGTGAATGAAATTTTAAATCCCTCCTTTGATCATGGATG
CATATGAATGCTGTCCACAACTTCTTGCTAAGAATGACGGGAGCCCTGATCAAGGATATG
CTGGGTGACTGGCACCAGGAAACATTAC
.
qlt:
3334444476787575777977;>KAC@;G>ELVUTKNLDHL>RESZXOC>KB7:8>;?@
<>:<8664684<:9=7AAHG;J[l_W_dU:<9>9:HBaU[OUO:9=89:::::B;;<::;
JRLgLLLUUU_HgYgUN?AF<FALadgdglggQKRQOOGIKRddNGC?B?UN==<=:?YN
KCgKKBI=VakdkkkWkYk[[VdaBC;9<=[=FBNak[dT[TST[kkVLLLOTTalkYMU
SOVTKGT[kkYddlGGJ?;[[addld[gdggggldddddaddLLJE=@J;ULgggladdg
lllY[dOOULCJa[aPaaV[_gbU_bgFggbb[][gb>D=LE;lbbbbbO[[gU_XbbMb
S[d[bledebbbebbb8?EF>:EQKWBbPSZeUID>QFCO[bZ[DUNN_ebb]NWRVKW]
]_ed]SSOLL_eH_b]eR_]V_HWPW]]eXed__TWZPRPSedbeEV]VZddRede_[_V
e_TW][WW[bbVV_G_]be]VHD:8]_L_]][[BARJN]KNePUGRUGLHWVGeNTSUWY
bKiDObU_QJV:\VHMQQPWOSUPTFCURYUFVRJKQQP]GJIINTGeI\SN;eJEH?8W
HO_E]CGNYPDTMNGVMDFFN;=ME]_IF;_:[_L:9PGJB7?KBFG46=RGM<75NM?:
HB967ML?M6IB6IMKMADF?JEJHI5D78?<AJ7NFCF[76=DK<D?LRF@95L=D?:<
FHG95455@C:E5B=Q^VV?<:B6=ELGLKO8TMV@IO>5BVH<6>6J<A?M@88P6478
;L=:989:9N9G<7@=766=5F8:9<J5:H6>596744767F4EL?44J57H;34E5364
7;6QD9<:8@EE>5:748;7A6684833
.
frg:10
clr:22,852
}
{RED
iid:1395
eid:1128922824
seq:
ATATTCTGTTACTAGAGAGTCGTACTCAGGCTCGGGTCACAATAGAAAAGACGGGAGGAA
GAAGAACACTAGGTTGCATCAGGGAAATTGTCTACTACGACAGCGACGAATCTTCCTCCT
CCCAAAAGGACGACGACGACCACGATAGACGAAAGACAGTTAACTCAAACTTTTCTTTCG
ATTATTCACGCATCCCGCATAGTTCAAATGCTCAATTGCTCCCCATTCCACTTGGCAAGC
CCCCTCACTTTGATGGAGAGGACTACGGATTTTGGAGCCACAAAATGCGTACTCACCTGT
TTTCTCTCCATCCAAGCATTTGGGAGATTGTGGAAAGTGGAATGAAATTTGATAGCTTGG
ATAGCCCTGTGTTTATTAATGAACAGATTCATAAAAATGCACAAGCTACTACTGTGTTGC
TAGCCTCTTTGTGCAGGGACGAGTATCACAAGGTGAGCGGCTTGGACAATGCCAAGCAGA
TCTGGGACACCCTCAAGATCTCTCATGAGGGAAACGACGTCACCTTGCTCACCAAAATGG
AGTTGGTGGAAGGCGAGCTTGGACGGTTCGCGATGATAAGGGGCGAGGAGCCAACACAAA
CATACAACCGGCTCAAGACCCTTATCAACAAAATAAGGAGCTACGGGAGCACGCGATGGA
CGGACCACGACGTCGTCCGCCTATGCTAAGGTCATTTACCGTTTTGATCCTGATTTGGTG
AACATATTCGTGAAATCCCAGGTACACCAGATGTCGCCCGAAGAGTTCTTGGGAATTCGT
TAGCGGCGATGATGATCTTCTCCTATAGTGAGTCGTATTACGGCGCAATTATAAAGCATT
ATAGTCTTACAATGTCAAGCTCGACGGATGCC
.
qlt:
444454455555675<9;5584579A96:LAL?C>;8<=;<97=8@GOOQ[GPbPFH[SL
GE:<;98445475799<:<@@<dd[OIUagRa[[GGFCIMHENIM=C=K=LGGIGGHRTa
PLK:=CGYkdKTkTNkYSUNLBGBWPHLULL[IQL[G=KQWKKG[VCCLWWadW[WWWTB
T[WWTMTLH[LYkaa]WQW[dGTTTOGQ[kQPTHQT]dHWQLLNG[W[VQRWTdK<CLQQ
T[dk]]GNYada][kddQaKOUFLHVHYTVVVOaOd[[[OOVLMSUkS=LVLSM=PVagT
[dddaddddTda[LTQTLUddg[[gTgUWgTdUaTRYKddlaaldd[ddadaadP[bYgJ
gaaRJ[[UgD[FPPP_abUPbaOUOOVNKUCVULJLJKbLIOOQOSUUOS[S[eI_HF[F
TT[SbPSOOS[Fd[SSbbbKHePQbWWSWSQQbHbXNHVPASP_K_RKSOdLQFOQRWAl
][eldWl]>Oe__WAPR_XVZ]PWV]]P>G>PNVNRbZZ[V>KTNL[QXZ[NTMPHSNeT
_JQJNI<]HZTF_JH_AT]WdA]INM@NVQHbbHbUZPGA]JJCJ_OUdEEGDSbXdQVP
EFVNSFbKOHd<THH8DD8<HQUdSXGUUGTKOFPQBISQMSSOCMLSHQ>ICB>MLQFS
>8OGKJAX;OH?<MJFOOGH]IE8U=WLOBM?HGB]JE<J:855<K@@H\=II?CADD8G
O?7I@DG=;9GKJNF7A>J7B>@LB;:;@4H6T=97>MADDC5T?DAD<JFN?LG>EE8K
IH;HMM:>P:K@9>FLT:6:CLB6799>:C:9BG@9O9D=5::965AEOMCM;5?8<N::
>?BB;K97<;@67A69EQJGDLA?N<6>=:56
.
frg:305
clr:25,868
}
{RED
iid:1396
eid:1128922825
seq:
ACGTTCTAGAGATTCGTCCCAAGGGAACCTGAGGTATGTTGTAGTAGCTGTGGAATATTT
TTCTAAATGGATTGAGGTGAAGCCTTTAGCAACAATAACTTCGGCCACCGTCCAAAAGTT
TTTCTGGCAGAATATTGTTTGTCGTTTCGGGGTGCCAAAGGCCATCACTGTGGACAATGG
GACACAGTTTGACTCCGAAGCTTTCAGGGATTTCTGTGACCAAATTGGTACGAAGATCCA
TTTTGCATCAGTTAGGCACCCGGAGTCAAATGGACTCGTTGAAAGAGCCAACGACATTAT
AATGACAGGAATAATGAAGTTAATCTTCAATCAACCCAGAGGAAAATGGCCAGATCAGTT
AACCAAAGTGGTGTGGAGCCACAACACGACAACATCAAGGTCTACAGGCTTCACTCCATT
CAAGTTGTTATTCGGTGACGAAGCAATAACTCCAGAGGAAGCTAAAACCGGATCAATAAG
GATAGTAGCTTCGGCAGAATCAGATTCCGAAGCTGCTTATTCTATAGAAAAAGATGCTTT
AGAAGGGATCAGGCTGCAAGCCGTGGAGAATATCAATAAGTATCAAGCTGAAACAGTTAA
ATGGCGGGATAGAAAGGTTCGGCTAAAAAATATTGAGCCAGGGCACTTGGTGCTTCGGAG
GGTGGCCAACCCGGAAACAGTGGGCAAATTGCAGTTGAATGGGACAGGCCTTTCTTAGTA
GCATCTTCGTCAGACCCGGGTTCATACAGATTGAAAGATATGGACGGCATGACATTCCTA
GATCTTGGAATGCGATGAGCTCGCGATATATGTATATCGATGTATTTTCATATTTTTATT
TTATTTCTCTGCATGG
.
qlt:
555577=BB=:;9Q`K=<8676QiiOLHeZlZH[>LK[Sl[V_[b__lllgl_lgggFgl
lllgTllllllkllllklllllllllkllkllkalllllllllllk[lllllS[llllll
lkkllllllllllllllllllllllllllllllllllllllllllllllllllllllllk
lllllllllllllllllllllllllllllkllllllllllllllllllllllllllllgl
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllbllllllllllllbllll_lllllllllllll
lllllllUlllblllllllllllllllllllllellellllliiiiiiiiiibiii^_ii
eViiiiii_eeiiieeieieiieieeiiiiii_]edTiiieiidi_ediiid_d[ieidV
idPiieidiieiPdde_i[_idbdYeiYPiiN^iibiUeUeebedeZiiiieXdLiWei]
eKdeFiRUPdUZiWeiXMe\]YeL^AiDi_ReU\ieY]RNQ_P]^U]]cW^_\\\TNVVc
NR^KFY]Y`L_M[^VTW>MTU_LUTc^^^UMMGNXYMMMCTcRFDMNMPTFYLLMM;J^C
cRHYOCMDSGTTJPNYYMLHDTVOKV^NAGRHMNHKL=8=^\CMLGI<=>IVRJ=<L>GP
ALKRNFHLGKDN:MCPL6R9M@OBHLA7<N>?Q>\G=N=GIDAEAGI7A:I?>7GI<D<D
>BA86B7B:9BQ455;=K9<M666<G75N4:B563444;I9E36>TTHA54?@STSAC9T
TD83N8F965:8==<7
.
frg:306
clr:6,847
}
{RED
iid:1397
eid:1127298141
seq:
TGTTCTGATGAATCAGCTTGAATTCGTGTAAATATCCCTAGTTGCTGAATTAACTTGGGA
TAGTCCTTTGACTAGTATGGTATGCATTAAGCCAAATGGTTAAGGTTAGTACTGAATGGA
AATAAAATTGAGGTTTATGTAGCAAAACTACATTTGATTCCATCCTTTGACATGTTTACC
ATAATCTATCTCTGATCTACTAGAAGTAAGAAGAGTAGAAAATAGCCTTAAAATCCCACG
TCACCACAGAGCTTGAAGCCAAATTGGACATTAATATGTGCTTAATCCTTGGCGTCGAAA
GAGCCATAAATCTTGACCACCAGAGTGGTAGTGATGGTAATTTGTGATAGAACTATGAAG
ATCTTGTGGAGACCGGATGACTCCTTCATATGAGAGCAGCACTATCTGTTGTTGAAGACT
GGTCTCAGACGGATATTGGTTTTTTTTGCTCTTGCTAAGCAATTATCACCATTTGCTTAG
TCTTAACAATCAGATGAGTTTTCCCAGATAAAACAAATTCTTAGCCTTGTCTGTTCTATT
CCGAAGCTTCTCTTTTTGCTGAACAATGAAGAGATCAAAATAATGCTTTATAGAACAAGT
TGGTATATAATACGAGGAGAATAGTTTGCCCCACTGGCATCTTACATCACAAATAATTAA
CTATTTTTATAAGTTCTATCTCAAAATTATTATACCTAAAAATGTTGCATTAATCGATAC
CCAATTTCGGAGCGGTATGAGTAATTAGGTAAACCATGGGCAGTG
.
qlt:
3144;7:V>K=8;<8=_iiiF?Tii_Ze__lVld[lll_llllllll_lllgllllllla
llkCTSETSJFGlkdllklkllklllllllllkllllllkTTNJkL[kWb\kkkllllll
lllllllllllllllllllllllllllllllllllllllllkllgkllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllklllll
llllllllllllllllllllllllllllllllllglllllllllllllllllllllllll
lllllllllllllllllkklllllkkllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllglll
lllllllllllllll_lllgllllllllblllllllllllllllllllllllllllllll
llllllllllllbl_llllllllllellbllllllllllllllllVllllli^Xiiiiei
iieiieiiiiiiiiiiic]ieee_Wie__i]iedTdeiideeidd]iidediUieededd
iiTWbbb_^dei__idbdLibVeXUiidNiiiTeeieeXdiZd^WQeeX`\^V]eYU\Ti
`YeXeieQXTN\N__^OcOc_TF]^NNY\MN_NQT^W\_N^MMR=]WMMNML_Y^L\MMM
PTBHJNNXOIM>^T^IFLTYLQMMOTMENIM^HJMDIc^YFJL89
.
frg:11
clr:6,762
}
{RED
iid:1398
eid:1128922826
seq:
AGATTCTAGAGATTCGTCCCATCCCAGAAGCACTACAGAGGAAACACACGAGACACAATG
TAGGGTTGGGCCTTTGGCCTCTTTCTCTTCCCTCTATTATGAGAGGGTGTACATGTTCCT
TATATAGAGATGTGAGACCCCTCAGGGGCAAAGCAGGTATTTGCCTACATAACCCCAACT
AGGGTTACTTAACACTCCCCCTTGGGCTAATACCGCGACCAACACATGCCTCGTTAAAAC
TCCGAAAACCCAGTAGGAAAAATGTGGAGAAAGAGTGCATGTTGATACAAATTGCATTTG
CACTTTGTTGCCTCGTTAAAAACCTCATGTGAGAAACTTCAAGAAAACTCACCAAGGGAA
AAAGAGTACAACAGCTGTCATCGGGACAGATTTTGATCCTTTGGGATCTAGATTCTATCG
AATCTTCTACAAGGGCTAACTTTAGAAATGTGCTCCCCCTGATCCATGCAAAACCGTATC
AATAAGGCAAAACATCTTCTTCTGGAAGTATATGCACATAAAGATTTAGCAAACGGATTG
CATATCCTTATTTCAGGAACTTTACCTCTACTCACTTCTACGATATACGAGGTAAGTGCA
CGTATCAATATAAATAAGCCACTTTGACTGATGGTGTTCGATCGACTGGATCTATATATT
TGATAGAAAGTTCCATAAAGATTCACATATTGATCATCAAGCTCACACCTTCAGGCATAG
AATATGACATTTATTGTCTCACGATTGTGATCAATATAAGCATTCGCTCCCCCTGACGAT
GACATCTGTCAAAGTCGTAATCTCTCATACTCAGCATATCTCAGATATATGTCTCATAAT
CATCTAGATACGAGATGATGAAGGTG
.
qlt:
45566=>DD?9::MXHO^>@7_iYC:_^eWWNVeiXClllllllWNdWllll_[W[Wlll
glgl_gllllllllllalllllllllllllllllkllkllllkllglkllllllllllkl
lllllklkklllllllllllllkd]gkkllllllllllllllllllllllllllllllll
klkkgllllllllllgggkgSTQLJTlllklllllllllllllllklkklllllllllll
lllllllllklllllllllg[dYRYdlllggllllll[YYTQ[lllllllllllllllll
lgglllllllllllllllggllllllbggglllllllllllllllllblllllllllllb
bllblllllelllllllllellll_lelllWlllllellllliiie[ieiie_iieiiii
iiiiiiieieReeieeiiiei_S_Zii\_iWieii__i_]iYb_YVdie\iieYQieibb
]_be^KdSeei^^Uee^VeTeebYQ@GQXdUbXiWQeZeeidX[Ki_`Ud\eiUXiI=\e
NMY__XQGO]]i^QSE\RSTPcPNCNU]MOPOVGNP`SQQNJ`OY\MMN`BRHT]MM^EM
MTMTMRPNMYMM^UNT^MV[NNYccQT@M[SJ[[>W@MLLQQOONELNQCMLRQMMLMOc
JEMCM>RcPM@LJ[FKMcT<Q;OIGKGLLCTMCLOLTO@LJBCFGK@@DANQ5::5@OS9
RN>E?BE==KZQ:4@G8E=GA>?NE8?7?LLIH69HI=M;?AGAMB>=8MNN=8KB<:MB
FNB=@=6C<M;GCFFO9>58<99;=@:8;2988356;4744643A77999@56;G;G54B
=;@@:>6G@E9:73=:?44<4317>2
.
frg:11
clr:5,805
}
{RED
iid:1399
eid:1128922827
seq:
AGGAGGAATCTAGAGATTCATCCTCACACTACATTCTTGCGCACGTGTTCGACATTCTAG
TGATTTGAGCTCCGTTCTAGTGTGCTAGTCTCTTGAGCTCAAGTCTGGGTTTTGTGTGTG
CGTATTCGCTGTGATCTTTGTGTCGTGTGTGAGTTGCTAATCCCTCCCTTGCTCCGTGAT
TCTTTGTGAACATCTTTTGTAAGGGCGAGAGGCTCCAAGCTGTGGAGATTCCTCGCAAGT
GGGATTAAGAAAAGCAAAGCAACACCGTGGTATTCAAGTTTGTCTTTGGACCGCTTGAGA
GGGGTTGATTGCAACCCTCGTCCGTTGGGACGCCACAACGTGGAGTAGGCAAGCGTTGGT
CTTGGCCGAACCACGGGATAACCACCGTGCCATCTCTGTGATTGATATCTCTTGGTTATT
GTGTTGTGTTGAGATCCTTCTCTAGCCACTTGGCAAATTACTGTGCTAACAATTAATCAA
GTTTTGTGGCTTAAGATTTTTTGAAGTGTTACAGGATCACCTATTCACCCCCCCCCCTCT
AGGTGCTCTCAATTGGTATCGGAGCCGTTCTCTTCAAGAAAGGGACTAACCGCCCGAAGA
GATGGATCCTAAGGGCAAGGGGATGGTGATCAACGACAAGGAGAAGGAGACCTTTCGTCA
ACGAGCCCAATGATGACAAACCCACCGACTCAGGCTCGGGCCACAAAGAAAGGACGGGAA
GGAAGAAGAGGACAGGCGCATCAAGGAAATTGTCTACTACGACAGCGACGATTCTTCCTC
CTCCAAGGACGACGACGAACAGATAGACGAAGACGTACTCAACTTTTCTTCGATTATCCC
GCCTCCCGCATAGTCAATGCCTCAATTGCTCCCCATTCCACTTG
.
qlt:
4444777555565776;:A:;@>J?7@8_VVH=_dUR_ZYXPQ[e_llllUeWWlle_[_
a<<<:96687D;:P?aY[VLYllldgXdggggglkk[L[OD<@=JCJEFFU[ak]lllll
kkkklkkdkllllllllkklkkkka[lklkkkdklkkkkklllllllllllkllllllll
llllklkllklklllllklkdddlkkklkkllklllkkllllklklklkklkklkdd]kd
kTQYd][dYkddldda]kakd]kklkk[laVlllkkklllllllllllgggggdgglg[l
gllllllllllgddgllllggllllllgglg_glVggbllglg_gbl[lballllllllb
lell_[eblb_eeedel[eeblK_ellelllellllel_lZQele_elllleeiNVbe_i
iei___beb_e__eeeeeeeee[e]be]eiiideX]ee_eeeiUiede[M@_d^FYdRDd
ddd^[idiYNeXebWdDVV^di^\dVWiWeLdUUVVTXT]dWeed[>\]^]eeeee\V_U
_QUGeSMQVQ9FNXeUSYTQUB^GNOPOPPM\KUN>CM]OOP]BNILI=:UH>]YNUBFc
DENMYMMG_MCCFWGD>MM^MPEFMWNMLLLGLMMNLE::AM<D;9<B<Y@LDY9NCHR9
[LGN;NYG>DLYMKLMA<N76:8;8BJMAGD<HHAOIGTE8<<B:=87DPO666<@JG:9
:<DB7GQ8O77=6<;?:>A?EL?9@?<R@N=F7::FOCFCGQE8IF;JR=S979=LJ6><
>9=?5446D;:M>7B99G83463444:EBME47769639749;GSK8:9B7:HF69;998
4:7;APF5567A6F9855>86:796I:536FI@A5A;866<A67
.
frg:307
clr:16,876
}
{RED
iid:1400
eid:1127298142
seq:
TGACTGCGTCTGATGAATCAGCTTGATTCGTTGGGGATGTGTGTCCTAAGGAATCCGAAG
AGCCTCCACATGCACAAGATCAACCATCCTCCTCCATGCAAGCATCTCCACCAACTCAAA
ATGAGGATGAGGCTCAAGTTGATGAAGAGCAAAATCAAGAAGATGAGCCACCACAAGATA
ATGGAAATAATCAAGGGGGAGATGAAAATAATCAAGAAAAGGAGGATGAGGAAGAACCAA
GGCCGCCACACCCAAGAGTCCACCAAGCAATACAACGAGATCACCCCGTCGACACCATCC
TCGGCGACATTCATAAGGGGGTAACTACTCGATCTCGGGTTGCTCATTTTTGTGAACATT
ACTCTTTTGTTTCCTCTATTGAGCCTCACAGGGTAGAGGAAGCTCTCCAAGATTCGGATT
GGGTGGTGGCGATGCAAGAGGAGCTCAACAACTTCACGCGGAATAAGGTATGGCACTTGG
TTCCACGTCCTAACCAAAATGTTGTAGGAACCAAATGGGTCTTCCGCAACAAGCAAGATG
AGCATGGTGTGGTGACAAGGAACAAAGCTCGACTCATGGCCAAAGGGTATTCACAAGTCG
AAGGTTTGGATTTCGGTGAAACCTATGCACCCGTAGCTAGGCTTGAGTCAATTCGCATAT
TATTGGCCTATGCTACTTACCATGGCTTTAAGCTCTATCAAATGGACGTGAAAAGTGCCT
TCCTCAACGGACCGATCAAGGAAGAGGTCTATGTTGAGCAACCTCCCGGCTTTGAAGACA
GTGAGTATCCTAACCATGT
.
qlt:
444456554;77;:>85:=79dk?F=;BAkllllllK<lllllllgkllllkglllllll
llkkklk[kXgkTJLLLH\kkkllkklkkkllllkkkkkkllllllklllllllggkkgg
llklkgkkllkkllllllllllllllllllllkllllllllllkllllllllllllllll
lllllllllllllllllllllkklllkllllllllllllllllllkklllllllllllll
llllklllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllklllllllkkklllllllkkllllllllllllllllkklllklllllllllk
klkgggkkllllllkkkkllkklllllllllllllllllllllllgklllllllllllll
llllllllllllllllllllllllllllllllllglllllllllllglll_lllllllll
lgglllllllllllllllllllllllelllllllllllllllllllllllllllllllWl
llllliiieeiZ_ieeii__iieiiiiiiiiiiiieiiee[ViiiidbdXiidediiiie
iiWTMiiiYdPiiieTNidibdieeeie\eiiediTee_eiXieiiU_eX]dieY`e_eQ
F]XiiPOeXeYi_XPP_]YY\NVccO\R\P^NT^`N_MWLc]McM_LMT^^c^[RMTATO
[LWSMGIMLT[AOMMLMJLJODNEc9NI[MMLYMQM^LRGFMNYMYQHXGRcYMEHAK@L
PJNPLJCECMNRPJBCH:6
.
frg:12
clr:21,796
}
{RED
iid:1401
eid:1128922828
seq:
TGACCGATTCTAGAGATTCGTCCCGCAGGGCCACCACACAATTGGTGCCTCTCGCCTTGA
TTACAATGGAGTTTTGATCTCAAGAGTAAGTGAGAAAGAAAAGAAGCAATCCAAGCGCAA
GAGCTCAAATGAACACGGCAAATCACTCTCTCTAGTCACTAGGGCTTTGTGATGAATTGG
AGAGGATTTGATCTCTTTGTATGTGTCTAGAATTGAATGCCTAGCTCTTGTAAGTGGTTG
GGAAGTGGAAAACTTGGATGCAATGAATGGTGGGGTGGATCCACCCCTTACAAGCCCCTA
AACAAAACAGGGCTTGTGCTGCAAATGGTTCTTGATCCAAACGATGTGACATTCACTTAC
TCTCACTTCGCACTGCCACAACCCCAGGCAACAATGTGCTTGTCACAGCCTACCTGACAA
CAACGGCTTCTTCCAGGATAAAAAGGCACATTTGCCCCAAGCTTCTTATTGAACATCCAG
GCATAAGGATCCGTTGACAAAACAAATCCTGAACAAGGACAGCTGACAGTCAACTAATAA
CACCAAAGGAAATGCCGATACGTCATTGGCATTTTCGTTAATTCTCAACCAGATGAGTGA
ATAGACGAATGAGGTAAATCACAGACGGAGGTGTTGCCTCGATCCCGTATCCATGTGCTC
CAACACCAAACGATAATAATGGACGGCAGCCTAGCAGGCGAACATAGTCCAAAAAAAGGT
GTACAAAAAATGGCACGACCCTTAAGCGGCTGATTTTGGAGTCTTTTATCAGGGTTATGG
ACCAGGCGGATACCGTTGAAGGTTGGAATTCGACGGGTTCCCCGCACTTTTCTCGAAAGG
GCTCCTGTGTACGGATCGCTGGCGCTGGGAAATTA
.
qlt:
747455678>9::6677CH:9A688>68PSbD<QNNNLVL]bllOK_[]alllgglgglH
H?HT;=DMCIISWTVkdkaakDkklYaUS[]k]Wkaaak]dkdk]WaUPdkXV[lkkkd[
kldkkka]kkllkkklllkddkkkdklkdkakV[dklklklkllkkkkldllklllkllk
lkllllkkkkllkklkkklkkklklkkkkkkkklkklkldkdkYdkkkklkllkklkdkl
kklkdalalkkkklklklklkkkkllkkldLgN[kNaV;=;H46FLW[TQLCB9FU<TL<
N<P:=K9BD=O=GSBTGGTKKKG<>GKB;CE;DOCVBMBHHG:YLLVCKTLPKK8BCCGH
CS<G=<CBG<>G;:=<?7;A9>B8@;@NF;BHH??L<@79;;@A=IB;7@F:C=FE?>;;
;=59:;=;CC<>B9F9GM>99==@DM8:?<BC>;?:;>@>C>B>K:B;7:FHDC@BC=87
=97:97987;<=:8CF8A;;@AD:8=A=9;==<AADCGSC>H:@9D;8<>LDH@D?>DK<
<7?FPK5568:?BN:G7NFD><>@E>J@A@8ANENK9NC<>>F@:<<=B:?7P=9:9:><
E;:5@>;>96?7<89:97677?E8?>585867:;7778858:565G:B?985A67788DD
MM:5745GAC:5?8:576C:A9:F@::8B>A;A5>5:8=<:B>85:DA<D<?E>ING;A9
868>6EQ;AC76>78777A;7>:7<;9:9:YEJ:B58<7@557>^WM7>9::::97:@<P
87?:764EDJ78:64698>7799644AB44D464<^>><LM@58C><HVP8?9I=LF=7?
;F8G<;887565FI98D649;@98;767:?C57M9
.
frg:12
clr:17,284
}
{RED
iid:1402
eid:1127298143
seq:
TGTATCTGATGAATCAGCTTGAATTCACGAATTCTCTAGATATCGCTCAATACTGACCAT
TTAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTGAC
TTGATCGGTCGTAAGAGGTTCCAACTTTCGCCTTTAAGAAATAAAATCACTTCTGGGCAT
ATTTTTTGGGGGAACGAAGCTTTAAGGGCCAAGCGGGGGAAAAAGAAGATAGCATCACGC
CCAGAGACGTCGCGTGAGGCCCTTTCTAAAACGACACACCGAGCTCACCAACTGCGGAGA
CATTCATAACGGGCTCGCTTTGCAAACGGAGATTGCAGGACATGGCTCAAATAATATGAT
ACCACCTCTTCTGGAGCTCAGTAATAGACGAACCTAATTCACATTCGCATTGTTGGCTGT
GATACAAGAGGGGTTCACAAAGTCCTGATAAAAAATGCTGACCTCGTTTTTAGTCAAAAG
AACATGCTCGCAGAATGAACGGTCTCGGTATGCCACCAAAGAGCTTGGAGTGTTGAGAAA
GAGCAAATTTAAACTCATATCAAAAATATACGCGCATGGAAAGGTAGGATTACGGAGAAC
CTACGTACCCTAGCTAGGGCAGAGTCAATCATGAGTATTCGCCTTTTCTAGCTCACATTG
GTTCTATCTCTATAAAAGAGGCGCGCGATCGACCTTCCCAAT
.
qlt:
43444F?BODH95<?@MeeiiG:_lH8WelWlllll_gg_gb_lllla[llllllklk[l
lkkld>=89<;;<LIBKOlkSllkklkllklakPSLIKSkKC;8<:;<?889::<;;=69
PHPHKUKG;?=5;BAPHB;=B<7:=C==G<BB9?;8<B<<<=;<;A<<9998:6?:B6=>
<BBB=<<<8A<:98<<P89;:9=L<G=<<<H;H;::6;;98HA:<T;FJ==B:DBF888:
=<7<=<:B;=;B:=<BG=BG;=<E<M:A4B?899<<B<B<@:9>=<==?S<=9;===B<J
<:E;<:<<:8B<<=<8==6<<=<=<<<?@==H9:E8788=<<<<6B<:<89:<B=GKGI;
:<98D8<GF:E=FGP=F:;<98885L=F=;N:7:?C=;;;<<D@@;=:M<<<:OYE8:C;
AK8<G=9<P=>:8;?=<:=<@8=<<9:88868?8:;<;8<@:EC=A899=<<9;<<7:88
=<:;:<9:B><:9B=6>;>76<84654<88;:;::<<8E=<E9?;<=<;?CW;;=K;::9
8?:;<>A==C;<JD?:88788:6;=L:H:<<;;8<;;@9<94E;<;<=;:<9:<=<?GK<
;=;55:89=<:=@H>?;C=:;9G==@;;8;<9CL<@H<H;:;<<=<9:;<;9AB<::<<;
89B<=O;@:UH=?BG<B<><==88C87:=<<:88<A=8:9=7
.
frg:13
clr:190,696
}
{RED
iid:1403
eid:1127298144
seq:
TGTTCTGATGATATCAGCTTGATTCGTTAGATCTCCAACTGGGACGACTTGGTCCAGGCT
TTCGCTGGCAATTTCCAGGGCACATACGTGCGCCCCGGGAATTCCTGGGACCTTCGAAGC
TGCCGGCAACAGCCGGGGGAGTCGCTCCGGGACTACATCCGGCGATTCTCGAAGCAGCGC
ACCGAGCTGCCCAACATCACCGACTCGGATGTCATCAGCGCGTTCCTCGCCGGCACCACT
TGCCGCGACCTGGTGAGCAAGCTGGGTCGCAAGACCCCCACCAGGGCGAGCGAGCTGATG
GACATCGCCACCAAGTTCGCCTCTGGCCAGGAGGCGGTCGAGGCTATCTTCCGAAAGGAC
AAGCAGCCCCAGGGCCGCCCATCGGAAGAGGCTCCCGAGGCGTCTGCTCCGCGCGGCGCC
AAGAAGAAAGGCAAGAAGAAGTCGCAATCGAAACGCGACGCTGCTGACGCGGACCTTGTC
GCCGCCGCTGAGTACAAGAACCCTCGGAAGCCCCCCGGAGGTGCATACCTCTTCGACAAG
ATGCTCAAGGAGCCGTGCCCTTACCATCAGGGGCCCGTCAAGCACACCCTCGAGGAGTGC
GTTATGCTTCGGCGTCACTTCCACAGGGCCGGGCCACCCGCCGAGGGTGGCAGGACCCGC
GACGACGACAAGAACGAAGATCACCAAGCAGGAGAGTTCCCCGAGGTCCGCAACTGCTTC
TTGATCTATGGAGGGGATGCCGCGA
.
qlt:
41446<DMBL>78>>89Uiii[?iiUUWdiTQiiiW>llllllDNllWllllllXVllll
lY<;>:>;9>A:TTa[alkkkllllllkkllllllllllklllkddg]\PLN\\\kllll
llllklllllllllllklkklllllllllllkllllllllllllllggllllggklllll
lllllllllllllllllllllkllllllklllllllllllllllkklkllllllllllll
lllllllllllllllllllllllllkllllllllllllllllllllkllllllllllllk
gllllllllllllllllgklllkllllllllllllllllllllllllklllllllgglll
lllllllllllllllklllllllllllllllkllllllllllllllkkkkkkllgkklll
kllllllllllklllllgllgllglgdgldglllllllllllllllllgllgllllllgl
gllllllglllagllalbllllllleeleebbbell][_EO?GCA7IAOblllelld[ll
lOlelleZleeRWdRWeV___eeW_Reed[iieee__PdCM_]Z_PPZ_]d]ebeeN_dR
__eXU__dYbXUdee]FTZ]NC9?ALdd_i^i^eOOJUVLNUReHbRReOFB<QF>LHEG
HUO:RB@A:9CHS:<GUC=SSBMUQ@7<CDDHMB\@FPOHJN?_AMDFEGIDAMPNEJAC
9DNI<E<<BC7::QF::A@:45::7
.
frg:14
clr:5,739
}
{RED
iid:1404
eid:1128922829
seq:
AGATCTAGAGATTCGTGCTCTGATACCAATTGATAGTCGCCTAGAGGGGGGGTGAATAGG
GTGAAACTGAATTCACAAATATAAACACAACTACAAGCCGGGGATAACGTTAGTAATAAG
GAACGAGTCCGCAAGAGAGGGCGCAAAACAAATCCCAAGCGAATAAGTAATTGATACACG
GAGATTTGTTTTACCGAGGATCGAGTCTTGCAGAACAATTTCCCGAAGTGTGTTTCCAAA
GTTTGGGACGCGGTTAATGCTAGAATCGTATGGCGCTACTTAATATAGTCCAGAAGACAA
CGAATCTTAAACTTATTCAGATAAATAAAATAATAAAACCCAGAATTCCGGAAAAAAAGC
ATATCAATAATCGAATAGCGAAAACATCTTTGTTCAAGTAAAGGAATACATATTTAGCAG
AAAAGAAAAAACTAATATTTACGATAACAAGCATGTAAAAATAGTAAAATTAAAAACACA
AATAAGAACGTGAAAAATGAAAAAAAAAGAACGAACACCAAAATAACCATAGTAAAAAAA
AAAAGATAAGCTGAAAGAAACCTGAATTACAAAAAAAAAGAAAAAAAACAAAGGCAAAAT
TAAAAAAGAAAACTAGCTTGCCAAAAAACCAATATAAAAAAATCAGAAAAGACCACAGGG
AACGGTCAATAAGAATTTAGCGGAAAACGAGAACACCCGGACGGCTAACGGGGGGCACAC
AGAAGGACAAGACTCGAATATAAATTCTATTCTATATATAGTTCCGTAG
.
qlt:
545;I;7799<ATeGNON_eXlCLC[O7_lllCY_VllMllgYllllllllllllRL<=<
:=668;:;=86ddU6N?LYkklkkkk[kDYggEN;BJ;;9;;65895:B;?=;[\LgkYk
gkTNPaMTggL\MM[kP[TdSaSkNN[LY<FGaka\=<=HBH=NGB=TC<;BB=<8:6BF
DI=PVWMHGHPHBKQJF?B9BF:8;69<<8;9<<=:;::?<BBK<<:8<G8<<:;96B:<
7:BGMF<==B=:;45:;8::98=;<878;D<B<B<8>8<99<<9:::;==9=;<:6=;=8
<<?6=:B<<89;==BB:;<<<:<=B;K8<4;9;99<8HB::;:<;<9:<<9:=AG;?99<
98<;<I=65;69:=9;:;:9=868:;:<<;<>:=;=;5;;==79<9::;B:=;97<;;;;
<;:67G:;=8G7<<:<C<;9;<;;B8F8<G<B:9><:=@8:=:8==:878A<89=C:;<?
=9=<<9BC>:<99C:98:;:9A=C<:88=D:;=>;9=8=<A??;D<8=:;::<<9=;B<=
6<??9??<=?=:96@CCN==8<;;G:8;::9HEP<=?<=54<FCT:=:;L?:9:;9<;<:
;:;?;<DB>>:54;<;<<<:;?F<H:DG:9:;<9:7<??K=B5;=F<<:?<<;;L<@=:8
B888?=:>68><9:GF;8;<;:9;E:F8>?C<<::98@;;<CB==;E:<=<:9997D?M8
:;;=7:;<<=;>C>;9:?;B9;:8:9;9589779>9===@878>97?88
.
frg:14
clr:3,739
}
{RED
iid:1405
eid:1127298145
seq:
TGGTTCTGATGAATCAGCTTGATTCGTTTTCTTTTTTTCACTAAACTTTTATGGTGTGTT
TTACATTTTTTCTTGACACTTTTTGAGACTTTGCCGAGTGGCTGAGGCACTCGGCAAGCT
GTGTGTGTCCGGTAGTATATAGCGTTCAAGCATAGAAGTTCAATGGACGACAATACTGCT
GCCTCGTCTTTGAAAGAATTTTTTCCTCGGTAGTGCATGCAAACATGCAATGCACTGATC
CGCATACAACAGTGTAACAATAATGTGGGGTAACTCATTTTGAAATTAAATATTAGTGGC
CTGAACGTAATAAACTTGCACATGTATGCTAGTGGCCTAGTGGGTATGCGCGAGAAGAAT
ACCTAGATTTAGTAGCGCTACGCCAGCAAAACCGTATCTTTGTATGGTCGTACGTACCGT
TTGTTTTCGATTACCGTGGGCACTCCAACGACTATCATATGCACATCCAAAGGCACCTAA
CGTGTTCATCAACAACCGTATCGGCTGTCTCTGAGACAGTAAGCGCGTGTGTACTTGCTT
TGCTAATAATTTCAGGGAGACAAGGGGCCTGCGGCCTGTCACATCCCAGTTTGTTAGCTG
GGCGTTGGTCCATCCGTGATGCGTGGACTGCTGATCTCGCGCGCGGTCTTCGCAAAAGCC
CAATGTGATTTTGGTATCCATGCTGTCGTCGGCACGGTCTGCATCACTGTGGGAAACAC
.
qlt:
311346;:P?I<88;6=Iie^[E_iYeii_iiiiiillN<VV[llllll_e_llllllll
g_<@>ADLggMMPdlgkklllkllgkllllkgklllllllllkda=KGBEJYkkllllkl
lllllllllllllllllllkllllllllllllllklllllllllllllklllllllklll
llllllllllllllllkgkkg\gkklllllllllllllllllllllllllllllllllll
lllllllgkllkklllllllllllllkllllllllllllllllllllllllllllkllll
llkgllllllllllklllllllllllllllllllllllllllllllllllllllllklll
lllklllllllkllklllllllllllllllllllkllkklllllllllllllklllllll
llllllglllllllllllllllllllglllllllllllllglllllllglllllllllll
llllgllglllllllllllllllllllellllllVlellellllllllllllllllieii
iieeeieieiiiide_Q_Ve]eiiiii_ieiedUTi_iee]ediied`biiidNdd[eii
ieiibed_U^dReiieUiSKieeeiVROeiTeiUVeee]eeeeee\I]K\XQXeee\L]e
``Y_cN]VNcc[^OPRNTXH__UU]JYM@RHMNH`_UPYSTNMOMMVU^O[GDWWM<=;
.
frg:15
clr:6,717
}
{RED
iid:1406
eid:1128922830
seq:
ACGATCTAGAGATTCGTCTCTTCGCGATTTGGGCAAGATCACTGCAAGGGATTTGTTCAC
CAGTCCAAGCTTTGTCTTTTGTGTATGGACGACGTGCGGTTTTAGGCTAGGGACAGGGAG
TTGTAGCGTCACCAAGGTGCCAGTGTCAGAATGCCTGGTCCCGAGGTTAAGCTGCGCCAA
AACCGTGCCAAATGGATTTGGTTTGAGTTCAAACTTTCCCAGAATGTGTTCAAGGTAATT
TGGCACGACTTTGATATTTGGATCTTCTGGCTTTGAGTTTTGAAAAACAGAGAACACAGA
TGATCTTTGGGAAGAGGTCTGAAAATTCAGGAATTCAGAAATCTGAATTCCCTAAGGATT
CATTGATCAAGGGCTGATTTGGGAATTTATTTGAGTTATTTTGACTAAGCCTTCTCAATC
TTTCTTGTTGCTTAATAAATATACTTTAACTTATATAATTGGCTCAACTCAAAATTTTAA
ACTTTTCATCCCCTTTTTCATATTTTCTTGAATTTTGTTCATGGGGCTTACTTAGGGTTT
GAATTAGGGTTGCACATTCTTATCTTTCAAAAGTCTCAATTGTTTTGATCATGACACTTT
TAAGTATATACATTTGGTGAATTCTTTCTTACTTAAGCTATTTTGATGCTCATGCTTACT
TTGGTTCACATAAAATAATGGCTCTTAGGTTTGGCATTTGAGAGAAACCCTAGTGACACT
GGGGTGTCACACATCACGTCATGTTGTGTGAAAGAGAAGGTCATCATAATAGGGAGCCGA
GTCAAGCCCGACTTGGTGGTCCACCATATGTTGCCCCGCCAT
.
qlt:
5445799::;77:NNMUeSdQ^eHTLYARRiiLXMQ[LAPMiiiTVlll_HNlll_bJ9=
9646644H[bgllllllllllllblllllllllllllWUPddaTLR[__dllllllgN_l
lllgllllllgl_glllllllalllllallllllklllllgkllllllllgllllllldl
llllllllllllgllllglllllglllllldllllgllllagllllllllllglllllll
lllllllllllllllllllllllllllllllllllllllggllllllllllgllllllgl
lllllllllllllglllllllllllllllllllglllgllllllllllllbbllllll_l
llllllllllbblllllllllllllUlllllllllllllllllllllbVZUll_llWlll
lllllllellllllZllllliiiiii_ieeiiiiiieiiii_eie]iiieViiieiiiii
iiiiiieVii_UZeiii_eWeiiii_ieiii]diiidWidPiii^eeieebiie<iVbii
ei]Ue_NY_QiidbbZieeZdebeeiebHeiiX\eeVNNdeiEiiVVZRXXdeeLXXiii
SLcXQeQ_X_]JXiiiiP_YNU`WYc\RLX_K^OOOK\N_Gcc_MYG[HPMOK_LMMMLN
^NUNK_MLMMMM[^YMMYK^IJMTJJJA@KcS^NGQScJLN@^?QYKINCK687MR=9JM
VcT^FT@Q>KDMCTLFKINFP>V>@V?Y?@7QE@M6EQ<F<QGRQJKLF=<@\J;7H<6S
89>9BFDOF?P=LKE74OG:DB5776>@=ED9:75455?544
.
frg:15
clr:12,811
}
{RED
iid:1407
eid:1127298146
seq:
CGTCCTGATTCGCTATACTGACCATTTAAATCATACCTGACCTCCATAGCAGAAAGTCAA
AAGCCTCGACCGGAGGCTTTTGACTTGATCGGCACGTAAGACGTTCGAGGATCGACATAA
TGAAATAAGACACTACCGGCCGTATTTTTTGATTTTTCGGTAATCGCGGCTATCAGAATG
ATGGTTCTGATCACTGAGACGGGCTTGGTAAGTGGTATTCTTGCTCTATGCAAAGGATAC
ATTGCGCTAAGAACGCGGATTTATGTGGAAATCTGGGGTTCCCCTTGTATGTCTAGCCTG
ACAGAGTAACAATCAATGCTTGGCTTGGCCACCCAGATGCCTAGTAGTTGTTTCAGAAGC
GGATACTTGATGCTTTGCTGATGAGGACTCACACTTGCTGTTCACGCTAAACTCCCCGAC
AGATTTTATGCCTCGCCCGACCATCTCGCGCTTTAACCAAACTCCGGATGAAGACTTCCT
ACTCACCAATGCGATCACTAGTACTAGGGGTGTCCAAGTATTCCCCAATATCTGCAGTCT
GGGAAAGATACTGTAGATGCGTTTCTTGTGACCCTTTGACTGTTGCATTCGCTACCTGGT
TGTCATTGACCTTTGAAGGGCCATCGATTACTTCTTCACGCCCATGTGCAGCCTCGAGTG
ATTATGGCGATATGATGAAGCTGATGATTTGATGACCAGGATCCTGGCCGGCCTGGGTTA
GAAATCCTGGAAGAAATGAAACGATTTTGAC
.
qlt:
122488696:<L9:555_^iNX;5YYRIAPiTAieie_RCTbddTA_[eWW]leld]dHe
lbMel466=:;7:658;Lddda[Tgg[[kkSKTTkSHIB::67497945:57957:8;;:
HSQFAM=47<45<B8<A:<8G=?=<?==?<=<6<@9B;B8;9<;8;<=B<9=G<G=>>=:
;:<9;;?;NK<=86;;;:8<=;<:<:<;=<88<B:;88=H=HSF=B=>:PBE=;BF<CG:
>EHF;<B?<:?<?:=C<BHMTFFFJNGB<:HIH>=:D9;>:::?=:88<8B;98C9A=<=
=8<>8>B:LK9;8<<:CB;?IGD=8G:B==>==KB=K<B;:::<;D84:=:<<B:=K@:<
;<=FBG9;;:<9<8:HI;:;B8\J=B8==N88@@C=F;CC:<B=:AG=J<:<==<=;788
6:?88:<?<EJ<GCB:B::Q<G:<B8;9;;=<:<<B=<B<:BCB>:OG==;8:B9::=57
::B=<9<:9;<<;BC;=L<CD?<=;?<<<<:B<<><9=;;<978<5@=:;B878:?=?N<
C?>9K;BE=B<<D?<;GI;<8<<8;<86;C=<;BC===<=99>>B8=<:87;;:B<GS?;
<E:==9:@<P=K<CGD8A<<=;C9@9;<:;<H>A<;:::>?<ATBCA<BO:=><BC<<HP
P<DP<<;<>A>>===CQ<7=;;ODEKJ;<?CI:>K:;F<<?>>:B[B>>SA<=9E;8:?<
98;>?>H;H<A:::<:?H>:9:@<9:9=G8A
.
frg:16
clr:162,401
}
{RED
iid:1408
eid:1127298147
seq:
TGTGTCTGATGAATCAGCTTGAATTCGTAGAGAGGGAATCACGGCTTGTGGGTAAAGTGC
ACAACCTCTGCAGAGTGTTATGAAACTGATATATCAGTCGTGCTCGCGGTTATGAGCGGC
CAAGGGAGCTCCAGAGATTAGTGATACTTGATCAGAGATACTTTGGTACAGGTGGCGATG
AGATTGATGGTTCTGATTACGATTATGGTATTGGTAAGTGGTATTCTTTCCGTTTGGAAA
GGATACATTGGGCTAATAACTTGGGTTAATGTTAAAACCTGGCTTTCTACTAGTAAGTAA
TAACCTGACCAACTAAAAGCAACTGCTTGACTTATCCCCACATAAAGCTAGTCCACTACA
GCCAAACAGGATACTTGATGAGTATGTTGATGTGTACTCACCCTTGCTCTACACACCAAA
CCCCCCCCCCAGGTTGTCAGCATTGCAACCACTGCTCAGGCGAAGATGAAGCTGTGGAAG
GAGACTTCCAGGAGTTCCAAGACTACGACGAGTTCTAGGTGTGGGTTAGCGGCAACCCCC
CAGTCGGCTGCCTGTGAAGGCCGCGTTATCTACGTTTCTTTTCCGCACTTTGATTTATTG
TAAGAACTATATGGACGTCTTAGACGTATGATGTAATCGACTATTTCCCTTATTAATACT
ATTTTGAGCACTGTGTGATGATGTCCATATTATGTAACTGCTGTGTACGTGAATAACTGA
TCCTGGCACGTACATGGTTCGCATTCGGTTTGCCTTCTAAAACCGGGTGTGAC
.
qlt:
44444:<;S>G<6::67Wlll@8Nll[glaldgallaPTlkkllllllllllllllllll
llll]ddTLTIKDkkllkllklllllllllllllkkllllllllllllllllkllkllll
lklklllllllkllllkllkkllllllllllllllllkllllllllllllllllllllll
lkkllllkllllllllllllklllllllllllllllkllllllll\glllllllllllll
lllllllllllllllllllllllkllllllllllllllllllllkkllllllllllllll
lllllllllllllllllllllllllllllllllllkllllllllllllllllllllllll
lkklllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllg\gggllllglllllllllllllllllllllllllgllllldl_gllllllllllll
llglllllllllllllllglllllllellellllllllleldlbllllllllllllllll
lllllllllllllieiiiecVieiiiieiiieibiiiibiiiiideeeiiiiUYi_bdid
]iidi_]Yeeddi^i_eeid[^AiYdbe_i^OibiediSe``edieeYiWVeRXXe_e]S
eXii\ViT\XYeiQ\XeNM_`IUOc]M_^LIcO^PWQT[cM]cN^TMCMU]TcM^[M[[M
ONTMWRMMMOMOTLMET?PNMMLAIMINLcTPDTLRMHCccQKN@ZTDKCMF9
.
frg:17
clr:5,771
}
{RED
iid:1409
eid:1128922831
seq:
ACGATCTAGAGATTCACAAGCCCTAGTGACTAGAGAGAGTGATTTGCCGTGTTCATTTGA
GCTCTTGCGCTTGGATTGCTTCTTTTCTTTCTCACTTACTCTTGAGATCAAAACTCCATT
GTAATCAAGGCGAGAGGCACCAATTGTGTGGTGGCCCTTGCGGGGAAGTTTTGTTCCTGG
CTTTGATTTGAGAAGAGAAGCTCACTCGATCCGTGGATCGTTTGAGAGAGGGAAGGGTTG
AAAGAGACCCGGCCTTTGTGGCCTCCTCAACGGGGAGTAGGTTTGCAAGAACCGAACCTC
GGTAAAACAAATCTCTGTGTCTCACTTACTTATTCGCTTGGGATTTGTTTTGCGCCCTCT
CTTGCGGACTCGTTCCTTATTACTAACGCTAACCCCGGCTTGTAGTTGTGTTTATATTTG
TGAATTTCAGTTTCGCCCTATTCACCCCCCCTCTAGGCGACTATCAGAAAGGAGTCAAGC
TCAATCCTGAGAAGTGTGTCTTCGGGGTGCCCCGAGGCATGCTCCTAGGGTTCATCGTCT
CCGAGCGAGGCATCGAAGCCAACCCGGAGAAGATCGCGGCCATCACCAGCATGGGACCCA
TCAAGGACTTAAAACGTGTACAGAGGGTCATGGGGTGCCTCGCGGCCCTGAGCCGCTTCA
TCTCGCGCCTCGGCGAAGAGTCTGCTCTGTACGCTCTACGAGCCGGTGTTCGCTGACCCT
GAGCTGAGAGCCTCGCACTGAGCGCTCTACAGGCGCTGTCTGTGCCCGCGATGAAGCCTC
TGTCTACGTTGCGGACATCAGTGGTACGCCCGATCTG
.
qlt:
444677<D@;769N>5888:b^R]Ydd[JDRS]i]eeeTAYIAieVOll]lllP@_bbA@
Fbeelbl__dlll_g_llllllllllllllllWKll_gllllllggglaallllllUall
lglllaallllllllllllllgllllllllllllllllllllllllllllllllllllll
llllllllllllllglllllllllllllllllllllllllllllllllllllllllllll
lllllllgllllbllllllllllllUllllllllllllllllllllelllllllllllll
lllllllllllllllllllllllellllllllliieiiii__ZRiieeiiiideiiiiii
iiiieiiieiiiiieiieieeiieeiiiieiiiiied_ii_ibiZeiieidiWeeeiiii
iiidbiidRdiieebiiieeiieTiYYYSYieide_ieedPeidd_LiIR_iiQeeXdie
i[QdeeeeiiBiiY`iXiXe_X]Biie_eLWWWU`L]ON`cN]O]MR?cRNPNOQOMM][
MWFcA^M]K`RMNOJ`^L^T>NMWMHQ[;PP<MLMMYSQGGDYONMMGOMFKM^CEBWJG
MLF?A@ECGIGccD5D<PARRQLTCcOBMFFRcVJ;V?C@KC;CC6L<BLR>I:BOOMMC
KBFLCJFL8@E=I>=Q64479>CEN;<CRC=M6845@513441344466<4567636C<<
ACG:H>:EK;G?:6G:=::<G@46::444344664D5944>927KC@A5A95D864C976
B=255<=8:46<6=;8459:C44@=7456355<@968
.
frg:17
clr:6,741
}
{RED
iid:1410
eid:1127298148
seq:
TGGTCTGATGAATCAGCTTGATGACGAATTCTCTAGATATCGCTCAATACTGACCATTTA
AATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTGACTTG
ATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGGCGTAT
TTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTCCACGGG
AAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGGTATA
ATTGGGGGCAAGCACATGTCGGAAAAGTCCGTGCGGAAACATAGCAAATGTAAGGTCGGA
CGAAAGCTCCTGAAGCAGATGGGTTAGAGGAACCGGGTAGCGATATTGATGAGGTGATGG
ACAAACACAAGGAATTTACCCACTCCTCGATAAGGAAATGCTAGACACTCACTGAAAACC
CCCAAAACCTCTACTTCTGACAATGTATAACAACAAGCCTGACTACAGCTGAGAGAGCAT
GTAGTGTCGACAAAGAACAAA
.
qlt:
5354J>MUDE869:67SelllV_WK[laXllllglla[gkllllkdlllllkklkkllkl
ll][EJJQTLNS\UglkXlklkklllklllkllllk\kllklkkdWPA[L[Wkkgkklll
kllkklkllklkklllkklkakklllkakk[kkakkUTkkkOGkUSNkkkdkkkkklakk
kkkllkLCCHJKTHMFYO[YUVVQkTFHENGFPK=HGL][[a]kdBSW=B?=D;<:;<=[
d]TWTHdK]kGMUGQH\R]TTLPCCJB=GKKG=<EFKkOPPaFJWB==99;GPLC;:===
=C=M=@B;::9:9=<==K?BI<:<9C;:?=B=?<>>L=NB:=<>@O>C;B<=>CH;==<G
?<8<@BHC=;;BCH:?;;B==C==<V=F<CWC98:>=<@9:6<::9=;MK:<;==?<9;=
B;<:89=:>C;:;@=<;<E?9NA;EC=AJB=<;<<:<R=H<;IFH;FC;B=<<;;:;;;G
>H:FA::98:;8=?89C:;F<=9=9@C@=B=OE9:=;;9:OHA@=E88A99:::9:7=89
88:;>=8;>B<867<==988@
.
frg:18
clr:307,550
}
{RED
iid:1411
eid:1127298149
seq:
TGCATCTGATGAATCAGCTTGAACGAATTCTCTAGATATCGCTCAATACTGACCATTTAA
ATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTGACTTGA
TCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGGCGTATT
TTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTCAACGGGA
AACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGGTATAA
ATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCC
CGAAGCGCCAGAGTTGTTTCTGAAACCTGGCTCGGTGACGTTGTTATGATGTTACATATG
AAATGGTCAGGATACACAGGCTGACGGAAATAATGCCACATCCTACCATAACCCTTTTAT
CCGCTCCCTCGCCGAATAATGGGAACGACCTGCCCCGACCCCAGAGACACCGAGTGTCCA
GGGAGTAAAAAAGTAAACTGTGTCCGGGAACATATTTACATTGGGGGTGTCTGTTTCCCT
GGAAATGGTTGCTGTCCCCGCTTGGGTATTCCTCAATGATGATATTATCGTGTGTTAGAT
TCAATTGAACAACCTCTAGAAGGAGGGCGCGCTTTGAGTTTCCGTTAGGATCGA
.
qlt:
21344T?KSCB87:>68RdiiY?UWi_Wlllllll[S[Vllll__llllll_laalkkll
llaQTa\GHJLBkU\kalklkllllllllllllkggkllllllldkQd]kdakkkkkklk
llllllllkkkklllkllllllllkkdkkXkkklllkklkdYlkkallllllllklakkk
kklddaTTWddkdkklkkLUTDGaTJJKMKLkTMTYk\\O[dlkLNUFKU<=<;<=kkdk
kkkkklkkkdkk]kakakklkkddka]klkkdkkdklkkkkdakk[aWWWkkkk[RWWOW
KVkWTPSYTTa\NTYdlWd]aTLPaTVGKdLkD=J=<GBMKHNRGBCCaCBG\TCLBGBF
FFG4F=;BC=>TG<BN?LLG=MWV=F:=F:86:;M<9B:=<@?8;:=F98I<;>=?>G>C
G?D9E;;<<<GBJ98CBGLCB:<=<<=<;B<<SKTKG<BK<;C<C=<;9?H=H9:::;==
HI9?;?@CJCE<;?G;;9<9:<9@M?:L?9@B;=<D<??:D:>;B<ABA;=:?<:=H?:C
F==<<8<;=;<F>JCC9<;;:>9>9868MS9OJIB<=>::<<<=;:B9G868:898?8BC
9::9:8::D=A;F>A9;889@E<@:;=88:88=;=<96<A:;4;6:;<:=A<H>>B889>
878<9:779?B988:E;5:F>>8=6:865<G5?D:>6895;78568879D;=A8
.
frg:19
clr:484,695
}
{RED
iid:1412
eid:1127298150
seq:
TGCATCTGATGAATCAGCTTGATTCGAAAGAACCTAGTCCCCGTTGAGGTGGTCACAAAG
ACCGGGTCTCTTTCAACCCTTTCCCTCTCTCAAACGATCACTTAGACCAAGTGAGCTTTC
TTTCTTGATTTCTCGGGTCACTTAGACCCCGCAAGGACCGCCACACGATTGGTGTCTCTT
GCTTCGCTTACAAGGCTTTGAGAATAAGAATGAGAGAAAGAAGAAAGCCAACGAAGCAAC
AAGAGCAACAAAGAAACACAAGAACGATCCTCTCACAAGTCCTAAAGCACTAAAATTGAA
TTAGGGACTTTGATTGGATCGGTTGCTTTGATTTGTGTCTTGGAGTGTTGCACTTTGCTC
TTGTATTGAATGAAGTGTGATGAATGCTTGGATGGTTGGAGTGAGGGTGAATAACTAAAT
AATTGCACCATATGAAGACAACGATCCTCTGTAACCAAAGTTGACTGGCAGACGATGGCC
TACACCTCTCACGAACTCATCGCAAATCCTTCATGCTCCACATCTTGTTGTACCTGCTCT
TGACCTAGGGGTGAGTACAACAAAGGTGAGCTCACATATGTTCATCGCTCAACAGGTTGT
GGGCAATAATGTGCATGAGCTCACTTACGATGGGAGCTCATGTGAAGTGTAAGGTTTACC
AAGAAGAATGGTTAATGTTGAGCATTGCTTTTAACAAGTTGGTCAAATTTTTATTAGCAG
TTACTAAGTATAAGTAGATACCAACCCAATTAAATAATTGGATCACAATGATAATAAATC
CCTT
.
qlt:
44444G=BTDJ;7;?98W_iiiRllMYllblAKlllelllllllll_a_glagldlglll
kklkk[S[[[ddlkSklllllllkglllllkWkllkllkkllllTkll[kkkkgklllll
klklkkgkU\klklggkkkkkllkJkkkkkkkddkkkkkkkkalkkYkakkkTk\bTd\[
gY]aaMdkkkaKNMkJL[[[kK\PYd[HgkHa[=SBYY[dlkQgb[YWaDLOPkNF]NM[
HOBYFOGKYLTaIkaR[L[FJJ[[KKYSOSKUISCGGNOMT[OVVQYTOT[[>LSLYPMQ
Q[S=UUNLQTSLKGMTUSSONT=FK=DLUQVL[VH8L=L@OTHE<<G<BFGBKTTKUBOT
CGT=DJlgLg[lT_PYl=l[TldlalH[YTIaFaQKXbRYIQgTOgK>DBIXPTdROKBS
TTTY[TO[UKKLHC[O<TL=aUTYdUUTYLL<<=?C=H::ILBTALOI>U:P>9J>CBRP
VN6TYbbJPC?>;UEIUVS[b?B>98;GIOHOIObHS]]IPGP[KBM@GGESGNGSLNF<
>>=8HKQ8>KFOH_FTLH=;:F?8C9;@T?NRMDHNRJQHKKLHQO>AKKGHH?89AHI>
N>HEDREE=EPDQ]VSUV<Y]]BHRVXQ5QOHA8U@QVOHMPPQVV<QRKLG6@PRMQF>
7AGWM9ZQPQLNMD74@>PKN9MRUSOD<NNNO?NEG=>MMFMMFM`M]TVMMTLJ9>B=
=BJIAHA=NRSKH7TLGO@LH?<:;QQGGH@7DJJ@868779>E<@G9>:A:;MJA>:>A
K845
.
frg:20
clr:5,780
}
{RED
iid:1413
eid:1128922832
seq:
GACGATCTAGAGATTCGTCATGCTCAGGCCCAGGTATAACAAGACATAGGAACATAAACT
CATATTTCATGCAAAGAGCAGGTGGAAGGTTGTACAGTATGGCAATGACAGGCCAACATG
AATACGACGCAGCGGTCATATTGAACGGCGTGAAACCATCAGTTGCCAAGGCGATACGAA
CGTTTCTTGCATCGCTGGCAAAATCTGGATCAAATTTGTCAAGAGCCTTCCATGCATCAC
CATCTGACGGGTGCACCATTAACCCATCTTGTCTGTCCGTATAATCTTTATGTCACCTCA
TGTGCATAGCGGTCTTCCTCGAGAGAAACAAACGTTTCACTCTAGGAGTGAGAGGCATGT
ACCGAAGTTGTTTATGTGCAACCTTTGTCACCACCTTCTCCCCATCTTCATTTACAAGCT
CCACGTACCTCGACTTCCCACATTTTAAGCATTTCTGTTCTCTGCCATGTTCCTTCCAAA
AAAGCATACAGTTGTCTTGGCAAACATCAATCTTCTCATACTCCATACCAAGACCTTCAA
GCAATTTCTTGGACTGGTACATGTCTTTGGGCATCTTGTGACCCGTAGGAAGAACCTCGC
TAATCAAATCCACAAGCTCCTTGTAACAATTAATTGAGAATGCAAACTTGGACTTGATTG
ACATCAGCCGGGTCACGAATTCGAGTACGGTCACGTCAGTGTGCCCGTGAAGAGGCTCTT
CTGACGCTTTAAGTACGTCAAAGACTTCTGAACCTCCGGTGTAGTGAATCATGATGATCT
GGTGCTAGTCAGCTACAGATCTCAGCATCTGTCATCTATCACATCATCTCACGTCATCAC
TCTACTTCAGCTGCTCGTCAAGGCGTGAC
.
qlt:
65657:8=F;;9?:OOFUN>Te]lE8^lPlDClleSPglSQ_ll[[lallllaWllllll
NAkllllV[llklllllllklkllllllllkklllklllllllllllllklllklllkll
llllllllllllllllllllllllllllllllglllkkllllllllllllllllllllll
llllllllllllllllllllkgllllllllllllggllllllllklkkllllllllllll
llllllllllllllllllllllllllllllllllllllllllllggllllllllllllll
lllllllllllllgllllllllllllllllllllllgllggllllgglllllllllllll
llllllllbllllllllllllllllllllelllllllllllbllllbllllllll_llll
llellllllllllliiiiebiiiiieiiiiiiiiiiiiiiiiiiiebiiiiiieiiXPii
iiieieeiiiiiiieieiiYdeii_eiie^ii[ieee]deeie_Uei^JQeeiL^eiUGi
eededieeb_iHeTeiMQU_Uei_eei^e^\YS`eX]iLeUQWUUKi5WeUEiXSJe_N_
NM^NXM^]OO]MXNcO__OQMU]MMUPLMMMOMM^UU@^TJTGM[QMMMPDTHKMTMEIM
LLHSVLLYTKYMGVMMGWRLMM>XEBS;FCCQIMLLNRQGYDNL^OMGMGO?^?DEMMFG
GFGR<ADNcP@LCEL9GBLFcN9P;G@DDCELF?=;;@><I>@77CALDRODKLGONCEA
DI;P>GM6A7578IH856@8M8?N>LGMH6@5>:=M4><@F7=AFDH<C43=@?HDF9K9
K89D>GG>GCG@H8G@:=4:7I:335D43
.
frg:20
clr:7,862
}
{RED
iid:1414
eid:1127298151
seq:
GAGGTCTGATGATATCAGCTTGGACGAATTCTCTAGATATCGCTCAATACTGACCATTTA
AATCATACCTAAACCTCCATAGCAGAAAGTCAAAAGCCCCCCACCGGATGTTCATGGGCC
GACCGGAGTGAGTTAATCCCCGTCGGCTACCTTGACTGGCCGACGGGAATTAAATAATCC
TCGTCGGCCTTATTTTGGCCAACGGGGATTAATTAATTCCCGTCGGTCCACGCGCAGGCC
GACGGGAATTAATGTAACCGACGGGAATGCTTTGGATTGCTGTAGTTTTTGGTTCTTAAA
AACTGAACTTTGCCAAAAACCTTCGACACTGTCAACTGGGAGCGTATTAAACGAAAACAC
AGTTTGTTACGTCTATTTCTAAATTAAGGGGAGTTACGTCCTTTCTATCCGTGTTTCATG
GTAGGTTAGTTGGGGGAATAACAAATTTCATCCGAATATATTTTTTTTTTTTATAACGGT
ATAAATCAACATTATATTAAACCCTGGGCGTGACTTTTTTAAAGGGCATCAAACCAAGCC
CCCCTTTATATGGGATTTCAAACCCAAAGGGGTTAAACCCCCCCTCCCGGGCCATGGGGG
TAAATCCCCCCCCCTTTTCCCCCCAAAGAGTGGGTTCAAATTTTTGGGGGCCCCCCCTTT
TGTTAGCCCCACCCCTTTCCCCCCCCCCGGGGTTCACAATTATAAAAAAAAAAAGGAAAA
ATTTGGTTTTGGTGGGGGGCCCCCCC
.
qlt:
312228:BP@A5:88;7>A^QRN:=]\<F^iei[^dONNIVIO^OLO_bYbiTPB@d_UG
VVdWBA9<74445555545=SQKHHZIHLBB>8978:B==I??99A>46:994555><77
;>H?YBA;=<A=<LaUHUTTT?=L=?DLRRDCMBN<COB=G=[B=KCSPSQH=?=C>=SK
NWCCC=K<GKMTTTTTPCHJGJGGGHENWRTOKTMNMaTWWTTPPYSSTIUAL<KP<SKP
NaPBNTaSMWKKNTP[ALN=dKMPBKJGTBIdddTaHGJCHR?H;GCGKPPNFVTTPWUF
PKFIGG<=E\D<;==BJJ<<HJWN:TOLRRaISGEBNNCDJ;BC<G:CP=;<:=QKa]HK
H=>SLI@<<B;:CG]UUG>8=;CCCH:@;<;:59HDF==J<KNILJHLC=9888=:<@=K
BA@@F;>B<;9<B<BCC>=:=<<L@C<C<9?JG==A5:<E=;<:=G=CCBF=@;=F<<<;
:<?BC=?8<::;;=A=@<HF<?===PG;E::NKCGLL=CF>GECK<=<=;=CCHCC=?<=
PGK=JOG?<<<>I:CLGH?LRK<KBBKDPNB<==AL>>JONOG99<K>;WC??=<<BC;=
7:B6::DHPMBCG@@GGCILWRRL?C===V=HKEC>CL==OHBBD?G=<;=<<KG=;@:=
;;;<=<==G:=G==>BB@=GCB<=@==>@=G=:>>;<><<:;>:==dW]]=BJEA;<<=B
<=>;;;5>:<56B:GJCL<==<=<=:
.
frg:21
clr:109,744
}
{RED
iid:1415
eid:1128922833
seq:
AGAAAGAAATCTAGAGATTCGTATAACAGACCATACTTACTTCCCCCGATGCTAAGGTAG
GCGACGGGTCCGAAGAGGTCCATATGTAGTAACTCCAGTGGTCTTGATGTAGTCATCACA
TTCTTGTTGTGATGAGTGCTTCCCACCTGTTTTCCTGCCTGACAAGCTGCACAAGGTCTA
TCTTTTTCAAAGCATACATTGGTTAGTCCTAACACATGTTCTCCCTTTAGAAGTTTATGA
AGGTTCTTCATCCCAACATGTGCTAGACAGTGATGCCACAGCCAGCCCATGCTAGTCTTA
GCAATTAAGCATGCATCTAGATCGGCCTCCTCCTTCGAAAAATCAACTAAATAGAGTTTG
CCTTCTAGTACACCCTTAAAAGCTAATGAACCATCACTCCTTCTAAAGACAGAAACATCA
ATATTTGTAAACAAAAAATTGTAGCCCATGTGGCACAATTGACTAACCGTCAGGAGATTA
TAGCCTAGTGACTCTACTAAAAATACATTAGAGATAGAGTGCTCATTTGAGATAGCTATC
TTGCCTAAGCCTTTGACCTTGCCTTGGTTCCCATCTCCAAAGATGATTGAATCTTGGGAA
TCTTTGCTCTTGACGTAGAGGTGAACATCTTCTTCTCCCCCGTCATGTGGTTTGTGCATC
CGCTGTCGATAATCCAGCTTGAGCCCCCGGATGCATAAACCTGCAGACATTTACGCTTGG
GATTTAGTAAACAACTCTATGGGTCTACAAGGTAGTCCATAGTCTTTGGGACCAAATGCA
GTCTTGTCTCCTGCACTTGGCCCACTTCTAGCACCACTTTCTTATTCTACACAATTGGCA
AGAAGTATTGCA
.
qlt:
6546479<::78:885566956O><:988RPF=leeeeeelllleeeelbll_Hlg_Pgb
<=<;:788:8:=JKKddlllkakkklkkkllllklk[lkkdTTMULFLSMK=akaklkkk
llllllllllllllllllllllllklllllllllllllkllllllllkllklklklkkdY
gSkklgkkkkkllkllllllllllllkllllllllllllllllllllllkllllllllll
lllkkllllllllgYbgdglglglldllglgl_llllllllllgdglgglllllllllll
blllllllblllllgllllllllllllelbbellllelllb_ll_lllllUblbllllll
llllllllllleel_lllleleelllllieeeeee_eeeeeeieeiiiieeeiede]i_[
eeeiiii]eeeibeeieddiied[_i_]eieiieiee]diiibbVY[iiee]diRLXHU^
eXeeibdbddRVeeeeeQddV^XXRQNYidUiZeUUXe_XeQeYQXi\ei``T\J]\[__
X]YK]MNQCUYE\N]`SQNPQ<INK[>FMMTEMQYOM?:^RKJAMQ=UM[JMMMMW[HNJ
JMJYMQOMNDMTKDLB67EKMBMGOALQNGSOGMMLO^TVNG@JHGT@DE5N>T=HELSB
LCLLH@QAG9>SH?ICGKE@ICAHFB?647HCNGGG8SG48DE;N6G7F7OF<@=LGBBT
A4:R?646IR<;5CAF?M?@ALD9M5>=8D><EA:84579F=5?8JB7K7A783G7CI>K
6:9>9C4479B76585C9774@<<4B=@47;8D4<66DN76649:C8B6:A45E5>9@4B
:6K;854:5775
.
frg:308
clr:22,843
}
{RED
iid:1416
eid:1127298152
seq:
AGCTTTCTGATGATATCAGCTTGATTCGTTATTTGGGATGACACAGATCCAACCTGAGAA
ATTGCTTCAAGGACACGACACGTATATCCTTGCCCATCAAGCAGACCAAGTTTATTTCTC
GACATATCCATGCAAAAAGTTGTCTAAATGGAGGGTTGTGTACAATGTAAATCCCCGCGA
ACGCATATACACTCCTGGTGAGGACGAATATCAAATTGGTCACCTTGAGCAGGTTGATGA
GGTGTTTCAAGAAGAGTTGCCAACTAATTTTCATATTGATCCTGCACCGGCATTAGATTC
ACTAGTTGTAGACGTTAACGACTTAACTTTTCCCGAGAGACGGAGAAGACAACCGGTTAG
GAGAAAAGTTACATGGCGACCTCTGCATAGAAAAGAACAAATAGATCCTGATTTTGATGA
TATTTAACAAGTAAAGTTGTTTTGTTATTTCATTTGTTTATATTTTAAGTATTATGTCAT
TTTTGATGCACTAATGAATAATTTCTTATTTTTTATGCAGGATGCCGCCAAAATCAAAGA
AGTCAGTGAAGGGCTTGTTCAAGGGCCTGGGCCTTTTTCAGGGCAGTTCTTCGAGCAGCA
GCAGACGTCGAGAGCTGTTGAGCGCGGTACATGGAGATGAGGTAACATATCTTGTACAAA
TAAATTTGTTTACATATTTACAAATAAATCTTGAGTTGTATGTACCAGGATGAGCAGCAC
ACTGAGGAGCGGCACATTGAGGAGGAGGAGCACAATGAGGCTGAGCAGCA
.
qlt:
557444957;8@>888878KlllbGll[__VWlllglVClaVdlkkkllkVlllllkkkl
lkllklaA;8=H>=CTKgkdlllllllllllggklklllllllalklkklkkk\kkllll
llllllllkklllllllllllllllllklllllllllllllllllkllllllllllllll
llllllllllkllkllllllllllllllllllllllllllllllllllllllllllkkll
llllllkklllllklllllllllllllllllllllllllllllllllllllllllkllll
llllllkllllllllllllgkllklkllkgkllgglllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllgl
lllllllllllllllllgglllllllllllllllllllllllllllllllllllllllll
lllllllllgllllllllllllllllllllllllllllllll_llllll[llllllZlll
lllllleliiiieeiiidieeii__eieiiieiiiiiii[iiieiediii_ieiiieeii
eiiei_iiiei]ieeidWiiiViddi^WebUeiiiXXKiiCNHeedZeieeeiiNd`URW
_eiOUii\OiVUYM_\_i_\\Dc]UN^P`^Pc]^NWQ[JMRcMMYYSL]MK``L[UQWMX
JTYYPJY[>WOPMNMIWRTTKNYBMT>XWAMKPM^MYP@IIRMP8MH9<9
.
frg:22
clr:19,768
}
{RED
iid:1417
eid:1128922834
seq:
TACGATTCTAGAGATTCGTCTCATTTTTTATCACAACCTCTACATATGATATCATGACAC
ATGGACAGGTTTCATGATTTTCTGACTTTTTTGTGTTTTATACAATTTTTAAACACCTGG
ATGGCAAGTTCACGGTCATGTTGAGTGAGCATGGTGCTCGAAGTTTCCGGTCTGCTCCTG
AAATCGGTCATAACTTGTGCTAAGTAGCATGGATATCATTTTTCTATGCACGGTTTTCCA
AGTTTCGAGTGACCTGCAGTTCAAATCTGAATTTTCTGAAGAAATTCAAATAAACGAACT
AAATATACTAGCTATTGCAAACACTGTTATATTTGTCCCAAAATGGTACATGTAGGTCTA
CATAGTGTAGTAACATACCACAAAAAGTTTGGTAAGGGAAAAGAAAAAAATAGAAATATT
CTTTGCCGAGTGTCTAAATTTGACACTCGACAAAGACCTTGTTTGCCGAGTGTCTAACGT
GGAGCACTCGGCAAAGATCATAAAATGTATACTTTCACTACGGGAAAACAGTTAATTTCC
CATCGGGCCAGGAACCCGACGGGAATAAGCACTAAACCCGACGGGAATAAGTAATTCCCC
GTTGGTTTAGCCCTTATTCCCCGTCGGGTTGGTCAGCCCGCCCAGGGCGTCCCCTTGGGT
CGGGGATAACGGTTTATTCCCCGTTCGGCGCCGCCCAACGGGAATATCGTAAATCCCCCG
TCTCGGGCCAATAATCAGAGCCGAACGGGAAATAAGGGCTTAATTTCTCGGTCCGGCCCC
TTACAACCGAAGGGGGTACATAAAAAACCCCCCCCCCCGCGGGGAGATAGAACAGTATTA
AGCAATTAGGGGTGTACTCATCTATTGTGCACTATATATCTTCTTAGGCGCGACAGAGGA
CGGATACACC
.
qlt:
43474759;>B?87:NP=MYYL>IYRRYCJMC9G9YiidddeQDiiZ^_]iZON^eiWVZ
N_URAC?IHbllVKlllllllll_lllllllgM__lllglll_Wlllgg_ggl_alllll
lllllllllllllllllllllllllllllllllllllllllllllllllllllllllgll
lllllllllllllgllllllllllllllllllllllllllllllllllllllllllllld
lllllllllllllgllllgllllgllllllllllllllllllllllllllllllllllll
llllllllllglllllllllllgllllllllllllllUM[elllllllllllllllllll
lellllllllllllellll_lbllllbellllbll_l_llllWllVQll^[lQll_Z^Wi
_^__eVUOeRVi]]]XiP_ieb]]WZ_]U`SW^eNdPRdV_O_H_@@JdFCeGVTZVWZT
VLe@]TTTXASOVidEWHKNVBi[?KbCONLNVi[PANLQTPiCViYSFEOROEEBiHAV
??QN?bH<8=C9;B7>=EZAMiQQO:AT>=9DE9^E?\CAYDIiLLRHOGA>:DRNF`eC
A@8989LA98@]N=F6:C9]^===M>`@99?H867:B^<:7UH@ON<7;A>KI<7@5;75
;Dc_>O<@87CECF6=>L9DN=895;9A55A:79K<;?8G^HDK9C9>6FBF>8=KNK@7
555::G7D78<;:7>@66D7PJ6986=cIHRE8F>DLM6<<AB9RFD68:64:59>?C::
:769666748@ALK>755:9955>5544:?JJJD:;7:4887>77484E5;84:745747
?564848597@A78536<8544444345A>95498<;5>57436444557597695887<
749@656741
.
frg:22
clr:8,815
}
{RED
iid:1418
eid:1338942758
seq:
CCGGTACGACGGGATAGCACTAAACCGACGGGAATAAGTAATTCCCGTTGGTTTAGCCCT
TAAACCCGTCGGTTGTCAGCCGCCAGGCGTCCCTTGTCGGGGATACGGTTATTCCCGTCG
GCCGCCGACGGGAATACGTAATCCCCGTCGGCCAATATCGAGCCGACGGGAATAAGGGCT
AATTCCTGTCGGCCACTACAACCGACGGGCGTTACTAATTAATCCCCGTCGGCTGACCTG
GCCGACGGGAGTTACTAATTAATTCCCGTCGGCCAGGTCAGCCGACGGGAATTACTAATT
AATTCCTGTCGGCCAGGTCAGCCGACGGGAATTATCTGGGCCGACGGGAGTTAATAGTCA
ATTCCCGTCGGCTATGGTCAAACCGACGGGAATTAACTGGGCCGATGGGAGTTAACCTAT
ATTTCTGCAACAGCAACACCAAATTAGATATTTCTCACACATAACATACACAAAACATAT
ATATCACAAACATATGACAAAACGTATCACATAAACATATAAATCACAAACGCATTGACA
TCACACATCACAAACACATCATTGACATCACACATCACAAACACATTGATATAATTCACA
CATCACAAACATTTCAGATACGAGAGTGTTTACACAAACATAACGTCCAGGAGTTAAAAA
CATAACGAGCACGAGTTTAAGTGTTTAGAGATAACCACCACTTGGGTGGTTAGAGCTTTG
ACCGCTGCCGCCTTCACCACCAGGAGGAGGGAACGCGAAGAGCGAGTCAACAAATCCAGT
CCCTGCTGCTGGATCAGACCCACTTTCCACCCGCTTCAGGCGTAACCTATGCAAGTTAGC
AAATATCAACACGTTAAATGCAAATATCAAAAAGTATACAAGTGTATAAATTAATGGAGA
GTTATCAAACGTACCTATCTCATGTGCAGTATATGTGTCGGAGGGGCTGGTGAACTGGTG
GTGGATGAACTGGGTGTGTTGCAAATTGGCTC
.
qlt:
6568357A78K^=6686>EEXV8GeR^VKYYRJJG_IJb]RWiei^_eii]]iPNWll?<
8546765E;?CKbllll[_llll_WllgllllllllllaPJ@@LG?DPUllllllgllll
llllllllgggdgglllllllllllllllllllllllllllllllllllgllllllllll
llllllllllllllllglllllllllllglllllllllllag_XggllllllggbHH[bg
UUggadgd[ag[[d[[dddddddgggglddaWP[VYWadgdd[UdLOPLd_YbbYYYY[[
bVYbbablabgIUbbbQaUOPU[UWUUbUgg_gg_aUbUOUabl[gb[Oa[RaUPbOHHH
[bbb[[bTebbbelblbSb[TS[RZbZ]]Pb_XbbbbdlVO[bblWdZHdZXW__QZZ_Z
]][WbWl_Q]][]]SZVSWWR][[_eZ^Zb[bbe_VZ]QVEVC@@@HLeN]GLPSdb_bb
]bV][LPL]beINLIJNRHDVL_[V_]d]][_eXZ]PUZVLNNb^ZYEBGLPUZSPUFSL
bbQZQbZd^[eXb_dQdL__TUSV_VXbbVQXdeidebeee_\eXYZ[RT[Z_YTedPWe
RNedRVM\eSX]\WXUAiNYQG]QeYSeMKWY\?XUUReH_DM_PM`OHYN^TNNHLNNK
VNXOLNO\\LLKMMTQNMLTOMTBMMMN^_WOVSM_YMLM[[GFDNHWHCMJL[MSL^MQ
MBRTHLTIMPHTMAJEMOIMOLLKLHOK?YNJMHLHMSNBSGLLMMRN?APDKONKJCXG
EHGJRAJRDGSC78?CKV=VEBC;N:TIKIcCCFADQGONDC=R9>BIPENE<AL:=PEF
HNCGCAD;5@@GN?65>CJM:CL@FC=ADOGDEMA==<84;99E5:M=O:4969=EK648
@?:=;B5K7:G;97;9<::344;I;E9442569G?6=@@<576@E>33@<5=8;<?C=8C
B4CC45643;:DH<4438A7<>B98>5:5342
.
frg:22
clr:7,964
}
{RED
iid:1419
eid:1338942759
seq:
GGACTAATATACTAGCTATTGCAAACACTGTTATATTTGTCCCAAAATGGTACATGTAGG
TCTACATAGTGTAGTAACATACCACAAAAAGTTTGGTAAGGGAAAAGAAAAAAATAGAAA
TATTCTTTGCCGAGTGTCTAAATTTGACACTCGACAAAGACCTTGTTTGCCGAGTGTCTA
ACGTGGAGCACTCGGCAAAGATCATAAATGTATACTTTCACTACGGGAAAACAGTTAATT
CCCATCGGCCAGGAACCGACGGGAATAAGCACTAAACCGACGGGAATAAGTAATTCCCGT
TGGTTTAGCCCTTATTCCCGTCGGTTGTCAGCCGCCAGGCGTCCCTTGTCGGGGATACGG
TTATTCCCGTCGGCCGCCGACGGGAATACGTAATCCCCGTCGGCCAATATCGAGCCGACG
GGAATAAGGGCTAATTCCTGTCGGCCACTACAACCGACGGGCGTTACTAATTATCCCCCG
TCGGCTGACCTGGCCGACGGGAGTTACTAATTAATTCCCGTCGGCCAGGTCAGCCGACGG
GAATTACTAATTTAATTCCTGTCGGCCAGGTCAGCCGACGGGAATTATCTGGTCCGACGG
GAGTTAATAGTCAATTCCCGTCGGCTATGGTCAAACCGACGGGAATTAACTGGCCGATGG
GAGTTAACCTATATTCTGCAACAGCACACCAATTAGATATTTCTCACCATAGATACACAG
ACATATATATCACAATCTATGACGTATCGTATCACATAATCGTGTAATCACAATCGCATT
GTCATCAATCATCACAAACACATCATGACATCACTCATCCACAGCCCATGAATTAGTCAC
TCATCAGAAGCTTCAGATCGGAGTGCTTAACCTAACGTACGTTCAGGATTAAACTAGCTA
GCCAAGTTTAGGTCAAGCTAACCCACTTGTGATAAGCTTGAACCGGTGCAGC
.
qlt:
5484666:FIMTRPi`KQEiMG?<iMKiidiN^]bZiiTSiiSKiie^lZbeeXlll[@9
88876486A?_O_llllgglllV__llllllllgllgllabJ[LMMRgblllllladlll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllgllllllllllllllllllllllllllllllllllllllllllllll
lgllllllllllllllllllllllllllllllllllllllllllll_lllllllllllll
ll_lllllllllblllllllllllllllllllllllllllllllllllellZZ_ZPieei
eiieiii_iiiiieiieii^bee_id]i_^_eeeiiiiiiiieee_iiieiiiieiiib_
_eid_i_iiYdiiVYiiiii^i_UVd]ddiiKeeiiidiieee_^b[b\[UeYYYeeeNW
VdVSPZbW@HUUA:STeKVNTXYNBQQLUOKGNLUUPGGVRUdeQROOQTMHSQYOiFNN
GIKNUSOUKG:WHU:?_XKS\FMN>@NT=8FMLMARKXIHSDXNIORIPMM97BKETIMD
DMUMM?AMMLQUM>;OKF@GLJEG:CVGKRJMHMLMXDBAMLF?AMHA=EMO<@BLL;>8
BL58DF;7?DM??88;KQD=D=H@<N=K>=>86FE>GCL?JEA8EC555=A:BMI=8C>4
8CCDH9=G>@@GF;6556?NOBA;545HR@B@C869>>>5;6758A?3:<NML568@8J5
=5;5BD=56H6>?<D6=@;5:4=31765;9J>:77<5H663385>D;5954553?8I769
674;7643;8>IK5=784333443;36<584738774>E4774=9K7833<:23854553
739463>D84332395467D8737537=<4>48599:BB:6422335@>575
.
frg:22
clr:7,798
}
{RED
iid:1420
eid:1338942760
seq:
ATTTTGCGAGTGCTCACGTTAGACACTCGGCAAACAAGGTCTTTGTCGAGTGTCAAATTT
AGACACTCGGCAAAGAATATTTCTATTTTTTTCTTTTCCCTTACCAAACTTTTTGTGGTA
TGTTACTACACTATGTAGACCTACATGTACCATTTTGGGACAAATATAACAGTGTTTGCA
ATAGCTAGTATATTTAGTTCGTTTATTTGAATTTCTTCAGAAAATTCAGATTTGAACTGC
AGGTCACTCGAAACTTGGAAAACCGTGCATAGAAAAATGATATCCATGCTACTTAGCACA
AGTTATGACCGATTTCAGGAGCAGACCGGAAACTTCGAGCACCATGCTCACTCAACATGA
CCGTGAACTTGCCATCCAGGTGTTTAAAAATTGTATAAAACACAAAAAAGTCAGAAAATC
ATGAAACCTGTCCATGTGTCATGATATCATATGTAGAGGTTGTGATAAAAAATTGAGACG
AATTCTCTAGATATCGCTCAATACTGACCATTTAAATCATACCTGACCTCCATAGCAGAA
AGTCAAAAGCCTCCGACCGGAGGCTTTTGACTTGATCGGCACGTAAGAGGTTCCAACTTT
CACCATAATGAAATAAGATCACTACCGGGCGTATTTTTTTGAGTTATCGAGATTTTCAGG
AGCTAAGGAAGCTAAAATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATT
AAATTCCAACATGGATGCTGATTTATATGGGTATAAATGGGCTCGCGATAATGTCGGGCA
ATCAGTGCGACATCTATCGATTGTATGGGAAGCCCGATGCGCCAGAGTTGTTTCTGAAAC
ATGCAAGTAGCGTGCCATGATGTTACGATGAGATGTCAGCTAACTGCTGACGAATATGCT
CTCGACATCAGCATTTTATCGTACTCTGATGATGCATCTACTCACAT
.
qlt:
4337D=;868;E7<_=I^PEKLD>?RVi_IHB=JDJTeTD]ZiidZ`_beeO>[NWeiiW
V?@X=8U68G886>GlWWlllllTllbllllllllllllll_[UK?<??UUlggllllbl
llllll_l__l_lllllglllllllllllll_gggllgllllllllllllallllllllg
lgldllllgllllll_lllllllllllllllllllgllgdlglllllaglllglllllll
lllllllllllllllllglgglgllllllllllllllllllllllglllllllllbllll
llllllllllglllll_lllllllllllllllllllelllllllllllllllllllllll
lblelllllllllellldelllellllllllllellllellllllliiiiei_eiiiidi
iiiiiiiiiiii_diiiiideiieeeeeeiiiieieiiZTiiVii]iiiiiYYiiiei]e
idYiieididieiiiiiieeebi^ii^_VdiieiieeideieieidRieiRIWiZ_dbR>
DdUe^YiiVVY^iiedKVVUUFeXee^^eXOi]eU\eiURYYeReXQiLUAVS[HNXiie
[SN_N_^MU`PcON^\MTMPN_Y`HUPc_Q]NYI^^c^]PTMMKOMMTMYONEccVYGMM
^KMSLYGNQYFMMLccMP[MIMTNKUMTQ>JM[cVNYPMMI[MLNCLMLYLSGOMMLYGN
McGJK>O=GDGE>?6@OGMMMFcJHLLOOcEEOCGTCLR\=IRSFB@LA:PJL;MEcB==
BDN465=B?N569NJROQOQN9M:JCE\G=FB?NICI?D98;N89F5J8>:T>L>MDQ8A
>E:36744I=A787:7:6C<8A7?;23::@;6@5E5F9A<GFF7<@38HG6E63523B@4
44437A7B?B=@=@NK6<5F::A:5E5B@;?=<D@9113967B3322
.
frg:22
clr:4,935
}
{RED
iid:1421
eid:1127298153
seq:
TGCGACGAGCATCTCACGACGACTACGTCGTCACCGACGCGCTCACATGAGACTACATGT
ACCCAGAAGTTTCATTCCTTGACTAGAAGATGCTGCCCCTGCCTACAAATTTTTTTTATG
CTCATTTCTATACGAAGCCAGAGGGAATGTTTGGAACCAATATGATGTGACTTAATAGGC
AGGAATGGTTTTCGAATTTCGACTTGTTGATGGATCTATGAGAGGCCTTTATAGGTTCAA
AATCGGAAAGGATGTACCTCTGCCCAGTACCATCTTTGCGTTGAAATGATGAAACTGACA
GCGCGGGAGCTGAGTTGCATGAGAATAGAGTCTCGGGGTATTGTCTCCCTTTGAGTCTGT
TATGGGCCGTCTCGATGTGGGCTTGATGATCGAGGACCCTTTCCTGGTCACGTGCCTCCT
CATGTGTTAGACGTGGCGCGGGCAGACTAACGGCCGAATAAGATACAACGATTTGGGCGT
GGAACGGTTGCGAGACTGTCGTGTACCCTCCGTATGCCAAGGCTGGGCCCGGGTCGTAGC
TGCGCTCCCTGCCGTGCGTGAACTCTGATCCCGTCTTAATAACCCCGGTGGCGCGTTGAG
CTATGCCAGGGGTAATGGACTTGTTTGAGTGGGTCTGAGATCCACAGCTGAGACAGTCGA
TTCCGATAACGCAGACCTGGCGGTATTGATAACTTGGTCTCT
.
qlt:
D676645945498463212435543143365C44444545444544768=9K665544>7
54444444445445;A=:<>H><D8?=85888:9:8<7<<B87=A:68=:779<=L<G<D
BGCK;::48;;:=7F?=9<:;=<G:>=;I===9BC=<8<@=GCGHBFBT=G<:8==?;=:
:BF=M:=49<;:E:<9:<?M8?6==B:;BKKF<WTH=<>=:<;HH=B<=:?@<<B=G?=9
99<<;<B<?CGH=G==B;IKFPCB99;=<<:<:<G==B;;B;HH==>==CBAAGB=HP8F
8<>8H6:=FEH[O<NTHG85BK=HB8P:H;;H;EI<=JWC=<?;<;:9:=8<GKC<:;B<
AL;=B:<@:BB=C98<=<<8GC=<GD:<JNC<K<BA<B=:<B:7FP:=K<;;GB=<?P;?
?@;P;<A<?8=LACL?=;=:;;9=9<:;><:E>I:CNGCC=:T=HA?=L<L:<<L@<CFU
A9F9:I<9:E?;J:;;>>99:?B=@=:>=?>99::888:A8M9:AHHC>:=D;9=GAKBA
IQ:D@8D7=:K@B<8;<87H87669:788866:789<>78<788876:7M=S@>VGDFBC
8A@9=8A:7:8DGG<:G:8:6<?D:9D9><A6D:7;?C@>?B<<LFNC:<>A>=9A9:::
><E?56797:6578>B879CBCD::BHA7977:=>A7:7899
.
frg:23
clr:74,696
}
{RED
iid:1422
eid:1127298154
seq:
GCTGTCTGATGAATCAGCTTGAATTCGTTCTTGCTAATGCTCAACTGCAACACAGTGTGG
AGGAAGAGACACAAAAAGTTGAAGATGAGCACAACAACCTGTGGCTTGATGACCCAGCAT
CACAATCAGCTAGGGATGATGAAAATGCTTAGTCTTGCAACCTACTTGTCTTATGTCTTA
TGAATTGTACTAAACTAATGATCTGTGCACTGTAATGAACTATAATGAACTTATAAACAT
AGGAGCTGAGCTGCACTCTTTTTTCCTTCTTAGAGTTTTCTCACGAGGTGTGAGTTTTTA
CCTACGAAGTTTTTAATGAGGCGGCCATCACACTAACAACTCCTAATAATCATTTCTTAT
ATGGGCCTGTGTGATCTGTTGTAACTGTGTCTGTGAGCCTGTGATCTGTTATAACTATGT
GCTTGTGATATGGTATAATAGCTTGTAATCTGGTGTAATAACTTGTAATCTTGTATCTTA
TATGTTCTTATGTCTTATATGATGTAATAGCTTGTAATATGGTATAAGCTTATGATCTAA
TAATTCCGCTAAATGTATGTATTTCTGTTTTTTTGTCAGTTTGGGCCAGTGGGTGGCCCG
GTTCGTTTAGGCCCACCGTGCCGTCAGGCCGGCCCGACACGTTCTGGCACTGGTCGTGTC
GTGTCTGGGTAGGTCACTAGGCACGTGGGCCAGCATGACCCGGCCCAGAGCATTAACGGG
TCGTGCCTGGCCCGACACTATATATTCAGACCAGGCTTAAGCTGATTAGGACCATATCCA
.
qlt:
87444888@9:=8<9;BKlllIKVllalllllklkkkllllkkklllkkllllkkllllk
lkllkWkP\gY\Sakkkllllllklkllklllllllllllkklllllllklllllkllll
lllllllkllkllllkkllklllkllgglllkllllklklllllllllllllllllllll
lllllllkllllllkllllkllllllllkllkklllllllllllllllllllllllllll
lkkllllllklkklkkk\\glkg\\gkgkllldkllllg\glllllllllllllllllll
llllldllkkkkgglllllklllllllkgllllllllllllkllllllllllllg\klll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
klllkklllllllllllllllllllgllllllgglllllglllllllglllgglllllll
llllllllllllllllllllgl_lllllllllllllllllllllllllllllllllllll
lllllllllllllll]lZlellllieZ[iiii___deX_eiiiidVee_ei_I_iZRiii
_biedbiWeL[UieXbieeiZiede]YdZi]dQiiedVbdedee_idZV_^i^eeRTiWY
XdiX_XiYNVeKXUX\QYXCRTYSVe\e]YTPSPK[^YHU^OTH]NMMcCMLMNM_V[cc
M^MM[A_N^ELcUM[IIMN[TOPMHOP<6Y<CIJQGIFM^>LMLG:=M<DX;ACMJD787
.
frg:24
clr:8,776
}
{RED
iid:1423
eid:1128922835
seq:
TACGGATTCTAGAGATTCGTCTTCTAGTTTGTTCCTGATTAGGCCGTAACTTGTGCTCAG
TAACATGAATATCATTTTTGCATTTACTGTTTTTCATTTTTCGAGTGACTTGTAGTTTAA
ATCTGAATTATTTGAAGGAATTCAATTAAATGAACTAAATCTAATAGTTATAGCAAACAC
TTTGATAATTGTGCCAAAATTGAACATGTAGGTATAGAGACTGTTTGACCACAGTAGAAA
AAGTTTGGGAAAAAAAAGAAAAAACAAATATATTTTGCCGAGTGTCAAGATAAGACACTC
GACAAAGACAACTTTGTCGAGTGTCTCCTGCACTCGGTATAGTTAATTATCGCCAACTGT
AGATGGTTGCTGACAACGCTTTGCCGAGTGCCACGTTGTGCCGAGAGCCAGACACTCGAC
AAACCCACCTTTGCCGAGTGTTTTTTTATGACGAGTGTTTTGCACTCGGTAATGGTTGTC
TTTGTTGAGTATTTTTTTGTCTATTGTAGCACTCGGTAAAGTATTATTTACTAAGTGCCT
GAAACTTTTATGCTCGACAAAGCTCTGCTTGGCAAAGATCGTTTTGCGAACACAAAGGTT
GACTTGTCCCTTGTGGTTCGGGTTGATGAAGAGTGATTGTCAACGGGTAGCACTCTGGGG
TAGTCAGTGGACTGACCAGAGTGTGAGATTATGCTTGTGCAACCATGTCGGTCGACGTGT
GTGTATAGTGTGAGCACAGGAACGGTGGTCGATGGCTGAGTGAGTCATGCAGCTCGTGAT
GATGACCGGGAGCGATGAGCATGCTGTCTACTGACGATCGAGCAGCAGTGACCACCGCGG
GTGGCTGACCCTGGAACACACTTGTGCAGAATGT
.
qlt:
64477:568<87878>RUEVeebeKINllZJ=lY_ll[[XMb_llllllllllllllaTd
dH@P=LLCCST[XNkklllklallklllllllllkTlkglllWkkT\S\lllllklllll
llllklllllllllllllllllllllllllllllllllllllllllllllgllllllllk
lllllllllllllllklllllllllllllllllllllllllllllllllllllllldlll
llllllllllllllllllllllllllllllllgglllllglllllllllllllgllllll
lllllllllelllllllllllllllllllbUlllllllllllllllllllllll]lllll
lblllllllllllbbiiiiiiiiiieieeieeVeiiiiiieieieieei_]iebiiieie
]i___Q__iiiieeieiVeibiii___edi[_Lieei[iiieibiiibidii^iORiibe
eiieWieiTUd_iiiYYidQiXdeiiJ^OeZeieZXSeiiU\XUe]MRYUX\e\Uie^cX
WUW\N\^^]\W_W`_OXLM][NP`XP_RRMOWKT_N=MKMMMc^VMMB_YMKH5[?KMBN
MTAJNYLMWIINYP[RGMMLWPLPLRAKOQ:Y:ELL@PPBL<JMLYHAM?MILRMBG\TN
>M>DSJL=CI8>QQNCMC9N9HQEON8DI<=CI><=J@LLIFGJ>INDD=DANCC>ABL>
C4>5?:FL:C6745E=?DB;<?A>;9;E4B=J;CC:F@=>:9636EFMMDA>9AM99>JB
@:5K79;<K6D584A?<94443D>7924EF6<ID:K7A54>4896H9J6D=>9B:C7=CD
643>6>=A5=D87:<966435B;4537@47@311
.
frg:24
clr:15,850
}
{RED
iid:1424
eid:1127298155
seq:
GGAATGGCTGATTGATGAATCAAGCTTGATGATTCGTTTCTACGTAACCTGGGATGAGGC
TGGTTAATCCCCCGACACCTGCTCGGACCTGATGCTGCTCAAAGGTCCGACCTCGTTCCA
GATGGAGAATTTGACGATGGAGAGGTCAGGTGTGTGTAACCCCCGGGCGCCTTCTGCAGT
GGACCGATTATGTCTAGACCCCATACGCCGAAGGGCCAGGGGATGGATATTGGCTGCAGA
GCCTGAGCCGGCAGGTGGGTCTGCTTCGCATAAAATTGGCACCCTTCGCAGGTGCGGACA
ATTCTAGGGGCGTCACCCACCGCCGTTGGCCAGTAGAGGCCTTGTCGGAAAGCATTCGCG
ACAAGGGCTCGGGGTGCTGTGTGATGGCCGCAAACCCCCGAGTGTATTTCTTGCAACAGT
TCCCTACCTTCGGATATGGAGATGCATCGCTGGAAGATGCCCGAGGGGCTTCCATGGTAG
AGCTCCTCTTCATCGCCCAACAAGACGAACGACTTGACTCGTCGCGCTACCCGCCGAGCC
TCGACTTGGCGGGCAGCAAACTCTTCTCGGGAAACATACTGCGTTGTGCGGGGCCTGGCA
GTCTGAATTTTGCCTGGGCTCGCTCTGTCTTTCCTCAACGTGTAGTGGCTCGCGCTTGTG
GGGGCGTATTGGATCTCGGTCTTGAACCAAGGGTGGGTCGAGCTGATGGGGAGGGTT
.
qlt:
A344467577545656=7666558=NFJ:@87898;A<><88>877:8@6689768;>;;
;999999868658:8;79;9<88<B<<EGCK::GB<=D?=@;C@H=?>B==<76;779:;
=::=:F;=C=BIA:G<THKF;;L=;<=:=OQKKCGC?E:=HBH@=====<CKTIGNI==<
ULVGC>V?8K<=ABBB=NHGOO;NKE8<?<BH;K=KPM<N?EVPKI<CCPMHBKB?B<;K
=KTR[NHH=G<K=<TLWNQKUFGLHLP:B<<=5<=KTGBF<;<==B:6<G;K?LG=C[CH
CBODH=<;B99:<G@:DG=;=<<B?COWLCF>;=<6F8=<GCWTBP>CR=H==CGC=<<<
M=<BIKCLRO?BKO=QMGOCRCCE==B<B=CF<;BG=CH<TBCa?OWQRLKKTH<;9:;=
GCCG8TLB?PB<;::N@<<K;SSCJ=NLN;6<=C:;R@G=CBKV;H::=G:D;P?><<C:
P??GG?;B9>H;TTCGMK>:BC<FV@C]QCGUC?DG;D7C:=G<BL>LLLKT=NLCTB;C
BLDIDC;=B9A=;58<:;@:CJ;<<;;;<9<?KU>H@;>=C=:9<;;>;CKPG=H@PCC8
:9?<:8::;>:C;=FP::C<G>EP>>B@C89878CE9CB<:::N=>L:AUC<8:@F:A:H
A><:9=;M<:8:F;NB?A8<ND>F>8886>FH9?@:?F8>8;LLR88:I<6LBC@97
.
frg:25
clr:24,714
}
{RED
iid:1425
eid:1128922836
seq:
CTTCCATACAGATTCGTCACCAGAGCGCTAACAACGCGTTTCTGAGTTAGCGAACGGCGC
GGGGGACACAAATGGTTAAATAATGATAACACATTGAAAAAAGTAAAGAAGCCGCTGATC
ACTTCAAACACGGTAACTGATGAAATCGAGCGCGCGAATGTTTTCAAAATGAACGGCAAA
TGGTACTTGTTCACTGATTCACGCGGTTCAGAAATGACGATCGATGGTATTAACTCGGCG
ATATTTACGTGCTTGGTTATGTATCAAACTCTTTAACCGGCCCTTACAAGCCGCTGAACA
AAACAGGGCTTGTGCTGCAAATGGGTCTTGATCCAAACGATGTGACATTCACTTACTCTC
ACTTCGCAGTGCCGCAAGCCAAAGGCAACAATGTGGTTATCACAAGCTACATGACGAACA
GAGGCTTCTTCTAGGATAAAAAGGCAACATTTGCGCCAAGCTTCGTAATGAACATCAAAG
GCAATAAAAACATCCGTTGTCAAAACAGCATCCTGGAGCAAGGGACAGCTGACAGTCAAC
TAATAACACCAAAAAAGAAAATGCCGATACTTCATTGGCATTTTTCTTTTAATTTCTCAA
CAGAAGGTGAATTGACTAAAGGGGTAAATCCAACAGGACCGGGGGGGTCGCCAGAATCCC
GTACTCGCATAAGGGTTCCAATTAACAAAGCGAGCAGGATTGGGCCGGCGGCTAAACGGG
TCCGACAGGGGTTTCCAAAACGGGTGCCAAAAAAAATTGCATCACGGATAAAGACGCTAC
ATTATTGGAGCCATTATTCCGGGTTATTTGTCTCCTGACCGAATACCTTTTTTAAGGGTT
TTAGAAAAATCACCCATGGGGTTTCCCGCCACTTTTCCCGAAAAGGGCCCCTGACGGATC
TCTTGCGCTGTAACTTAAC
.
qlt:
43344344445656759<85:56<569?N9<888=?C6:;756CQHC>BHGGGAFLO;HF
66666454645444889;:7?:>:EH=>L@7GDM::99988899766776:779:9<URM
ERUSO<<GFA[O[BPP[RaYORPCPVSHPCPPUPU;IC>aCGG?H9;FJ?JGAL<@=;87
6;@@RLLLWILWEUEULEFE?KYLLE<EIG:JAAAUULEYUTJaOdVALTOTTUT;;::9
dTLUYLDL>IUCTLOA:;E?NRTRYWUdPW[UTMTTIUHJAOPMCAF>==CaS[YS_TQK
JICGC<RCFUJgJaaQSDROTSb?<<IBDbV[O[HKOGEa>C<>CCMOLK=CIGGMJUHO
HGEDO?EHBI[U[9JR?GST9GOE[Q=EH?KE]?M?BEHHSGSCBCVZQPFCEHE<>MNI
:O==>EMMEHO8L>ASM9:9:89VPACPNPQHOH>NS@NK<;9<7:98=KOA>?NE@AHC
VFALODL>HEFCHF?9B>TFM@7;6568:<DOOFM9J888:<XCD@:E<GHN:;?9LGPL
VC@<@ABF?FFDKE::<GDFB=JBB:I:7C@LALEFB>E;DORKHQENHE>ACJ>HDZCP
AE49C:@7:NN8=BN?8J75>@BCJP=FD=N88>H7?D>9AA8C;E98L7<G595<:;9?
>>N58C8BH:996C;7:BM8;78G<>>HC:<5>;@Q?AA86C>:9<DD>:DB56B85;M@
@EDEC9>9=A@9<5>6HMJP:AD>>;:@?@DJ7HQ87FGGABA=:9675:<798>=9A;6
A9:87@9;?6K79T@887:56MMID?7:875@6>7>;A8796@7ACDACAMRGA=4:D=C
K@;7>BB@?857G?4686JM=>H8IHD5788?>RC:<H757FGF:G;AFF?5@K7A<:75
6>D855685:6>@A=8843
.
frg:309
clr:780,902
}
{RED
iid:1426
eid:1127298156
seq:
AGTTCTGATGAATCAGCTTGAATTCGTTAATTCAGGGCGTTACACCAGCTAAGGCTCCTT
CTTTGTCGTGTGCCATTTTAAACACTTGGCACAGAAACTGCGTTGGGGCCCATTAGAGCT
CCCTTTACCGAGGGCGTGCTGGCCTGACATTCTTTAAAGGCTTCGTCACCATCTCTTATC
ACCGTTATGACGACTTTTTTACTTAGTGTCAGCTGGCACTCGGCAAAGACTTTGCCCAGT
GCCCGACATAAAGTACTCAGCAAAGAAGGCTACACTGTCACGCTCGAATTTAAGGGCAAA
CTCGAACGCGAATCAAATGTGTGCTAGGATCAAGTCTCACACATATGATGACTCATGGTA
TAGAAACAAATGTCACATCTTTACTATATAATAGGAGTTCTATACAAAATAACTAAATAA
TTGCACCATATGAAGACAACGATCCTCTGTAACCAAAGTTGACTGGGAGACGATGGCCTA
GACCTCTCACGAACTCATCGCAGCATCCTTCATGCTCCACATCTTGTTGTACCTGCTCTT
GACCTAGGGGTGAGTACAACAAGGGTGAGCTCACATATGTTCATCGCTCAACAGGTTGTG
GGCAATAATGTGCATGAGCTCACTTACGATGGGAGCTCATGTGAAGTGTAAGGTTTACCA
AGAAGAATGGGTTAAGGTTGAGCATTGCTTTTAACAAGTTGGTCAAATTTTTATTAGCAG
TTACTAAAGTATAAAGTAGATACCAACCCAATTAAAATAATTGATCACAATTGATAATAA
ATCCCCATA
.
qlt:
574489;R>H879:79_lllH>Kllalalkala@lllllllakdlkkllkllllllllgk
lllklkgSkkkllkklllllllkklllkllllklkkllllllROP?KOlllllllkllll
g\\glllllllkklllllllllllllklllkgklllllkllllllllllllllkklllll
lllllllllllklllgkg\\kllkkklllllllllllllllllllllkgllllllllkll
kkllgklllggklllllllggllllllllllllllllllkllllllllllllllkkllll
llgkllkggklllklklkkkkllklkggklllllkg\\klklllkkkkklllkgkkgkkl
llkllklllkkkkkklllkggkgkkkkklllklkllkklggggllkggkllkkllg\kll
llllkllklllk\gkllkllkll\\\\\ldkkUk\ggklkgkklllUkQkSSlklkkllk
Slkkggggbgllgglldllgllalglllggggllllllbgbggggggl_blgllll__[a
dUJPSeCbblS[_FPb_bleelll[dllelledlellll]llZll_eiZIeee_ZMiiWi
iid]e]deXcKi_]YiiZie_GeieeeQdQi^^[VZ_bZYdNiee]bdMi_PSGcZbL_N
eWdi9iWLXiXTWUeEYCWeiO`PQUYRMii_XeYNWMQY]AHYJcRJcc^MOPKY?OLV
XNPMSCcTWSWM<]MRMRMM?MU_DSQcYFMSYDYcQJMOEMMSLML??SDBJK8ET;Tc
MKK[^MDGE
.
frg:26
clr:6,787
}
{RED
iid:1427
eid:1128922837
seq:
GGATCTAGAGATTCGTCAGAAGAAAACTGAAAACAAAAGAAAAAGGAAAGGTAAAAGAAC
AAACCAGCACAGGGCCAAGTTCCAACCCGTTGGCCCAGTCCACTTCCTAGCCCCTTCACA
CGTGACTGCCATTGTTCCGTGATGCGTGGGCCCGACATGGCATCCGCTTCCCTTTTTCCC
CTCATCGCATGATGCCACTTGCTCGTGGGGCCACATTGCCACCCTCTGCTCGCGCTCACG
CGTACAGATGACATGTGGGACCTGATATTCAGAACCGTCTTCTCGGTCTCAACTTCGATG
AATGACTATAGAGTTCTTAACAGAAGCACAATATTCAGGGGATTGTAAGAAACCCAATCC
CGGTAGTTTCGTGCCCTCTGTGGCTATATAAAACCGCACCCCCTGCGCCGTTCACCATGT
CACGGGGCTTTGCACCACCACAATGATATAGGGAGGCGGAGTGCGCCGCTGGGGGCCGCC
TCCATGGAAGCCTCGCTTGCGAAACCATTTGGGTCAAAAGGACCGGCCATGATGGCTCAC
GGATTCCCTTGGGTGGTGTCCATGGCCTCATCGAGGGATTCAGATGAGTAATCCATCGAT
GATTGCTCGCCAGTGTTGGGTCACGACCGTGTGGCCACGGAGCACCGTGGCTAGGAAAAT
TTGTGCCACAAAACCTGGTAAGAACCCTCCTCACATGTTCATTGTTGGATGATCATCATT
TGGCATCGTTTTGATTAGAGTTTGGCCGTCGGGTCGCGGTGCCGGTGGCTATGCCGCCGT
GTCTGGGCACTGTTGCCCTGTGTTCGGCAAAGTGGAGAGCAGCACCGTGGCACGTCAGAT
GTGTGGCACGTTAG
.
qlt:
645:7<?8<99:NZPZF=D<=89==?JO_R_llKClllKlbUb_l_bbggF=bllPIb:;
>:;:84<;;85=<BlaUlllllaVlllllllllllkk[]dTLNUklllklllgUklkllk
lllkKGBHBHLTHJJQl][Wdd]la[]k[]llllllllkkklgllllllggklllkgg\\
gglllll]dk\kdlllladd[Tdk]Ykaalllllllllllllllkkdkakllllllllll
llklllllllllklgkllllllllllkPgllklkllllklllllllllllllllllglgg
ggglllllllllllglllllllgllglllllllllllgggl__gggllllllllllllll
gllllllllllllllllllllllllllllbUbllllllllblllllllllllllllllll
lelllUlllllllli_ei^eie_Zi_Z__ieiiibieiii]iieeeieeiiiieeeeb__
e^V[ii_ieb__iieiiV_dZi^[SYbeiQYiV^e_ii[[idHi_i_dVei[Rii\ibVd
diP@^JIKQVVYYXiVHeS\UTeiVH^edUdeQ^SiRI<eYU>iDXiBXYXQGIH``OXW
XU?e\QeYNORLWK_SY`cYN[SVMYANWN\M]YETKMMNN=MWLRMHTNKMMAMYccML
cTMDPFPDMP^YXHMBEB8IQ;YQGTDMMNMLMJISYOYRMMGJ>IMGLBLM>LRSRRM^
OLIDLRQGJ\\KHMDIM8XLOcOFC8<IFMD\B=LA>CO7LBAD;>>:5:CCG>@>FC@;
?5EJMVJ@FGIL>CGAF:BED9;CK?G?K\Q<75GK7>4BJ8FE@@<85G79<LM:57N;
:6775>5;@56645
.
frg:26
clr:5,839
}
{RED
iid:1428
eid:1127298157
seq:
GCGTCTGATGAATCAGCTTGATTCGTTACCGGTGCACCGGACATCAAACAGTACATGTCC
GGTGTGCACCGGACACCCAGGCGGGCCCACAAGTCAGAAGCTCCAACGGCTAGAATCCAA
CGGCAGTGATGACGTGGCAGGGGCACCGGACTGTCCGGTGCGCCATCGAGCAGACGCCTC
CAGCCAACGGTCAAGTTTGGTGGTTGGGGTTATGAAGCTCCCGTGCCACTTTGCCCAGTG
CCCAACATAAATTACTCCACCCAGAAGGCTACCATGACACGGGCGAATTTATGGGCATGA
ACAAAATCGAATCAAATGTGAGCTAAGATCTAGTCTCACACTTATGATGACACATGGTAT
ATAAACTGAGTCACATACTTACTATGTAATAAAAGTCCTATACCTTCTCCTAAATAATTG
CAACATATGAAGACGACGATCCTCTGTGACCGTAGTTGACTGCGTGACGATGGCTGATGC
CTCTCACGAACTCATCGGCATTTCCTTCATGCTCCACATCTTGGCTAGCGGATCTTATTA
TAGAGGTGATTCCTACGAGGGTGAACTCACATCTGTTCATCGCTCCATTCGTTGAGAGTG
ATAATGTGCATGAGCTCACTAACAATAGAAGATTGATGAATGCCAAGGTAACGTATGCTA
TGGTTAAAGGTGAGCGACGCACAACAAAAATGGTTAAAATGTTATTAAGACTAAGTACGT
GTAGCTTGATACTGAACATGTAGAGAATGGTGCAAACATGAGTTGCACATCCA
.
qlt:
5654<8<O>F=7:967]illb?ll_l_PPllllla[alllaVlllllllklllllllggl
llkldkkYUkklklllllkllllllklllllllllkklllllllllllllllklllllll
llllllllkkllllllllllkllllllllklllkklllllllllllllllllklkkkkg\
gllllllllk\I:I\lllllllkYkR=>=<H?B=;;88;@<B5::<9=?<;;=B@:9<<B
<<<8?C<<<@:8=:C@C8<68<=:=;:B<=G=:?<G?A;<;=:<9;:==:<:<<<;99;=
;?I?<>:5:=@CCH<=BE;K<HL==C=?>?<<<<==<=C<=:;=IHOB@=88<=<T==B>
G:99::===EFG=G<K=<BB:<B@>:B;G::@BC<CC<B=<9:@>=:C<8B<<:<=<;=;
;=;:B<<=?G;;KG<KK=@HC<=HBLC?;@@;9<=L?=H9=>8:=<?<:B<=;;;<B:;8
9<LLL;::E;CCF;LI;E>99;<<C>?D;?TBJ?;;<><@::>:979=<<A;@@<<><;:
=>;>B=<=>9B9@8I;::?>9<<H=<==9:8?=>8:9=788><HHBK>88=8:E=D9=FE
;=;8:@8@:9>:C8=C@8::99::D8C::A;=:88<::9<7:889:5:7899<9:6889:
8B998?L<H=<:=7@><<<:;58=98;;;=EG8A>A>@9H;=<==;NK?5:9>::AE:8=
>>N8>O=F<AB>:;:9797874=UANF:H;6@;8D><<;:=;8::9;888868
.
frg:27
clr:4,761
}
{RED
iid:1429
eid:1128922838
seq:
TGATCTAGAGATTCGTCCATTTTACCAAGTCCTTTGACCAAACCTTGATTTCCATCCCCG
AATGTGATAGCTCGTTGGGGATCTTGGTTTTTCTCATATGAGGAGAACATCCTTTTCTCC
CCGGTCATGTGGTTTGTGCACCCGCTGTCGAGTATCCAACTTGAGCCCCCGGATGCATAA
ACCTACAAAACAATTTTAGTTCTTGACTTTAGGTACCCAAACGGTTTTGGGTCCTTTGGC
ATTAGAAACAAGAACTTTGGGTACCCAAACACAAGTCTTGGAGCCCTTGTGTTTGCCCCC
AACAAATTTGGCAACTACCTTGCCGGATTTGCTAGTAAGCACATAAGATGCATCAAAAGT
TTTAAATGAAATGGCATGATCATTTGATGCATTAGGAATTTTCTTCTTAGGCAACTTAGC
ATGGGTTGGTTGCCTAGAACTAGATGTCTCACCCTTATACATAAAGGCATGATTAGGACC
AGAGTGAGACTTCCTAGAATGAATCTTCCTAATTTTGCTCTCAGGATAGCCGGCAGGGTA
TAAAATGTAACCCTCGTTATCCTGAGGCATGGGAGCTTTGCCCTTAACAAAGTTGGACAA
TCTCTTAGAGGGGCACTAATTTTGACATTGTCTCCCCTTTGGAAGCCAATGCCATCCTTA
ATGCCCGGGCGTCTCCCATTATAAAGCATGCTACGAGCAAATTTAAATTTCTCATTTTCT
AAGTATGCTCGGCAATTTAGCATCTAGTTTTGCTATATGATCATTTTGTGTTTAATAAAG
TCATATGATCATGATAGCATAATATCACATCTCTACATCTAGTACAAATGGTGACATGCT
CAATGTAAAATAGTAGAATGGTTTGGA
.
qlt:
45777;I=A;::QZKQMCebi_LPK<9HZllb_lll[OH>lllllll[WlllH:glRUa=
A;<D7Egg_Ylllllllllllallllllllllllk[klkkgL\\[lllllllg\glllll
lllllllllllg\glllllllllllllllllllkkllkllllllllllllllllllllll
lllllllkglllllllllllllllllllllllllllllllllllllllllllg\klllll
lggg\glllllglllllllllllllllgglllllllbabgOgglggllllllllllggll
llllllllllllllllllllllllllllllllllllllllllllllllWllllllllllQ
lZUlllllliieiiiiiieeieeiii^_iiiiiiii__V_Z_iiiieeideediiiii[_
i__Q_eeiUdiidiei]iieiieidieiiib[QYeiideeXi^ieiiW\eidG^i_idRV
WbiU\ii_dUWi^eWiNiTOeUWWeSQVQK]W\^iiUV\e_`RC\OLeK\Q\iTWG^UGP
K\^U\NcCONOQQ]XNN\XNN`Q_\=[MMM^^MWEOPcVRHWJHNJMNS`YMMWMLNIMO
MYM[RQ76?Bc[WMMJMRSS^^RMM@>MOXLQGMWTOM^MEPHKEMXCJL[DICMLNGME
HC[<TMJ^Q<JINMMT=BKKKHM^NGHMJ[GLLJC^?LMcML\?9\BLcLLB;=Lc\EQG
@G:D6>LFOQ>LJE>Hc<9>RORMAN;F\\;@AOI<?AKI=G>F\SI8855OE<766\:7
@N98A=EGJK?@=E6KBMCMD67BHDD6@MMD>:>I>AEBM?<JDBRDAM;5AMAA<B7>
<;@8B5;??H3334313<5438KE942
.
frg:27
clr:5,849
}
{RED
iid:1430
eid:1127298158
seq:
TGCGTCTGATGAATCAGCTTGATTCGGGGCACGATGGTGGTTATTTCGAATAACTCCCGT
CGGCCTGACGGCGCGGCCGACGGGAGTTAGTTAATCGCCGTCGGCTGTACGCGGGCCGAC
GGGAGTTAGTTAATCCCCGTCGGCTACGTTGACTGGCCGACGGGAATTAAATAATCCTCG
TCGGCCTTATTTTGGCCAACGGGGATTAATTAATTCCCGTCGGTCCACGCGCAGGCCGAC
GGGAATTAATGTAGCCGACGGGAATGCTTTGGATTGCTGTAGTTTTGGTTCTTAAAAACT
GAACTTTGCCAAAAGCCTTCGACACTGTCAACTGGAGCGTATTAAACGAAAACACAGTTT
GTTACGTCTATTTCTAGATTAGGTGAGTTACGTCTTTCTATCGTGATTCACGGTAGGTTA
GTTGTGGATTACGATTTCATCCATATATATCTCTATTTTATAACGTATATATCAACAATA
TATAAACACTGGGCGTGACTTCTAGAGGGGCATCAAACCAAGCCAATTAACATGGTATCA
GAGCCAAGGCGTATATCCTCCGATCCATGTCATTGTGTATTATCTTCTCTTCTCCTACTG
TCGTCTCAACTTTGGCGCCGCCATATGTAACCCACACCGTACCTTCCCCGCGTGCCTCCT
GAGACAGTGTCAATGCCTGTAGGTCCCACACAAGGCGGAATTTTCTCTCGCTGAAGGCCA
AATA
.
qlt:
45544L=DU<B88<979QlAG;9FGllllaLMlaallllklkakkklkllllllllllll
lllkkk\RP[lkllllllllklllkklllllllllllllllllllllllllllllllllk
lllkklllllllllllllllllllllllllllkllldllldllgllllggllllllllll
llllbllggllllllglalglll_KHlblllblllblllllel]ddWbbbVbbK_SZV_W
S^_H_b_[Z_i]eV_i]iNee[=__iZeZZ_Z_Z_iVii]eXeiiQ_iU^[[e]i[[ibe
eSVdeiY^QiKiiVVZiQVSNeRQeXeQXDQX`ei`N`eU_ReSicWO\Y^^NHWM]_cP
\=YNNM\YSUMZJNQSOYNMTB^ETMJMUDMSYMFQE@FPCJGAYKGWICMQWDM9K?ME
<MGB:J>ECHLQCY@ZMH7BAE@AC><:;BEHC=:7T\F>:7IHLJL=9988;?85877?
;7:8I788B>IJ5>>?ND8C=:<M=>7FQF@BMJ863346<?6646I<;68;?>;48CCD
565:8844:797::54486>>6<;9H85A6K9A7D475>8684>339361331343958D
76;56:6444B?386345757?332573786;847379996:E97=854494:1235114
1314135655434411344233235C443333865484433>D4537667<55446636:
4211
.
frg:28
clr:5,539
}
{RED
iid:1431
eid:1128922839
seq:
TGCGATCTAGAGATTCGTCTTATCTTCTAAATCTACTCAAAGGTCGGGGGCTACACCCAT
TGGGTGCACCTCCGGTGCACCCAATAAAGTCCAGAATCTTACAATCCAAATTGCCGACCT
CTAAGGCACAAGCTCAAAACTAAACTTCGGTCGAACGAGTGATCAGAGCAAGAGTAGGCA
ACAGGAAATTATTTTTCGGACCTTGGATCTTTGAGTAGATTACCTCTAAATCAACTCAAA
GATCGGGGGCTTGTGGGGGATAGATATCCCCTGGGTCCACTAAAGAAGTAAAAGGCCTCA
CGAAAGGCCCGAGGGCCCAATAATTCGTAAGGTCATTCTTTCGTGGGCCTGGGGAAAGAC
AACCAACAAAGAAGAGAAGACGTGAGACCAGATTGGTGCAAGCCCGGACGACCCACATCG
TCGAACGAGTAAAATCGCAACGGAGACCCGACTTTCCCGCGCTGACGCCCCCATGCAATG
AAGCCATGCGAGGATAAGTCAGCGAAGGTTACGTAAGGGATAAACTCAGGAGATTCACTA
CCTTTCACGCTACTGTGTATGTTGTGCATATCCGCGTGTACTGCCCCCACGCTCGAGTAT
ATAAGGCCTTAGGAGTGCACCCCCTTCAGTACGATCGACATTGATTAAGATTGTCACCCA
GCTAAACTGTCTAGCGCCATCTATCATAGAAACCTCATGCACCACGCACTAGACCACCGA
ACATATGTGATACGACGTCGAAGCGGCAGAAAGTCGGATCCTGCCATGACGCAAGCTCAT
CGGAATGAACCTTTGGAT
.
qlt:
44456;@;C?@;>?ROHWbZPTHd_i_W@=MPi_^elQ;[ll[Olllll_llb_Slg_Sa
bMDELH97<CTa[VdKdaVddVVYa][[d]kaVW]LNTMP::::G955;=U[aGkSg\\a
Y[]WRkIRWO\dkkkVLY]d[V[WakkdWdO]MTW[]k[[kdk]NGk[VLL]kGQP=YL[
YTSQda[dkkadda]YYO\dW[TVaGSV]kkdk\SU]T[ddd]ddSUHLL[WLH]aaWGU
NkdT[UY\TM][lOdTUY[kWWBQILVRLPTYkQ]Q[VCW][LSHW[CWOOPTMYLTMPG
DK[SKTkSYTGYL]]QVTQGGGGLUKGCTISkH[O[[[KKUTLOdCHGSKaGGTSBCHUK
<?LT?F;=;;:G@:dJ[L<UBH<IAEH;ABGJIOY?HVC>7AHBCHKQC>VPJO<@;RO>
DJ<TD<=M<JB<GCCI?>OISH>P8FA>B=SDOOGE:CGCCSWHQ9;AH>=;=MWO>8ES
F:7:>7KWP=SIQOB>C8>E:9>9H>6F>WLGEKL?:><KAVP6@D>><=LDbN@CG8CN
>=E@G;89>FN@AH=DG79AG:97989GAA9<::><?SC::8>8:88@:<858;?G878C
:8886C?99=F:9>A>NJW;>>==9F;655<799;<A:858<I@GK8>98C>>>?D@:@D
::BDF;76658>CG:8A?88?BD<=>8RB<D6=8>@7CH5;5:88=;>::=5?8895575
D86?@BE6=86H59:45<558A6B>;=;7;5<78755F<88:F?E::98=;:78556495
5@@>:59>B9755>:A97
.
frg:28
clr:5,770
}
{RED
iid:1432
eid:1127298159
seq:
CGTGCATCTGATGATATCAGCTTGATTCGTGGTCCTTTTGCTTTGGGCTAATACTTTCTC
CCCCTTTGGAGGAGTCGCCAAAAACGGAGTCATTAGAGCCCTTTAAAATAATTTCTTCCC
CTTTGGTCATAAATAAATGACTGAAGAATATACCTTACTGAAATAATGATATCTTCAGGA
ACTACGGAAGCTAAAATGAGCCATATTCAACGGGAAACGTCTTGCGCGAGGCAGCGATTA
AAATCCAACATGGATGCTGATTTATATGGATATCAATGGGCTCCCGATAATGCCAAGCAA
TCATGTGCGACAATCTATGTTTTGCATGGGAATTCAGATGCGCCCGAGTTGTTTCTGAAA
CATGGCAAATGTATCGTTGCCTATGAAGTTACAGATGAGATGGTCACGCTAAATTGGCTG
ACGGAATTTATGCCTCTTCCGACCAGCAAGCATTTTAACCGTACTCCTGATGATGAATGG
TTACTCACCACTGCGATGCCAGGGAATACAGCATTCCTGGTATTACAAGAATATCCTGAT
TCAGGTGAAAATATTGTTGATGCGCTGGCAGGGTTCCTGCGCCGGTTGCATTCGATTCCT
GTTTTTAATTGTCCCTTTTAATGGTGATCGCTTATTTTTTCTCGCTCATGCTCAAGCCCG
AATGATTAACAGATTGCTTGGTGCAAGTGATTTTGATGACCAGCGTCTGGCTGGCCAGGA
GACAGTTCTGGGAAGAAAATGAAAAAGAGTTTGC
.
qlt:
3343545BD;MHG@:7><79E^^^V=iiUYid]ieiee_TXei__]Z]PHPGW]eb[[Ua
a[ll=:9744888<987<K;@KFIOKKYBUkTkk\=gK=JK=9:56489;65;:9:;;9<
KSUU\TCWHL[C>=><:KRV@GBLC;JG<CCCI<:;88;:B:=<;7:<:;<=?C<<8;=H
;8;:<8;;855:<;B<=KF<BC<;B89B999BG=JCC;:=J=MTFBB;D;H=9;B9=D<=
><:C=D9=GBBT?S;PKCPLFMGBC<NKG=:BCCBB<NG==<I@J<FBC=:H9<;8=BB8
6F=:D;GE=LH<FB>8<=:8<8=H4:BKB<:==<<<=U=MB<??:9aG<KWCKKOBSdB<
H<;J<;<<<5I<886:8B==:986=<488>EG:6LBJN=[MKH<=::9;<;9;:;B<<:B
N98<=98::B;;CB@C=GB;<K=B8:?E:FHN8:<<>68C;;<MSNB=MD>=?<==<<MB
BGVNTWCLT=<<G?;S?<<M;<:=DC<GGC<J=JB=NDMICQ@8B7NK=dTOVTVEHMB=
<K>BW=HT?TL@K8<GCCLPBE<9AA=?=H=<H9<:KLWD;99B:BAKB:HK:5=8:;?K
T=:9:;69FNM:KG<HN8<;8:==9DTF=G==GB8;;99<F=<=LVVN:N;?G<<:9:;<
IHCCB<<CB<699DFJ:FIMFCG<8MB@L[>H:<8M=YXF8IT?;9;=L<CKB9599@;<
<<:;>@?TJPUELA<;NLK;P;?;F;;<:JU:<;
.
frg:29
clr:7,167
}
{RED
iid:1433
eid:1127298160
seq:
TATTCTGATGAATCAGCTTGATTCGTTTGCCACCTCCCTTGCTATTTCAAAATCTTTCCC
ACTTGATTGCTGCATTAGGTGATAGGAGTTGCTTGATAACACCATTCCTGCATTACCTTC
CTTGAAATTTGATTACCTTCCTTGATCACCTGTTTTACAAAAGCTTTTTGATGCTTAGCT
TTGCTTTAGAAAAACAAAAGGTTTTGTTTTGACAAAATATGATGTGGCAAAAGAGGGTGG
GATGTTTTTCGAAAATAAAACTTGATGATGGATCTATCAAAGGCCTTGATAGGTTCAACA
TCGGAAAGGATGTACCTCTGCCAGGTACCAACTTTGGGTTGAAATGATTAAGCTGAGACC
GGGCGGGTGACTTGCACGAGAAGAGAGTCTCGGTGTAGTGTCTCCGTCTGAGTCGATTAA
GGACCGTCTCGATGTAGGCTTGATGATCGAGGACCCTTTAACTGGTCACATGCCTCGTCA
TGGGTAAGCCTTGCCTCGGGCAGACTAAGGCCGGAATAAGATAACACGAAATGGGCGTGG
AGCGGTGGCGAGAGTAGCGTGTACCCTCCGTGGCAAGAGGCTGGACGGTGGTGTAGCTGT
GCTCTCGGTTTGCGTGAACCTGATCCGGTCTTAAGAACCCCGGTGGCGGGTTGACATATG
CAAGGGTTAAGTGCTACATATGTCGTGTGATTGGAGATCCTCAGCTGAGTATAATCGATT
CGGATCGCCGTTACCTTCGCGGTTATGAAGACTTGGTCACT
.
qlt:
444489BW>F86<866[lDC;9EHUlllk[[<klllllllllkklllkHllllllkkkk[
alKNODLSNHHlkkkllllllkklllklllllllllllllllkklg\\gklklllllg\g
kkllllllllllllllllkgklllllllllllllkUklllllklaYYDTTlklllkkdlk
kllllgklkllllllllllkllklkllkkllllllllklkllkllllllllllgRkllkk
lkkllkgkkklllllllllllkkklllllllllllllllllllllllllllllllkklll
lllllkllklkllllllllllllllllllllllllllllllllllllllkgklkk\Nlll
llkllllllllllllllkkalkWkTldklggkkkllkdlllllllkkkgkkdkl]lkkkg
\kkklS]kg\glllllkllllllkkllldlkllklglllllllllllllllllllllllg
lg\Ollllllllllllllllllllllllllgllllllllll[lllllllllllll_lell
lelll_lleWWNl_lldlZ[lZeeiiiiiieiebeiKeX^Veiii]eZBYiXiWe]eiib
i]eeXdbUViiiYYVii_RieiYU^iedXedeei>UYUiiediHi\Xiie\ie_QIeedX
UN]eiNVeXeMXiVXPeL^UPc`cNNcE[NH]WI]M_MM^\[MN_^_cASLLMRK^MONN
[D>OEX<?[E85L>JPTMGQXXIMMGMT^?[FDIPEMMC97
.
frg:30
clr:6,758
}
{RED
iid:1434
eid:1128922840
seq:
AGATCTAGAGATTCGTCTGGGCTGTTTGAGGGAATGAAAGTGGACGAGAAAAAGGGCGAT
TCTGGTTTGAGGGTCGAATCACAAACCGTGGTTTCTTTGCCTAGCCCTGATTAGGCCGCT
CACCACCAAATCCCTTATTCTTCCCAGAAGTTGTGTATTTGGCTTCAACAGATAAGGCTG
TGCTGACAGCCTTTCCATACGTGAGGTCTATGCATGTGGCCATTTTCCTTTGTAGCCGAT
CATTCAGTCCCCGCATAAAACAGTTCTTCTTCTTCAAATCCGTATTCACCTGATCGATAG
CATACTGCGACAAGTGATTGAATTTGTTGAGGTATTGAGTAATAGTATCTCCACCTTGTT
GTAACTTCATAAACTCCTCTTGTTTCATATGCAGCACTCCTTCGGGGATGTAGTGTTCAC
GGAAGGCTGCTTTAAACTCATTCCAGGTGACTTGATGGTTATCAGGTTGAATAGCCATAA
AATTTCCCCACCAGGTACTGGCAGGACCACGGAGTTGTTGTGCGGCAAACAACGGCTTCT
GCGTCTCTGAGCATCGGAGAAGACCAAACTTTTGCTCGATAACCCGAATCCACTCGTCAG
CTTCTAAGGATCTTCTGCCTTGACGAATAGAGTGGACGAGTTTCCGAGAAATCCAGATAA
GTGTCTCACGGGACCCTGCGATACCTCTCCCGCCTGCTGCTAGAATGCTGCTGACCCGCA
TTTCCTAAGAGCGGGTATATCGCGTGCATCACCAAGCGCATCGCCTCGCTACGTGGGAGA
ACTGAAGGTGGTTGGGGTA
.
qlt:
45677>E9=998YUPZdXi_eWZW<ie_H>C:E=DGll[VSlleV[lllllllllPPHLH
UGCQgllllllladllllgaVkalkllllllllllllllk\kkllllllllkklllllll
ldllklkllllllllllllllllllklllllkllllllllllllllVllkllllllllll
lllllllllllllllkklllllllglllllllllllllllllllllggllllllllllll
llllllllllgllllllllllllllllllllllllallllglllllllllllllllllll
lllllllllllllllllllllllllllllllllllllll_ZVlllllllllleiiiiiii
ieiiiiii]iiiiiiiiiiiiiei__eiiiiieiiiiiidYiieii_YMidiiiiOieei
iiibSiZiiiiYY[ieiii[iie^TdieidbiiiR_i_H_edeUQdTie^^deZedQe]Y
YVUi^VQQ\V\\Q_i_e_ei\UY=WPAUU``QN>IU_M\\N_N^_PVc]NQ^VP]M___M
^MM_\``\M[9MMTVMNc:WcA[?[K[TMY^c[PM[OLTMMNMWWM[MNOYDMQVGCNOM
LMHMQG8<<69KDIMLYEJD?NEBCOL;MD665:C5:CV=IZE:I;V:K\:KFPA=J>8T
DHC5AFF>@RSCA?SE?N9N?9WC:<7@7ZDA6F<I>ELAF@8>F;8<AKCMJN;R?7:9
@Z7DN>==583;9J?57K998@5<4=8:I8?;H7=A7@7F>:6<HD<G69K;>7FP=C76
B:9D748:5:6325DHK7;
.
frg:30
clr:5,796
}
{RED
iid:1435
eid:1127298161
seq:
CCCAACGCCCAAAGAAGCAGCATGAATCGGCGTGCCCCTCATCTGGTCCATACCATATAC
TCGAAGATCAAAAACCCCGATGATAAAACAATCCTCCCCCACAGAACCGATCTGACTTTC
CTTGACTTTCGATATCATCCTTTCTCCCTCGTCCTACTTAATCTTTGTCATCCCTATTGT
TGATTCAGAAACATTTTGAGGAGCGATTGGACCTAAAATGATGCGTATTCAAAGGGAGGA
ATGATTTTCTGGCCTCCACTTGATCATGCATCTATGCTGAGTCTTGATAGGTTCATGTCG
GAAAGGATGTACCTCTGCCAGGTACCGACTTTGTATCGATATGATGGAACTGACACGCGC
GAGATGAGTTGCACAAGAATAGAGTCGCGGTGTATTGTCTCCTTCTGAGGATAATATGGA
CCGTCTCAACTTGTGCTTGAAGATCTAGGACCCTATCCAGCATCCCATGTCTCGTCATGG
GGAATACTTGTCTTTAGTCTACTATGGCCGGAATAGAATACCGCAAACTGGGCGTGGAGC
GTAGGCTAAAGTAGCGTGTTCCCTGCGGAGCCCAGGCTGATTCCTGCGGTTTTGCGTCCA
ATGCTGTGCGGGAATGTCCTTCTAGTCTTGATACTCCTTGTCGGCGCGTTGAGCTATGTC
ACAAGGTAACTGCTTCTGTTTGCGCGGGATCGTAGATCACAGCTGATTCTGAGCCCTTCC
TATCTTCCAGACTTAGCTGTTAATGATTACATGTTCCCT
.
qlt:
433444445655468:889=:78:758:89D>:=>>AE5:8>:998<<9K@>;9?=<><;
:E:9455<9544968:<=55<775><>968C=<<<<<;:7:>89;:8;;44458=G>C=?
A:;;==:=:??M9F;:>?CLHL;;<F<;<9?==;>>:;59=A=C<?:CC;><=@=<@?<;
;G:<<D@:M=69=<;<=<=C:B?=N9:<<=G:=<>=9KKKPBJAC8<<=<<5D8=::FB:
?9:8;;<<BA=8<=<G4=7B=B<BCG=<<JKG<>B=<<<;<?<=H?<<;;;<<B;:=8<:
<=:B=FF:=<;=:KEF==<;;9=;;B8:=F==B9<=:=G;:7?EDB=;I=<<D;<;C=B:
<?>E:K=:DLCN<9?G<<=8K=H==F9B?9:B?867:>9===<:=KFB=:<::9:JDCK@
E:8B=9?;<87898;=>;B=6:EN<8::BGF?=:7<;788;9:L==;?::<D<;;;;<G7
:9=::??<BG@==<:>89<;:<=<7:B8:;::BB<:<W<C:8:G;K;9;B8=I<<<:@9:
<:=;B<;?<9<C=7<:9<;<9:<H?G<<=:867G=F:;789:::8C6:?;<=GL:=;8:9
;AD?@?;<L<?L:;;;;>==C<<?H99;@<>AC><<:9:<>=H@TOHLCB<B>9B>;>@>
=<<>>E<=:;HO<=:=@D>8=A7:CH7;7:::;977=?==DPMP@>689=>=L9:9::;F
<PO85?@8;@NK<:>GED>7<:8>B>88>=9;<7<C:<8
.
frg:31
clr:30,757
}
{RED
iid:1436
eid:1127298162
seq:
AGCCCCTGCTGAATAAAGCTTGTGAATTCGCTCACTCTCTATATAAGGTTACAACGATGT
AGCCCCCCTATCTCCCCTCACTGACGTTGGTATGGGCTCGTCGAACCTCCAGTATGAGGG
GAGATCTTATTTCAGAAACTTTGGATGTATTTGATGACCTTGCGATTTGTCTTAGTCCGA
CTAAATTGAAAAATGTAGTAGAAAAGGTGAAAGAAAGAAAAAGGAAAAAAAAGGGAGGGA
TAAAGCAAACCGGAAAATATCATAACGGGAGTAGGAAGATATACGGCTTGACCTCTTGGG
ATGGACCGGCCGGAAGAGAGGCAGAGATGTAGACGGAGGACAAACCGCCAGGATCCGGAT
TTAACTGAAATTTGTCCACATTGGATACGATGAAGTTGGAAGGCAATTGGATGGCCCTAA
GGCGCGGAGAAATGGCGGATACTCCGGAACGTCCTCCTGTCGTCAGGGATGAAACTGAGG
AAAGAGGGGAATGGTCGCGCTATTGCCGAGACTACAGGCGAGAAGTACTACCATCTGAAG
CTGTTACCGATGCACATCAGGTGGCCTGTTTCTGAGACGGGAGGCCGGGCTCGCTCTGAC
ACTTTTTTTTTTTTTGAAAGATTTCCTTTGATGCCGCCATTCGCGCATATTCTTGATTAG
AGGTGCGCGCGTGGCGGAAACTGAGGGATCCATGTCCTCAAATCGCTGGGGCCAGTGAGC
CTCCGGTCTTACTAATAGTTTGTACCCTTGACTTAAT
.
qlt:
343634446457744665;>8885887759AB8A==S@HA99867<:97789==;8C>?9
;48;9:998558<;;?9=:;<::B9899:;;GHOBB<?=<<<;<<99C>:8:<<:=N<;W
IEED==GBF<G<=89<5?;=BC:BB?B=GKFHJY<BAG<=:8:76=:587;9648:558:
8756;=59<B748<;;:8;6:<==:8::=9;:<8;697766;;55894548;;<<:=B:4
;6<=67;B574;8955465<;96;::88<:8;64FL==NOTB8:E<;<B=K<6>FBK<::
;;:9<B=<<<:<;B<==<::;?==EAA9;9;=LEB:>:<A:=BCAC<<;<===9=LFMK>
=8<;=G<L;LLCBC==:FC=>>BBKBD>===BEF==:=;:G:A???>=H=V<H:>BB<;<
8::CF<@B=::U<O;;:?P=VNILC=99<96;=GCG<AN<L<8?><<<T=<H96D=HG=:
=::;H=CFKN=FE;<<<<D8:;8;7;<=;;:=A<9;8;8<;<6;?<79<<CK=;<;;C:9
?>?>=<?A?F<?==;FP9<995PR:E@L=<?:ALK;;F==?J@><C?:9<CD;=:89;?;
>;H@??J<IB>E>>?=E;D;AI>>99>DC98AO>98E?B9==B<CGE<89<><:;N<G@<
HB===CABK99B<9=9C>9<:<=<9D>M=9877=998=;@GLGA7678:>8=97<AH<8@
>:7>CA887;KC=>C<<<8<<G:>:797<><89B<8<
.
frg:32
clr:30,754
}
{RED
iid:1437
eid:1128922841
seq:
CCGATCTAGAGATTCGTCCATGTCGAGGACCAATCCTAACCACAAGTTTGGCGGTGACGA
CATGATACGAAAAGCTAAAAGAATGGTAAGTTTGATCTAGCTATGTCGATCAGCAAATAA
TACGATTTCTTATGAATGTTTTTTGTTTATACAAGAAGCTACGAGTGGCCAAAAGCCTAG
TGACATTGAGGTCTACCAGGAGGGCCACAAAGGACCAGACCCGAACAACCCTGACCAGCT
CTGCAGCCAGACAGCCACAGATCGCTTGTGAGTTTTGGCTCAAAAGTTCAAACGTTCAAA
GTATATAAATTCCTGCATTTGTAAGGTTGTGAATGATGTATAGGAGGCATATGGGGAGGA
GATGGTTCGTCGCCATGGCCCTGACTTCGACTGGAGCCATGAACCGGTGGATCCCTCGGT
GGTGTACGCAAGTGGTGGTGGCAAAGCGCATGGACGGTAAGCTCTAACTTATGAAATTAT
ATGGTTGACACTAAATTGATTATATAGTAATCACATTTTTTGAATCACTTATAGATACAC
ACTCTTCGACGGATTCATTGACTCGTCGTCGGTGAGATCTCAGAGGACGGGTTCATCTTC
CCGTAGCTCATGCTCTCATCGACCGAACGAGCAGGAGTTGGAGATTATGAGATGCGTGAG
AGATGAGACACACGCGATTTATGTAGCTTGCATGCACATACCAGCGATGATCAGTGAGTA
CGCATATCCGACTCTAATTATTATATTTCAATACAACATCTCGTAGTACCATATGTGTTT
ACGTATGCACAAAGCATGCACAATTCCCCGCCACCAATGGAGCATGCAACCACCAGTTCA
AACG
.
qlt:
444569=D?;7<8NTX=E9:<QQeOeb^Y>P>eiieeeiiKBTKllllll[[llbl[U[b
_?UKCbbgNgglllll_lllgll_lllllllllllllgaglaglllllllaallllllll
lllllllllllllllllllllllllllllllldlllllllllllllllllllllllllll
lllllllllllllgllllllllllllllllgglllllllllllllllllllll_llllll
llllllllllllllllllllllllllllllllllllUllllllllllllllllllllell
llllllllllllllllllllllllllRllellllll_lllliiiiiiiieieiiiiieii
[ZRie[iiiiieieViiieiiie^_iii]ieiiii]ecVeiieiieibiiVU^YQiiUiR
idVi]bdeebeibYNFi[ZidbPiibeeeb\ieVZ\iSieUeeeYO]U^]eXd`iUWeYX
]XieLiV]MT_YMiOP\_XMP_P``_PI\OR`NPNOcccc_MMMMWLMM[^\TMTMW`H]
JMT_EPQRVMEWM>MMEMNUMNQMLJ[NFBE?FLY=LFMMLJ@WAHQAMcJBLLCLMLMH
OCBJ[ELMGEN[AMNJMCRSFTEHEOLGBVEOCL>J<FF?KE9H@7LAL:66<ROG>D\4
N>A:BC6C6N8=87=8A4Z6=<?<448F@Q>N<N:5>74B:=G>AAMB4367FD=>66?D
>8K9;N4<F9K:<>8A?7456<7449JC<96:?DC?C=@:E9A5B85K6234967476==
445A:4B8757H5427<5335434484598:A4422:9D<?4C<=44B44449D8=A671
1121
.
frg:32
clr:6,767
}
{RED
iid:1438
eid:1127298163
seq:
TGTTCTGATGAATCAGCTTGATTCGTTGCTTAAAACGTCATCTGCATCAAGAACTAGTTT
AAGCTCACGACATCAGTTTGCTCCTGGAGCGACAGTATTGTATAAGGGCGATAAAATGGT
GCTTAACCTGGACAGGTCTCGTGTTCCAACTGAGTGTATAGAGAAAATTGAGGCCATTCT
TAAGGAACTTGAAAAGCCAGCACCCTGATGCGACCACGTTTTAGTCTACGTTTATCTGTC
TTTACTTAATGTCCTTTGTTACAGGCCAGAAAGCATAACTGGCCTGAATATTCTCTCTGG
GCCCACTGTTCCACTTGTATCGTCGGTCTGATAATCAAACTGGGACCACGGTCCCACTCG
TATCGTCGGTCTGATTATTAATTCTGGGAAAACGGTCCAACGAATATCTTCAGTCTGATA
GAAGACATAATGAAATACAGAATCATCGATTTGAAAATGCCAGACATTCGACCAAAGACC
AAAACTCCTCTACTTCTGCCGATATGAGGATTATCATGAATGGGCTGGCAACCCGCCTAA
TGCCCACTTGAAAAAGTAGTTTCATCACCATGGAAACATATGTAAATATAAGAGGGCCTG
ACACTGACCATTCAAGTCTGTCCTCGCTTTGCCAGTCCTCAAAGAAGATAGCTCGGCTTT
GTGGGATCGAATTGGTTCAACCAACATGAAGGTAGGGTGGGTTGAGCAGACGGAAAGAGA
ACGCTAAACTTATAGGCCAAGTGCAAGAAATTCTCGGCTCTCCAGAGAAATACAACCTAT
AAAACCG
.
qlt:
4144:BGNCB:7:966QiiiiXiiTWlZll[bbld_ll_[lllllll_lllllllallll
lkH[]HBKBSDklkkkllllllllllllllllllllllllllllldlkkklkllllkgkl
llllllllllkgllgkkllllllllllklllllklllllkdgggkggllkkklllkllll
klkdlllkllklkkkYkkkkkllllakkYka[lkkkkkkkkkkGdkdkkkklllllllkl
llllkllkddl[ddklllkkkkaklkk\Kl\\kkdkkbklkkakklklkkkka[]TaWkT
GMT\VT[kWd\\UkkkkSUWaTKTUTBLTkkT9:9G:4TIH\B:@<=:<<=MWTQ==BH<
<GGNKOaBK;CCNOB=HG?HE<F;=K<<B=8:=BO<I?J:58===:<<;;;@<8>?BE:B
:<;7;9=B989::;G=<:<:KA;==;:78<::8=:9A=D<<I?S=L==<=C=@?;;::=A
<9B<7<9>=>8BB;?B::998=??:8S::A9<;==APP?9:6458:=B;;?:;;9;;=H:
:;;;;O==;<H::A<>=H;B=:?888698<=9EN[N:J:;G?<A=ORB=>;<<@CC9:::
;<@<9@D;:9:;;99;:>KE=>GFOB?989:7C>9>>>=<;888:=:C78@7K:8:;;==
>98:=9:6;8:8;8:88>GO;C?HNB;B:G?<=A<<8A<@<98878D<<>:79:AD:68H
<9=:8CF65;7=8E8?899:888<<6:>8;89:57@<587H:86=B6A<<:88C<:::B7
666:866
.
frg:33
clr:421,779
}
{RED
iid:1439
eid:1128922842
seq:
TTGCGATCTAGAGATTCGTCAATTTGATGAGGTAAACTGCCCACCGATCCACACCTGATG
TCGACTGGCCATTGAAACTGTTGCTCATGACTATGATGTCATAGTTATTGACAGCGCGCC
TAACCTGGGTATCGGCACGATTAATGTCGTATGTGCTGCTGATGTGCTGATTGATCCCAC
GCATGCTGAGTTGTTTAACGACTCCTTTGCCCTGAAGAACTACAAAAGGTACTAGTTTTC
CGGATAACTGTTTCCAAAAACCGACAAAACAAAACACGTGTTTCTGAAGAGCACTAATTT
GCCAACCATTGTTATATCTTCCACGCATCTAACATTCATCGCCCGCGCTCTGGACCAGAT
AGCACCCAACACAGGTAACATACACATTTTCTCAGTAACATCAAAACAATTAAACAGGAA
AACAAAAGAGATAGAAACCAAAAACCTTACAACAAAAAGCAAAATAAAATTGCTAAAACC
AATGAGAGAATTATAAAAAAAAACAAAAAAAAAACCCCGTACCGGACAAAAAAAAAGATT
TGTAGTTTTATAATAGAGACTAAATGAAAGCCCGAAGCAACGGCCCTAAAAAATCCTGGC
CGCTCACCATCCAACAAATTACAAATACAATAAGTTTCCAAACCAGAGAAAAAAAAGCAT
CTAAACACATGCTTTGGCATTACTAGAATTAAGGC
.
qlt:
644556;>>A><8=<WdKMUGPTicTECZJ;C:O<@b_lbUW:ll[Yd_V<XBllglXD4
4548;8FC=D>dkkkkkllllklllkKllkkkkadkW@;7465667=;<B<\Pdlllkkk
kk[kkklTYN\dkkb\Wk[k\XaR\kTdUNYY[BSJHSK=TWKaBSHCK=<BB69<8BCC
<;;=MJB?B?:HM<8=8=<D;;;:677;B59<8F?<88<8886886;;99<B998;6;;9
:<=:5<B:<B=;=@:<485<58F<:85<;998=:889=89;?<=<<H<8?8<=8:G;<B<
=9<:<;86><:=9:><B<<877<;8;?9BB:CB<:=:;;89<=;B5:=;:9A:<<=;8:9
;:;99:8;::99<<6:=G<=<:69;<8=<;;<9;:889;8;889=B;=78=;9=8<:?@;
;<=<<6B9<;8<9;:<<;864;<<;<=<B;BA888?:8866=B89:;9<=:::;8<K:=;
=<<9=98:<<;8;=98:B:<?G:<;;<8A<><;89;=:98:=<85889;<6?8?789;::
<>;>89>::B9<@7?:==<:;;9;48<;76;<C<;A;:=;8:<==B89B@<?<9<=<=:B
8648:76=<;B<;9877<?8=>:<D:<9:D9?:9=9<8<<67<:95::8=6B<:98;8<;
9568989;676::<;;96999::9>99C<:9:=98
.
frg:310
clr:207,639
}
{RED
iid:1440
eid:1127298164
seq:
AGTATCTGATGATATCAGCTTGATTCGTACGTGATTGGATGTATGAAGGTTTCAAGAAGG
GTGGATGTCACACAAGTGAATGGTTTGCCAAGACGCAGATGTTTCTAGACCATGTAACTG
CTTTGTCACAAATAGATAATATTAGGTGTCCATGCAATAAATGTAGAAATATGACGAGCC
ACACCAAGAGGCAGGTCACACTACACCTGTGTTCGCATGGTTTCGTGCCAGGCTATAAGG
TCTGGTATCTCCATGGTGAAGATGTTGAACGAGCAGTAGAAGTAGAAGTTGATGACGGTG
AAGATGATGTTGATAGGATGGACCAGATGCTTGAGGATCTGCAGCCTGAACTGGCACCAG
ATCATCATGATTCACCTACACCGGAGGTTCAGAAGTTCTTCGACCTTCTCAAAGCGTCAG
AAGAGCCTCTTCACGGGCACACTGACGTGACCGTACTGGAATTCGTGACCCGGCTGATGT
CAATCAAGTCCAAGTTTGCATTCTCAATTAATTGTTACAAGGAGCTTGTGGATTTGATTA
GCGAGGTTCTTCCTATGGGTCACAAGATGCCCAAAGACATGTACCAGTCCAAGAAATTGC
TTGAAGGTCTTGGTATGGAGTATGAGAAGATTGATGTTTGCCAAGACAATTGTATGCTTT
TTTGGAAGGAACATGACAGAGAACAAAAATGCTTAAAATGTGGGAAGTCGAGGTACGTGG
AGCTTGTAAATGAAGATGGGGAGAAGGTGGTAACAAAGGTTGCACATAAAC
.
qlt:
44544D59747>8;B>88PiellQllYe]VlllJPlllVUlllallllklllkkklllkl
lklkkTTJGBJBOHkkllkkkllkllllkkllllklldllllllll\klllklllkllll
kk\gkklklkklllkllllllllk[lllkkkklkgdklkkkllkkklllllklllkllll
lllllll\Uklllklkkkkkkgklkllklklklldkklllklllkglllkdlk\klkkkl
klkllkllllllklllklllklklllkllllllllkklklllllklllllkkllllllkl
lk]lkllklllkkllkllklllllk\llllllllklllklllkdkllllkkllkkkllkk
llkglllllllllklllllklllllklllllkllklllllldllllllllllllllllk[
klklgllg\gggglggggglglllllglllllllllllglllll[glllllllglllgll
lblllebelllllbbbbleblllllbbeleblll_bel]l_llellllllll_llii_ii
]eeii_Xiiiiiiiiii__iieei_eiZe^eeT^^_i]]diieedV]eiYQeiieSMiib
iii_^QdUiiii[beXiWiXebPdiZiiXVCiiYQ[RVSRDUHeXiXXU\iiY_UiNKQi
ee]QAU]D\RPNPYc^QVMc@NNQMN_UMNc]]TT^TN\WHcVVPQJEU<WLMGNMMT^D
[HLHMcFMYMMPLQ>^R^c^Y[JOT>J9KOGOQOJ^N@N<MYHGMJPA><:
.
frg:34
clr:11,769
}
{RED
iid:1441
eid:1128922843
seq:
ACGATCTAGAGATTCGTGAGGGTCCACCGCGCCGGAGTGGCAAAGGATCATCTCATAGTG
AGCACTTGGTTCTTGCGAGGACCAAGGGGGAGCGATACCCTTGCGCGGGTGCTCCAACGA
GGACTAGTGGAGAGTGCCGACTCTTCGATACCTCGGGAAAAATTGGAGGAGTCTTCTAAA
CTTTGCTTTACATTCCGCACCTAATTCAAGCACTTTATATTGTGTATGTGTTTAGCAAGT
ATTTGAAGTATTATCTTAGCTTTGTTACATTTCTAGTATTATATTCTTAGTGCTAGTTGT
TGGGGTGAAGTTGGGCTCTTGTTTAGCTCTTGCTTAGGTTTTAATTAGTGTTGATTTTTA
GAAAAGCCCAATTCACCCCCCCCCCCTCTTGGGCATCGTGATCCTTTCACTCAATAGATT
GTCTTTAAGTCAATAGTAAACATAAAGGGCATGAATGTAATTTCACTCAGGTTGTGTCCT
ATGCCTATAAATAGATGAATAGTACCCATGTACTGTTCACGCTAACTTGTATTCGCTCGT
GCGTCACGCTTGGACTTTTTGCCTTCTGTCAAGCTGAAGGTACAAATGTAATTCAATATT
GTTCTTATTCATCCATGATGATATAGTAAAGATATATTAATAATGTTATATGATTATTCA
TGTTATTTCTCATGTTTCATATGCTTCGTCTTTCATTAACATATACTGCGATGATAACGT
ACGCCCTTCATGACCTTTGTCTGAAGATCGTTATATCCTAAGGAAATACTGCTTCGAGAC
GACGGGCATTATCATTAGCCTCTTTTCTATGTTGCCTTGTTCTTGATTCATACCATTGAA
AAACAAGTCCCTAACATTGGCGGCAACT
.
qlt:
8578:7?G<<98:SVGQYZM>79787GZ_ZdR]P[[?[lTUKKTUSPVH>HEHG@FL=Q[
EMDKOYkk[[dd]akVLaQTUWUNO]kdddkW]add\ddkkkl]PT\ULWlkkd[PW]Vk
[dk][aLWkYkGdTPkTaNkWdkddkIkdaddbdS[Wa[[[[[YaQkWdkFJYOVdN\Y\
Ykkk]QWWWRVVa]]WGNWWWWWLO]]IKGKGSUTdadd\]kLaKWT\N\UOSNBMLGMG
WWOQdkUU]kddkkkaakB]daad[]ddUkSSWVUI[kd[ddTSPTOTbITg[aaLR[aQ
[aTTTTaa[LLY[YHLTYLYdEULW:Iabaagaaa[;QJUOJUJUUN8HVSJU[UOKJEO
9aWHUJOUSHCOSOBIIHPSSSSQ[S[[MQbQGEAKM>=OHQQZPQHN>HKO==DG;RKH
Z>KGLNID:IlAFLR;?KDHRLTN@@HVJEFHZOGPe@==?LDR<HZ_<CONP_E^NV<@
D?G=AAHA>AGPSAUNJVB@J:GQH;@>@Q?KZKY<@IFTWPH8;LVSUPZPNUL__SNF
UUJAEFD@D_GA:VHOUNJMLHUULVNVDH>BONMHUI8KESUSULP\LNJQSRLTRUNO
\HMMILNEMO>ROO:OSQFUNKMRI7AMHMIRHMPLIDMIINIMO=HMMMNMLHJ[CMB8
K^CMMGDMKIKHG[ENMLM?NIMLKMM>:QLMCHDF@C;GKLMBC?=H<?YIKV6@B5PG
D@:DCD:N86CRSCHHJDSDLGQJD5E>RQLAC;>@C>:C:<65D95>57VCF?>9546:
BS5FR==CD7>6NB@?>4B6476NL8=::6H9ME>>C=B<6>9M:>67D<?97<@@D6I@
=KH;6GC@:<75H?C8B<>8595A4594
.
frg:34
clr:6,858
}
{RED
iid:1442
eid:1127298165
seq:
TCTATAGGCCGGGGGATGAAGATAACAGGTTGATTCCGGGCCTATGGTGGTTATTTCGAT
GACTCCCGTCGGCCTGACGGCGCGGCCGACGGGAGTTAGTTAATCGCCGACGGCTGTACG
CGGGCCGACTGGAGTTAGTTAATCCCCGTCGGCTACCTTGACTGGCCGACGGGAATTAAA
TAATCCTCGTCGGCCTTATTTTGGCCAACGGGGATTAATTAATTCCCGTCGGTCCACGCG
CAGGCCGACCGGAATTAATGTAGCCGACGGGAATGCTTTGGATTGCTGTAGTTTTGGTTC
TTAAAAACTGAACTTTGCCAAAAGCCTTCGACACTGTCGACTGGAACGTATTAAACGAAA
ACACAGTTTGTACCTCTATTTCTAGATTAAGTTGAGTTACGTCTTTTCTACCGTGATTCA
CGGTAGGATAGTAGTGGATTATACTCCGTTCCCTATGAGGGGCCCGGAAAATCAACGTAA
AATTCTTGAAATTTTCCCCGGTAAACCCCCGGCACTTCTCCCCTTTAAAAAATTAAACCA
GAAAAAAAATTCTTTTCTGCCCCCTTTTTTAATTTTTTGGGGGGGGGGAAAAAAACCCCC
TTCCTTGTAAGAAGTTTTTCTGGGGAAAAACCCCCGGCCCCTTCTTCCTCCAAAAAAAAA
ACCCCCCTTTTGGGAGAAAACCCCCGGACTCTTTTTTTTTTTTTTGGGGGGGG
.
qlt:
47667455554486845:469:867:;<:9<>>:BK9=<?=B<8<CCCWLCHKPLC@<=8
=9<<BKCT9<85===857;<8;C=98D9PF8B<G;;@DGB?NGCJ=HKC;K<KIHM=BG<
M=F=WW=MG<KBTWWQaWWIBMCWKNKFBOBGK??H;@CBTKJYKJN=TF=HBS[LHLBA
<HB=\STWFFPFQK\]Wa[YUNWLKSHNMFQPUkVWWTENTQE[kdY[Y[LTH[kKWE\F
]aB[dTDTJ@KGKG=HKGNQBJ<K;9789:AEK:DB<=?K?N@HN=>?==89A58?FIDM
<?C<::<>MMH8>==8:@E9668;;77<K<IJ=E:E:G8@J<C;99;F:@:?HF>E?EC@
@MJFI>9>;E;9@=8G@KBEGI@>8F=HM=A98ES<889899N9E@A>8:7=75AKCDBA
;A;7C9D6:::66<:>@?9@?46455989<9DD8:8556JF<<>?<>@:::<9998676>
C=:766:<::8>HNF@FF=>A68<D:>?>;7:547;:D6R]S<C<<9>:8;655554444
4555:78889<7DAA@5;7:=<;8:CA>A>88;FEDA77;@INME>:5AHBINE>>_WOB
44646?547867679?==:5767:68=G=79<78644657654744:74466?HMPG?=;
77;A>@977:9::A6;<577::>J8:6577777:7478445448845844775
.
frg:35
clr:25,599
}
{RED
iid:1443
eid:1128922844
seq:
GGGGATCTAGAGATTCGTCATCACCATGTCAGTGACCTTCGGGTTCATCAACAACACTAG
AACTGAGCAAGTTGTGTTTGACATTGTTGACATGGAATACCCTTACAATGCAATTATTGG
TCGTGGCACCCTCAATGCTTTCGAAGCAATTCTTCATCCTGCCTATCTTTGCATGAAGAT
ACCTTCGGATCAGGGACCCATCGCTATCCATGGAAGTCAGGAAGCTGCAAGAAAGGCCGA
AGGTAATTGGACTGACTCAAAAGCAATCCATAACATAGATGGAGCTGAAGCTTCTGAACA
GTACAAATTCAGAAGGGAGAAAGCAGCTTCAGCAGACCAGCCGAAGCCTATGCTCTTATG
TGAGGACATAGCAGAGCAGAAGGTGCTGTTAGGCTCTCAGTTATCCGAAGAGCAGGAGAA
AACCTTGATAAGGTTTTTGTTCAATAACAAGGATGTTTTTGCATGGTCAGCCAATGATCT
CTGCGGAGTTAATAGAGATGTTATCGAGCACTCACTCAATGTCGATCCATCCTTCAGACC
CAGAAAGCAAAGGCTTCGGAAAATGTCAGATGATAAGGCCGAAGGTGCTCGCAACGAAGT
CAAAAGACTCCTTAGTGCAGGAGTTATCAGAGAAGTGAAGTACCCAGAATGGCTAGCTAA
CACTGTTATGGTAAAAAAGGCCATGGCAGTGGCGAATGTGCATCGATTTTACAGATCTTA
ACAAGCTTGCCCGAACGATGAATTCCCACTACCAGGATAGATTCTTTAGTGATGCAGCAG
CTCTCAGAGCTCATGAGTCTGTTAGACTGTTATTCAGCTATCACAAATTGGA
.
qlt:
7675697=C=:=@<U_PQE;SH8[D>dibA9OYlSEedllU__[]V9TVHA?@SVSaPPE
RUddggKUQCTT[dLkV[lllk[lllkkllkUklkkkkkkkkkkaaNYdlkkdkkklkll
kkkklkkkkkkkkdakl[kkkkOkkakddklkkkkVkkTklklkllkgkkkaUkkkaYll
lkggklklllkkdgkkllklllddkkkdYUdldggd[dUTggdaggldggglglglgldl
ldldggggggllllllglbbggglggllllllgglllOOgllllllllgbllglglllll
lellllblll_]llllllllebbebblllledllellllblllll]el_eel_^llllll
llldlledlleieXi]ebRi_[^Ti__i[iie_iiiiieeiee__ieiieie_dViiZii
ee_e__iUeeiV^Wieiid_edG^ei_eYeeiRVi[YiiiieVeii_eZ[_YHdeiddie
e\iediiXT_W^eiXieXOdOeeeieiZ[eeieeeiXHeUiSeUe_MYK_eYU\UXLiNW
WLRei^TQN]]N\LO\OEOX]\PP^@XM9cL\`LW`>I8W@_`>cN`Q`MMVQYNL^^@I
MC[cTB^DXRMLWMFHR>J7[[EMTMNRMD^G[[IL[JOKQRLTWGKQGEJH6LOLLSDI
MIMLTAGDIRXBMcYTVC==?:P8DI:7=<HI=JGGAVCTOOROGPC\\IEF?<IBA<L;
HPCA;JK<S:IA7O747DCMAC=>;M@=>?I<7645CB@>?=6@8RB@7M<C<HJD;BDH
AM58696J;?@;>?E:6=@;H8<98K?:F8?=6@:4>9@@>@6>4C5DG743
.
frg:35
clr:7,828
}
{RED
iid:1444
eid:1128922845
seq:
GCAATCCGATATAGACATCATCTCCTCCTAGCCTTTGCTAATGGACTGCACTCAACTCAG
AGGAGTGGTCCCCTGGAACTTCCACAGAGAAAAGCTAAGGAAGGGCCTAAAGATCCCTTT
TTTCTGCACGTAATCTGCTGCTTGCAAAAAAAAAAACCACCGCTACCCGCGGTGCTTTGT
TTGCCAGATCAAGAGCTACCAACTCTTTTTCCGAGGTAACTGGCTTCAGCAGAGCGCACA
TACCAAAAACTGTGCTTCAAATGTAACCGAACACAAGCCAACTCTCCAAGAACTCTGTAG
CATCGCCTACATACCTCGATCTGTTATTCCTGAAACTAGGGGCAGACGCCAATAGCTATA
AAAAACGACCTACCGGGTTGGACACAAAAATATATTTTTCTGGTAAGGGCACACGGTTCG
GGCTAATTTGTGGGTTAACTAAAAAAAAACCCAACATGAATAAAAACTACAAAAACCGAA
ACGAAAATGGCTATAATTTGTCTTTTGAAGAAATCCCCCCCATTATCAGAAAAGGAAAAA
ACCCATGCCAGAACTGACGACCGGAAAATGGAGCGCTACTCGATAACTCCAACATTTACC
TAATGGATAAAAATT
.
qlt:
222233378475:5;584755:78;8:68;<984444554574E;59E886D6<A8::74
57:4455495444787444=<54?==996B;?67645499777474775775:;;99::>
:::E:A9:<;;A;;FI<FA><<BG@?<9:9;CB;G<<;B=:D=:::8=:;B;;9569;::
=CB=H<H[AE79<O=KLGKCB=<QG?K>HDNE<W>I;?BLH[PNDAT:;<<:M<B>8?;T
HGCKQF=?=FGD:;=@AC;G<FTB::><;;K<><J:=6B=<E9<=>JCCEN=>=<:=@=;
<K?H=CF=WWCD=<<<<;>GCG?AG>=>D:<N>=G=:?==C;<:9?>E??=@:9:;=W=?
>:;<==?9A<=NBB=<7;D>8D8:=C:F\A??886=B=I=AC<:B<<C=<C<:?:<=CA9
9<C<;FD=;:?KQI=IF?=;<=A>==T=UGCHC:<=9;8G;<B=CHK;;D=CLGNCB<:G
<;<=8:H9:<<;=?GIGC<><>A@CKD;P<:TK?FB@>>C=C=><;:<;RYBCKFUaCKG
K;;:;>C<C=;:=CB<K9:?>@;<P=EA<==@;C;BAW<?:<B8A?=?=L?I:C;:<B=?
:OC::=9;=@CC=<:
.
frg:311
clr:425,613
}
{RED
iid:1445
eid:1127298166
seq:
TGTGTCTGATGATATCAGCTTGAATTCGTTGGCGTGAAACCATCAGTTGCCAAGGCGATA
CGAACGTTTCTTGCATCGCTGGCAAAATCTGGATCAAATTTGTCAAGAGCCTTCCATGCA
TCACCATCTGACGGGTGCACCATTAACCCATCTTGTCTGTCCGTATAATCTTTATGTCAC
CTCATGTGCATAGCGGTCTTCCTCGAGAGAAACAAACGTTTCACTCTAGGAGTGAGAGGC
ATGTACCGAAGTTGTTTATGTGCAACCTTTGTCACCACCTTCTCCCCATCTTCATTTACA
AGCTCCACGTACCTCGACTTCCCACATTTTAAGCATTTCTGTTCTCTGCCATGTTCCTTC
CAAAAAAGCATACAGTTGTCTTGGCAAACATCAATCTTCTCATACTCCATACCAAGACCT
TCAAGCAATTTCTTGGACTGGTACATGTCTTTGGGCATCTTGTGACCCGTAGGAAGAACC
TCGCTAATCAAATCCACAAGCTCCTTGTAACAATTAATTGAGAATGCAAACTTGGACTTG
ATTGACATCAGCCGGGTCACGAATTCGAGTACGGTCACGTCAGTGTGCCCGTGAAGAGGC
TCTTCTGACGCTTTAAGTAGGTCAAAGAACTTCTGAACCTCCGGTGTAGGTGAATCATGA
TGATCTGGTGCTAGTTCAGGCTACAGATCCTCAAGCATCTGGTCCATCCTATCAACATCA
TCTTCACCGTCATCAACTTCTACTTCAGCTGCTCGTTCAGGCGTGACTCCCCGTGCAGAT
ATCAGAC
.
qlt:
433446:;O>EG9;CA<>^iiiF>Tie_lll[lll_QlOUg_llllllllaallllllkl
kllllC=<BBJGENJLNTdkklllllllllllkkkllllllllkllklTdk[U[kkkllk
llllkkllllllllllllllllllllllllllllllllllllllllllklllllllllll
llllllllllllllllllllllllllklllllllllllllllllllllllllllllllll
llllllllllklllllllllllllllllllllllllkklllkllllllllllllllllkl
llllllllllllkllllllllllllllllllkkllllllklklllllllkkklkklllll
lllllkkakkkllllklllllllkllllllllkdklkklllllllkklllllllllllll
llllllllllllkllkllllllllllllllllggdddgllllllldlllalLglglllll
llgllllllggggggbgblblllllllelllllldeb[edl[ll_lbelllldlOlbbll
[[_ll]bee[_lYWVKLZe_bi[[b_HeiiieeeVb]b[__VZZe]eW]b]S]_VTiRYH
eeVU]NbdLQZZWVZKIVeVUYeQUeFeb]d[]PTeZRdUbWQV<dL_AR>UVbLdHP^X
BPJDTKRB<QJNUQKTXKSUHLUNJMUKDHMOHBMIIURK_WI`FDMKHE]LG<CFBB=;
HLMMMML@F>C=AC9D=MKJ=MGDHEG6NMUC@J<9??<=EAC:H?IC@LKJC7=5EBA:
95:75C8
.
frg:36
clr:31,779
}
{RED
iid:1446
eid:1128922846
seq:
TCGATCTAGAGATTCGTCCAATCAACCAAGAAATAAAGCAAATGAACACGGTGATTTGTT
TTACCGAGGTTTAGTTCTAAAGAACCTAGTCCCCGTTGAGGTGGTCACAAAGACCGGGTC
TCTTTCAACCCTTTCCCTCTCTCAAACGATCACTTAGACCAAGTGAGCTTTCTTTCTTGA
TTTCTCGGGTCACTTAGACCCCGCAAGGACCGCCACACGATTGGTGTCTCTTGCTTCGCT
TACAAGGCTTTGAGAATAAGAATGAGAGAAAGAAGAAAGCCAACGAAGCAACAAGAGCAA
CAAAGAAACACAAGAACGATCCTCTCACAAGTCCTAAAGCACTAGAATTGAATTAGGGAC
TTTGATTGGATCGGTTGCTTTGATTTGTGTCTTGGAGTGTTGCACTTTGCTCTTGTATTG
AATGAAGTGTGATGAATGCTTGGATGGTTGGAATGAGGGTGGTTGAGCCACCTGCGTCCC
CCTCACCCTTCAGCACAACATCTACGTCTGGAAGATTTACTTACATAAGGGTTTACTAAA
GGAATTCCCTCCCCCGCATAACCGGAAGGGGAAACGCTATTACGTTATACAATATACAAC
GCAAAAGGGAAATCGACAAAGAATAAGCCAAGGGCAAAAAGAAGGGGTCCAAGCTCCCGA
GAACCCCCCTATCTGAGCTCAAGACGCGACACCAGATTAAATCTTGTTTAACGAGGTGCG
ACCCATCCCGAGAAGAACCCAGGCACTTCGAGAGCTCCCGGATGTGAGCAGAGAGGCTTT
TTCTTCTGCCCGGGCAATGACACTGTTAAGGTCGATACCTTCCAAAAATAAAAAC
.
qlt:
24337B:=?;9::NTBGQBUNOG<>\E9YVYB;D^iYTX]i^NYiePCdi_Z_TOi^OP_
G;?@=>F?I]lU[lllllbll_lllll_llllllllllllllllll_lglllllllllll
lllll_Lllllllllllllllladllllllllllllklllllllllllllllllllllll
lllllllllllllllgTllllkllllllkllllllllllllllllllllllllllllkll
llllllllllllllllllllllllllllllllllllllkklllllllkllllllllllll
lllklllllllllllllllllgllklklklllllllllllllllklllllllllklllll
lllllllllllllllllllllllllllklllllkglllldllllllllllllllllllll
ggklllllllllllllllllllllklkVldU@46C@<P\LPDDJCB67797:B6@998;<
@=;;99=>:8=:98=78K<<;<<?=:G;;E===C;@C=<:<;<<C:;<C9;8:<::=?A>
9:<:;<C?<<<@@A>;@B<<;9<A<?F;<<=<I<<=?>9:;;;?><9;?@>?959:6:;9
;;<?:7997>=;;==;89;;:9;9=>9:IB<><=98U;;<?:;BB::=<>:=9:;<<>;;
?BB<=<<B88:>9<;=:9>:B<B===I;8:;9887C<B<8>6:;=::C>=;9<C@99A;=
<9GA8=:99=@@=A79788796788688:ACA7:F7:7NNC9E>88>=756@E?BB;8>>
A98D=D8K?B;?H989:57@6447677869<>:=D69LC<77::?8;8@89:;85
.
frg:36
clr:5,829
}
{RED
iid:1447
eid:1127298167
seq:
TAGTTCTGATGAATCAGCTTGATTCGTTAGATCCTCTGTAGAAGTCCTCGATCACGGCCG
CCTCCGTGACCTCAGGGATGCGGTTTCTCATGGTCTGAAACCTTTTAAGGTATGACCGGA
GAGTCTCATCCCCCCGGCGCTTGATGGATTTGAGGTCCCATGGTTGCACTGGCTTGTCGG
AGAGAGACTGGAAGTTGGCGGTGAAACGTCGACTGAAGTCTCCCCAGTCGTCGATGCAGT
GTCGGGGTAGATGTCGTAGCCACTGCAGCGCATCTTGCCCAAGGACGATGGGCAGATACG
CGGTCATGACGTCTTCGGATGCTCCGGCAGCCCGAGCAGCGGTGGTGTAGACGGCTAACC
AACCCCCTGGATCCTGCTTAGGTTCATATTTGTCGACATTGGATACCTTGAAGTTGGGAG
GCCATTGGATGGCCCTAAGGCGCGGAGTAAGGGCGGATACTCCGCATGTGTCCTCCTGTC
GTCGGGGATGACGTCTGTCCCGGGGAGGGGAATGGCGGGTGGGTGGTTCCTCGACCGTCC
CCGGGTGGTACCACCAGTTGAAGCTGTTGCCGACTCAGTTCGGGTGGCCTGGCTTTGAGT
CGGGAAGCCATGATCTCGGTCATACTCCTCTCGACGGCGAATTTCGTTCTCATGCCGCCG
TTCGCGCAAAGCATTGATAGAGCTTCGCGCGTCTCGGCGACTGTTGATGGCGTGTCGCAA
ATCGTTCGGCGGGTGAGCGAGCGGTAGAAAGATGGTTGGCCGCCTGAGTGA
.
qlt:
44444;9B_<@77;>@K[lBF:;GHkkkll[Ullllllklllllllllllklklllllll
llWS]IILBIM]kXkll\klllllllllkllllkgllldR[]LNSWkkkgkkkkklllkg
lllllggklg\\gkkkllllklllllllllllllllllllllllllllllllllllllll
gkllkkllllkklllllllllllllllllllllllllkllkgklllllllllllllllll
kkllllllllglllllllllllllllllllllllllllllllllllllllllllkkllll
lllllllllllllkkklllllllllllllllllklllllllgglllllkbggkllllllg
ggkg\\lllkkgkk\\kllkklkkgklkllkkklgklklllkkklllkklllglllkdl\
kdlllllllkllklllllllklldWlUSkkkggklkkkklkglklklkklkllkklllkl
kllklkkgklllllllllllllllaaglNCR5AVaLNlH=YlaKl]X__lblbbbll]ll
lggllbllag_lbllbllllllllllZllllllFllWXllllll[lZPlllldllliiZe
eiieeibee]ii_eieieeeediieeZ_iiiiUUd_ieedWNi_iWYiQAeZei]iYUee
beedX`dPiebb[Si^MZeVii\iiVSVddQEiieiYUHNOQiKQUJQ^QHON\E`RRNT
PD]M\P[XUC]NPI[VGTAKIMV_DU;G^M>[>RY@LP[=TMLMIME=PN7
.
frg:37
clr:5,769
}
{RED
iid:1448
eid:1128922847
seq:
TTATCGAATCTAGAGATTCGTCTACATTACTTGTCCGGTGTACACCGGACAGCCAGGCGG
GCCCATATGTCAGAAGCTCCAACGGTCGAATCCCAAAGGCCTGGTGACTTGGCTGGCGCA
CCGGACATATCCGGTGTGCACGACTATCCGGTGCACCATACGACAGTCAGCCACCACCAA
ACGGCTAGTGTGGTACTGCTGCGTGGGATCTTATACAATCCCCTTTCCGATTTGCCTGGT
TTGTCGGATGAGGATTTCTCAAATATTTTTCAAAAATAACTCACTGTTGCAAACGTGGAT
CAAAAATGCTGAATGTTTTGAAGGATGATTCCAGGCATATCTCATTCGCAGATCTCTTGG
CTCAGTTCCAAATACCCCTTGCTTTAAATTATGCAAACTAGCTCAATTACGAACTTCGAT
ATTTGCTATGTTTTGTGGTGGCATTTCTCACCAAAATCGTGGAGATTGAAAGGGAATTAG
GCTTTCACCTGTTCCTATATAATTCTGGTGGTTGAATTGTGAACACAATCTTTGGACTAA
CTTGATTGCCCATTGTATAGTATACAGGTGTTAAAGGTTCAACTCAGCCTATATGAGACT
GGTTTTTGGATTCAATCGAGAGGAAAGGGGTGACCTAAGGCACCCTGGTTCTGCGAATCG
GAAGTCACCGGGATTGAACGGAACTTGAAAGGTCCTAGTCGGTCAACAAGGGATCTCAAA
ATCATTCCTCGCACCTTTCAGGAATTTACAAAGGGGATCCATCTATTAGTCACCTGGAAT
AGTACGGGGTAAAACATTTGAGGGACTTGGAGGAACAAGGAAGTCGGTTCCCCGGTTTCT
CCCCGGAAACGGCTCCTTAAAGAATTCCCGGAGATGATCTG
.
qlt:
4244355455;>8=998NQ@DMDEK8OOMTP]T@<>HOPXMATPDACCF;?@9F@XV;@A
7@?6554768789Q?AKOKKK<<A=AEQ_K]TOBB8BBP:@CF:CHGC:>IOJU[K;GB>
CGAFV?CHJRIFFHCVKPA=D<SF[VbUaUaUdUUL[LUTPAYLEHLJFLLU=LTLKJAB
AIEEFYdTTYFUI:=AGPLTLJ<@;D<L<DB?C;=?<<C?===<K;=B;<=BBI:;?::<
EC;:?:I?;:<E;A;=L;>>:?:;F=EEA;=@@L@==;;;A;;<A<;<:;:;<<::C@H<
;:8;<@IRGD=<=BA<<@<<<:;><<:;>>B;9;>@=CCE9;BHBDB?6;C:>9?@;<>;
==@><FEE>;;6C>=F>:=>?D888?=;H>DHO9?BDO8O:DKL=<<C>999FHHOM;DK
LH<MBG@:H>9G;7;6L>LFC;==8799OFH=:;7=D<C<=:@DK=?D8:E@@>A8=RH8
>:E=<>>9A?<56::>>78>8::86>SDCC97@CHGE?@97:775;@5IN@E<C9FC=AF
FFBC9@A<:A879?HCDGHBH=8@999>@DA<<;=:<;:8::AB@L8>FA<:;:6=>E:8
8=9SGI>N>PIEC:7A8588?::=:PMH=HE=K=F:D=5;:FS>GJFA:8:8>=6DH9=:
@O=889?>>IA?I@;>><DEE::5:9?>J=<85=??5:9DD==:9C>?ALLHB66B555K
L5;A9>858748><E:AC59;>ALLM:5;@;G@5;7M66H<;9B<5776<:9896D>@;5
67;:<;<C85<?<:>66:55?65<559777695>7:;MA::664:>9:<7::<:B5>979
;YC>556>9:>9:6<867;@A5<879C<>>69596855644
.
frg:37
clr:10,869
}
{RED
iid:1449
eid:1338942761
seq:
GGCTTATACCCCATCACCCCACTTCAGTCATCCAGTTTTCCCACTTCAACTACTTACAAG
AGCTCTAGCATTCAATTCTAGACACACCCAAGTGATCAAATCCTCTCCAAACTCCACACA
ACGCCCTAGTGATTAGTGAGAGAGATTTGCTTGTGTTCTTTCGAGCTCTTGCGCTTGGAT
TGCTTTCTTCTTTCTTGATTCTTTCGTGCAATCAAACTCACTTGTAATTGAGGCAAGAGA
CACCAATCTTGTGGTGGTCCTTGTGGGAACTTTGTGTTCCAAGTGATTAAGAAGAAAAGC
TCACTCGGTCCGAGGGACCGTTTGAGAGAGGGAAAGGGTTGAAAGAGACCCGGTCTTTGT
GACCACCTCAACGGGGAGTAGGTTTGCGAGAACCGAACCTCGGTAAAACAAATCCACATA
TCTCACTCCTTATTCGCTTGCGATTTGTTTTGCACCCTCTCTCGCGGACTCAATTATATT
TCTAACGCTAACCCGGCTTGTAGTTGTCATTGTTTTTGAGAATTTCAGTTTCGCCCTATT
CACCCCCCTCTAGGCGACTTTCACATCCCAAATCTCCTTAGCGCTCTTTAACCCTTGCAC
CTTATTATACTCCTCTCGACATAGAGAGGCAAGGAGTATAGTAGTGGCTTGGGAGTTAAA
ATGTTGTATTTGGGCGACTTAGTCCGAATCGTAATCTTTGTCCCCTACGGTAGGTACCTG
CACTCCAAACTCAACAATGTCCCATATGCTTGCGTGTAGTGAGGTTAGGTGATGCCTCAT
TTTATCACTCCACATACATAATCTCACATCAAATATGTGATTTGCCTATGACGGAAGTAG
AGAGCGCGTAGAATGCGAGGATAGCGTAGGGGATCTACTAAACTCTGCGCTCTGTGCTAG
AGTACCGAACGCCGCGTCGGGCGATGTTGTGGGGATAGATATCCCTGGTCCACTAAAGAA
AGTTAAAGGCCTCACG
.
qlt:
754448676766746<BJG@:@@ADN?BJID@C9;BNK_]8>B@?AH>=EPZVHGHA=>B
eJ888566676759A=O][NWdSFWORWVAbbSb_eX>SDQLAQHEA867::MPE=EEXP
U[bZbe__Zbl_][[OQeSPbQbMWOVV[WdblNbPbebbb]HdbbdeVblS]VbelbWO
elOdbbeSdbSeeWSPZHLWSLZZWNG[D@HLeAV[_W[A]]__FO[ZeeXW_EOZN_Re
LWQeKWbdHZZ@ebC_ZLWbRe[AVie_eNXd__Z_=[R]ET_PiVFbZW>_ZUZZ_^[[
deNVeeQ_NdeV_?_]W?b]V[___LiDiN_R_dbbd]NeeS__beV[Mdee_LiZ_ebd
bTA_NdeeeDZ]beZ]_S[eK_Vee_LLebeRJ___]FWdd_VMRRO[_]bieiVRebei
^eid_eiebYVeeebXdeeiLZ^H_edQe_ed]Zei_iibebd]]eV_K_dRd_deeed^
^ee_^[[Y_dedeei[WediT^]]idbebeedNbd_^_YNeRQe^dOY[iieYV^^^iWe
dOUU_bY_ei_ieedUeRiiidOebieeZTdi^eeeU^^bXd[ReeeVEFWed^VYiUTZ
_dY^Xd\eWdiWeii^WddXYe``eee]eK_YeeUUXPXYQUeVViQX^N\JO_MMPOOM
WNP@^[ATL]]]^MVE[@`MMGSMTEM[LNWO`QMVM]TTJM[[[MQLMV@[FMBMFNMT
=FLXJPG^[R[MEJNDCMTFQ^MHMMGMMMIMGIG846KIRKAD<DMEMGDLBQ@FQCGT
WWPIHKJGFDC;B?RK:=:ACL\5;798JNN\HB@785546\AC<E=N75559;M@=EM9
GN@578<>N@8NIME5497A44ADAM>=<SNG9=8=7;@7I=;A4@9668C?E?7C6G74
F59J44B6;47>;3868@4313449=56648665539<:367>I>7;B8@C7;><?<65C
6963=F97:78966@6
.
frg:37
clr:15,907
}
{RED
iid:1450
eid:1127298168
seq:
CGGACCTGATTAATACTGATGTTCAGCTTGATTCGAGTACGTCCCAGGGTAATGGTTTCG
GGACCATAAGAAGAAATCTGGCCAAGCATTCCAGCTGGTCGCTAATCGTTGAGGGCATTG
GTGACTTACACATAGACGACCATCACACCACTGAAGACTGCGGGATTGCTCTCGGTCAAG
CTTTTAAAGAGGCCCTAGGGGCCGTGCGTGGAGTAAAAAGGTTTGGATCAGGATTTGCGC
CTTTGGATGAGGCACTTTCTAGAGCGGTGGTAGATCTTTCGAACAGGCCGTACGCAGTTG
TCGAACTTGGTTTGCAAAGGGAGAAAGTAGGAGATCTCTCTTGCGAGATGATCCCGCATT
TTCTTGAACGCTTTGCAGAGGCTAGCAGAATTACCCTCCGCGTTGATTGTCTGCGAGGCA
AGAATGATCATCACCGTAGTGAGAGTGCGTTCAAGGCTCTTGCGGTTGCCATAAGAGAAG
CCACCTCGCCCAATGGTACCAACGATGTTCCCTCCACCAAAGGTGTTCTTATGTAGTGAC
ACCGATTATTTAAAGCTGCAGCATACGATATATATACATGTGTATATATGTATACCGAGG
AATGTGGCTGAGTATGTATACGTACAGTATGATACTGAAGATGACAAGGTAATGCATCAT
TCTAGACGTGTCACTCTGAACGAGGCGCGCGTTGCGTTTTTCTTTATGGTGTGTCGTGTT
TTTCGCTAGGGCCCACGGATCCTCGGCCGTGTGGAAAGACGTACCCAAGCCCTGA
.
qlt:
44544457:444444689:HM>:88EPWRH:9:?L>CA<7:<@87658F:688LH9<:87
;<;;;455:58989965:?SP=H?M:;LBGWH9HEM<:=<;=;859:;;;;<:8E54:;<
>GadWMKKFGGQWXKd]IkWTNWWCRRWWLGMUVLCkKKaH:;<G8BJBHK=BB=@DTTB
U]TOFFBJJYK][a[KTBQMGLTF<SB=<M;IC<TVWV\N\GPI\MTLTK=S\PTV][W]
dSWDKBDCLdSUTL[][VaMC=[K?THCUKCVEdV[WWLVB]WLFL[?LQ<YOLTI9@TP
<JNJHHOLdOCUQWLCGKKW[[WdPKO;F<OW;TKLCOCWGLd?<UC[[aTTKVKHMGWL
RRL=CTH9:BGCDCJ=A7RHUOLV=KABdOR[TKMVLVB:B=GS[[GT\GKHd[C[CTGE
B@WLHYTPVCLWHLTK>DCIaK;K@8GB<=;<?<?N<<OLGaDF>CCQHK=CIBFT=LG<
PPGUJGkQULUOOVkE=EG<CHLH[CFECGQkRkdD<F:FILUBTBK@;;B=T?BB;SHH
=@CBEL?UEOTMPEALB=A98@GHHF?YHaVFC=B<C=Oa?O::><;:BO9>M>C>>>==
R>;L87::=8<E>BES<?AH;9=?<AL;A@OMHB9APNC6F;>A;<GS@:9GKXD8>L<8
:?=99<:98G;G>;GFAENJA:H9PFFK]I;C=::8;:=DDND>Q:<N=>>8@HW><:DN
?BFD<H;8><<89B89<:<88;;9PK97<>M>LCC8C9?98688<<C>>;85888
.
frg:38
clr:706,769
}
{RED
iid:1451
eid:1127298169
seq:
TGGTCTGATGAATCAGCTTGATTCGTTGCTCGGCGCTACAACGAGACCGCAGACGAGCTG
GCTAAAATAGCCTCGGGGCGAACGACGGTCCTCCCGGACGTCTTCTCCCGGGATCTGCAT
CAACCCTCTGTCAAGATCGACGACGCGCCCGAGCCCGAGGTACCCTCGGCTCAGCCCGAG
GCACCCTCGGCACAGCCCGAGGTACCCTCGGCCCCCGAGGGCGAGGCACTGGACGTCGAG
GAAGAGCAGAGCGGGGCCACGCCAGATCGAGATTGGCAGGCCCCGTACATGCAGTATCTT
CGCCGAGGAGAGCTACCCCCCGACCAAGTCGAGGCTCGGCGGGTAGCGCGACAAGCCAAG
TCGTTCGTCTTGCTGGGCGATGAAGAGGAGCTCTACCATCGCAGCCCCTCGGGCATCCTC
CAGTGATGCATCTCCATCGCCGAAGGTCGGGAACTGCTGCAAGAAATACACTCGGGGGCT
TGCGGCCATCACGCAGCACCCCGAGCCCTTGTCGGGAATGCTTTCCGAGAAGGCTAAGAC
TGGCCAACGACGGTGAATGAATCCGGAGAACGAGAGAAAAAGGGAAGGTGGCGTGGATTG
CGAAAGAAAGGAGATTATGAGGGATAATCTGTTGGAACGAATAAGAACGTGACAGTATAT
GAGTTGGTTGGGGGCAAGAAAGAAGAAAAGAAGGGTGGGGGGAGGTCAAGGAATCGGATG
AGGAGCCTTAGTGAATGGTTTTGTT
.
qlt:
41447<GMAE87;>89_iii_@iiWZi^iillZlll[QbPlllllOgllllg_lllllll
l@G=<<<M;:akklkllkllllllllkklkllllllllllllakaSaW[aak\gkkllll
lllll\klllllkllglllllllllllllllldlllkldkllllllllllllkklllllk
llllkkllllllllkllllldllkklllllklllllllkllglldlllllllkllllkll
lllkl]llklklllkkkldlklk\dkkgSlakkklkkkkldkkkkakkdllldWdkkkkk
lSkkkdWVYFYNSaW]]OKKMKVKTKFKOkTkkk]kkkdakk]]kK[[]T\[LTJJ]LU\
Wk\NddWTdadaPTWPGOQ[NUdTNk[WdL[daYW\PLWTUNUTWaad\d]GJG<GTTSQ
KHEGaNEK<=<B<=E<HLWCMB[DD[=KGH?KFGQdTNJB:G;aWLOTK<TSWLH?NVRL
W]KBKLW<=?8;;?9989<C===PL=BF=FTBKCWF]KLTH?BGHG<P::9:G:=<=;;<
?N>:><=9;8>?F<K::=?::<58<<HH886<8B888<9:7=<I;=<::;K;8;IE9>;?
5?<99E99;:::<=;;<==<;<;7;:8?@CB<?=<99:>>AFBE9>;<?=<999C=98:@
B7:89;C:CC??9;57@8:8A;CHE=>@KA@A>;888?Z:8>:7=9=A?:C788:@>8<:
9:6<?977::<96858KK@:?@=C9
.
frg:39
clr:5,743
}
{RED
iid:1452
eid:1128922848
seq:
AGATTCTAGAGATTCGTCCTGTTGCAGAGATAGAGAAAGAGGAAAAAGGAAAAGGATATG
ATAATGAACGACGTGGCGTACCTCTTTTTGACGCGGTTATTACGGTGAAGGCGAAGCGTC
GCGCGCTCCTCCCGCCAGAGGCGCCGCGTGTCCCGCCGCGGAGTTAATGCGACGGGGCGT
GTAGTTGGCGGGGCGGCCGTTGCGCGTGCGCGATCCGTTCGAGGAACGGGTCACGGGTGC
ACCGTCTTCACGCCGTGAGAGGAGGCTCTCTTGTTGTCCCAGGATGAGACGTGAGCCTGG
CTGACGACGTGACTGCTGCGCCCGCCCGCCTTCCACCGCCATTACTGCCGGCCCACTTTC
GGTCGCTTTGACCGACGCGCCAGGCTGGCGCCGCTGGGTCGCCTCGAGTCGTGGCATAGG
CTCCGCAACCGGAGAGGCGCGACGGTGGCACGAGTGGCGGTGCGGTTGCTTGCATGCAGC
AACTGGCGCGCCGATTGCTTGACGCGTGGGTCTGGGCTTCCAAGCTGGCGTGTCAGAAGT
CGGAGAAGCGCATCCACCTGGCGCGGTTGCATGCCGCCTGCATGGCTGCCCGCCCCTTCC
GCCCGTTGGTCTGGGCAAAAGTGGGGGTCGCTTGTAACCGCTGGGCGGTCGTGCGCACAC
GCGCGGCGGTTTGGCTTCTTCTGCCCTGAGCGGTTTGCATGACATGCGGGACCAGCCCCG
AGTCGCAGGGGGGCCTTGGAGCGTGTTGTAGAGACTAGCTGCGGCGTCTGGGGCGCACGT
AGGAAGTGCTTTAAGGAGGAACTCTTTCAGAAGCAACCATGTCTTCTCCTCCTTATGCGT
CGGTCTTTCAG
.
qlt:
44477?=?>:7:9P[L;87:EiiTEYAibB8__edZeYX_ie_QZlYllblllllXM@<9
55869787ALabbblllllllllllllg\lllllaaUYaH;988;<ggbdllllllllll
lllllllllllllllaalllllllllllllllllllllllllllllllllglllllllll
llllllllllllllllllllllllllllllllllggllllllllllllllllllllllll
lllllllllgllllllllllllllllllllllllllllllllll_lllllllllllllll
lllllllllllllllllllllllllllllllllldllllllllllllllllllleiiiii
i__iiiiZ_ieeiiiiiiii_iiiiiiiiiiiiiiiiiiiie_iiiiiiiieieeeiiTi
_iiibeebiieid]dWideiidddi]die]eeieiiibiiUididTeidiYVUUeieTU\
beeeiR_ee_WiQdS]iLi^iYQQdeOVZ\\_XiYeUOIDNEY\\`eiU_QiLYNIc_NN
YUO\B``P`OPNPM`PMMM_VMMLYYNM]MEPVBUMMUJ^HGLV^HMME^WMM^^[RYMY
LLYGMINLQ@MMT^NLPccPKQYcccVDIQLOF^CMFNGMOLMZJ>:IASEDVCCLDc;D
MMKGMOCLW@cHDL@GGIH6@BN9\7@NBAW>?7\<PGGJNF>=GR<>S>M@M<8JRLC8
MBEA@B7ARNTTF9><6>9Q89<7J8984<6C3>7I;7D4597?CC;74A9?=5::55>=
6::73236H7N<>443374947;C6I@644;=84@8CC<8?49@8;C6D86>7664=358
8<74;6?==64
.
frg:39
clr:5,772
}
{RED
iid:1453
eid:1127298170
seq:
TGGGTCTGATGAATCAGCTTGATTCGTTGACCCCGAAGCGATGGATGATGTTGGTGAAGA
ACGCCACCGCCTGCTCGGACCTGATGCTGCTCAGAGGTCGGACCTCGATCCACTTGGAGA
ATTTGTCGATGGCGACCAGCAGGTGTGTGTAGCCCCCGGGCGCCTTCTGCAAGGGACCGA
CGAGGTCTAGACCCCATACAGCGAAGGGCCAGGTGATGGGTATTGTCTGCAGAGCCTGAG
CGGGCAGGTGGGTCTGCTTCGCATAGAATTGGCACCCTTCGCAGGTGCGGACAATTCTAG
TGGCGTCAGCCACCGCCGTTGGCCAGTAGAAGCCTTGTCGGAAAGCATTCCCGACAAGGG
CTCGGGGTGCTGTGTGATGGCCGCAAGCCCCCGAGTGTATTTCTTGCAGCAGTTCCCGAC
CTTCGGCGATGGAGATGCATCGCTGGAGGATGCCCGAGGGGCTGCGATGGTAGAGCTCCT
CTTCATCGCCCAGCAAGACGAACGACTTGGCGCGTCGCGCTACCCGCCGAGCCTCGACTT
GGGTCGGGGGGTAGCTCTCCTCGGCGAAGATATTGCATGTACGGGGCCTGCCAATCTCGA
ATCTGGCGTGGCCCCGCTCTGCCTTTCCTCGACGTCCAGTGCCTCGCCCCTCGGGGGGCC
GAGGGTACCTCGGGCTGTTGCCGAGGGTGCCTCGGGCTGAGCCGAGGGTGCCTCGGGCTG
AGCCGAGGGTACCTCGGGCTCGGGCACGTCGTCGATCTTGAAAGAGGGTTGAT
.
qlt:
444449=BS@G:6;966Qeil_UllS_llMClll_algllaallaalkVklllklllkll
lkQ[[<OJHHPllllllllllllklllllllkkllllllllllllk\klkkkklllkkkk
lllllllllllllllllklllllllllllllllkgkllllllkggklllllllllkllll
lklllllklkllllkkllllllllllllkggklllkklllllllllkkllkklklllllk
llllllllllllllgkllkgdlkllllllllllkkkggkkklllllllllllllllgkkl
llllklkkklkklk\\\kkllllkkkklllldlllllllllllllllllgkgUggkkkll
dkk[dklklkglkllllllllllllllllglllllklklllkkklllllllllllkklll
lklllllllklllkkPlllllllllllalkkkkllklklllllllklkllllklkllllk
lkll]llllllkkllkllkklllklkllllllllllgll_llllllllPUgl[_lglVVl
OlVag[lglllagbllled[_lb_VellP>:978:EOXeOU]]lll]lb^AiFiee]eST
=KZb_eVX]ieZiiieeii9=6865?H^bdZXYddedZ`dP9]OUK7bibURdeiYiOPM
SedYJLJQUUXTeFC8958ATUP`RiUSeBOXQO^IESVQCQXN^P^[M^C\MMM^IGMO
PJM^M^HWUMMMPW[L^WLMCDW^LINLQVHMNG87BD;<D677;7DG;=?D9
.
frg:40
clr:6,771
}
{RED
iid:1454
eid:1128922849
seq:
AGATCTAGAGATTCGTCAAAGTATTTATCATTTGGTATCCTATTGTGTTCAAAAGGGGGA
GAAAGTAGTATTTCAAAAATGGTATATCAAAACCCTCTTGAACACTAAGAGGTGGATCTC
TTTTAAGGGGAGTTTTGTTTAGTCAAAGGAAAAGCATTTGAAACAGGGGGAGAAAACTTC
AAAATCTTGAAAATGCTTTGCAAAATCTTATTCATTCACCTTTGACTATTTGCAAAAAGA
ACTTTGAAAAGGATTTCCAAAAGAGTTTGCAAAAACAAAACATGTGGTGCAAGCGTGGTC
CAAAAATGCTAAATAAAGAAAGAAACATTCCATGCATATCTTATAGGTAGTTATATTGGC
TCAATTCCAAGCAACCTTTACACTTACATTATGCAAACTAGCTCAATTATGCACTTCTAT
ATTTGCTTTGGTTTGTGTTGGCATCAATCACCAAAAAGGGGGAGATTGAAAGGGAATTAG
GCTTACACCTAGTTCCTAAATAATTTTGGTGGTTGAATTGCCCAACACAAATCTTTGGAC
TAACTTGTTTGCCCAAGTGTATAGTATACAGGTGTAAAAGGTTCACACTCAGCCAATAAA
AAGACCAAGTTTTGGATTCAATAAAAGAGCAAGGGGCAACCGACGCACCCTGGGTCTGGC
GCACCGGACTGTGTCCGGTGGTGCCACCGGACAGTGAATAGTACTTGTCCGGTGCACCAG
GGGACTCAGACTCAACTCGCACTTCGGGATTTCCAGGCGACTCGGCTATATCACGGACTG
TCGGTGTACACGACAGTGTCGGTGCGCAGAGTCGCTCGGTCGCGCGCAGCGCTCGCTAAT
CACGACTGTC
.
qlt:
556:::B89;9:SZNYS_R_CQFAi_ZVDCllllTb_VllgllllV_YlV<lllglllgl
glgkkkkllllllkVlldkkgkallgURYkklllllllllllakllkS[lklkllllk\g
klkk]WU\Yalllklllkllkkllllkgllllllllllllllllkkkkglllllllkkll
lllllllllllR[ULSYllllllllllllllllllllkggkllllllllllllllllkll
lklllllllllllklglggllgglllllllllgglllllllllllgllllllllllllll
lllllllgglllllllllllllllbblllbblllllllllllllllllllllllllllll
llllllllQlllellliiiiieiiiiibiiiiiidiiiiiiiiediiiiiiidiiiieii
iiiiiiiiidU[__iWiU[YY_eidKiiibedT[YiYGYYYYiMUFYYVYYdiUY\OeeL
de\\eULVYWiUedSeTXiWXPYSiiiiUGW\K^XiJOiNA\KG^VW\M\Y]^N^\\JXP
RR_QM__Mc]PEWH@WM\]MYMNUS`LMNMMWMWNU^c^EW?NMHPMTYVOO[W<PNM^T
^N<XAD=GLVccTPGJ<LQAJMMccW<T>M88:cVHPIWE@B846:GIGAAETC<LBLJ@
<@J9T;EL9Q<6:?O>G>9B65=C=@8H8>L>D<?CL8BOCGR;I6@CF=HD9?CF>L@?
QS@;<IG:5A8MM9B<MM686>3474D6O4Z@8984659M=J;69<F<6MC86I7;J;DJ
>C;87I:C6476349?:G>C?85994@:44368D865:4;:455365:4A468;4=8C=B
84>?A7:D<6
.
frg:40
clr:3,800
}
{RED
iid:1455
eid:1127298171
seq:
GAGTTCTGATGAATCAGCTTGATTCGTTACTTTTTCTCGGGCACTCGGCAAAGAGGTTTG
CCGAGTGCCAGGGAGCACTCGGCAAAGAAAAGCGGTCGTTACGGCGACGGGTGACGGAGA
CGGCTTCTTTGCCGAGTGCCACCTGGGACACTCGGCAAAGAGCCCGCCAGGGACGGTCCC
CATGTTTTGATCTTTGCCGATTTTTCTGAGCTAAAGTAGCTAAAATGAGCCCTATTCCCG
AGGGAACGTCTTGGTCCAGGCCGCGATTAAATTCCAACATGGATGCTGATTTTTATGGGT
ATAAATGGGCTCCCGATAATGGCCGGCAATCCAGGGCGACAATCTATCGATTGGATGGGA
AGCCCGATGCCCCAGAATTGTTTCTGAAACATGGCAAAGGTAGCGTTGCCCATGATGTTA
CAGAAGAAATGGTCAGGCTAAACTGGCTGAAGGAATTTATGCCTCTTCCGACCATCAAGC
ATTTTATCCCTACTCCTGATGATGCATGGTTACTCCCCACTGGCATCCCAGGGAAAACAG
CATTCCAGGTATTAAAAAAATATCCTGAATCCGGTGAAAATATTGTTGATGCCCTGGCAG
TGTTCCTGCGCCGGTTGGATTCGATTCCTGTTTGAAAATGGCCCTTTAACGGCGATCGCG
TATTTCGTCTCCGCTCAAGCGCAATCACCAATGTATAAAGGTTTGGTTGGTGCGAGTGAT
TTTGAAGACAACCGTAATGGCTGGCCTGATATACAAACCGG
.
qlt:
41334667D<E;7AD?ALY[YQ@_ePeTEL_eee_ebe[bbWHVdlTU[abgPlag[ddg
ad=@:5<;69=;GE?J=V[]HQMOOT=]WLdHQKKBUFFNKTBB=>?H8=;<KVLKKK;U
MBSCTWTKOPdTT=KG<TCC@HB;=<<?<>;=B:<<==B8K<=B=<=B<>=<F?DG=DHB
:;<=C=FDN;<<IC==;<:K:@=::<9UP?:;><8A:?:<==FBGGNKTKT>?B=F<<:<
?G;NCC<G=B=GB<<=<=;=<F<G<=>C==?LWGN?GC<GBF<HMCFQP?OK===IKTLK
MPKMTLV\MCGK<<;<><GCQ=HAVLHNKGJ=;N?LB=RH=KKJIHKH=CHPP=@?Gd[[
aCLYU<HBGG=GWB;aB=KB@LLQLH[[NFBQTN@FM]<SCB<GHLWOQ]:L>KD<LCSL
V?:KC>Q>L?KO?RL?O=B=BKGKT[?HCTB;BKSETTAJLLUELALIO?LEL=AA<J?J
CUaaPBCFJB??CCFO>KO>>G;=<=DRV>B=I>@8;Q>?;>77;HEMH;;BQMPOSOK=
LMHPGPD8@>GGPK:JO:SH9HCHR>G@:H:76F>FLP@K=E@NK:C;F9<;9EOHP<F9
9K:<;GAK@8Ad7P9CA:6?FB6HNVJJBC6EJ@5:>AB;5:U:eGLA<H?@;5@CF;<8
888B899:B9E@=8HNKIU<6U9;B@9<>CH<B7HA9>B8HE>=:9:A<IAH?8D:5EOB
LNE<G7BE>9><AP8L;GLN7<ND@<578<:6MKRG8?=:9
.
frg:41
clr:8,201
}
{RED
iid:1456
eid:1128922850
seq:
AGAAAGATTCTAGAGATTCGTCATATTTCTACATTTATTGCATGGACACCTAATATTATC
TATTTGTGACAAAGCAGTTACATGGTCTAGAAACATCTGCGTCTTGGCAAACCATTCACT
TGTGTGACATCCACCCTTCTTGAAACCTTCATACATCCAATCACGTCTATCACCCATTAT
TGCGGCTGTGTGTACGAGTAAAGAGTGCGTGTGAGACAATCATGTTTCTACACGTCACAC
ATATATACATCTATAGGTAAGTAGTATATAAAACTATATATATACATAAATAACTATATA
TACACATAAATAACATCAAATTAACATGATATTCATCAATTAACAATATTTGCAAACATC
CAATCCATCAAATTAAATTATAATTGCAGAACATCAAATTCATTACCTATAACATCAAAT
CTATCAAATTGATTAATGCTTGCATAACATCAATTTCATTAAATAATAACATCAAATACA
TCATATCATATTTACAAAATCAAGTTATAAATAACAAATATCATACATCAAATAATATTA
GGTCAAACCATACTAACAAATAACAATATTAAACAAATTATAATCGCATTACAGCTAACT
CCCGTCGGCCATAAAACTGACGAAAATTAAAACATAAATCATTTGTTAAATCAACTATAA
TAATAGAATTAATATTTACCTAACATCAAGCCACACATAATATTAAAACTAGCAAGGATA
ATGCATAACTCCCGTCGGCACAAAAAACCGACGAAAATATCAATATTATTCTCATTACAA
AATAGATTATCCTCGACAACTCAAACTTGAACGGGGACCGGATGGGAAGCCCCGGGTTCT
GGGGTAGACCGGGGCGTCAGAGTACCTGGGCGGAACAGACGAA
.
qlt:
644846:6756744577::79F@NXO^dQTPG8__ATUb_SD_i_N[O__bbS[VWWSSM
;<98:;;;=559?CFHMRPHP>\gl[gdaCdYUdP[g[lddGOGKYF?OT[Va[kkkVkk
kldlklkkkkkkkadkdkkkllk]ddkdkkVdkkakkXUa]kSdkkkkkkkkkddadkkk
klkkkdklWkklddkal[daldkkkdlkkklkllakkkdkkaklddllT[dOk[kkTk[k
Uddkdk[k[a[Tdak[dTTdTadYSYagd[[adadd[[Y[TadaUUd[a[addddgdddd
ddgdgagggWYdaa[abYdggggggggllgggggb__VSaVY[aaaabbbagYYab_Vbb
aVbVbYPV[ROb]ZZUU[[b[UUU[b[UblVaaaaSSbabbO[Vaab[bSSK[[[[HS[e
lebbU[Sb[beeSbbTOlbb]lbKWYWVVbbQOSZQWWW?KQPQQGLPKVS]ZKRV]__]
e_[O_SVWW][ZJ]ZHKVHJXKPVVVWVRTPZXdd]RW[d][V]b]Z[U>H[VWZZ][Ue
>TMWLJLJ_DUVZZNQ_C6=8789B@EWTS>NQQLPVT[OUKHEPHLLXP]UNPQHQUEN
NNKILQAWJIGTMRGUQHXHKHZUQMCVL>KM<>?6;6LPA=NQO;LP]JSQIHLCGQKH
IHHNLBSSENN@BNMM99MGA?;<;EF6H9:F:ILP9PCL<?67=;H@=ALNH@IGEA:?
=:N@:@MMLLJLNA9<D9B7HEHLLM:>96M7<OM>G:D=>8:@A@><9L579;HM55;5
YEC@;F<=957@>MCFM?B69;:LLCLJBB@99>7@M6===9>=V4465ELC9:N?84>4
C<M@48<D==?44::5>8468?<=75?CL@8964544855;93
.
frg:41
clr:21,869
}
{RED
iid:1457
eid:1535245854
seq:
AAAAATAAAAAAAAAAAAATAAAAGTTAAGGAATTTATATTATTCATATTTTTAGGTCCT
TCCTCTTCTTCTTATTTTCAAAACCCTAATTCCCCTTTAGGGTGTGGTTTAACTTCCAGT
GTTTATTATCTTATTATCCTTATTATTATTTTTATTATTATCATTTTATTTCATGCACAA
ACATATAAAACTCCAACATAATGCACCTTGTTTTATTTTAGTATCATTTGTTTCACTCTT
AATTATATGCATGCTCTTTCATGATGCAATTAAACGAATTCTCTAGATATCGCTCAATAC
TGACCATTTAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCAACCGGAGGC
TTTTGACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGACATAACATCACTA
CCGCGCGTATCTTTTGAGTTATCGACATTCTCAGGACATCCTGAAGCTAACATGAGTCAA
ATCCA
.
qlt:
45555554455455554445;::<>:88848:=567=9HELb@@7@;::@:95<:C:9:=
MV[GUKMKIKPDH;<;::6;7:<;<?C=<BDBB<<EK;<:GF<V=TGBQKN?VTWVLL<C
F==EKHPSGPJIWGFKBEPBFFD@MKNPMMI<=C=<=7:B<C=BFMAG<DB;:GaNCDHD
<MKUTUGKGHOFNG;:<<=<H\\aGSYaYkE\PKWWUaAP?HBI?GLKFKTFGJ=MMOUK
KPJGTNGNEB=?H8=<<BFM<?LPKTGK>FK=ABB<KPKT[KQ>I<KBF@JJUU[TS[[S
EKBFHAPTW\Q==?DBFB:BDM===F<C?H?C65B::<=FGMKKBE==BB9NCCF<K<BH
BFDCB=8F<FEPLFGPKM>ICB<THFTFXM=B=BBA<<BA;:P:BF<DB:ID:T:=8B<=
QKA8B:K8AC9B::::8=<=?KD:?<A:C>:B:<;<;6=:=;F<=::;<HTH;=8:8?7<
G9B<=
.
frg:41
clr:36,484
}
{RED
iid:1458
eid:1535245855
seq:
AATGAACCAACAGTACTAATATGGAGTGATATCTAAGATATATCATTAATGTGAAAACAG
AAAGTTCCCGGTAGTATATATAATACACTAACTTTTGAGAAAGAGAAGGGGAAATATGTA
TGTATACACGTACGCACACATATAACACATGAGAGTATATATTTTAAATTTATTTTTGTA
AAAAGAAACACAAGAATGTCAAGCCAGAAAATAATGAAAAGATCACCCATTAGGCATGTC
TTGGAATAAGGTAGAAAGTACTGGGATAATAGTGAGGATTTTGAGAATACCTTTTAATAT
TCTTTTGACTTTTGAACTAAGTATTTTACTTAATAAATTCCTTAAACTAAAAAAGATTAA
CAAAGCAAACTCTAAAATTGGTTAGAAACAAACAAAACTGAATCTACAGATATAATAACC
ACATTGAAAAAACTATTAATTCAAATAATTTTTAATAAAGATCCTTCACAGTACACCTTT
AATATCTTGCATATTCTAAGGAAAAAATGGACTGCAAAGAAATTTTGACTCCTTAATAAT
GTTTGTGGTTTTGGCATGCTTATCTGACACTACTTTGCAGATACCGAACATAGAGCAAAT
GTATAACTCACATCCTAATACGGAAACCGATGAGGACCACCCCTGTACCATCTGGTTTTT
GAATTGGACAATTTCCTGTATCTACTCTGGGCCCTTATAACATATTTTATCTCGATTGCC
TCCTATTCCAAGTAATACCCTCCATTTTAATCCATCGTCTG
.
qlt:
45754444554454875E<;;>=GKO>B9;6;=BZKGC?979;>:99C<JO;TLB?:<<C
KG;;;=7:67:77;=;<?@@Q?L??C;BC==KMGK=JDGHBE<J=C:;:;:9:9:<BG=B
TQBKUGK:QE@:F<=8:VW?PDTPLLTOLUTN=NKM=K=JAFHQGBFKaaPPT[]daUB<
8=B8DOIMWBQ=<FK=GJ=H==GGKB<MBKKMWGMF7?=GKQaWGGPG=KTK<FHLTMUH
PPSBEGIG>BG;?FYVTPGWS\\GBNFHG=K=M[=<B9NBSFKGBMHCGNVWTTKVIB=<
BB@dSSTadKJHGHHSUNE=<=<?BBFJ9?>B<7B:<G868?D=C:TJE=:<BA<OLKGC
LGGKDE==<88B=GMH=GKKB<CC@BGCCKKKFD9>8<;GM=<<<7H;=MKEN:F?NBSW
QSITWdaPAMKKTM[K=NKTLLG=F9D7:MVCCGAQF6F=@:?BH?Q<<GCCFKGPKBVD
NBKIC8:<B<CHA>DP::=8DHIIHFH9D;:=CTH;FK=CGBKG?IBK=?8B<:>:?<:;
BTKUM>CC:9ESD=F;K@6>=?LTC@?8?=<==:;8=B;<@>;9:;:89;HCEO;:IC<;
;<<BC;FB?>9HC=E;;?A>:9=J>G9A=L<CH9:;9?G:KOL@C;>@==IGO<;9:=<:
<<;8:B:J?>FC:8=8:AB>8>:9CEH@>P:HW9A=>8C7?>??>F:8;E<9;>98:7<6
?FKEE=D9F>>A@@<HEDG<?>:<=?8<7:7878:?97587
.
frg:41
clr:17,746
}
{RED
iid:1459
eid:1514872993
seq:
AAAAACTGCGTCGATAAGGCGGCTAGTGGCCCAGAGGCGCGCTCCAAAAATACCTGCAGG
TGATTTGCCGGACCCGGACCCGTTCGACACGGTCCGAGGGCTTGATGCCTCCCTCTGGTG
GGATTCTGTTGGGGGCCTTCGGCTTCCGAAGGTCCTCAGAAACATGATTTAACAGTGTTT
CTAGAGTGTAATGTGTGAACAGGTACCTTCCGACTTATGTCAAAGAGGGAGAACCTCAAA
AGATACGAAGGTTGGCAGTGCCGAAGCTGTGAAGCAGGAAAGCTTCGGCATGTTCGCAGA
AAAGGGAACCGACTTAAAGATGAAAAGGCCATTTAGACCTCGATAGATTGCTATGGAATT
ATCACCCAATGTAAAGGGCATGTATGTAATTTTGTATGGGTTGTATTCCGTGCCTATAAA
TAGGTGAACAGAACCCCCGTACTGTTCACGCTGACTTGGCATTTGCATTTGCGTCACGCT
TGTGCTTTGTATCTTCTCTCATGAGCGAAGGTACATTTGTAATCTAAAATCATTTCTATT
TTTCTATGTCAATAACATAGAAATGCTTCTATGATGATGCTTATATTATATTTCATGCTA
TCATATGATCGTTCGGATTACTTGTTATGTTCACGATCGTATGTCTCTTATGACCTTCGT
CCGAAGCTCATTATTTCCAGAAGGGAGTAATGCTTCCTAGGACGAAGGACTTTAACATTT
AGCACTTTTTATGTTGCCTTGTTCTTAACTCTTAGCTTTGAGAGCAGTCCGCAACACTGA
CGCACACCTCCCGTGAAATCACTCCAGTTCATGACCTTTGTCAAGCATCC
.
qlt:
64457544446658475=DEG=:CL;:P8?G<D>[CB@GKKWOQ;=NWGCHWOHOWC;SS
ISO>>>=9;?<TFMOIEKFI@C==C=K??;B<<GC?daa[[ad\CdkYd]aa[RTNddTk
YWVV[YWkTYkCGLLFWW[[QKBUTKDAGD<;:<8::9<OGHd[kkVLWPNGKPTVk]LL
[LVGa[GaCLTWkOWTYWROLR[GWW[WTW>GQV[OTKNCLLFLBaCOMUK[LW[KVLRT
TPkR[U=TD=O=Na<@GCDWUTGdKK[]kHLIC?ILCWWK@>EQL[HOLKPkVS[GVQV[
LGTHQ=ULLVG[QLKI8DB[V[XGFYV[Vd[aa[[MkddddIJCN=LEIS=BQTTCLNGN
[LTLTJ@=ADTFH@HTLLLYUdLWUaJMUUC>CC?CSa?;<JP;UJRRUC;UCRCKMIaM
JG;>>IOGH>A>KHYbUSSH[SVe[TK8HM[MO[GKS[:AEPM9>98@>WQKH;FMRCA=
=O@OWKAE;>H>F<AKAZAH:5>>8>HKH8=8=:7@@;@<VZN]LRDJNAHOMLEREZDQ
KG::98>C@@<BDKH>@Cb@R<8DD88<LGOIGQAQT:D@:9HTQTNT@P>?9<;9K@8<
HOiGKZSF9855<>6555?PNKMO8:BLQ<NH8B=Q68CFGHTHHIA;@HE><>=9>8@:
>;:EQCDOEEJHLFBBIH<<E@I58C5;@D:U>HDEBAH7;@=6NI<FE;DNOB>;<>>;
J6L?DF<>HNP@I<<B6N?<C:??HE8<6FI?>JG9?JBF:5A6;D77J85>Q[8E5;>5
FMM9>?GDOM;;:<KGD:7777E==99M>;:FKD858AC8>6867=AD77
.
frg:41
clr:17,827
}
{RED
iid:1460
eid:1514872994
seq:
TTCAAGAAAGATCATCGAACGCGCCTGCTGGTCGCTGTGCTGCTGAAGATAGAGGGAGTG
AATAACAAGCAACGGTGAAGATTCTCGCGCATACAGGGATTCTTCCTTGAGGTGGTCCCG
GTGATGAGAGTCAGAGAGTTCAGACGGAGTCTTTTCCAATAACTCTCGGTTCACTCCAGA
GATATGGGTGCGACGGACCCTCCGCGATAAAGACATTAAAGGCATGCCCGAAAAACTTTA
TATACCTCCTCTTATTCAACACGTTTTCAATGGAGCCATTTTTCTTTGCATATTTAATTA
TGTTTCCAAAGGATTCGTCATCTTGAAGCTAATCCATAGTATTTTCAAATCAAATCCAGA
TACATAATATCAATATTTACCCTCTGTGCTCGCACACTGCTTCCTTAGCCAAGTCTCTTA
TGCCGAAACTGTTCTCTCACAGACGTTTTTCTAAATTTAGGCAGTCGGGCACTTTGGAAG
ACTCATTCTGTGTATAAGAGTTAGTAACTAACCATAATTCCGAACTATTTTGTATACATC
TCAGACTTACATCTCAGAAATGGTCTTTGAGAGACATCAGGATCATTATTTTGCTAACGA
ATTATTATCTTCCTAGCACGACACTCGGTCACTTTACCTACATGAAAGGAGGACAGTTTT
C
.
qlt:
4444567;797575:754:58AD555?76>979<9777<:9<A8787<F8=9;C888::>
<<<99558<<97:79;<;=;C9<<HC;C;=B<B;:;::9<64548;:7=?9B;<;98<<=
G8=8:=:<B<=?>B:G=BHA<ABGCTD88:<9:<9<;9<9<FFJL::8<==7<=<;;9;=
<;<;=L=GNK;=6AG<=><=FJWHC;:?==ICB:;=>GHB=98:=C9B89;GG<KC=C:M
=CC?ACBK?=KDCWI>AD;;8BH<<:<BB<Ga<=9:=A?=====:BBS@<=:B?P;F=BB
>;?B=a\BFA=<?=JI<;F:@<8BHD::D<;7=C;=CH:F==NR@K;9<<=@=;?G8;<=
<::<<<<<<=9::9;<:=L??V:FBT<;=H::<=>CC:;<=B<;KBG98<C=<==:5:<K
CCH==;7F88L;KKBG:M:>GD?:BFFGKF<@B=??::;=<9;=:8@;E;9B;=>I8>=<
<@<=98::<C=FC=:?B9A9;<<9=MQ9<<<<<<8@=;<==<=E;54@B=G>;E<OB9AU
;>W:><BM=:;<<8;:9B<;?CNAG=>;AL=THOKSH<=:CC<JOKEC???<B=;H?<<;
?<E?::C<C<=>::<>BFOIG89A=99<CC>;;;C;:>9><<?D:>;G;A;9<<:;:8B<
B
.
frg:41
clr:38,660
}
{RED
iid:1461
eid:1514872995
seq:
GCAGACGGAGCTCGTCGACTAGCTAGATACATTGTGCGATGGATACAGGGGCCGAGGTGA
GGTCCCCTCTTTCTTCCGTTATCATTTTCTTTCCACGAATTCCACACGGTTTTGGGGGGG
TAGAAGGTACGTCTGGTTGTAGACGGAGCACGAGGGGTCGTGCCAAGGCACTTGCACTTT
GCGAGCTCGCGCGCGAGACCGCACGCACTTCCTACGAACTATCCGTGCGCACGTCGGATC
CGAGCGCTATGCTATCTCTAAGCCGCGCGCTAAAGGCACGCTGGGCCGAGCTCGAGGCCA
CGCCGGGGTCGTCACGACACGAGTAAGTCAAGGTCGTTGGAGCGGGAGAGCACGGCGCAC
GCGAGGTTGGGGGGACACGACCCGTGCCTGACCGCTCTGCCCCCACGGGGCGCCGTTTGC
GAAGAGAACCTCCGTGCCCAGACCAACCAAGACGGCCATGCCACTGTTATTCGGGTCACT
GAGGGCTTCTCTTAGATCGCTCTATTTCATCTATTTTTGCAAAACTCAGTCTCCATCACC
GGCATGCTCTCCCCCGGAGGTCAAACCTTCCATCCTTCACTTAGTTGTGTTTCTATTCAT
CGACTTCTTCCATCAGCATCCCTCTCACAGGAGTTCTA
.
qlt:
654547;74<7;58:878:8876B7>A7A5?6:<:E:V<7=96868=;8:=8=>9A@=L8
9AC:8<989E<99>=<=:?;><99<<AAA?A9;;<;:9<=<988=::98IKQGTH@<9=:
:<==8<?<=8<>CCT?>;8C?BB<GKB?BC=KH;BKF=CB<QB<<B=H=<CC@C;?<G<<
GG=GRC;=BCC;KBBK;IEJNDHCTP;:>?=;;G=?H<:?==<GOGUEKF<BG@<;B:?R
KHkJ<G<G@=;@<P=CDG<CLC=B?=FCHCB;>=CK<<:=>:F;=<=BPC;DHCP@A=GC
C<DDBCCKTNFPL[BGTL?OC===@:=<=:;B9;;;;CHB@FTMB89<C;=PN=:9EHHK
FK<BLLDCBKF7:C=<;GG<;K<?;K<KBOB9?@=G=6=KHUD>A?B::KG=<;==?@?<
::=:8:;;===<6=K>;MKM8?:89=<7<@:9<<<;<8<555BCE@9668;<?:;8C<;<
?=;::<AL=9<;;:9CV;:CP<H>>J><<HAF<C>?<CC<:89?;>>>=?I<<;>@>=A=
;8=9@U:CC;:<MIH>=;=:A<:8A98<=>9;H<>?988>;8<==F?GDOQ9LKA@:?9=
J=::=87::D@7H>89:H;D:8<679:>9>8A@>::O7
.
frg:41
clr:23,636
}
{RED
iid:1462
eid:1127298172
seq:
TGCCTCCCCGAATAATCAAGCCTTGATTTCTTGACGATTCTCTTCATATCTCTCATAGTG
ACCTTTTTTTAGTTACCTGACCTCCATAGCGAAAAGAAAAAGACCTCCGACCAGATGATT
TTGTCTTCTTAGATAGCTAGGACGACGAGTCTTCGATCCCGACGAAAATTGAGCATCTTC
ACGTGATTCAAAAAACGTTATTACTGCTTGGAGATTTAGTGTCGACAATATGATTCCTTT
TGCCCGACATTACCGTCCATGCGCTTTGCCACCCCCACTTGTGTACACCACCTTAGGATC
TACAGGTTCATGGCACCAGTGTGCTTCAGGGCCATGTCACACAACCATCTCCTCCCCATA
TGCCGCCTATGCCTCATTCACTGTCTTACAAAAGCGGGAAATTATATACTATGAACGATT
AAACTTTTGAACCACAACGCTCCGCTGGAACCGTGGTTGACTGGCTGATGACCTGGACAG
GGTTGTTCGGCTCAGGTCCATTGTGGACATGATCCGCACCCCTCAGTGCCAGAAGGCTTT
TTGGCCACTGATTACCTTGCTGTAGAACCCACATACATTCATAAGCAATCGTATTGATTT
GGTGATCGACATGAACTGATTAACCTTACCATTCTTTTGGATGTGTCGATCATGCCGACA
CTGCCAAACGTGTGGTTAGGATTGGTACCTCGATAATGTTTTGTGATGCGCTGACTCTTT
TCTTGAAGCCTTCCGAATGCCATATATCGTACACCTAAGCATAGAACTCAT
.
qlt:
1343363354:55786577557?:767@D848=988>9?N;F=?8F@:AG8:C847?8;@
@>@:9=876446749::;:=9=9IA<B<9?8?RFLBNBLKBB98>?<<;7=9<;D:===>
<B<?ECUB<<<=B=@>C=D;=L;?BE;==@G==?D<=<==BB=CEK;K:=C=:<H;BC>H
<;::EB<8<<;<<BL<QKJFBBSFFSA4?G<9<<G<B=<<G>=98<?G=H;9<?:<N=B9
<B===:P9<E<K8<=:<<:BFF:==BGF=<:B:99;;;<<E5<<=<:<;;;<845>=GH=
:<;;<;;?>;KWPK8AJFJFB;<==<@9<B:;?BEP=;:=::==<;9<<:?;<;:;98:L
???==HM=GC;?:8IBL=G=?:<8;F>@=J=P:G=59=K<9?<><@DLCB8<?KE<C8<=
;>=;<CCLCKCC;;;<CJ<D>IFAB=CCT=KOB:MGGDJ?BBIB@BI;88I9;===;?<8
::8:B==<<=CGM8EF8BB<B::;C>9L=<<7:=>9<HB>D>;<=;HK9J=?;;:?>CC<
<>H?899:;<<:>C:<DB:;9V;H<O>8>:D:SAHCBKFM?P=9@JEELA99=;<:C9;=
C8;CK<<>?@8:AA>?G=GED>A68E>C:8@7<=8@:D<8:D9K:N>8::8AKG6?@><:
78<6:<;C==C:7::8?@::IALB:89HFF988877:8A7:IDC:M<@AF>BCA<7;VAD
@B:<9>G58@779F=?L?@>@9589;><:5:>:<=<>:<98>6:9575889
.
frg:42
clr:128,761
}
{RED
iid:1463
eid:1128922851
seq:
AGGTATTGAATCTCTAGATTCTCTCCCACGTGGAGCTTGTATTGAACATGGGGAGAAGGT
GGCCCTCCGGTTGGACATAAACAGCTTCGGTGATGCCTCTCACTCTTAGAGTGAAACGTT
TGTTTCTCTCGAGGAAGACCGCTATGCGCTTGATGTGGCCTACACATTGTCCGGACCGAC
AAGACGGGTTAATGGCGCACCCGTCAGATGGTGATGCATGGAAGGCTCTTGACAAATTTG
ATCCAAATTTTGCCAGCGATGCAACAAAATTCCAAACGGCTTGGCTACTGATGGTTTCAC
GCCGTTCAATATGACCGCTACGTCGAATTCATGTTGGCCTGCCATTTCCATACCGTACAA
CCTTCCACCTGCTCTTTGCATGAAATATGAGTTAATGTTCCTATGTCTTGGTATACCTGG
GCCTGACCATCCTGGCGACGCCTCAATGTGATGCTTCAACCACTGATTGAAGAGTTAAAG
AAGCTATGGAAAGGAATGCAAACCTATGACTGCTTCAAGAAAGCAAAAGTCCATCATCGA
GTTGCCTATCTGTTCACAGTTATGATTTTATGGCGTATGGGTATTATACTCTGGATGGAG
CGTGCATGGCAAATTGACGTGTCCTTATTGTGCTAAAGACACAGATTGTTTTCTTCTGAC
TGCTTGTCGCCACATATGTTACTTTGATTGATCTTAGATGTTTTCGACCCGTGAAGTCCC
CCCTATCGAAGGCTGAGAAAGAATTTAGGAATGGGCACCCATCGGTCCTAAGGACCTGCC
CTCCGACCCAGTGGTATTATAATTTGAGACATATATGAACTTGCCCACCGAGGGGGGAAA
GGGTTCCTGGTTTTGGAGAGCGACCTACTCGGA
.
qlt:
633464556475744756786447:;6?95D888678<F>C=@>B>>?9F@8:H=D<>H8
E:=?:7456797;9<<=B;99?<<@C=G<?<9=BE=?<?::;=<G96:8<;:E<;<=GHH
BL@CCB==<?8D=GPB=VDD<;H<LO<=?;QLB<KBF:B=L@>=>JBOKB<TFUGP@GDG
LC<J9>C=CIC==H9;B;<RGW==B;B]GWB9C@BJ=<KKG@CQ]HRO=FI;@:;=IHDC
?FB<9>QQLLOM=@?:=:GCCH<88E=:9;<L<9::C<B<JGU=@:5<DE;?GDLGLG?G
BUULVRND;GLGKOTMKLC<H:B=;HWMKL@BWHLQBOSIKBL@LWQIM8A:KHGHFM8?
PUKWaV?CKFQVVPOHLA86<<=:D=E>8D<B87BBBBKLI@??==B<BS:HGK<=BEG<
<DEEBB;<==<8BN=E7<<C<?;9<;;K:??<A<LLEC?=EJ?;B:;:=;8<PGCIEC9:
;58@B=>C=9>C;:89<B;OLE@?@C:HVH>EA<:9788EG>9@=D=68D=88=?8<B>8
AA:>?8@<:>=A=C=8C=A98;==>==8=8@>=8:>FK:@CBEQ>9F;HF@;<EK;:7A8
:@8@8=HF=6:7;7HGOQLHOBDGF@ANQ@89<:AA98<<:<76I:=A8AHF?9=BC69K
AZFNND?9<BB8;G<=9D;O<@:5>8E8BK?>:CB95?8J;:A9@7B;J>7?><85:878
CTED6N=AEV:@8;6=6:C78?=@=SE<>?C9?ANA;C>;;9;;5:8<5EC:8;<<?:<H
<6565;75<9=5M:7<9:C?5?8GD;7;87A<4777;75CM67;8959:5E757@77BTG
;N747E75;7=<YIK<5:;97G877:?9:76:4
.
frg:42
clr:37,862
}
{RED
iid:1464
eid:1127298173
seq:
TGGGTCTGATGAATCAGCTTGAATTCGTACGAATTCTCTAGATATCGCTCAATACTGACC
ATTTAAATCAAACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTG
ACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGG
CGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTCA
ACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGG
GTATAAATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACATTCTATCGATTGTATGG
GAAACCCGATGCTCCAAAAAGTTGCTGAAAAATGGTGAAGGTAGTTTTGCCTTTGATGAT
GCTAATGATATGGTGGTGCTGGCTGGCTGAACTGATTGAATTCCTCTCCCAACCTACCAT
CATTTAATCTATAACCACTCCTGATGATGCATGGCCCCACGGCAATCCCATGCAAACGGC
AAATCCATTCTTAAGAATTAGATGAGGTCCTGAATAAGGAGAATTATTGTGCGGCAACGT
TCCATTTTCCTGATCTTCGTTTTTGTATGTCTTGTTAGTAATTGCCCGTTATTATGGCAG
TTTGCGTCTTTCAGCTCCTTCAGGAAGGAATCATAAAGAAAAAAGGGTGAAGTTGGGTTG
CTTATCTATTGGGATGGACAACTGTGTTGATCAATTGTGGTAATATATTTGAGAAAACTT
ATGTTG
.
qlt:
1122187<PAI:6;<67Vc]YH<OiiMeOQeYVRiii[NYePUZUiY^iZX_eeii_NiW
QllW<<977769988?=QUll__llg_lgllllglllllg=@>;879;B=;7:<<BFGLa
kkllllllklkkllkllWlWk]kgkkkllllldklkkkkkkUTCGGE=KKkaklllkkk]
LGKGJJP\kkkkYdkdkkakakkkkdkaWkkW]d[kLkda[dkdk]kdkkTdkWddddkY
ddkkdlkkk]]kdRaKP[Cd[dWdWTMTOWR[]]]aWNTdYM]NJNWOKNWTU[R[ad\U
QFTVaTa]kWaNTaK\NP?UIHNB?9BDDCG[KBBWCWES=87:<B?BGTCLWLH:;=F<
>K?5BFC>LB=;87=:;F5B@GA:BB<H?;II><=9BD?=H:<;<;==;;88::CMBP>C
;@6KH=MY<<;?;=<;7:=<8B8<888<=;<:=FN;B;?C=:7<:;;==?<?PL>HH:?<
G?:<=?==D9;=;:88?><<=:HD??=>?<=:D::8<B=K<C?=;@=F6:<=;<KK=F<<
<?<9BD;CF@<:8<8<8989=;<9><==<9;=:;<9A:M9;>?8:6=:::>>;=98;5;:
=;D98:<=<;<<B<<=;;9;;<?<89:;<=>AEE:??A=@@AJJ@?;>=<IG;<<::<=;
><<C;F=;;;FB;;><BC::<@<:@;9<O<<;:><;9:>99:>9::9;:C8=;><=?;?;
;98@89;<;=;EDC<>8879=67<888<H;=>:98:98?9>K87;>G<;@:=<::;=679
9<>9:7
.
frg:43
clr:591,776
}
{RED
iid:1465
eid:1127298174
seq:
GACTGTATCTGATGAATCAGCTTGATTCGGACGAATTCTCTAGATATCGCTCAATACTGA
CCATTTAGAGTCATTAAACTCCATTTCGAAAGGAAAGATCCTTCCAGAGGATGAAGTGAC
GTGATCGGCACATAAGAGGCCCCTAATGGCAGGGTGACGAATGAGTATCACCGGTGGCAA
ATATGGAGGCGTCTTCCCGCGGGGTCTGCCTCAACGAAACCAAGTGCACTCATATAGACG
TGCTGGGATGTGCTCGGCGTCGGTAGTGAATTCAGGGACCGATTCTTATTGGGACGGCTC
CCACTACACGCAAGATAATCCCCAGAACTGGGGAGCCCCCGAGGTTCTCTTGCAATTGAT
TTTACACCCCCCCCAGTCGGAACCCGAATAACCAATCAAATCAAAATTGTATCCCCTAGC
GAAACAAAGCCCAAACTTAGGTGGATGAGCCAAATATCTCAGGATTCCTTTTACCACCTT
AAGAGCCATTCCCTAGAGAAGGAATGGAATCTTGCGCCTGCGCTCGCGGAAAACATACCA
TCCGGGGAGATGCACATGAATTGAGGCTGAAAAGGCATGACCGGCTAACTTTTGATCCAC
AGACTTACGTCCCAGTTGAGGTCTAGATGTTCTTTGTCCCGTGGGTGGGTTTTTTTTCGG
CTTGGCATCCTTCATTCCAAATAGCGTATGGATGACTTAGAGGGGCCTTCGTTGCGCTGA
TGAGGGGCCGGCCCTGGAAGCTGGATCACCTATATATCCCTATTAATTTTTTTTTTTCCC
CTTTCTTAGAATCCTG
.
qlt:
31242114?AG:;=559899DUNNNLUL>CD?<N<OVVNV<?9@C9BAQKTD;8C>LI]>
:F?FL;88544446466569744:8857;68>89FE:>;=996475:<<77575558BE<
:E<><=<;A;J==[VLV=@<<>@C>C=C?=<9:<:<B9<;9=::96<;==<A<<CRQC<=
?<;=;9:?=<==I:?M;=B;===E<H<C=<<=@=<N<@::8;=;;==<<<FC=<:<B:=;
:E<9;9889BDE@AG<:9=<K<==<G=GC<B=KA9:<<<::<;<:==C<;>=9==<>:;<
<<G<8<=CC<:8;=K====GCBC@9A:??==;?:J<HTTC<?<I:BF=GNF?B:BLLQG<
C=>K;;<HQA=K=<H<;I9<;G@<;:C8;I?><8:999::?=<==C66=9@B<<<98M==
<;K:@D:>;=C==<A>BBC:B9H?G<:967;==?;C;F=B::;H;<?9:<><D<46B689
;;N<B<?Q;<GB;<P?BK=B;THAF[GH;:I<=:<;B@<=<>><;9B<MB;HB=;;L===
<=<:=85>8B>;9>;VC9:==;<G;;88<<9<7::<8795<<9<;8;:;9:AHT<EKD:?
8<@L><?D;=C<;:J==>JAKAC;T=@?<;;>;FIF>=F>==BB@<?A=<;9;=<@A<77
9><C9:<<?>>AO=@FE9I[<>E?=<<B?<<?<>=<?FF<:>G?;;BJH>;9:>B>:8:O
<9><><;<FE;8EC=??<:78H@@SFHAL@=9?><<A=>;E9>=99A:><QE==:AHAB>
<>9><9@856484664
.
frg:44
clr:140,787
}
{RED
iid:1466
eid:1127298175
seq:
TATATCTGATGAATCAGCTTGATTCGTGCTTCTACCCTTAAGATGTTTCCAAGTTGTCCA
TATACCTCGCACCTGCGCAAAGTTTAGTCGTCAAGGAAGGGTCGGCCTAGCCTCGGCAAA
GCCCGACCCTCCCTCGGGGGCTAAAAGGGGGGAGACCCCCTCTGCGTCGAATTTTTCCTC
GAAAAAGGATCTCTTTTTAGCAGGATTTCTTTCGTGCCTCTTGACTACTTCGGAAAGCGG
ATCCTGGAAACGACGGAGTACACGTAAGCAGCCAAGGCTGACCGAGCCGAGGGACTCCTA
CGCCTCCGGGATACGGATACCTCACTCATCACCTTCTGCGATAAGTAACTCGCGCTCGGA
TAAAGCGACTCCGTGGGCCGAACAAGTCTTCACGTTCGGAAGCTCTCCTGCCGAAGCAGT
CCTTCAAGCTTTCTCGACTAAGTCGGGGACAGGGCCTCATGGACGGGTGAAAGTACGCGT
AAGCGGCAAGGCCGACTGAGCCGAGGGATTCCCACGCCTCTGGGATACGGATACCTCACT
CGTCCCTTCCGCGAGAAGCAACTCTCGCTCGCACAAACATCCCTATTACCGACAGGAAGT
CCAGATGCTCGAAACAAGAGGAAAAAAGACGCAGCTTCGCAAGCACGGCGAGGGTGTGTT
TTCTGGCCTCGGCGGCCGCAGAAAGCACACGCTACAAGACGATCTGATTCTGCAGGCTCG
AGTCTTCACGCTGAAAGGGAGCCGTAGCACCCTCGGGCATCGACGGCTTCTTCAGCAAAG
TCCAACCCAGCCTC
.
qlt:
44544A:EO=E957878AlDJ::FIakkklllkdkllllllkkkkllllkkkllllllkk
lllKJSGH=:G=kg\kkklllllkkkklllllllllllllllllk]d[aGLNdkllllll
llllkllllkllllllllllllllllllllllllklllllllllllllllllllklllll
lllllllllkllkkklllllllkgklllllllllllllllllllllllllllllllllll
lkllllllllllllllllllgllllllllllllllllllllllllllllllllkllllll
llllllllllklllkklllkgkkllllllllllllllllllllllllllllkllllllll
lllllllllllkllllllllllllllllllllllllllklllllllllllllllllllll
llllllllllllllllllllllllllllllllllllggglllllllllllllllllllll
llllllllllllllllllldllellll[WllbllllllllllllZPledii]ieiieeii
iiiiiiiieeeeeidiideeiiiiiiiiiiieee[__idiiiiiiddibdide]diiede
eeZ\iVi^iiZiiebXeeiOVYVYiii_iOdeXdee\iSeURLCN\]iYXSQM?8C@VN^
Q\`Rc]FUX`T_MVPL^_OMLXW68=MVWV^YTSMIMNTNBMH[M[R@MYMOM;?IEMNG
MLL[LMQGVTVMMG\7I\ASFPTNAX?MMMcQLG9VMCKRRMLLBNEVPPOLLLOMOVPL
JNK?IBNEF@L>=8
.
frg:45
clr:5,792
}
{RED
iid:1467
eid:1128922852
seq:
AGATCTAGAGATTCGTCCTCGAGGGAGTGTTAGCACTCGCTTGGAGGCTTTCGTCGCACT
TTTTTGCAAGGGGACCAGCCTTTCTCGGTTGCATTTCGTTCCGGTGGGTGCGCGCGAGCG
CACCCGCCGGGTATAGCCCCCGAGGCCTCGGAGGAGTGGTTACACTCCTTCGAGGTCTTA
ATACCTTGCGTAATGCTTCGGCTGGTCTGGTCGTTCCCTCATGCGAACTGGCCGTAGCCC
GGGTGCACGGTCGGGGCCCAAGCTCTCGGGCTGGTATGTTGACGCTGTCAACGGTTCGGC
CGGAGCCGGTTTTTGCGAGAGCAGCCCCCGAGCCTCTGCACAGGGCGAGAGGACGATCAG
GGACAGACTCGGCTTTTTACATACGCCCCTACGTCGCCTTTCCGCAAGGAGGAGGGGGGG
AGTGCGCCATGTTACCCTCGATGGGCACCGAACATGGTGTCTCCAGTGAGCTGCAAGCGG
GTAATCCGAGTGGACGTCCGTGCCCCGTTCGTTGGGGGTCGGCTAGGGGCCCAGAGGCAC
GCCCAAAAGTACCTGCGGGTGATTTGCCGGACCCGGTCCCCTGGCGACAGGGTCCGAGGG
CTCGATGCCTCCCTCCGATGGGATTCCGTTACAGATCGTTCCCGCTGGTCTCGGAAATGT
CCTAGGGTACCTCGGGAGCGCAGCCCGAGCCTCGGTTATGTATCGAACGTACCCCTGGTC
ATCCTCGCTCGGTGTCTGAGCGACTGTGACCCTTCGGGGCAGCTTCGAACCTTGATCAGT
AATGGGCGCGGAGCCCGATTAGCTGAGCGCCATGGAATCCTTCGGGGGGGCTGGCCTTCA
ACCCTGACAAATGGTTGTCGGG
.
qlt:
445:7<A?=79:PYKUYFdA5:6AbXQNO>YWWb]_lllllllll_[[llllelgRB=@D
aa\\\MYQNglllalaalllggglllllllllklllkdN[[TTkdllllllllllkllll
lllllllllllklllllllllllllllllllllllllllllllllllkllllllllllll
lklllllllllllllllllkllllkklkklllllllllllllllkllllllkllllklll
lllllllllllllllllllllllllllllglllllllllllllgllllllllllllllll
llglglllllllllllbllllllblllllllllllllllllllllllllllll_elllll
llllllllllliiiiiideeeiiiiee_iieieie]__eeieieidiei^Ui^A_iiiii
i]_ib__dSeiiebee^^^bebiee]bdeeee[beieUibeebeOebidVeeeXYUZeii
^VX_W]eNiL\iUdMX\_XXQeMW\eS\XYLLYUi]eUNP\_KP\I]]_N]]KPc=^PK_
NT_PL^\^PQMI]M`OM_]@MW=]PRIMHHL>YUE^MMKOMLM[MJYRJM[NMHO=VAcR
PMLC[MMBQMFTPMAH>TENYXQFL=JLJMOJWAMNRLDI?OA9DOENCLQIH9QYKLQD
FLMBBTD?EMDIEHVC?>C=DLEED=@F8=9KKDPN7<DRG@EFGPFGRRBMIF?:@A5<
@EMB4556A@EM8A7GGO@975IC@=76A4NDCH=GMN943487>:5A;885:JFFBICA
E@=NNL87=97N8DM>9J45F6DCH?C5D6<76;A9H7G=9B;CJMOMJ99D9?69>>53
5CI69@G554636=;6;4A543
.
frg:45
clr:5,846
}
{RED
iid:1468
eid:1127298176
seq:
TGGGTCTGATGAATCAGCTTGAATTCGTTAACACCTTGAGGGGCAACCCCGGGTGTGCGA
TCGGACCCAAAACACCGACAGCTGGCGCGCCAGGTAGGGGGTGTGTCGACGATCCAAGCT
AGCTCAATGGCCGTCACCTTCCACAGCAAGATCGCCGTGCGTCCCGGATCTGTATTCTGC
TTCGGGACAATTTCATCCGTAGCGGATGAAGAAGGAATTCTACACCGCCTCGCAGATCTG
CCGGAACAGAAGTCTCCTCCAACAAACTCCGAAAATGCTGGAAAGACGCTACCTCCGGCT
CTTCGGAAAAAGATCGTCTCCGGGGAGGCTGGAGCTAGAAGCTCGCTGACCCGGAAGACT
CCGCTGTCCACTTCCCCGACGAAAGAATGGACACGGGTCGTGAGAAAGAAGGAGACCAGG
GAGAGGCAAGTCGTTCTTCCCGTTCCTCCGGCCTCAAAGGAGAACGGAAAGAAAATCGCC
GCGACAGCAGTACCGTTCTACCCCGATGTCCTCTTCATCGGGAGAGCAGAGTCGCCCGCC
GTCTCTGACGATGAACCGACCGCGCCTGGAGAAGAACCACCTCAGCGAGAATCCCGCCGA
CGAATTCTCTAGATATCGCTCAATACTGACCATTTAAATCATACCTGACCTCCATAGCAG
AAAGTCAAAAGCCTCCGACCGGAGGCTTTTGACTTGATCGGCACGTAAGAGGTTCCAACT
TTCACCATAATGAAATAAGATCACTACCGGGCGTATTTTTTTGAGTTATCGAGATTTTCA
GGAGCTAAGGAAGCT
.
qlt:
444448=@XBI<78867[iii?;Kll[l[dl[Ollll_V_lllgllllllllllllllll
lldkXkDAA<<??\gklllklllllllllllllllllllkllllladIWTGYSLTkklll
llllllllllllllklllllllklllllllllllllllllllllllllllllllllllll
lllllllllllkkklllllllllllllllllllkkkllllllllllllllllllklllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
gglllklllllllllllllllkllklllllllllllllllllllllllllllllllllll
llllllllllllkglllllllllllllkllllllllllllllllllllllllllllllll
lllllllllgggllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllll[lllllllllllllllllellllllllllllllllllliiii
iiiiiiii[eidiieeiiiiiiiiiiiiii]ii]iYUdeeiiieeiiieiV_eiiediei
ZeiYYiiii_Y]RUd_iieiXOeeeeiieVXWVieeieedN_edeeiRKie\eIUYQ`XM
iQQ`TYNiieX__``^N[E_]]O?_N[c^\_TKMURMMNMTDKMMRMNNN9H9FHD9WM[
c^MCQHH[MGS[WcLNNPMHGMLSRVKJC^TMJEMIcccccMPJIMMAEMECL?>TTJMD
>TH:ML<V?TC@A<8
.
frg:46
clr:6,598
}
{RED
iid:1469
eid:1128922853
seq:
TGCGATCTAGAGATTCGTCGGCGGGATCTCGCTGAGGTGGTTCTTCTCCAGGCGCGGTCG
GTTCATCGTCAGAGACGGCGGGCGACTCTGCTCTCCCGATGAAGAGGACATCGGGGTAGA
ACGGTACTGCTGTCGCGGCGATTTTCTTTCCGTTCTCCTTTGAGGCCGGAGGAACGGGAA
GAACGACTTGCCTCTCCCTGGTCTCCTTCTTTCTCACGACCCGTGTCCATTCTTTCGTCG
GGGAAGTGGACAGCGGAGTCTTCCGGGTCAGCGAGCTTCTAGCTCCAGCCTCCCCGGAGA
CGATCTTTTTCCGAAGAGCCGGAGGTAGCGTCTTTCCAGCATTTTCGGAGTTTGTTGGAG
GAGACTTCTGTTCCGGCAGATCTGCGAGGCGGTGTAGAATTCCTTCTTCATCCGCTACGG
ATGAAATTGTCCCGAAGCAGAATACAGATCCGGGACGCACGGCGATCTTGCTGTGGAAGG
TGACGGCCATTGAGCTAGCTTGGATCGTCGACACACCCCCTACCTGGCGCGCCAGCTGTC
GGTGTTTTGGGTCCGATCGCACACCCGGGGTTGCCCCTCAAGGTGTTAACGAATTCAAGC
TTGATATCATTCACGACGAGCCTCAGACTCCAGCGTAACTGGACTGCAATCAACTCACTG
GCTCACCTTCACGGGTGGGCCTTTCTTCGGTAGAAAATCAAAGGATCTTCTTGAGATCCT
TTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAACACGCTACAGCGGTGGTTTGTT
TGCGATCAGAGCTACACTCTTTTCGAGTACTGGCTCAGCAGAGCGCAGATACAAATACTG
TTCTTCTAGTGTAGCGTAGTAGGC
.
qlt:
46656:=;?E<98:ILGQedIAY<9:7:;iZZilZNNKl[OlllllllF<lllllllabO
DFYPC[UgdaVllllgllllllllllllglllllllllllllllllllkkllllllkkll
llllllllllllllllllllllllllgkllllllllllllllllllllllllllllllll
gglllllllllggllllglllllllllllllllllgllllllllllllglglllllllll
lg\glllglllllllllllllllllllllllllllllllllgllllVgllllllllllll
llllllllbllllllllllllll_lllllllllllll_lllllUllllllllllllbOll
llel_lllllllllllllllllllllllllllllllllllii_iiiiiiZiiiiiiiiei
^iiiieeiie_Z_eiieiidieeiieiiieiiiieieieiiieideeiiiiiibieie_d
TiddeiU_Ziiiieiibeei]^V]Viiei]d]ViV^^e^^e_Yi_iibieiWiG^eeiYe
d[SidYY^iY^TedQeTZe_T_Uii\XQHLX`[Gii\eYFOeiQcM_TV_P_L[^OAXXX
PN^NNPYMLNYM<4JTLN`OMU]MLG`LQMPCMYYHMKNMTTMMN[MBEMSKLKTMDJML
WIMOFDHMTMCMMcWBRcO>GMcMSJHEIB>YOWc\ILRMcGICCJJEELA=DG<DEDIJ
\\\\\BCDF<BCDFNJHF?NDQQAB=MCCWEAMZ\\S=6896>H<F4;DMG;;B3Z<N8T
56443<=D6G8IN:>46;:GNNCG9II9J<GCB7A8;<@;9G796775465G7F:9;@;F
5<@;:64=33;5A4C::E8F7;75
.
frg:46
clr:5,587
}
{RED
iid:1470
eid:1127298177
seq:
TCCGCCGGGGTGAATCAGCTTGATTCATTCTACTCCTCTTTTCACTCCGATGATAGTGAT
TTTTGAGGAACACTCCATATTGCCGAAAGGTCATGCCTGCTACTGGAGGAGGGGAGGACG
TCGGCACGGGGATGTTCCAACTTTCAGATAATGAAATAAGAGACAACCGGGCGGAATTTT
TGAGTTATCGCGATTTCCACGAGCTGAGAAGCTGGATGAACCCTATTCAAAGGGAAACGT
CTTGCCCCAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATTAGGGTATAAATGGG
CTCGCGATAATGACCGGGAATCCTGTGCGACAATCTATCGATTGTATGGGAAGCCCGATG
CGCCATAGTTGTTTCTGAAACATGGGGAATGCAACGTGGCCAATGATGTTACAGAGGACA
TGGTCAGGGTAAAATGGTCGACAGAATTTATGCCTCATCCGACCATCCAGCATTTTATCC
GTACTCCTGATGATGCATGGTGACTCACCACTGCGATCCCACGGAAGACAGCATTTCAGG
TAGTATAAGAATATCCTGATTCGTGTGAAATTATTGTTGATGCGCTAACAGTCTTCCTGC
GCTCTGTTGTATTTCGTATTCTTGCTTGTAATTGTTCCTTTTAATCGTCGATCGCTTCAT
TTCTGTCTCGCTTATGTTCTAATTTATAATGTTTTTGGGGTTCTGTGTTGGTGCGTAGGA
TTTTTGGTCTCTCAAGGGTTAATGGTTTTCGTCGTTTTTTGATTATTGTATT
.
qlt:
4344633787476877756:7::9;98CAH:8A6:77<8::5866A:E=87679?@=;88
=777664644644474898;:::79?8>7768;;=;@;::<<9:;BB;5457869:<<@@
F@=<=?;:97:H9;=L>?=;?<D=:86><BGGHPCB<=<97<6=:;F=BC@D<<C:<D?C
<9GPG<C?<H57SBOIHI=8@<78<66;G=<E@D=;AID9BH::=<==CB<CC<<====A
WGGN?B::=;K==;<<I<;V99<B96<:<??K<BBC;>BA:<=CC=;BB=<TCQGC;HA<
@A9<<C;<B<<J99;DK<=<<B=:;MPKBK=ABBH?>C<=C=<?99;<G=CB89=?:K=L
CK?T=<a=<;L><?CBBN==B==L;<=CC;@4<>C?G=>=?;CTWL;;?<G=;BUCG\9P
=TN=9<;H<KIGFJHMK<;BNG<<K<=C=CH@D;;7;@GB<NF=<PF;<<<@DIKBOSWH
@8Q<@GHL[[H]UHK<A>K>;=LC<S<BP<KGTBBKOKMC=::=B;9=B<BD:@@<BB99
;<>A>9HF?HA<TLB=:PL?;@6:S?BKBLA=T;7M?A8H:SH9;9896689:::A;BK=
<B=L;?;:E:CUR=LA=BIC>CCP8;:=<=;KJC;<@;@A<9=<;>;9==?;999=>=HJ
EHB<:><;9>;>;BH><=<BC>G8::??CG?=:M?I9<@:;87BA:;<>9DIH;:<<9A8
><9:;<=8<<>>?>C9989H=<GEA@>=>:78758876=>76;=57=:98;6
.
frg:47
clr:673,748
}
{RED
iid:1471
eid:1127298178
seq:
TGTTCTGATGAATCAGCTTGATTCGTTCTGCATGGCCGACCGAGATGCCTCCAGTCGGCC
CGTAGCACGACCATCGGTAACAACGGAAGGGTCAAGGATCTGACCCTGCAAGACAACACA
TGAGGGGCATGGGGAGGAAGAAGCGATGACCCTCTTGCATAAGATAACATGACCAGGTTG
GGGGCCAGCGCCAGCCAACCTTACAGCCACCATGTGGTGACCAACAATGGTCGGAGCACC
GATAGCGTTGGTCGACACTACTGATGATGCAGGCTCTCCATCATAAGGATTGCCCCTCGA
TTCCCCATCCAGAGAGCTAGAAGACAAAAGCGATATGATTTTCTCCTCGGATGCTCGAGC
CCACCGCCCTGCGAGGAAGGCTAGTCACCGGGATAACGGAGGGGTAAAAATTAGGTAAAT
AGACACTACCCACCTTTCCTGCGATAGGTGGATCTTGGTCCGACCTTGGTGAGAGCACTT
CGAAGTGGGATGCTTACTGTCATCAATGGCCAGCCGACAGGACCCCAAAGGGTAGGAGGT
AACGAAACCCTCCCGACTAAGTAACGCTTTTGGAAAACGCAGGAGCAACGAATGGGATCA
ATTGGGGGTAAGCATGGAGCAATCCCCTACTTATAGTGCCCGACTGGTTCCTAAAAGCCA
GTAGCGGGCCTCACGATTCTTACTTGACAGCGACAAGCGACAAAAGAGGACAAGACACTG
TCCGA
.
qlt:
3143577F>H;9:=;I\ieYO?id_idiiY_eii_^ieLAllQQQWlllll_Vlllllll
g9<<<:88:9>:>U[dgglllllllllggklllllllkkllklLWBDB6;<[gkdkllll
lllllllllllllklllllllllllllllll\\kklllllllllllllllllllllllkk
llllllllllllllllllllgllllllllllkglllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllgkkgkllllllkllllllll
llllllllgklllll\Pkllllllllllllll_lllllllllggllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllll[llllllllllellellll^lellliibiii^eiii]iieiieieii__[
iieeiieeiiiiiiei]dei]edidddiiiiiieiii_eeeZdiNe]edeidViiidVeT
b`iidiiiUdiWeUdiiiS_dYeeiiee_Uee_\e__^Ci[_iLTi\N_M\NV^^]NV`N
_W`L]\RKO_\]MO[_IR]UMNPN^WPMM[cWOTDRUcUMMM^c^MYDYPHMWMYKM[MW
KNP67
.
frg:48
clr:7,722
}
{RED
iid:1472
eid:1128922854
seq:
TGCGATCTAGAGATTCGTCCGAGAGCTTGACACTCGGTAAAGCCTCCTTTGCCGAGTATA
TGATATACCGAGTGTCTTGCCCTCGGTAAAGGAAGTCTTTACCGAGAGTCTTATTTCTCC
GAGAGTGGCCCTCGGTAAAGCACCGAGCACTCGACAAAGAGTCGGATTCCGGTAGTGATA
GATGTTCAAACGGGCCACCTGGCATGGATATGGTCCTAATCAGCTTAAGCCTGGTCTGAA
TATATAGTGTCGGGCCAGGCACGACCCGTTAATGCTCTGGGCCGGGTCATGCTGGCCCAC
GTGCCTAGTGACCTACCCAGACACGACACGACCAGTGCCAGAACGTGTCGGGCCGGCCTG
ACGGCACGGTGGGCCTAAACGAACCGGGCCACCCACTGGCCCAAACTGACAAAAAAACAG
AAATACATACATTTAGCGGAATTATTAGATCATAAGCTTATACCATATTACAAGCTATTA
CATCATATAAGACATAAGAACATATAAGATACAAGATTACAAGTTATTACACCAGATTAC
AAGCTATTATACCATATCACAAGCACATAGTTATAACAGATCACAGGCTCACAGACACAG
TTACAACAGATCACACAGGCCCATATAAGAAATGATTATTAGGAGTTGTTAGTGTGATGG
CCGCCTCATTAAAAACTTCGTAGGTAAAAACTCACACCTCGTGAGAAAACTCTAAGAAGG
AAAAAAGAGTGCAGCTCAGCTCCTATGTTTATAAGTTCATTATAGTTCATTACAGTGCAC
AGATCATTAGTTTAGTAACAATTCATAAAGACATAAGAACAAGTAGGTTGCAAGGACTT
.
qlt:
4113487;@:96:@QMEIMI<L8OGP^ViD>9WZZE@MFQANZdXi__iiieiRiYM>84
4445:97668<PNleebel[bbllll_bllllllgll<<>;:77:9LQDKJPgllgllll
lllllllllllllllalllllllllllllllllllllgllllllllllllllllggllll
lllllllllllllllllllllllllgl_llllllllllllllllllllllllllllllll
llllggllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllgglllllgglllllllllllllllllllllglllllllllllgllllllllllll
llllllllllllllllllllllllllllllelllllllllllllllllllelllllllll
lldlllllllllllliii_ie_iieieiieieiiiiiiiiiei_Xiiieii_iiiiiiei
ediebiiiiiei_biiiiiei^iiiiieibeiPeidYiiiQiii_eddddVidWedWiee
VdeiedddeeeedZeiidVebVeeWeZie]^eedeidUYeUdUeZei_eYM_\U^XNeTY
iYY`=e\YYXUUUXX_NXcHWKK``WN^DccNN`VN`\NO\;O^HMM^>M_MMcK_NK[X
L^OMUMMLLNMcccMHMOMJBIBEHQcccNMMSGMHQONOLBXMM^c^MMNMLKO;XB<;
MccccWE^>FMGOGLOQK>RYDGHMDJE\?GIC^CGEJETLOKMELBOGICCLFC;MCEL
FC>EJHJNKAQ\AN==B9>B=ILOA=5Z?9=77;BC8=94;S@;45:78;?G<55K754
.
frg:48
clr:7,835
}
{RED
iid:1473
eid:1127298179
seq:
CAAACCTCTGATGAATCAGGCTTGAATTCGTTACCATTCACTATATAACGTGCAATCCTG
ACAATTACTAACCCGATCATAGACATCTCAATTTCTGAGATACTTTAGTTTCTTCTGATG
GGCACGCGTTAGTTTCCCCCTTTATCATAAATTAAACATAAATTTGGGCTTTCAACAAGT
CATTTTCATCAGTTTTAGTGAATAAAGTAGGATCGGCTTTTCCAACTTAGAATCCTTTAA
TGATCAGGAACTCCCTAACGCATTCATACCATGCTCTTGGGGCTTGCTTGAGCCCATAGA
GCGCCTTCGAGAGTTTGTAGAGCTGGTAAGGGCACTCACTATCTTCAAAGCCTGGAAGTT
GCTCTGCATAGAATTCTTCCTTGATTGGGGATTGAGGAAGGTACTTTTCAGGTCCTTTTG
ATACAGCTTAAAGCCATGGTAAGTATGATAGGCCAATAAAATACGAATTGACTCAAGCCT
AGCTACGGGTGCATATGATGCCCCGAAATCCAAACCTTTGAGTTGGGAGTATCCCTTGGC
CAAACTAGGGCCTAGTTCATTGTCACCACACCATGCTCATCTTGCTTGGACAAAAGAGCT
GATTTGGTGCTGACAACGTGTGACTAGGACTTGGAAGCAAATGCCTGACCTCATGGATGG
TGAGTTGTTGGCTCCTCTGCTCTGCCCCCTGTGTCGTTTCTTGTGAGTGCGCCCCTATGG
TGGGGGGGTCAAACGAGGTGACGAAAGAGAGTGCTCTACAAAAAGGGGAACCCCAAGAAT
.
qlt:
41122136546856485565<MJ;67;E@7746:788<F:?8598798D>79987=<<=I
B8=:8:4@75745545556999778889468694447454584566556;EE;<?;@BFE
9;;LT=N<<8P=?<<>L@<MB=OB;;=<C==;699=;P=C[B=B==<887:97>?;<<:8
B:<<<:=<<;J=::7=@;:=;<9><=<<H;KWDC<<::;<<=::<PCLB;GB=CE<C=T=
=KCCBB?[H=?;=B=>=:9K=<?GK:?CB9<<M<<<<<D=<@<=:H?=<F=??BGC=B:9
;<<<C;?<;@>U<BHH=G<<=:9:<=8<8:=V9;<;<988B=BBBB==RS;@8D@A<C<>
HD9=<=C<KM;B?;CK<CB=<BC8:<:7455:<RHKa[TTS=KCCDC@B>==G=7;BCCO
VI==<:<<;;;>86B;F[JD=?N=C=C[<INLCL@?<<>H;=F;8K=<?B<<=H9<DPP;
U=BLL?;BB:CD9<=:U=?:H9>G<A<:=?@?<SSGCB=GL>;<F=:H==@?<BL=H[;;
<<8<<<;=G;?9=9F<<FD<>PEL88679:?MB:Y;GHDBQKILBC=B:J<:S=;@<:<<
7;<F=99698859<@R==>9<BC48I=;=E99L<DF<?<96@[<<A58;:KTL<:89<44
8=IG>BFEC54?9E6;?8F:59<<;:@44<:;59;;976<<<;K?9:=T?<A@E;8:[9=
:AMTRUL;@A<@<89:<:84:=:=E;GY99?;<?<769<<@:>=JJA;99::<<<<><;9
.
frg:49
clr:109,778
}
{RED
iid:1474
eid:1127298180
seq:
ATATCTGATGAATCAGCTTGAATTCGTGTGTTTGGCGCAATTGTTTCATCGTCTAATTTA
TGTGATAAAAAATTAGGCATGTGAGTTTTTTCTAATGCATGTGCCATCCTCTCTATATCC
TCCGTGATACTTTTAATCCGATTATCAAAAGAAATTTTAATAGATGGAATATCATCGGCT
GACCTGGCATCACCTATCGTGGGGAGCTGTTGCAGCACGGCTAACATATACTCGGCGTTT
ATCTCCCTCTCTTGGACGGTCTTCTGGTGGCAGTCTACCTTGAAGTGCGAGAGGTACCAC
TTGTCCGCCACCTTGAGCACCTGATCCTTTTGTCGGTGGGCCTCCTCATCTATTTTCTTC
ATGTCATCTTTTAATCTTTTATGCTCAGCGGTCGATAAATTAGTCAGCCTTGTGTTGTTG
TTTGGAGAAGCACTATTGAGATCCTTAGAATCGGCCATGTAAGCCTGATTTTGTAGATCT
ACAACTTCGTCCCCAGCGGAGTCGCCAAAAAGTATGTTGACACCTTTTCGGAGGCGCCAA
TCACTCAAAAGAACCAGCGGCGGTGCTCTCTGGTCAGGCGCGGACGGTCCGCGGCACAGG
GACGGACGGTCCGCGACCTGGCACGAGGGCTAGGGGTTTCCTGCCTGACGGGCCGGACGG
TCCGCGCCCTAGGGGCCGGACGGTCCGCGACCTGCGACAGGGTCGACTTCCTCCTCCTTG
CTGGAATTTAGATCTCGTCCCCTGGGGGAAAAGATCTTAAGGTGCTCCGGGTCGACAGGT
CACCCGGGGCGTCCCCAGATGACGTGGAG
.
qlt:
4554I9?P:F;7=;66WlllXL[llkkkllllllkkklllllllllkklllllkllllll
kkkkkLLSLLYdklk\Sllllllkggllklllllllllllllllkklgklgkllllllll
llllllklllklllllllgklllllllllklllllllllllklllllllllllllk\lll
llllllllllllllllllllgglllllllllllllllllllllllllllllllllllllk
llll\\\ggklllllllllllkkllllllllllllklllllllkllllllllllllllll
lllllllllllllllllllllllllk\\kllllkkllkklggg\Ugggkkllkkgg\ggg
llkgklllgggglllkggkllkllkklklkllkklllllllkklllkk\\klllllllkg
lllllllllllllllllllllkllllllllllllllllllllllllllllllllllllll
lldlllggllllllglllllllllllglglllll__llllbdllllllllllWlllllWl
llllllZUUllllZldeiiiiiieideBReiiTDWbiiTeeii^QidZdideiMDdddZi
iTVZiYKeiU^ideiUCieiEbLFMeHeQIUWGiiXUidX^\XDeXOL7?eXLYOWVMG[
L`^XXTO_]MN5ccRSTGE_LL_LONMXOS>MM66<BDGJcQCYDMLQMGPTGXQGOMCM
INF^BDMcMM>LQMJNKNWYTOCMVccIV\\PG@CKFJ@6:;:I?I?LC\L:PCPEGNRD
HDGSD?UOED@BNFBC::MAC@:<9A>33
.
frg:50
clr:4,806
}
{RED
iid:1475
eid:1128922855
seq:
AGATCTAGAGATTCGTCGATGTAGTAGACCGGGACGCCAGGGAATTCAACAACAAGACAG
AGCGTGTGAAGCAAGAGCTGTGGGTAAGTCTTACTATATTGTAAAATATGTCTCATTCAT
TGCACATTCTTGAAATAAGTCTTTATATGCAGGATTTCTTCAGATGCAAGGCTGGATACG
AGGCCAGGGCAGATGTGGTGGCCACCACGAGCTGTAAGAAGCTCGTCATGGACATGCACT
ACGAGGCGCGAATCCAAGCCATCGTCACCTACCATGGCTCCGTCCTTGGTGAGAAGGTGA
CCAAGTAGGACACCCGAACCATGTCGTTGACTAGGGACCAATACTTGCAGGTAAATACAT
CACTTTAATATTCGTGACAAAAAATTTCCTTAATTTTATCTTCTGATATGCAGTGTACTT
GTTTTACTTTGTAGATGATTCCTTATTGGTGCGCCACACATCCTCAGTGCTGGGAGCAGA
TGGTGGATAGGTGGTGCTCTCCTGAGTGGGGCGAGGTGCACAATGCTAGTCGGGAACAGT
GTCTGATGATGCAAGGTCCCTCCCACCACCAAAGGTAGCCGTAGTCTAGCAAATATGTAG
AAGCATGGGTACACCCTCTTTTTTTATTTAGGTATATAACACTGGATTAGATATGATTTC
TAACTATCTCATTTGTTTTCTGCAGCCGACGTCACATGGTGCCAACCTTGCTCATCTCTC
GCTATGCTATGGCCCACAGGCAAGACGATGTCGACGTCACTACACCCGATGACGACCCGA
GGCGTATAGCAACCCCGCTGTCTAATCCACTCATGATACCTGCCATGCTAGAGTCATGTG
CGATATGATTGAAGCCGGGCA
.
qlt:
44577:@D;78:QNCQeNE=SAOEYXF]BYi__@>_]T=i^YQNMlNAYVLlQFlleWNP
898768KGH>U[_Ullllllllgglglllllgll__llllgVYMMMdglllllaallaal
llgllallllllllllllllllllllllllgglllggllglaglllllllllllllllll
lggllglllllllllllllgllllllllglllllllllllllllllllllllllllllll
lllllllllllllll[lllllllllllllllllllllbUUllllllllllllllbll_ll
Ullllllllllllllllllllllllllliediiiiic[__iiiii_iiiiiiiiei_iei
iiiiiiiiiieiiiiieeeiiiiddiiiiiieediideiiiiieiiXedieeeiibieii
ibiiU^eiieibiUiViiLieeeeeWeidXieed^UdeediiieePdTi]eii\cReeT`
PiiTceUR_YeXi]\cN^__WWP]\AMc^^_]Q`M[M_MTVMWM]M`MMMTB^_RUNKMM
^LTNNYHMNMMLIOWUFMWMMMWEMPOLOI5Y<QGCMLMWMM[<GNLRLOM^VFCGLFQ:
JQ;MKKYcMFLL=MVGJ>9cRcc\BLBcPACADD?987KBBLLDJC@DP<N>;>AN@\>L
LKCBLHHFII>>\GI<\\L=<:>E@I>9QBHEE689MN;744389;;87D=9>7=57566
I9E44?GEC;@>9D:94=9=4<66E98K;@=H9G9?GH6J@A:B3@:I=:@D4=D6C;6B
8D4444437@:::I?7699:46533<7B4:8@63763473=@5D88=37424<8C47@45
61154;585434494438334
.
frg:50
clr:5,781
}
{RED
iid:1476
eid:1127298181
seq:
AGTATCTGATGAATCAGCTTGATTCGTTCCATCGCGGCGTTTTTCGCCTTTGCATGGATC
ATGATCCACTCAGTAAAAGTTCATTTTGCCGAGCAGGATATTAATGATTTAAAAGAGATT
AGCGCCACCCTTGAACGGGTACTAAATCACCCTGACGAAACGCAAGCCCGACGCTTAATG
ACGCTGGAAGATATCGTCAGTGGTTATTCCAATGTGTTGATTTCCCTGGCAGATAGTCAG
GGTAAAACGGTGTATCACTCCCCCGGTGCGCCGGATATCCGCGAGTTTACGCGTGACGCC
ATACCCGATAAAGACGCTCAGGGTGGCGAGGTGTATCTCCTTTCCGGCCCGACGATGATG
ATGCCAGGCCACGGTCACGGGCATATGGAACACAGCAACTGGCGGATGATTAACTTGCCG
GTTGGCCCGTTGGTGGACGGCAAACCGATTTATACGCTCTACATCGCGCTTTCGATCGAT
TTTCATCTTCATTACATAAATGATTTGATGAATAAACTTATTATGACCGCATCGGTAATC
AGCATCCTGATCGTCTTTATCGTACTGTTGGCGGTACATAAAGGTCACGCGCCGATCCGC
AGCGTCAGCCGTCAAATCCAGAATATTACCTCGAAAGATCTCGACGTTCGCCTCGACCCG
CAGACCGTGCCCATTGAGCTGGAACAGCTGGTACTGTCGTTCAACCATATGATCGAGCGT
ATTGAGGATGTCTTTACCCGCCAGTCCAATTTCTCAGCGGATATCGCTCACGAAATTCGC
ACACCAATTACGAATCTC
.
qlt:
55445?:;B9I;6:<68bl>G;7ClalllI;lllllllllllllkkllllllkllkgkkk
lllklSTPTbVGdllllllllkllllllllkllklllklllllllllllllkllkkkkkl
lkllllllllllkRgllllllllllllllllllkkllllllllllllllkllllllllll
llllkkgSgg\klllklllllklllllllllllkklkllkkggkkllllllklllkllll
llllllllllllllllgllgklllllllllllgkllllllllllllllllllllllllll
klllllkllkggllkllkkkklllllkklllklkkkllllllkgglllllllkdlkkggk
lllklllllllllllllkgklkkkkllllllllkkllllkkllkkkgkkkggklklllkk
llllllllllllllllllllllllllllllllgglRggg\gldggRlgllgglYlllgll
lllgbgggggblllllllllll_WllllVlll_lllllllell_llllllellllell_l
eXlllllllldlZXe]__dei_biiiiViiZ]iiKeeeebiZ__GieYeiddieYUZi_e
eXie]eNb_iebYKiebedTbidTYCRbSeeiVdieJUDe\eXeUUZceUZiYeLUNieW
`XK\H^YR^Oc\SV_VU>OWN]MQNMMWS[cHMRUcP`OK_QAML[L[MLXMI[GWBNM>
MJTOMIOI@QJ[L^@AK^WKL[GOQVV@PKcQDGMGOLFLWDDGMLLNLLLET\D>JLFL
MHCJDEGPPPMAMJ;FG8
.
frg:51
clr:5,796
}
{RED
iid:1477
eid:1128922856
seq:
AGATCTAGAGATTCGTCACTTTGCCACTGACGTTGCTCCGCCAGCGGTAAGGGTTTCGAT
AAAATCGCCACCTTCGCCGGCGTTGCCAGGTAAGGATGACTTTCCAGCAGAGACGCCAGT
CGCGCCATTAAAGTCTGGCTGACACGCGCATCGCCCTGGAAAGGATAGCGTTGCAGCAAT
AAATCGGCAGCTTCGCGTGACTGCTCGTTCTGCATCAGTTGCCAGGTTAGTTGATCCAGG
CGGGTAAGATTTGCCGGTTCTTGCTGATACAGCAATCGTGCCAGACGCAGAGCTTCAGCC
TTGTTACGGGTCGCCACGCTGACAGCATAACGCTCCTCAAGCATTTCATTGGCGGGGAGG
GTGGCGAGCAGTTTTTGCGCTGCGTCGTACTGACCTTCTTTTAACAGCACCGGTAGCGTC
GCGCCAACAACATACTGGCGGTTGTCGGCAAACTGTACCGTATAATTCGCCAACGCCTGA
ACGGGGTTAGCGCTGTATTTAGATAACAGATAGAGCCAACTTTTCTCTTGTGCGTCCGTG
GTAAATAGTGGCTTATTTTCAATGAGATAATGCTGGAGGCGTGCTTTTTCGCCACGATAA
GCCAGCGCGGTCGCGTAAGTAATATATGACTGAGGATCGGTGAAGATCCCCTGTGATTGC
AGTGCCAGGATCCGATCGTCCAGCTGCCCGGCAAGAAGCACGTCAAACCACTGACGGCGT
TCTGCCGCGCTTAATGTGTCTGCTGGCGTGCTTCATTGTATAGCGTATCTGCCTGGACAT
TGTTTCAGTAGATGCCCGTGCAGCAGATCGTCGCAGCGTTTTTCTTCGCGATGCAGCAAC
GTCGCATCGTTCAGTTGGCGCTCTGGCGACAGGTA
.
qlt:
445;D;B9879:MVQVF;Iiiii_B7KiiMTeeiiilllllV>lllldllll_Wlllglg
UOG[gg_gWVllllllllllllllllaTllllllllalllllllkPllllllllllkkll
llllllklllllllllllllllllllllllllllllllklk\kllkllllllllllllll
llllllllllllllllllllllllllllllgglllllllllllllgglllllllllllll
llllllllllllllgllllllllllllllllllllllllllllllllllbllllllgbll
llgOgllllllllllllllllllllllllllllllllllblll_Ublllllllllbblll
llllllllllllllllllllllllllllllllllllllllU_lZl_llllllllllllll
lllllei_eiiiiiiii_iieiiiiiieieiiiiieieiieieeeeii_e_Viiiiieii
iiiiiieeiiiiiiieedieidi]iibdbiTi_ieedKi^[iieedee_ibiUibeiiVi
dU^iVdiW_iOWiUdHiieXMReee\XX_eddLeiY^LeUdUiS\W^iWYQ\QQeYeXYi
NNLNY__\\\I`P_\MPWNPN_O_NNON`LT]L6VMIMNRN\QN=MLKWURL^JONAONI
KML^>TLLFMLLXAMMRQIMNEKLMMHYNIRENKRQQCMOSSLMGTQ?EHJGMMDHEHMJ
FMJYEPHJHHGG>IEV>IB:DMDRKK<I?PACFICC<P>QKK>RQ:K@FGN?KDC69C7C
=I7Z<B597C<EDB7G=7>7AH<>:;MB<C47>?@6?56ZTT=N775449@9HGG6:GKC
G?;6>FGH:>;@G9G>=4476679E<;9>55DF57
.
frg:51
clr:3,872
}
{RED
iid:1478
eid:1127298182
seq:
AGCTTCTGATGAATCAGCTTGATTCGTAGCGTAACCAATAGTGGTAAAAATCAACGCCCA
GGCAAATGCGCCGAGAATATTCAGCGGCAGAAAGATTTTCGGCGGCAGCTGGCTGGCACC
AATCAGCGTCGGGCCAATCACCCGAAAGCCATACATAAAGCGCGTACCAATGACAAACAG
ATACGGATGGCGTTGGATAAGTTTCTGCGCCCGCTCAATTTTATCCTGATGTTTCGAGAA
ACGGCGTAACAGCTTGCCGCCAAACCGCCGCCCGCACAGATAGAGCACCTGGTCGCCAAT
CATGCCGCCAAGCGCCACAGAAAGTACCACCAGCGGGAACTTTAATAGCCCCTGATGCGC
CGCAACGCCTCCCAGCAAAGTCACGGTTTCACCTTCCGCCAGGCTACCGATCACCAGCGC
GGCATAACCATATTGTGAGATAAGTGTATTGAGATCCATAGGCCAGTCTGTCTCCCTTTG
GTTGCCAGTAAGCATACACCCTGTGAATCATTCACGCTGAAAAAGGACGTTCATCAGACA
GTGAAAATTACATGGGCGAACAAAAAATAATCACAAGCTGACTTATACTTGAACTGTCAG
GTTCATGAACTCACAACAAGGGGGCGGTATGAGCCATGTCTGGGGACTGTTTTCCCATCC
CGATCGTGAAATGCAGGTGATTAATCGCGAAAACGAAACGATTTCTCACCATTACACCCA
CCACGTTTTGCTGATGGCGGCGATTCCCGGTGATTTGCGCCTTCATTGGCACTACACAGA
TTGGCTG
.
qlt:
4444479;V9B878966Zl>B:9>lgglgllal[akVlllllllllllllllllllllkk
lllkkkg\NLddkllllllklkklllkgllkklklkllllklllllkkkggkklllllll
llllkllllllllllllllkllllllllllllllllllllllllllllllllllllllll
lllllkklllllllllkllllllllkllgklllllllllllllllllllllllllkllkl
lllllllllllllllllllllllllllg\\llllllllllllglllllllllllllllll
lllllllllllllllllllllllllllllllllllllllllllllllllllllllkllll
lllllllllllllllllllllllllllllllk\kllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllOOllll
lllllllllllllllllllllllllllllllllelllllllllllllllliieiiieiei
ieiiiie_iiibeiiiieiieei_QOS_iedididiiiiii_idieiiiiii[^iiieXO
^NieZiiieeiYUeVieXieiiiiiiiZYQiiVi\X_iXeeiie\_NXiL^^\N\YN`\U
NM]WW\N]McMOcLO7=T^Q@OLRN`OYMW^cTSO^^TUMQH^[UUMMMMLM^MMLNcTM
MMLMMO^TP^MNMVDNXLMYPKG:;;T7E?<TM=cOOPJPPCRSGRMKKLKPJNP@CHPM
95ALGP;
.
frg:52
clr:7,785
}
{RED
iid:1479
eid:1128922857
seq:
GCGATCTAGAGATTCGTCAAACCGTAGTTTGCCATAAGCATGATGGAGAGAGAAAAAGAA
TGCTCAGTTTATTGTCTGAATTTTCAAAATATTCACTCGCTGAATTGTTATACAAGGCGC
TATTCTAGTTTGTGATATTTTTTCGCCACCACAAGGAGTGGAAAATGTCTTCCATGACAA
CAACTGATAATAAAGCCTTTTTGAATGAACTTGCTCGTCTGGTGGGTTCTTCACACCTGC
TCACCGATCCCGCAAAAACGGCCCGCTATCGCAAGGGCTTCCGTTCTGGTCAGGGCGACG
CGCTGGCTGTCGTTTTCCCTGGCTCACTACTAGAATTGTGGCGGGTGCTGAAAGCCTGCG
TCACCGCCGACAAAATTATTCTGATGCAGGCCGCCAATACAGGCCTGACCGAAGGATCGA
CGCCAAACGGTAACGATTATGATCGCGATGTCGTTATCATCAGCACCCTGCGTCTCGACA
AGCTGCACGTTCTTGGCAAGGGCGAACAGGTGCTGGCCTATCCGGGCACCACGCTCTATT
CGCTGGAAAAAGCCCTCAAACCGCTGGGACGCGAACCGCACTCAGTGATTGGATCATCGT
GTATAGGCGCATCGGTCATCGGCGGTATTTGTAACAACTCCGGCGGCTCGCTGGTGCACG
TGGCCCGGCGTATACCGAAATGTCGTTATTCGCGCGTATAAATGAAGACGGCAAACTGAC
GCTGTGACATCTGGGGATGATCTGGGCGAAACGCGGAACAATCTAGCAGCTGATGATGAT
CGCATCAAGATGACGATTGGCGTCACGATGTCGTCACGCCCACGGATATGACAATGTCCC
CCCGTTCTGGTAATGAACGC
.
qlt:
555677A:8<;8:NVHUNU=;KYZblblllQEM;lgllWP_l_alllglglglllllkl[
NPLkkDNklklllkllllllllllkNlllllllk[lllllllllllllllllklkkllll
lllgklkllkllllllllkg\\klllkllllllllkllllkllllllllllllkllllll
lllllllllllllkkkgllkllllllllklklllllllllllllllllllllllllklll
lllllllllllllllglllllglllllllllllllllllgllllgllllllllgllllll
lllllllllllllllllJUlllllllllllllUlllllllllllUllllllleelZ_iie
iieiieeieeeeZU__ZZ_iiiiieiiedeeiie[Qiiiieiieiiid___iebid_iei
eeiREeieiibi^^biZdiWiedieidibi^eWYeY^eSieUUe]^^Y^ieeeeee_XXB
i_eeeX\_eee`OP]PMMN]c]ON^NONUWN]NV[_N_M_TL[Qc_PKMWK\T\[MMMMT
MKMUMPP^ccMDMYTTMKNNKNNFMF^NCAITEOPKPOLMNSQKK@NMHODH7CQJKLL>
N9KL;CAC>LKRNIN@LBALAGHJM?JDPAM@N@C9NFP;=>9>CQ?>LGGICL>MAW?;
6494GBCB99<JJF:BDCT>=>9A<A687DD6:@MMAHA=NG<EMG:M8>>8CN<?MHF:
7>9>36DG5:89GNM<@?:@G?=IN756HJ8746278249@8>:569><=:=37=@48=@
:6:896=>4=57:64?555<855;7=6D9D4:45:7>8@E:3=78?<54359535:=C85
<43365839944386;3111
.
frg:52
clr:6,749
}
{RED
iid:1480
eid:1128922858
seq:
GCGACGATCTAGAGATTCGTCGATTCAGCTTGATTCTTCGAGACGAGCCTCAGACTCAGG
AACAAACTGCAGCTTCTCCTGGCTCCCTTCACGAAGGGATGCCCGTGCTCTGGATTTGGG
GGATCCTCTTCCCCCCCCAAGCGAGTGGCGTCTGCTGATTTTCACAACAAAAGCCCAATT
TTACCATCTGGGACAACTCGGCTTTCGGGAGGGTACATTTCCCCTGGTCCAAGTGGCTGG
GCTTGCTTGGCATGATCGTGCGGCTTCATCTTCAGAAGGGTTTCCTCCAGATCGTCTTCT
TCTGTGTCACCGATTGTTTGTTCTGCTTGTTCTGCATCATCAGGAGGGACCTTCTCCAAA
ATCGCCAGCCCGGATCGTTTCTTTTGTTCTGAGAGGGGAACCGTCGCCGAATCTTCAGGA
TTATGCTCCCTCACGTTCAACCCTGGCGGTACCAGCGCACGCTGGCCCTTTAATTATGAG
GTTGGGGACTTTAACAGTTGCTTTCTCCGGACCAGTTTTCCAACAGGATTTCTTTCGATT
CCCAACAGACAAGCTTTCTGCGACGGGTCAAAAAGTTTTGGGAACAAAACAGTAGCAATA
GCAATGAATGCTGGGGGTAACTTCCCACCTACGCGTCTGCTTGGGGAACGTTGCCCGCAA
GATAGGCGAAGCGGCCAGGATTTTTACACAAGCGGGACCCCGGCCCGCACTCCCCGGGTG
GAGGACCGGGAGAAACCGAAGAGGAACTCCGGCGGGGGGGGGCCCCCTACCGCCTGGGGA
AATTGAATCATTTCTCGGGGACGAGTTCGGGAAGGGGGGTTTTTTGGGCCCCTGCAGTGC
TCCAAAATCTACAAGGCTTTTTTACTGGAAACAGC
.
qlt:
424455478<9LM==MK_?G]8NDCeA:R\OD59=@SWK;5>8?6B>ETND54HV>M644
4454445@@K768:>@M=7?H<8B?6:?97457557675786=;>:;FHIEE?>A=HA<K
BLL85I?LLKH?HTSHK=GC=;D59<:88:8;;EB6BOC=9=78<<=6C7?HTGHCAL<G
GGCVK=LBG?B:=::::G?S:;=<<<:DB:@=>>==KLGGM<::<?9<KG<=G=N?HQYF
CCG=N<DEL;==CF8=;;8F697<=?<9<=<?><9G<8==;==C==BB<=<<<?GaCTPQ
VT=NB?>F<:<8C9<T?<:>8:;9GBIDD8<B8<<;<?:<B999B<GIA>E=?GCC;;C;
:<K=EB<A8<:9=GBG?<>::;=78:J;L<K[<N:A;;<J=<L;H;LL=UL:<AFAB<=<
:999;;:D<?<CF?P>:>;<=<;:D96>;;9;<>OJM<>I8EIG@;98C@<96@>;=:;C
>?9;9G79999<D<9>E=KC;:@E;9::878:98>:G<;=76:88:A>::>=7:CDE<:;
8:9?Q?9CQH8>=::E>==A>:HK?FA87==A998@@?KHF:77:9:>@:@8><AE:9:H
6D69<DHH<T:>M=@C>=@GD:GD@9AEH8<<AH@8BCK7@D@?7A:68]8<P8;<C6EA
7L8GRHJ8ZH8H<AFR>I?<7RPBB9H8<9::;7E6K78AL9886:6<8<AXE98>>55<
A>DAGGHKH:55G<<?::=:98<8H99E@:8899<N>:G>:ADQ>>>DA<;:=<9LQW:B
>7<:H=G>D55UPS=N;K=6MB8?85689RMB8BIMHHL9>G==B5<HA<G8A6858558
9A888D<88<9:C?EG>HLEKF85:5:8>;86555
.
frg:312
clr:94,861
}
{RED
iid:1481
eid:1127298183
seq:
GGGTTTCTGATGAATCAGCTTGATTCGTATCTTCCAACTGCACGCCACGACTCAAATCAC
GCAGTTTCGCGTCGTCAACCTGACCAAATACACGCACGGCATATTCACGTTCAACTTCAC
GGCTTGGGTGCATTAAACGGTTTGCCAGTTCACCATCGGTGGTGAACAGCAGCAGACCAC
AGGTATTAACGTCCAAGCGACCCACGGCAATCCAGCGTGCGCCACGCAGTTTTGGCAGAC
GGTCAAACACCGTTGGACGTCCTTCCGGATCGTTACGGGTACACAACTCACCTTCCGGTT
TGTAATAGGCCAGAACGCGACAAATTTGTTCAGCGGACTCACGTACCGAAATCAGGTGAC
CATCGATACGGATTTTCAATCCAGGGGTAACTTCAACACGATCGCCGAGTTTAGCAATTT
TGCCATCAACACTCACACGACCGGCTTCAATAATAGATTCGATTTCACGGCGAGAACCGT
GGCCGGCACGCGCCAGCACTTTCTGTAGCTTTTCGCTCATAGAGCTTCCTTTTGGTGTCG
CCTTCCCAGGCGTCTGATATGCTTTTGTGCAACAGTGAGTCAGAACTTACATCTGACTCA
CTGATAGTAAAGTCTGTTTGAACTCTTCAGGCCTTAAGTAAACGACTCGACGTTTATCGG
CCTGGCTTTGAGGCGCAACATACTACACTATCTTTATGGTTAAAGCTTGTTTCGATTAAC
ATCATCTTTATTTACCCAT
.
qlt:
875445@9;U:E@:9:68^illlWll_bgPllllMFallladgllkdllkllkdlllkll
llllFWM?:8<<<TL\\kllllklkklkkllkklkllllklllllkkll[[U[[Tggkll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllllllllllkllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllgglllllllllllllllllllllllllllkklllllll
llllllllllllllllllllllllllllllllllgkllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllllllllllllllllgllllllllll
llllllllllllllllllllllllllllbllllllll_llllllllblllllllllllll
lllllllllllll_llllllllllleieiiiiii_eiiiiieieeieiieiiiiZO_[ed
_idiei]YbeeeeidiiSeYdeeiidYOYbZiZdebiiPK^d>i_UeieWSiedeiTee\
VeiROiHd_^\RV^VRDNSU\SX_iY`YR>UGONNSOBOOOPNC`K_PAOMLCDKTHVNG
MQM^OP_\LB]<TQMMHMTMMNMYMMMP>XMMFQMR>FJ?><AACHG>WKN@I9T;LM>;
=MMA7LDH:K>:>:<D<55
.
frg:53
clr:6,736
}
{RED
iid:1482
eid:1128922859
seq:
AACGATCTAGAGATTCGTCATGGCGGATGTCTTTAAAAAGTATCTGGCGCGCGGGAAAAC
CGGACCGTTCCGCCACAGTGGTGTACAATAGAACAAGCTATTGATGTCATTCATCATTCT
GGCGGTAAGGCGGTGCTAGCTCATCCTGGGCGGTACAATCTTAGTGCTAAATGGCTGAAA
AGATTGGTTGCGCATTTTGCCGAACACCACGGTGACGCGATGGAAGTCGCGCAGTGCCAG
CAATCGCCCAATGAACGTACCCAGCTGGCGGCCCTTGCGCGTCAGCATCATTTATGGGCA
TCACAAGGATCTGATTTTCATCAGCCATGCCCGTGGATCGAACTGGGTCGTAAACTCTGG
CTGCCCGCAGGCGTTGAAGGCGTCTGGCAGCTATGGGAACAGCCGCAGAACACCACAGAG
AGGGAATTATGAGCCAGTTTTTTTATATTCATCCTGATAACCCACAGCAACGTCTGATCA
ACCAGGCGGTGGAGATCGTGCGTAAAGGCGGGGTGATTGTTTATCCAACTGATTCCGGCT
ATGCGCTCGGCTGTAAAATTGAAGATAAAAACGCGATGGAGCGTATTTGTCGTATTCGCC
AGCTGCCGGACGGTCACAACTTTACCCTGATGTGTCGCGATCTTTCTGAACTCTCGACCT
ATTCATTTGTTGATAACGTTGCGTTTCGTTTAATGAAAAACAACACGCCGGGCAACTATA
CCTTCATCCTGAAGGGGACGATGAAGTGCCACGCCGTCTGTTGCAGGAAAAACGCAAAAC
CATCGGTATGCGTGTGCCTTCTAACCCTATCGCTCAGGCGTTACTTA
.
qlt:
54466:7;@:;9;9MXIZPY[iUHiVD8ZMe_i[T_LlWPUWVl[ll[lelllll_bO=<
;:78758EILlllaTgalllgllllllllkllkklk\STJ=EB::>NNHkkkklkkllll
kgllkkllllllllllllllllkllllllllllllllllkllllllllllllllllllkl
lllllllllllkllk\\gllllllllllllllklklllllllllllllllllllllllll
llllllllllllllllllllllllllllllllgglllllllglllllgllllllllllll
llllllllallllllllllllllbllllllglllllllllllllllllllllllllllll
lllllllllellllllllllllllllleebllllllbllllellelldllllllllllll
llllll_llllllllliiiiiiieieii_e[eeeei_di_eie]eieeeeieeiiiieeb
ieebeiiiiediiVYYiieiiibieeeieeieidiUOiiNiKeee_KeeeiiVieeeiee
eeie^ieeb_QeiNeiiZWiideEdCNiee]\UiSeSiWiLieNeYQQ^Qe\L_L\_QeX
QY_\YM^NP\MM^NPMPNNT\^]NM\\M`VH^W^MMOVMXMTTcT_U@@ICTMIQCRLXI
MMMSOS^XYJOPSFPMNMJMMYMP^HSQL^GWNQVRcccOMIHGJMMKPA[PDHKIOJME
CHIWMAMGLKMF=:GP>H<@<467I>?ND@>L858?HLCJ8TLKDGALSSQ>>>?AQ\K?
HHJCHMADFNIGCPCV@D?@;@BD@RJ:6:9777=4679BD>>;:83
.
frg:53
clr:7,823
}
{RED
iid:1483
eid:1127298184
seq:
TGTTTCTGATGATTCAGCTTGAATTCGTATGATTTGCTTGCTAAGATTGAAGAATTGAAC
ATATCTCTTGCTAGCCTTAGGATTGAGAATGAAAAATTGCTTGCTAAGGCTAAGGATATT
GATGTTTGCAATGCTACTATTTCCGACCTTAGAACTAAAAATGATATATTGCATGCTAAG
GTTGTAGAATTAAAATATTGCAAATCCTCTACATCTACCGTTGAGCACACTTCTATTTGT
ATTAGATGTAGAGATGTTGATGTTAATGCTATTCATGATCACATGACTTTAATTAAACAA
CAAAATGATCATATAGCAAAACTAGATGCTAAGATTGCCGAGCATAACTTAGAAAATGAA
AAATTTAAATTTGCTAGAAGTATGCTCTATAGTGGGAGACGCCCTGGCATCAAGGATGGC
ATTGGCTTCCAACAAGGAGGCAATGTCAAACTTAATGCCCCTCCTAAGAAATTGTCCAAC
TTTGTTAAGGGCAAGGCTCCCATGCCTCAGGATAATGAAGGTTACATTTTATACCCTGTC
GGTTATCCCGAGGACAAAATTAGGAGAATTCATTATAGGAAGTCTCACTCTGGCCCTAAC
CATGCTTTCATGTATAAGGGTGAGACATCTAGCTCTAGGCAACCAACCCGTGCTAAGTTG
CCTAAGAAGAAAACTCCTAGTGCATCAAATGACCATGACATCTCATTTAAAACTTTTGAT
GCATCTTATGTTTTAACTAACAAATCCGGCAAGGTAGTTGCCAAATATGTTGGGGGCAAG
CACAA
.
qlt:
4444497;N?B>8:877_iilA?HllUdbVlVHll_lllllaalkk[llllllakllllk
kkkHJBJBHH<:kkkllllklkklllkllkglllkllllllllkgaaGUQYTWakkllll
llkllllllkllllllllllllllkllllkllklllllllllllllllllkllllllllk
glllllklllllllllllllllllllllllllllllllllllllllllllklkgklllll
llllgglllllllkklllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllkldlllllkkllllllllllg[llllllll
llllllllllllllllllllllkllllllllkllllllllllllllgllllglllaalll
lllllllllllllllllllllgllllllllllllllllllllllllllllllllllldll
lllllllllllllllllllllllllllllWllelllliie_^iiiiei_iieiiiiiiii
i_Viiei_ieiiicbeiiPRii[_i]idHi[]T[ieidiiiedieeeeiiei^Viieedd
dQeieeieeXdi\eeddHiLQiiRUVT\ie]\eii_\PcPL]P_P^]\]PN\_OMcM``_
Y]KP]HcWOc^^YMYQRL[LMYMSS[A??M^TH[OS[TLEK[O[JM^MLYWPMLc\NHMD
MMDMV?NOHVGcTNDNPMJTPN\BLQD8NJCGETCVCDJIFRBRN@9BIPBC\ZSL@:AD
NEN65
.
frg:54
clr:7,782
}
{RED
iid:1484
eid:1128922860
seq:
GCGATCTAGAGATTCGTCCACTTGAATCCTAAGAAATACTTCAACTCCCCCATCATAGAC
ATCTCGAATTTTTGTGTCATGATCCTACTAAATTCTTCACATGTAGACTCGTTAGTAGAC
CCAAATATAATATCATCAACATAAATTTGGCATACAAACAAGTCATTTTCAAGAGTTTTA
GTGAATAAAGTAGGATCGGCTTTTCCAACTTTGAATCCTTTAGTGATAAGGAAGTCCCTA
AGGCATTCATACCATGCTCTTGGGGCTTGCTTGAGCCCATAGAGCGCCTTAGAGAGTTTA
TAGACATGGTTAGGGTACTCACTATCTTCAAAGCCAGGAGGTTGCTCAACATAGACTTCT
TCCTTGATTGGTCCATTGAGGAAGGTACTTTTCACGTCCATTTGATACAGCTTAAAGCCA
TGGTAAGTAGCATAGGCCAATAAAATACGAATTGACTCAAGCCTAGCTACGGGTGCATAG
GTTTCACCGAAATCCAAACCTTTGACTTGGGAGTATCCCTTGGGCCACAAGTCGGGCTTT
GTTCCTTGTCACCACACCATGCTCATCTTGCTTGTTACGAAAGACCCATTTGGTTCCCAA
AACATTTTGAATAGGACGTGGAACAAATGCCATACCTCATTTCTTAGTGGAGTTGTTGAA
GCTCCTCCTTGCAATCGCCCACCACCCAATTCGAATCTTGAAGTGCTTCCTCCATACTTG
TGTGGGTCCATAGAGGAACAAAGGGTAATGCTCACAAATGTGCACCGAAATCAAGGGTTA
CCCCTTAAAATGCCCAAGAGTGTCCACACGGGGACTCTTTTAAATGTTGGGGGCACTTGG
GGGGGGGGGCTTTGTCTCACC
.
qlt:
66667:;A:9898T]BTW@9Fell=8KdSbWOLlLUOggglVB[glllllUTlaVaaTLF
;IBF==<ddka[YkkklaSllllkkkklkklllllklkSaaklkk[lkklkgkllllkgl
lkkklkllkkkllkklkklkllllllgggldgllldgllglgllgllllagllllllll_
glllllllllllgllllllglggll_Vgglgllllllllllllllllllelllbeebbel
lbllllllelll__elllllll__lellleiiiibiieeii]ieiiiii_UZiiiiiiii
ii_iieiiiiii_QYii__ie_iiiiiidZiiiiibiid_iYQieiieiieiiUiiiiii
ieibiiUV^i[XieSiiieeiedWiReYeiie\ReeeVWQii\eYX\_PWY`_\\QPO_K
O^cU^RRS`KMMN_F`OMMNMMccMNNMG`SMY[RMNSGSYSYR[GLSMMAcFD[LMTMC
IAcMRIGNJY^AKLOATRHEG^QLRHMKNVFQCJLOM^HGD=Y>GF<IDROMNIcMEMcK
D=IKGI@L<B<JL8;:PLGGL>EOA8:;EKCI=J9=>A:QR85L;?<AJZ?DA?<=:454
47533:U:497=634D<=?E348G6FD<M=Q8=44>>945B9H97A?9H8=6K4738;97
4;744469<D;545798:;55356@=32996G6;A89469;8:443476955344246:7
6?8=C7487512132125434311144565335579B54535:71413>678558?B686
B?FB856355356;6447864=7886769@CC9:4485145875868676=634464653
?5@8>A7<313<313144432
.
frg:54
clr:5,652
}
{RED
iid:1485
eid:1127298185
seq:
TGTTCTGATGAATCAGCTTGATTCGTTTTCTTGGAGTTGCTTCACTTGAAATCCTAAGAA
ATACTTCAACTCCCCCATCATAGACATCTCGAATTTTTGTGTCATGATCCTACTAAATTC
TTCACATGTAGACTCGTTAGTAGACCCAAATATAATATCATCAACATAAATTTGGCATAC
AAACAAGTCATTTTCAAGAGTTTTAGTGAATAAAGTAGGATCGGCTTTTCCAACTTTGAA
TCCTTTAGTGATAAGGAAGTCCCTAAGGCATTCATACCATGCTCTTGGGGCTTGCTTGAG
CCCATAGAGCGCCTTAGAGAGTTTATAGACATGGTTAGGGTACTCACTATCTTCAAAGCC
AGGAGGTTGCTCAACATAGACTTCTTCCTTGATTGGTCCATTGAGGAAGGTACTTTTCAC
GTCCATTTGATACAGCTTAAAGCCATGGTAAGTAGCATAGGCCAATAAAATACGAATTGA
CTCAAGCCTAGCTACGGGTGCATAGGTTTCACCGAAATCCAAACCTTTGACTTGGGAGTA
TCCCTTGGCCACAAGTCGGGCTTTGTTCCTTGTCACCACACCATGCTCATCTTGCTTGTT
ACGAAAGACCCATTTGGTTCCTACAACATTTTGATTAGGACGTGGAACCAAATGCCATAC
CTCATTCCTAGGTGGAAGTTGTTGAGCTCCTCTTGCATCGCCACCACCCAATCCGAAATC
TTGAAGTGCTTCCTCCTATCTTGTGTGGCTCAATAGAGGAAACAAAAGAGTAATGCTCAC
AAAAATGTGCAACCCGAAGAATC
.
qlt:
44448:>d>H?8==68el<B98?>llllllllllkklllkllkkkllkklllllllllkk
lW[TJH==<FRkgkllklklllklllllkkllllllllklllkklkggU\kkklllllll
llklllllllllllllllllllllllllllllllllllllllllllllkkllgkllllll
lllllllllklllllllkkllllllllllllllklllllllllllllgglllllkllkkl
llkggklkkkklllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllllldgggllllllllllllllllllllllllgkllkggkllllllll
llkgglllllllllllllklllllllllllllllllllllllllllllllklllllg\kl
llllllllkkllllllllllllllllllllllllllllllllllllllgllllgllllll
lgllllllllllllllllVlgllllgllgldlllllllllelllllllllllllllllll
YllllllZZldl]leeiei^_iiiieiii_iiii]eeVieee]iicii]di_iid_iiUe
ddGiiiY[JiY]diiiTHieibe_A^eUWiii[eKbZ9edT`XiH^XOeLi\_iEeR]]S
eUXQTHOD6@7GBKGVQHSN\>PN^GNPOWN_IM_AKUTMKVLTRMPc`INMM[FNcPN[
BRYEPLMMDGMMQECJRQROIEY>[GONJRN?Q>M@T@HNcNGMccP;TCQRRGV<CLEJ
PcccLGB5GGCFMcMFF977BD8
.
frg:55
clr:5,801
}
{RED
iid:1486
eid:1128922861
seq:
GGGGATCTAGAGATTCGTACAAAAGCATGTTAAAATTAAAAATGCTTATGCTCTAGAAGT
TGAAAAATGTGAAAATTATCTAGTGAGATAAGCGCTTGCCATGAGACAATCGACAACCTT
AGAAATGAAAATGCTAATTTATTAGCTAAGGTTGATTCAAATGTTTGTGATATTTCAATT
CCCAATCTTAAGAATAATAATGATGATTTGCTTGCTAAGATTGAAGAATTGAACATATCT
CTTGCTAGCCTTAGGATTGAGAATGAAAAATTGCTTGCTAAGGCTAAGGATATTGATGTT
TGCAATGCTACTATTTCCGACCTTAGAACTAAAAATGATATATTGCATGCTAAGGTTGTA
GAATTAAAATATTGCAAATCCTCTACATCTACCGTTGAGCACACTTCTATTTGTATTAGA
TGTAGAGATGTTGATGTTAATGCTATTCATGATCACATGACTTTAATTAAACAACAAAAT
GATCATATAGCAAAACTAGATGCTAAGATTGCCGAGCATAACTTAGAAAATGAAAAATTT
AAATTTGCTAGAAGTATGCTCTATAGTGGGAGACGCCCTGACATCAAGGATGGCATTGGC
TTCCAACAAGGAGGCAATGTCAAACTTAATGCCCCTCCTAAGAATTGTCCAACTTTGTTA
AGGCAAGGCTCCCATGCCTCAGATATGATGTACATTTATACCTGTCGGTATCCCGAGACA
ATAGAGATCATATAGAGTCTCACTCTGACTACATGCTTCATGTATAGTGAGAAATCTAGC
TCTAGCACCACGTGCTAGTGCTAGAGAACTCTAATGCATCATGACATGACTCTCATT
.
qlt:
:75587:<=8<=9:N_IWLCIH_QTWHQVZllOQQ[lelll[V[glgl__lllgallll[
ZUB<;<@<Nkkkklllllkllklllllllllllllllllkkllg[glkklllllklllll
lllllllllllllllllllllllkllkllllllllllllllllllllllllllllkklll
lllllllllllllkllllllllllllllllllllllllkllggllgllllllggllllll
lllllllglllllgllglllglllllllllllllllllllllllllllllllllllllll
llllllllllllllUOblellllllbllllllllllllellllllllllllllll_iii_
_ieei___iiieiiiiiii_U_iiiibiiiiiiiiiiieiee_iiiiiei_iie__iddi
Vieieie^ddRii^K^bd[idieiedidVeid_dbebiii^Yidb^deUY^dNi^UiiQ^
idVVUeeeeeWYeii_\eY[UiYXXiH[EeeNiKcBRN`W_W\PW:^ccPM`WcccOOc\
QcMMc[OMMME_^IUYS[MT\NYNMQS^cV^MNGKUWMM?5>MVSD8<:MGXTIGM[MMJ
NVKQ?ENE;<:FIAEKII^DMGcNHMOEJF[MTPMMGOKEM5C95@RCEF:@FQcFJ?CC
AOMCA=IF@MFNA=KN<BGL57;6A>C844>:G=S\Q=CDD==L9@<7>7@<NB>FM65K
766475H>77N5748?4=@=;737G74347<96GK>D@78>E7544435:69548G?H?9
<:6;G:I699426=9>D8K@K=B6B7AA9<D8<:4E9=C577D=D7@@73587?8==
.
frg:55
clr:6,828
}
{RED
iid:1487
eid:1127298186
seq:
TGTTCTGATGAATCAGCTTGAATTCGTTTGTTAGCTAGCCATTCTGGGTACTTCACTTCT
CTGATAACTCCTGCACTAAGGAGTCTTTTGACTTCGTTGCGAGCACCTTCGGCCTTATCA
TCTGACATTTTCCGAAGCCTTTGCTTTCTGGGTCTGAAGGATGGATCGACATTGAGTGAG
TGCTCGATAACATCTCTATTAACTCCGCAGAGATCATTGGCTGACCATGCAAAAACATCC
TTGTTATTGAACAAAAACCTTATCAAGGTTTTCTCCTGCTCTTCGGATAACTGAGAGCCT
AACAGCACCTTCTGCTCTGCTATGTCCTCACATAAGAGCATAGGCTTCGGCTGGTCTGCT
GAAGCTGCTTTCTCCCTTCTGAATTTGTACTGTTCAGAAGCTTCAGCTCCATCTATGTTA
TGGATTGCTTTTGAGTCAGTCCAATTACCTTCGGCCTTTCTTGCAGCTTCCTGACTTCCA
TGGATAGCGATGGGTCCCTGATCCGAAGGTATCTTCATGCAAAGATAGGCAGGATGAAGA
ATTGCTTCGAAAGCATTGAGGGTGCCACGACCAATAATTGCATTGTAAGGGTATTCCATG
TCAACAATGTCAAACACAACTTGCTCAGTTCTAGTGTTGTTGATGAACCCGAAGGTCACT
GACATGGTGATCTTGCCCAATGCTACAATCTGTCTTCCTCCGAAGCCACAGAGAGGATGT
GTAGCATCATGAATCTTATCTTCTGGCTCTTGCATTTGTCTGACGCCTTAGCAAATATGA
TGTCAGCTGCACTGCCTGTGTCAACCAAGACATTGTGGACCAGA
.
qlt:
4444@;IV>D<79868[lllJEUll[kllkkkkalkkllkVllllllllkallklllkkl
ll[aRLFJNLPKkkkllllllkkkkllllkllllllllllllllkkkkkgSkklllllkl
lllllllllkggkkllllllllllllllkklllllllllllkllk\lllllllllkllll
llllllllllllllllllllllllkklllklllllllllllllllllllllkklllllll
llllllllklllllkllllllllllllllkgggkkggllkg\gllllgllllllllllll
llllllllllllllllllllllllllllllllllggllllllllllllllllllllllll
klllllllllkklg\lllkkkkllllklllllllllkllllllklklkklllkkIGRPkk
Ullllllllkllllllllllllllllllllllllllllllllllllllllllllllllll
lgglbllllllllllllVEl_glllll[llllllllelllllll_Pll[bllllNlllZl
[WllellldllYebbdlleZiZYidieiiieZbiei_eiie]eii]eedidb_VeedTii
edVidZiei][UYieeiZYiiiieiYNVSeVN`TZe?e[MidQ@diZXiiU^e?dReXMQ
GELLTX^OeXL`VQIB^OPVK]NNPO<\\^McP`OWM`OM^IRQG`_CMQL^BQDMM>[I
WHMHKMMMMMTEGMWCJVLPPJNLTOJRMANYHENcYMLRMMG5IFMLMM9OJVPIOJIR
CVCOCJNB@KAIBD@J?J;=;JCFNP@Q>M@IND?5:AE9AE;6
.
frg:56
clr:4,822
}
{RED
iid:1488
eid:1128922862
seq:
AGAATCTAGAGATTCGTCATCCCCGATGTGATAGCTCGTTGGGGATCCTGGTTTTTCTCG
TAGGAGGAGAACATCTTCTTCTCCCCTGTCATGTGGTTTGTGCACCCGCTGTCGATAATC
CAACTTGAGCCCCCGGATGCATAAACCTACAAAACATGTTTAGTTCTTGACTTTAGGTAC
CCAAATGGTTTTGGGTCCTTTGGCATTAGAAACAAGAACTTTGGGTACCCAAACACAAGT
CTTTGACCCCTTGTGCTTGCCCCCAACATATTTGGCAACTACCTTGCCGGATTTGTTAGT
TAAAACATAAGATGCATCAAAAGTTTTAAATGAGATGTCATGGTCATTTGATGCACTAGG
AGTTTTCTTCTTAGGCAACTTAGCACGGGTTGGTTGCCTAGAGCTAGATGTCTCACCCTT
ATACATGAAAGCATGGTTAGGGCCAGAGTGAGACTTCCTATAATGAATTCTCCTAATTTT
GTCCTCGGGATAACCGACAGGGTATAAAATGTAACCTTCATTATCCTGAGGCATGGGAGC
CTTGCCCTTAACAAAGTTGGACAATTTCTTAGGAGGGGCATTAAGTTTGACATTGCCTCC
TTGTTGGAAGCCAATGCCATCCTTGATGCCAGGGCGTCTCCCACTATAGAGCATACTTCT
AGCAAATTTAAATTTTTCATTTTCTAAGTTATGCTCGGCAATCTTAGCATCTAGTTTTGC
TATATGATCATTTTGTGTTTAATTAAAGTCATGTGATCATGATAGCATACATCACATCTC
TACATCTAATACAAATAGAGTGTGCTCACGTAGATGTAGAGGATTTGCATATTTTATTCT
ACAACTTAGCATGCAATTAATTCATTTTTAGTTCTAAGGCGGA
.
qlt:
4456776?<;868X[QQE>NiY_ReZLO9OAA_ZlllllllllQECllllllllllgVb;
997<Fdggdlldglllllllllllllllkkklllllklllklkkklllllllllkllkll
kaklllllllllllllllllllllllllllkllllllllllkllllllllllllllllll
llllllllllllllllkgkllllllllllllllllkllllllllllllllk\klllllll
llllllllllllkkllklllllllllllllllllllllllllllllllllllglllllll
llggllllllllglllllggllllllllllllllllllllllllllllllllllllllll
lelllllllllllellllllllelllllllllllllllllllllllleeiiiii__Z_ii
iiiebii__iiei___eiiei^bidei]eiibieiiiiiieeieii_Viieii[_^YYii
i]ieee_i[[Zeebiei\U^iiUiQ^Yie_dKed^V^edXdXe_eeei^@^UUWiiddK^
VUViULQW\IXYTi\S\XeWeKQ\W^Y\HOK5R`>^^]NWO\U\N\c[OTLKQ_]PKFM`
MP]<NVM`YMMUHMMY:PEMMVLMYMFTDUHVc[NMIMMN^CIMLMLML^JHMKQLORNG
MMLLcMMcRI\@Nc\\AKAMc\NMGDPBGFFIMCHLDLLKGLI89K6LJQLBG?I\Z<D@
ED9:FKLGOD@\\LD898\@CFAD=\=8BRGFP<AMJG=BGC38<F?MN6@G<N:?EDAD
AE@;M>6GJ<8:6Z:<9:K5784=;C8:6F9?:I?H:;575<C9I;?;H6:9JJ=4358:
?>6453:C9D=<E<?643337557AMNI>;6A454>9A86557
.
frg:56
clr:7,872
}
{RED
iid:1489
eid:1127298187
seq:
CCATGTCTGATGAATCAGCTTGATTCGTACGAGTTCTCTCGATATCGCTCCTACTGACCG
TTTGATAAACCTAACCTCCCTACCCGAAACTGATAAGAAAACAAAAGAAGAAGGCGCTCC
TCGAGGGTGTGCTTGAGGGGCCCCTGACGGCAAGGGGACGGCTCATTGAAATCTTGGCAA
AGAGGTTTGCACCTCCGGGGGGCTTCCGAGGGGTCTTGGACTCGAGGGAGACGACAAGGT
CCGCGTGGGCAGCGTCGCGTTTCGATTGCGACTTCTTCGTGCCGTTCTTCTTGGCACCGC
GCGGACCGGACGCCTCGGGAGCCTCTTACGAGGGGCGGCCCTGGGGCTGTTTGGCCTTTC
GAAAGATAGACTCGACCGCCTCCTGGCCAGAGGCGAACTTGATCGCGATGTCGGTCGGCT
CGCTCGCCCTGCTGGGAGGCCCTGGGCCCGAACAGGTCTCCAAGAACACCAAAACCAGCC
ATCGCGACACGGTAAAGACAATAAATGCTCTCCTGACCAGCGGGAATGAGTGGCTTGAGT
TCAGGCAGACTTACCCGAACTCAGGTGCGCAAAGGCTCGTGCGTACGCAGAGGACCACGC
AGCCGGTGCCTTCGTTGTGGATTTTTGTTCTTCATTAGCTCACAGTCTTTTTTTTTCGAA
TGTCTATCTGTTAAGTGAATATGTGTTTTTACAACTAGAAGAGGGTTTTCACGAGGCACT
CAATGACCCTGTAC
.
qlt:
4223348:GGG=55:<9<O^iUWRed8Q595=:OVAA?876>TBEK?:<:7A>QKS:CMA
OZV8974665:7558@>>>9C:4;;9?B87B@<7798:9794977447:9;6;79;;CC=
=B<BIR@?O<GG@===;;BGORLWRKN=WG=F?:H<IG=KM<;<?;==>;:<=<=LCL=G
GG]HO?<<ICCIT=GM:QBKKI=B=L?>WCTI?:=>=E9KF=C<9<;<B<=:=I=<<aTC
BF:K=;:<<<==>G<G<<H=BBMBKGLWD=KKLGT=CC<9D;=@=C=?CH<=H>9<KLHH
ACK@M====N<I===F:9:B?KSFKCF:<<L<GBB<F==NJFM;KKBMN?DSK:GC?B=<
<;H<<W<==;<97:B<=G<L@;==<;;98;H<<G:KBCLLV;<87=:PC@;<=>GD=<<=
=<GHQM;JB9G>B=<8<8<:<<:<7<C;;<:<:8@C:;8><989;G=;D;9::;>:@WGH
B9;7<98;99:G::8:;;:<<=<;<;:<9B;;98;:9<998B<8888@=88?:<;><><<
=;<B<:6<B;<<;8:=BH===>;87<:G>=5:5:58:9:998;?==?857::B;:5;?86
<:66<<;8:7;;E><?<;<?@=<DA><F<@GRB@@=9:==C99:9<<?K<<<GUFHI:@>
G>;:>:E;E@;@=9:?==B>D<9<O?CKGES:>>88=9BE?9;>C><H=7B:E>9=<:A8
>@;:@:8>:9@78@
.
frg:57
clr:64,732
}
{RED
iid:1490
eid:1127298188
seq:
TAAGGTCTGATGAATCAGCTTGATTCGACGAATTCTCTCCATATCGCTCTTACTGACCAT
TTAGTGAAACCTAACCTCCCTGGCACAAAACTGGGCAACATACTACAAGAGGAAGGTGTT
CATCTAGGCGGCGCTTAAGAGGCCCCTGATGGCAAGGGGACGGCTCAATGACAATCTTGG
CAAAGATGTTTGCACCTCCCGGGGGCTTCCGAGGGGTCTTGAACTCTAGCACCCATACAA
GGTCCGGAAGGGCAGTGCCCGGTTTCGATTGCGACTTCATCGTGCCATTCTTATTGACAC
CGCTCGGACCACACGCCTCATCATCCTCTTACGAGGGGCGGCCCTGTGGCTGCTTTGCCT
TTGAAATGATACCCCCCACCGCCTCCTGCCGAGGGCTAACTTGGTAGCGATGTCGATCAG
GTCGCTCACCAGATTGGAGAGCTAAAGGGCCAGACAGGTCTCTCAGAATTCGATATACCA
GCCGTTAGAGCCATAGTCTAGAGACTGAATGCACACTCAGACCTCTGCTCGCAGAAAAAA
TACCATCCGGACCAGATAACCTGTATTGACCAGCGAAACAGTCTTGTTGATGCGCTGGTG
AGCTCCCGTGCAGAATGCCCTCGGTGGAGGTCTGGATACTCATTTAGTACCACTGGATCG
ATTTTTTTGCGGAATGGGCTATCTGCATTAGAAAATGAAGAGATTGAAGAGCATGAGAGG
GGCTTGGATGGGAGGAATAGGGGAAGGTCTGGGAGAAGGATCACTGCAAAAACCCCAAGA
AAAATGCGGCTGCCCCCCCAACCGCATCCT
.
qlt:
321113656<:7546568BQPD:DMW<<IHK7M_EZU[?><N;Q<88K<6;:@]R>:98M
PD56748<7677777:<?96J;;B8<M;<89=;878U?8;95999:5:778;:5:6:==C
?:=<<==B<:H>IH?=<G>GBBCHLKLGQLWDCG?:K=<K<BG<<;?;;<:;9?B?==LG
GBL?;Q:G<=;IKFCRCJH6899<@;E=L:BK=KD<<==<=9<=<=69;<<<;BIA[B<:
GI98=<;<:;78;<CCQ=??AG;BGWGKCITCC[LLGT?CH<===<;?HCD=B@CB<><H
CHB<B?<R><C=WG=J<>BA<<P=FG?CC=E==L@C=@<G<BKI<G<>G>CC><B=:>:=
=BB<;LA@T;;9<D8<;:9;><:=<;9<6855;7:=8U?:DJW<:9;=<P:<;9<:=:K:
8=<<<A;B6<;:;=;=:;B<8=@>5=;B=<:9BG88B9:<:<5:::8H;8;<<:F<?==:
=89:48;<<;9=C:<89:C@@??;==H;==A68:GL?A<:=9<=<:E=:<@98G=<;?<<
>D=<=:<88::65<<;8<<;9<:8999;7;=9:<G:8:9::<<<7I95I<9@?<9:A;8?
:G;?CA8<>;:878;<@9=C<:<F<<;ACB;99>@EB;C<C=@<D;G=9;;<=67;B><:
;;::7?9:<?<;:;:><;98?<E<HG;<<;:8?G>=:?<G<><::K:S:989988<;HEB
>;EQH@7:79:787=O76A@HK778D98;<D;>=987=8>:8>9<8<>D=J9AA99::JD
K7489?8:8788C?>GH;96866886<9::
.
frg:58
clr:90,797
}
{RED
iid:1491
eid:1127298189
seq:
TGCGTTCTGATGAATCAGCTTGATTCGTTTGACCTTAGCCTCATATGGAAGATGTATAAA
GAGATGCTGCATAGGATTGAAGAAACCCGATGGAAATATTTTTTCCAATTTGCACAAAAG
CACTGGTGCCTCTTTCTCCAGCTGTTCCATCACATCTCTTCTGATTTCTTTAGCACACAA
CTGTCTGTAGAAATAGCTAACTTCAGCTAACGTTTTCCACACAGCTTCTGAAATGTATCC
ACGAAACATTACAGGCATGAGCCTCTCCATAATTATGTGGAAGTCATGGCTCTTCAGTCC
ATTCATCTTCATTGTCTTCAAGTTCACAGATCTTCTAAAACCAGCGGCATAACCATCGGG
GAATTTAATATCCTTCATCCCACTTCATCACTTCTTTCCGTTGCTTAGATTTCGAACATA
AGTCAGCTTTTTGGTTGGCCTCCGTTTTCTCTAAGCACCAGGGTTGGACGATCACATATC
ACTGCTAAGTCCATGCGTGCCTTGTCATTGTCTTTTCGTTTTATCAGGGAAATCCATGCA
TGTATTTATGAGGGCTTGGCAAAAGTTACTCTCTTGATGCATGACGTCAATGTTGTGCAT
CAAAATCAATGACTTAGCATAAGGAAGCTCCCACAAGCCACATATGTGAGTCCAGTTATG
CTCCTCACCAAAACCTTGATACCTTTTCCCACTCTCGTCTAGGACAAGTTTCATATGCTC
TTCTGTAATTTCTATCCCACTACGTCGCTTGTGCGGTCCCTTCGGGACGATGGGTGCCCT
TCCTAAATTCCTTTCTCTGCC
.
qlt:
345445>7<I>><89665_e:;:7:lGPll_N;lgggUllgaalkkllllkk@klllllk
llakISOB@=<FB[kkkkllkkllkkkkkkkkllkllgRgkd[[LIFLT[[\WV]akkkk
lllllllllllllllllllkg\klllllklllllllllllllllllllllllklllllll
klldb[kaldllllllllllllllllllllllllllllllllllllllllllllllllll
llklllllllllkkllllllkkkkkklllllllllllllllllllllllkklllllkkll
llllllllllllllkllllklllkklklklkkkkldlggg\TRLJ\\PJKgDRLGSL\U\
AC>R\=;>=G=A;8:6:<<B=;:8;<<===88C?BC<@?;56=769I:KC>:85>>7::;
@:;?<:IBQgM:P;=>9CF@CB=>MLF<;;><><;<:HB88JME:S=QQ<T=C>=9>:C<
;:>UCG[Z>@EHCR_LH@WJ@JAl>RIJLeAWCiiFWJ>ii@NR]L:_L_IKReVHSeWE
LeLOedNZWGY8iIRdLeeV]ii]Od[]eiiiii]i_Vi^NZeibbdiYeWiKdiTid\e
[ViidWeUdXieQe\eN`USeW=NUeRe`^c[NTKcOQTPWX__\^W]^M`TPMYTTRM^
O`M_ONQMQK^^OMYJMOTLMMT[c^TTcXPM[[OTLMT@NF^K@EHMVcRIGLNMXMMP
@COMXJCAJ\CJKVMG\RJLPNOCGPLSL:549LDC;M\QDD=9QMF??S=?\C;FFZBG
NFI<LZDCG@C?ZFD<G>B55
.
frg:59
clr:6,798
}
{RED
iid:1492
eid:1128922863
seq:
TGGTGGATTCTAGTAGATTCGTCGTACGCGTGGCGTGGTCTGGCGACGATGGCGGCAGCG
AGGAGGAGAACTCCCGCGGGGAGGTGGTGGCGCGCGGCGGGCGTGCCGGGCGCGGGGTGG
GGCGCGGCAGGAAGGTGCTGGCGCGCGGCGCGGTGGCGCGCGGCGGCTTCTTCCGACTGC
CGGGAAACCGCCCGATTTTTTTTTGTGATGTTGTTAATGACAAGGAAGGTACATATCCCC
TGTTCTGTTTTACTGGGCTCCACAGCGAAATCTCATGATTTCCTTTTATTAATGGATTCC
GCATATTGTCTTCTTCAGAAAGAACAAGTTTGCGGGTTTGTTGTTTATCCCAGGACAGAC
CTTCTCCTTTTCTCACTGGGATCGTTGCTAAGGTTCCGAGAGGAGAATCGTCACCGAATT
TCACAACTATCTCCGTTATGTTCAAACACTAAGGTCCAGCGTCTCTGGCCCTTTAAGTGC
TTGTTGTGAAGAATGCAGCTTTCTTCTGGGCTAGTTTTTATTCTATACAATTGCTAACAG
AGACAAGCATCTGCGACGGCTTAATTTTTGGAACTCAAAAGAGCGACATCATGAACGCTG
GGAAACTATCCATTCTTTCGTCTGTCTTGTGATCGTGGCCCGTCAAAAGCAAACCGTCCG
GGATTTTTACCACAAGAGGGAACCTCGGTCCCACTCCCGCGAGGAGCATCGCAGAATTCT
ATTATCAAATCTGTGAGGGGGGACCTTTTCACGTTGGGAAATTAAATCATTATCACGTAA
GAGTGGGGGAGGGGGGGTTTTCAGGCCTTCTCGAGGCTCCAAGTCCCCGGGGTTTTTTTT
ATTGGGATTCGG
.
qlt:
31344347757975<8?=>74575BM=DRLTR;<>8B67:9:6=DNFK[?VK=M@7768?
79;669464466667<9<>:BHCG:JF;bNHUJVPPG<K@I@<88687877A<=B<?;SB
JI==<B<<G?K:L<I9KCBI==<=<=B=BACI<=L?C=HDKC===9:<<986;;;96;;7
:99<;?8<:;><B=;;D@;6:;H;<<I<:?;;@?::=@>=<<97679=G=9><?:;=<=:
=B:DN:B<;<<;;<K=<;888<:<H@88<@9:9;;<5<=G<=89AB<G<<A<<;98=B;4
8=B<B=T=B<<:=:<99;>?<;K;B<=F:9:>:>7>:B;<;<:<<8=<<=9:;678<<@:
9<:;===78C888<76<:9BD<=<B?9B:<;:C?GN<GK:<<<=<=ND<BC?;9;=C:<8
=;;<<:;<;=:4<<<<;C<<::8<::79<<748=:C=;9:99B4@=;=;:<5::=9<=8<
;9<;<=<<CA;C:;:?B=<9<79<;=9;888<=8E9=9;7<:9:8948996579;<7<99
8:K=;<55:=<9I?<?KB;6;9688?@<:86>?8<;==;;<EFD7@?L<@9?CJ@<E:;B
>;7?C<<<;<:9@>D;9;<:<B=C<=F<;9;75:E9;>:9:=999EB;BB;G<;;=C>9;
<<C;@C<<;>B7;?:9888<>98B:B;<?>9I<<<987=87754799;999989P87788
8C>=:8H<<AC=>999OS:FB=9=><==98::88DILH>99<87;<>G<8A;>>89?7?:
<H8848FR@8@FONLAAKPDMF>E8>@8:98888:7:;=778:@=86877GNE<8B>D:G
>?68>D>>>:87
.
frg:59
clr:24,848
}
{RED
iid:1493
eid:1338942762
seq:
TTGCCGGGGGGGGTTCATTCTTCTTCGTGCATCGAACCACCACGGCGAAAGGGGAGGAAT
CCCACAAAAGGGGGAGATCCCGTCACATGAAGCTGGAGGACGAAAGCCCTACGAGACATC
CCCTAGCATGCGCGATTTGCCGATATCTTATATCCAAACGTCTCAAAAGCCCCTTCCCTA
TTGTGAATTCATCATTCTTCCCTATAACAAAAAAAAATACCAAGGTTACCTGTGGAAATA
ATCGCATTAGTTCAATCATAACTTCCAATAGGCTATGTCAAGTAAAAACACTATCTTCTT
TATCTGAATAATTTACCTGCCTATTATTCTAAGTATATTGTCTCGTTTCAGCTCAAGATG
GCCCTTGACCTGTGGTTTTGGCACCTGGTGTCGCCCTATAGACTACGTGAAGCCGGGTGG
ATTCGGCTAAAGCCCCTGTTGTTACTTACCGTCTTTCCAGAGTCTAACCATTTTTAAAAG
ACCTACTAGCATCAAAAAAATAACCTGCGCTCCGGCTACGAACCTACGGCCGGGCAGAGA
ACATTGAGAGACAAAGACGGATGGAGTGACAGTATTGCGTCCCTGTCGATGACCACGACA
GATTCACAGGAGATCTTTGCTAGAGAGCTCTTTCCTGGGTTTTCGGATAGTTGCTAGTCA
TGCGATTACGCGGCAAATCGGCGCTATGTGCAACATGCTGTAGTTTCCCCTTACTGACTA
AGACTATGTACTGACATGTGACTAGGTTCAATTACGATCATTACCTTGTCATTGAACGTC
CCGAGCAGTACTAACTTTTTCATTCTGGTCCGTGCCAAGTCCCCTAGTACTCTCTAGTCG
ACTCTTGTCTAGCAGCGTACTTAGTTTGGAAGAGTCGCGCTGACTGAAGATGGAACGAGT
CAGCGGAATCCCATAAATCGAGCCTTTGTCTATGTAGACGGAGATCGCATGTATCTAGCT
ACTAGGAATTGT
.
qlt:
6335::77677:55:85:8;?>6:885:5866878889<7F::@=78>;8989HF<EFG:
<E<4:7498788;5:546687>766<59:98777E77;:579999;;<B;<9<<57;;;<
GS:9877:<A<<95:<<<=979=<:;8;8:;<86;<7:;;56<;<:==<:;<<;6;==:9
:<:;:8;<<8;:<;9<==9<<4<:9BA<8B<::@=8D>=:<B99;;<<<==<<=9;G;<:
<<95<<:=<<:8;:6;?99;<C?;G?9;<:=;=9@@=<;?==<K;<:8759<=?;;=<<<
==C<GEC<<AC::=9:DD?977=<<<9965<<;C@=:@B=<;89@><<<8<88M:I:8;<
?;8::C;EE<;J=LO=I<<@;:<<L;CE@I<C>;;:9>8><<;<@@=<=VCAP?CB?=89
:;<>P<?:;;>><D;==H99G@?8><><;ECKH<=:9;88?9ECL@?=8C8:888:8888
;9A:9:<@8:=:EG<H:?>9::88D8C8?D88:FL><GADE@IMB<8C:?G8:A8>:<F>
9:>898:7L:<@E=<A88=A>99:D==>@86<8>9<>B>88C=8>9:=;:<>>8B>7885
?A::H><9<9><99?HNE=HI>;>P@CN9>=@>87779<A8:H;=;A58:EGAAAM:8;8
88?9><<9?98@=5==>8C:5><88@=<E@H988;><;<BNA8;5<655856=>:;5:P8
E>6A8;:5<8<><557IM>AF:@>5:>87><8<5>5CN7=7I7=>LH9<>B675788EK9
;86>9<D><@5757<=G@OLE9>D697>?878:K66G5;78>7AF@6=99;>6BL8GC65
A>D75=>548HN8:<777:896=C>B::7NJ<H75349784:77795435<>8M=56>55
47?52365@53848;;:97332437<93354:75E4475:696:4=67445622856538
5;6534@69557
.
frg:59
clr:40,873
}
{RED
iid:1494
eid:1338942763
seq:
ATTTTTGCGAGTGCAGATCGCAGGCACTCGGCAACATCTTTTTGCCGAGTGCCAGCGGAC
AGGAACACGGCAAACACTACAAGAATTCTACTGATCCCCGTCGGCCAGGGTAATTCCCGT
CGGCTTTCGCTCTGGCCGACGGGAATAGACTAATTGTCGTCGGCCACAAAATAGCCGACG
AGCATTATATTTATTCCCGTCGGCCCTGTGTTCTGGCCGACGGGGATTAATCTTTTTAGA
GCCCAGCCGCGGACGCGCGGGCTCATTCTTCTTCGTTCAATCAAACCGCCCCTGCCCTGC
CGGAGCGCCGCCGCCCCTGCCCGCCCGCCGCCCTGCCCAACTGCCGCCCTGCCGGAGGCC
GCCCCCGAGCCGCCCCGCCCGAGGCCGCCGTCGAGGGGCCCGACGCCCGCACGCCAAGCC
GCCGTCGAAGCCGCCCCCTCCCCGCCCGAGGCCGTCGTCGAGGCCGCCCCCGGCCCGCGC
CACGCCGCCGCCGCCTCGGCCCGCGCTGCGCCGCCGCCTAGCCACGCCGCCGCCCCTGCC
CGACGCCCTGCGCGCCTAGCCGCGCCGCCGCCCCTGCCCGAGCTGCGCCGCCGCTGCCCC
ACGCGGCCACCGCCCCCGGCCGAGCGCGCGACGCCGCCCCGACCCGCGCCCCCGCCTCGA
GCGTCCCCACACCGCCCCCGGCCCACTCGAGCTGCGTCGCCCCTAGACCTCGTCGTCCGC
TGTCCGCTCTCAACAAGTCGTCGCCGTCCACTAGTGTCATCGTCACCAGCCCACAGTCGT
CAGCCGTCAGCCAGTGCCTCGACGCATCGTCAAACATCGAAACCGAGGTCTCTTTCATCC
GTCCGCAGTTCCACTTACGAGTCGTCGTAGTTTAATCTTATTTCCAGATGTGAATTACTA
TGTTGATTAATTATCGTCGGTTGTGAGACGACGAAAGTAGTGCATTCATAATAGCTAGCT
CTTAGTATTATTGTCGAATCGACGTTTACCTGAATCATAATAAATG
.
qlt:
33446363445=G<<577N;EJMBCCEV_HE88??KXUUXXedKAJRiT^J>DEHQbLI9
77554445;:69CF<VVTTD=PZeb[_bbRMR]R]W]Z_KA=?6764589PLKWd]RS]R
VRXR_Z[OLN]edeYKSW_KWN>LQZXOe]ee[blVPGQMPLPHVRQDPQWeQ@bVIL:8
=:8>NXZedeebbddZQVZZbVQGQVbbOVW]PP]HHPPbKL?:7HWVbPbedbbl_RNZ
LCMKHNMM]ZbZXGSVOUXKOQebW_edbeb]bZRW[]SQ]WHKWVbSHMLPbeWWWbbM
PWQ_GROCDF=DCGLLQ_bKKKWLKKOGJL]WWd^OQWLHE[ZOW]PVS_^PV[Z_AKHL
SNOZ]]`lWS]]WZZbeX]VV^LREHJKJLPK@VHDHRFRPPeZ]KJKM?>>A>?HDK@G
KLLWNNDZIGODLCBEHP_WQJJSKHLPdNE?JHGA@GE=R??>DE=<8<:;98NPZNNG
A<;?<C?:B?@??<:@>979FCG>AAWVK@ADCAHNDGZbA<@?>>GG]SRNKLLN]bGG
MLeNVTUUbeHLQRGGQbU>EA:>98<E@@>>@GNM?AE>Q<8EEH?@GGANRGZS@CCE
G>BAA;<ELMQF@SCA9A<;MXdBBP@DHHP>L@EFDJDGNP=HOLCF:GGGPS<GKHNG
KGKH=>AHKEKEKM?MKGABD=I9<=<;;K:BKL:==>>>NDDKD>>@E:;BKDLJ?NB9
KH=><N?=@CMFBCBJ?E@<I<NFBAQ<775=A989><9A=9J>5M@MB9:;:@6:;977
>>C5>?><;>@E?7;>::L>8J8:HI67<5:65>:8><=7FNABD;55::8:6:7676<9
FGGA;666<76@;7B=5C<G8DL?JE868@><96699:H8:?=56=65:89@6;:==6@M
AB@HH58;L<474::;9?55774735:24;J4313866654423@;7<444E4:475213
5DC5475DD447211411?467333>7495555;6689?656=663
.
frg:59
clr:11,909
}
{RED
iid:1495
eid:1127298190
seq:
TGGGTCTGATGATATCAGCTTGATTCGTTCCGACCCCCGACTACTATCACGAAGTACTCG
GGGGAAACGAGACCGGAACTGTGGCTCGCGGACTACCGCCTTGCCTGCCAACTGGGTGGG
ACGGACGATGACAACCTCATCATCCGTAACCTCCCCCTGTTCCTCTCCGACACTGCCCGC
GCCTGGTTGGAGCACCTGCCTCCGGGGCAGATCTCCAACTGGGACGACTTGGTCCAGGCT
TTCGCTGGCAATTTCCAGGGCACATACGTGCGCCCCGGGAATTCCTGGGACCTTCGAAGC
TGCCGGCAACAGCCGGGGGAGTCGCTCCGGGACTACATCCGACGATTCTCGAAGCAGCGC
ACCGAGCTGCCCAACATCACCGACTCGGATGTCATCAGCGCGTTCCTCGCCGGCACCACT
TGCCGCGACCTGGTGAGCAAGCTGGGTCGCAAGACCCCCACCAGGGCGAGCGAGCTGATG
GACATCGCCACCAAGTTCGCCTCTGGCCAGGAGGCGGTCGAGGCTATCTTCCGAAAGGAC
AAGCAGCCCCAGGGCCGCCCATCGGAAGAGGCTCCCGAGGCGTCTGCTCCGCGCGGCGCC
AAGAAGAAAGGCAAGAAGAAGTCGCAATCGAAACGCGACGCTGCTGACGCGGACCTTGTC
GCCGCCGCCGAGTACAAGAACCCTCGGAAGCCCCCGGAGGTGCAAACCTCTTCGACAGAT
GCTCAAGGAGCCGTGCCCTTACCATCAGGGCCCGTCAAGCACACCCTCGAGGAGTGCGTT
ATGCTTCGCGTCACTTTC
.
qlt:
4444485=:5:;8:C?8CeilE:8BE_lll_lXYllllaaVallkllkklllkklllllg
gllaaTMKGLHULgglllllllllllllllkklllllkgklllllllkkk\\lllllkkl
kkllllllllllllllllllllllllllllllllllllklllllllllllllllllllkg
lllllllllllllllllllklllllllllllllllllllllllkllllllllllllllkg
kllllllllllkkkklllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllgggllllllllllllllllllllllllllblll
llllllllllllllllllllllllllllllllll[lZlllleeeiiiiiiiiiiiiie[i
iiebiiiii]icXiieii__iiiei^SibeidNieidbieiUieiVUiddiiUiiediVR
QieiZbeiViT`iieidb^_G^ebWi\XiKdOeQie_dKe\_\eSiQYQ\\ee_eeU\Pi
;eTceHicUW^HP_Pc`Nc_KW`NOSTR_M]cV_M[MSMM\\MTQM\KIYM[JATKQWLW
LQPM[YMT[CW;HLMFLLMQKc^MTHNLJMMcWWTMXNHHEYLD^QHRMRKLP?S>TAD@
SLMOA=G>OAKE??VBV:7AOJGETR46IAFSGEJN<>NKEF?CSL@K9HI=B7>KDJG<
>9?BFG>H9:6E?J>O56
.
frg:60
clr:13,795
}
{RED
iid:1496
eid:1128922864
seq:
CGAATCTAGAGATTCGTCATAATACCGAATCTCTTCAGTACCTCTGCAATAATCCCATGT
AGTGGGAACCTTAATCCAGCTTTTAGAAAGCTTTTGAAAATAACAATTTCATCTTTCTCT
GGCTTTGGGGTAGTCTCTTCTCCCCCGAAGCGCAATAGCTTCTTCTGATTTTCAGTAAAA
AAGCCCGATTTTACCATCTTGGACAAATCAGCTTTCGAAACAGTAGATTTCCCGAAGTCC
AAGTGGCTGGGCTTGCTTGGCATGGCAATGCGATAATCATCTTCAGAATCAGTTTCCTCC
ATATCTTCTTCTTCTGTTTCAGCGATTGTTTGTTCTGCTTGTTCTGCATCATCATGAGGG
ACCTTCTCCAAAATCACCAACCCGGATCGTTGCATAGCTTCGGAGATGGGAACAGTCTCC
GAAGCTTCAGTCTCGTCCCCCTCACGTTCAACCCTGGCGGTAGAGCGCACGCTGGCCATT
TAATTATGAACTTGTGAACTTTAACACTTTCTTTCTCCGAAGCAGTTTTCAAACAGGAGT
TCGTTCGATTCCGACAGACAAGCTTCTGCGACGGTTAAAAATTTTGGCAGCAAAACAGTG
CAAATAGCAATGAATGCTGTGGTAACTTCACACCTACTCGTCTGTTTATATAGTGTTGCA
GGTAAGAACGCGAAGCGCCAGGATTTTTACACCAGGCGGACACCCGCTCGCACTCGCTGC
GTGGTGGACCGCAGAGACCGAATAGTAACTCTGCAAGGTGGGGCCGCTACACGCTGGGAA
ATGATCGTTTCTCGCACGAGCTCAAGGAAAGGGTGTTTTTGGACCTTCGGCGCTCCGAAG
CTTAAGAAGGCTTTTTTCACGGATCCAG
.
qlt:
545777;G@<9:8NYIQE>SG8Pe_ee^]W_YlllK8lee_lllllUMlglllllVSll[
N?Q[O[llglllllllk[lllggkkllllllllgllllllkkkUU\kklkkllllkllll
lllllgU\klllllllkg\klllllllllllllllllkllkkkkklllgklllkllllll
klllkkllllkgllkkld]aUTklllllllklllllllllllllllllkllgklllllll
llllllllg\kkkklkkllkdkglgdlllllllllllllllllllllgllllllg\glll
glllllllllllllllllllllllllglllglgllllllllllllllllllllllllbbl
lllllllll]lllllelllllllllllllllllllllllllliidc_iiiiiiiiiiiii
iiieiiiiViiiiiieii_U_iibeiii[Niei__ddbiibibideidibiieidP_bdi
d_PRdede^^_^^i]id^beiee^_beRZYdRi\ed_^\ieUeUXOiZQVGiiVMViiHV
TU\^VUUQCUMCA]UQUUGI\SQLXXNeMK_LK\CDH^]^_Pc^Q\PJQT[TccPRNNN_
FN``UTLOUPT_MQM]AS_D^`JQNMMXUJMLMUKMMMMLJYL^<^GMHQMML:W<HMQ7
<>@OO:[<5@<@VP>MM=ABK@=>cc^LLMBJT==:GAEF<AFNAMFGHCALEFKCGJHH
H:FQ<B@D=GLCG<V8L@IHQ;EV>DHHLMFHMEA6>78NcGD=5@EMFC69>JR@O<6O
:B:G;MJE\7<=?O:D;8I6:?<65LGB<647>855RZZDJMF@8GF=DA8469;N=GJ<
GFCM?99@8OBMTSSTI:4:>>H<96;5
.
frg:60
clr:6,863
}
{RED
iid:1497
eid:1128922865
seq:
GGTTCGAGACGATCTAGAGATCGTCCGATTCAGCTTGCTATCATTCGAGACTAACTCAGA
GTATGGGTACTTCACTGCTCTCTGGAACTCTCTCCTGGAAAACTCCAAATATAAAATCTC
AAGAGCTTCTCGAGAGATCTTTTTTTTGCGCGTATAAACGGGCTTTTTCCTCTCAAAAAA
AACACCCACCAGCGGGGGGGTGTTGTTTGCCGGAAGAAGAAAAAACCTCTTCTTCTGACG
AAACTGCTGGGTTCAGAGCACAGAAAATGAATACTGCTCTTCTTGTGAGGGATGAGTAAG
TAGGCCACTTCTTGAAGAATTTTTTAACCCCCGCATACTCCGCTCCGCTAATCATGTCAG
TAATGGGAGCGGGGAGCGGGGGGAAGTCGGGGTGTTTTTTTTTTGGAGTAATCAAGATGG
TAACTATTTTTAGGGTGAGCGGATCGCCCTGATCGGTGGGGTTCTTCCCCGCCCCCAACC
CTTTTGGGGAAAACACTACCTGACGTGAGTAATATCCCTGGGGGGAGAGACAAAAAACCC
CCCCCCCCCCCCAAGTGGGGTGGGGGGGCTGGCCCCGCCCTGCAGCTGGGTTCAGAAAAA
AATGAAAAGGGATTTCATCCCAAAAGCCCCCGCTATTTATATAACATGTGGGAAACCCCC
TCTCCTCCATCCAAAGGACTTATAGTTTGCAGGTGGGGGGGGGGGGGGGGGG
.
qlt:
421144445>C9MCA6<G;>>=8MACF<:NE>DBMM85>8U98GA;:7O9A:877GI?9>
98544447554444:;67457486658=:866>44664556576647477:7;5789759
:9>@D@=?H@DBI:RCB?>??>??B;<=<>A=::986778::;;;9:<<@B8744<=B==
>:@<:=;<=:;<@;<@U>:;<D9BB99=D><<<BB;G<BF:=<=;;C=C=B?<IB<?D;N
B<;;CH==@??;8G<=I<9<=;;B;<B<99;@:<KH:=<<<B?999::=@<;;:B:=<=<
:@PIGGDH=<?<<@<:<;;:==CC87:<;<OF<??<=><:F;D:C:?B@;;<=B;B<<G:
G;N<KJ<=TB=KG>C;;<=<H==;=:B9:8H==?NKTYNTSUTGF;==;::8:B89C??<
<=:=<CC=CG<G<G;<>>9=G=?<=F=BK<V;=:8;?>HQB>K<:;DGB9;CB?KM<C<=
<:==;9<<:B8:?=A>>G?=G9??;:9;<<<=;<=KP;B?[GG5>?<@A><?B?=?B@G=
CGC=<<=@A<B8:<545;=89:<>=CCD::9::>?<;:;7:9?=;9;>C=8588C@D==L
C??<D<<F@=:GH@?C@E;C:>=C;?@<>?<8CJ<:<:>H@C=?<;<=<:C==B;:B=LL
?H=;H@B=;;;==GB:=C=;9:===<::B:<L::;=G@@CKAB=<===@=<:
.
frg:313
clr:358,710
}
{RED
iid:1498
eid:1127298191
seq:
CCCGCCCAAAAGAAAAAACCCTGATTCACCATCATCCACCTTTTCCTTGCAATCAGATTT
TAAAACACACCCCTCATATCAACTCAAATCGTGTGGAACCTCTAAATTCGTCAGATGCAA
ACGAGTCACTACACCCCATTATAATATCATCAAAATAAATTTGGCACCCCCCCAAGTCAT
TTTCAAGAGTTTTAGAGAATAAAATGCGATAATGTTTTCCTTCTTGAATCCTTTACTAGT
ATGAAGCCCCCTTTAGCATTCATACCGTGCTCTTGGGGCTTGCTTGAGCCCATAGAGCGC
CTTAAAGAGATTATAAACATGGCTAGGGCAACCACTATCTTCAAAAGCCGCAAGGCGCCA
TGCATATACTTCTTCCTTGATTGGTCCATTGTTTTTTGTACTTTTCACGTCCATTTGATA
CAGCTAAAAGGCCTGGTAAAAATAATAGGCCTTTCGAATACCAATTGACTCAAGACTAGC
TACGACGAGCTTTGGTTCCCCCAAAAATGGAATCTTTGAGTTGGAAGCATCCCTTGGCCA
CCACTAGGGCTTTTGTTCATGATCAACAACCATAGACATCTTGCCTGTGACCAACCACCC
CGTTGGGTTCAACCACGTTTGTAATAGGACTTGGAACCGAATGCCATAATTCTTTCCCTG
TGAAGGTGGA
.
qlt:
113225345744:667:657:5:7;::8:7:78978C<77<I@89<>885:6F>6:7686
6444444455689=768794986767?;7?65948876766676569<D;<P<=B=G==:
CB====;HC@>=CLCP?;?NEL:=<=>;885:758:<B<GKB=9<===CF==<:CG?==M
SJHC?;<K<=G=:=B<E;;9D=?=:::=J?>=:86:==H:<<==<>=>===<ID=<?@<:
:86<5::HCKCA=<:D<:EGM<BBC;>9DBBG<GL?CBGOGK=O?HB;KCDC==9COHNG
O<K:;<8M=?CCGC:6==;B=B9<D<KB??I:?;:;B<=<==;<?A<;::;>C;=<I=>:
7869:=5===II<=BFBKMGBCC<?;:E=<@BKNKK=<CA?C=BBG=<;988EB=<;??=
C<KMP9=?8<C<:BH:<=BKH?;@K:<;;:=@?C;8F9;G<8DB8:==:=F;9=?><=:=
>>=LC9E<?@A@<:=>;:K<FI:;<=;>=::G=G=BGFG@?;B<B@B=FPCGW=@V@?C?
C:C:9?==9C@=BB>=:DC<:=@B>@>?B<:;=<<=<;:F=;C?:9H@<;<>GC=HLJO[
?<LLD;;BGC>9<:>=WRLLI@;<<?;9CI;DC>GLCC;99>PNHD9G>@LC?>;@>:9=
;=P;W?CG<:
.
frg:61
clr:107,668
}
{RED
iid:1499
eid:1127298192
seq:
TGGGTCTGATGAATCAGCTTGATTCGTACGAATTCTCTAGATATCGCTCAATACTGACCA
TTTAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCAGGGAGGCTTTTGACT
TGATCGGCACGTGAAAGGTTCCAATTCTCGCCCTCACGAATGGATAAACATACGGTAGTC
CTCGAAATTTTCTCTATAACCTCCAGAGAAATCAATGCCTGACCAAGATAAGACCTACTG
ATTACTGAAAACAAACAGGCTCTAGACCTTCACCACAACCTTGAATGACTGAAAGCCTAA
CTGGACCTTCAGCTCGACCACCTGATGTCGTTGAGCAAAGGGTTCGAATGGACCGCTGAA
ATGGGATGCCCCAATCGTTTGAGCACTGCCCAAAACCTTCTACCCAATCTTGTGCCCATG
AGGGGACAAATCAGTTGCAGAGGCTTAAAACTATCCTGCAAATTCATGCCTTCGCCGAAC
AGCACTCATTTTACTGTCAAACCTGACTTGGCATGGATAACCACCTGAGGAATGATTGGA
CTCCAGAATAACCTGCTAACAACAATTTTGTGAGTCACGCGCAGATATCTAAAATAGCCG
CAGGAGCTTCTGCCGTTGTCGTCAGAGAAGTATTATTTATACCAGAGCATGTGAAAGCCC
ACCAGGAACACAGTTCCGGTCTGTCGCCTGCAAGCAGGAACTACCACATTAGAGATTCCT
TCTGGAATCTTTCGATTTTCTTTTTGGTTTTTTTTTTGATTTCATTTGGTTTTTTTGTTT
TTTTTTTTTTTTTTTTTTTTT
.
qlt:
421114:DH;E:89A7:\]iWQ;YY?^VNiiNYiii_AU_=_VZi_^eZPdlllllNl[P
lll<@:79<=<;=;GCV[bla<ggYaaYgg\[IkUdkTH:<;:494;:6:;:;;98<HRM
BG==K=GCGPB6;H?T?G:BIC98<G;=G:HC<D=K=G<;8<=8:=;?::<:<;<<:;<8
6;;;;9:::;9:?<;;9E<::=D<9::;C<?<<<<<G::::=<B<:?<<=:=E?BC<<<<
:<;B;:DBD=<9:?<;<:VOEW<C=<8;<GI=C@?@:;:@B<?:?<=:<BG<===;<BHG
KCGI:AB==H<==><@=C<;==><=:68:8:9:F:<=<BEE?<<E:;<?>==<<B<?;;8
9<D;;?;9;8<;L>C@9;<:;NE?BRH@F::;;KQ:;L@=;9;55965957A8;<:9<8E
=<?9<G;C97959:8=><=<=:FC<=<8:;;::=<==::;=;=:;=;?;=<:<<<:;:<;
@<<<<9<=;;==<:9;:8:<F;?=LG=<==9==<=C=<G<<;;H=CH=?:?G:=;<;:88
=9:99=4;9<H<::?:G=?;??9<=;9<:;<=@9:;<=;9=9CG<;@;:9=<;?;AI=;F
??;==@C@DJ;8I><<O>=:::9D9<9:@GB@@==<;:D?;;<8E@I=9<J=>:>:;>C7
HA<<9:>@E77==:9CE>BE?;GIKK:@::M;=A88C==D98@9@<:79A<C@7889789
C<9:8>8=7FGG>;?>>8=8=9858>K@K@>E89:5788549:9@9:96976569<:EVV
ZVNSORPH;@=;DEWXN]A79
.
frg:62
clr:190,735
}
{RED
iid:1500
eid:1127298193
seq:
ACTTCTGATGATATCAGCTTGATTCGTTTTGGTGATCTTCGTTCTTGTCGTCGTCGCGGG
TCCTGCCACCCTCGGCGGGTGGCCCGGCCCTGTGGAAGTGACGCCGAAGCATAACGCACT
CCTCGAGGGTGTGCTTGACGGGCCCCTGATGGTAAGGGCACGGCTCCTTGAGCATCTTGT
CGAAGAGGTTTGCACCTCCGGGGGGCTTCCGAGGGTTCTTGTACTCAGCGGCGGCGACAA
GGTCCGCGTCAGCAGCGTCGCGTTTCGATTGCGACTTCTTCTTGCCTTTCTTCTTGGCGC
CGCGCGGAGCAGACGCCTCGGGAGCCTCTTCCGATGGGCGGCCCTGGGGCTGCTTGTCCT
TTCGGAAGATAGCCTCGACCGCCTCCTGGCCAGAGGCGAACTTGGTGGCGATGTCCATCA
GCTCGCTCGCCCTGGTGGGGGGGTCTTGCGACCCAGCTTGCTCACCAGGTCGCGGCAAGT
GGTGCCGGCGAGGAACGCGCTGATGACATCCGAGTCGGTGATGTTGGGCAGCTCGGTGCG
CTGCTTCGAGAATCGCCGGATGTAGTCCCGGAGCGACTCCCCCGGCTGTTGCCGGCAGCT
TCGAAGGTCCCAGGAATTCCCGGGGCGCACGTATGTGCCCTGGAAATTGCCAGCGAAAGC
CTGGACCAAGTCGTCCCAGTTGGAGATCTGCCCCGGAGGCAGGTGCTCCAACCAGGCGCG
GGCAGTGTCGGAGAGGAACAGTGGGAGGTTACGGATGATGAGGTTGTCGTCGTCCATCCC
ACCCCAGTTGGCAGGCAAGGCGGTAGTCCGCG
.
qlt:
45448<AOHG>:8>89>_lBD::ECV_llllaXlAMllllllllllllllllllllllll
llaakOPAKLLLlllllllllllllllllkllllkkllkllkUglaggTkkkllllllll
lllllllkllllllllllllllllllllklllllllllllllllllllllllllllllll
llllkgglllllllllgkllllllllllllllllllllllllllllllllllllllklll
lllgllllllllllllllllllllllkkllllllllggkkklllllllggkkglllllkl
llllkklllllkllllllllllllll\gkkllllllllllllllllllggllllllllll
llllllllllllllllllllllllggllllllllllllllllllOLglllllllllllll
lllllglllblK<QO=WbbbllbPb[llXeeZllWllllllll]lldellllllllelll
llel_llieii]iie_iiiiiie[iiibeiiiiiiiiidi_WeRiiii_eieiiiYbiee
eiieiie]ibieYi[ViYidNibe]ieiiii[SiiddeZiiZ^diWeiQedNiedQHWei
d[OeXG[GVQSUZiYSUiRVVeOJH_e\XWX[U]iXe\UNMRI^^RNc^P\KW_N_cXWR
^N^KPL[H\_M[LMYc]HMVMQ``LROMMYE[YOCYO=^NMJ[>YSRK^ENYTILMTVSQ
MVQLLEYL@A8^7WA[CMEHLIXVNTBK=EKDICOMDGBHRCC:FLGMCCV>DSS>HHON
CATPCBAGB9N?<MHJHLWNFMWAK>CPM944
.
frg:63
clr:5,808
}
{RED
iid:1501
eid:1128922866
seq:
CGATCTAGAGATTCGTCTTGATTAGTACAACCAAATATTATGTCATCGACATAAATTTGG
ACACTAATAGGTCACCATCACAAGTCTTAGTGAAAAGAGTTGGATCAGCTTTCCCAACCT
TGAAAGCATTAGCAAGTAGGAAATCTCTAAGGCATTCATACCATGCTCTTGGGGCTTGCT
TAAGTCCATAGAGCGCCTTAGAGAGCTTACACACATGGTCGGGATACCGTTCATCCTCAA
ATCCAGGGGGTTGCTCCACGTACACCTCCTCCTTGATTGGCCCGTTGAGGAAAGCGCTCT
TCACATCCATTTGGAACAACCTGAAAGAGTGGTGAGCGGCATAGGCTAATAATATTCTAA
TGGACTCTAGCCTAGCCACATGAGCAAAAGTTTCCTCGAAATCCAAACCTGCGACTTGGG
CATAACCTTTTGCCACAAGTCGAGCCTTGTTCCTTGTCACCACCACGTGCTCGTCTTGCT
TGTTGCGGAACACCCACTTGGTTCCCACAACATTTTGCTTGGGACGTGGCACCAGGCTCC
AAACTTTATTCCTCTTGAAGTTGTTGAGCTCTTCCTGCATGGCCAACACCCAGTCCGGAT
CTAGCAAGGCCTCTTCTACCCTGAAAGGCTTAATAAGAAGAGACAAACGAGTAATGCTCA
CAAAAATTAGCTAATCTAGAGCGAGTGATACTCCCTTGCTATATCACCCAAATCTGTCGA
CGGATGATCTTTGATCGTCGCTCGACTGAGTAAGGACAGGGTGCTTCTCTCATACTGTCT
CTGGCTCCCTTGTCAACACCTCTCTTGAGACTGTCATCATCTGGATGGGATGCACATGTT
GAGAAAGT
.
qlt:
5338?;E89778NNII\U^^>9;FCOUQCIVH:Y^e[WV^GMQGDdieeXMe_iii_794
45677885:8?COWe[PbMHWXlllll_YlllllU_ll::::7:;68<:FElllVHllll
llgglllllg_llllllllllllllllllllllllllWlll__lllllllllggllllll
lllllll[llllllllllllllllllllllllllllllllllllllllllblllllll[l
llll_llllllllllllelllllelllllllllllZWllYZllllllllU_lllllllll
libiiiic]iiiiii_e_iiiiiiiieie_i__iiieiebeii[eeeiieieiieiieii
eidibiieieeiei]i[deeiiibdeiiiddiiiieieiiVdidXiedieieedQeb^GV
d\e_^VVeiieiIiTd]eiee\eeLiUViXWVVP_iL_Nd]TeUSe_QiUXYXOeYQ\LY
Ue@YTM_M`\NU[QWMNPYPVK_S^WN[H_VMYccULISDQc\VGVLMH8NM\LMOMNMY
I^YKM^MOEMMSNSMLMFYLLJYBJKQEMMPJRKKF[?LMMI>@HJJLVcMLHDQQBGLF
LMOGMG?LQ>BER@FQJL=VNDSHcEEN>C?CE76@<VJ5<5@<9cKH?V=A?@9I;HF;
<6\W\H?=D:JQA@BQCM7H=?BC:9545>;:9M;;;Q:M36:LM=:O:9UI8?8@3;;K
5:<39D<C@3C;;A5A;:E75::F69J@:4:455:AE;4;>456E988<8B58E8@;9;A
8?BB55@<A44<3974359>688348:5:BA<@84783565835346:5745<7E97>49
3345A631
.
frg:63
clr:4,788
}
{RED
iid:1502
eid:1127298194
seq:
TGTTCTGATGAATCAGCTTGATTCGTCTATGAACATATTCAATACAAAATTCATTGAGCT
CTGCAGCCCATTTTCCAATCCTTCCAGTAGCTTCTCGATTCCTCATAATATCCTTCAGAG
GTTGTGATGAAGGAACAATTATGTTGTAAGCTTGGAAATAGTGTCGAAGCTTCCTGGAGG
CCATCAAGACAGCATACAATACCTTCTCCAGTTCTGTATAATTTTTCTTTGACAAACTAA
GAACCTCAGATACAAAATATATTGGGGCCTGTCTCTTGACTTGACCATCAAGCTTCTCCT
GGACAAGCGCTGCACTTACCGCTGAGTGCGAAGCTGCCACATATAATAACAAAGGAGCCC
CTGGCATTGGTGGAGTCAATGTTGTTAGATCTATTAAATACTGTTTTAGCTCTTCAAAGG
CCTTCTGTTGGATTGGTCCCCATTGAAAGACTTCGGCTGACTTCAGCACTTCGAAGAATG
GTAAGTTTCTCTCTGCTGATCTGGATATGAATCTATTGAGAGATGCCAATCTTCCTGTCA
ATCTTTGAGCCCCCTTCTTTGTAGTTGGTGGCTCCATCCGAAGTATAGCTTCATTTTACT
GATTAGCTTCATCCCCTTGTGAAACAGCATCAGAAATTTCCCCTCTCCTCGAGACGCATT
TTTCTGATTTACTCAGGCCAGCTGGCTGAACCTGCCGAGTCTCTGCCAATCAGCCAAAGA
TTCCTCTGCTTCGGGC
.
qlt:
4344:8AQ@F:8;967X_?G:8=BS[l_b_l_l[_llllVSllllllllggkklllg\kl
llkW;<BEC@JL\llkVlllllllkalgkllllllkkllllllklldSkkkdlllkklll
lllllllklllkllllllllllllllllllllllllllllllllllllllllllkg\kll
lllllllllllkllllllllllllllllllllllllllllllllkkkllllllkllllll
llllllllglllllllllllllllgglllllllllllllllllllllllellllllllll
llll_lllllllllll_lliiiiieViiiiiieiiiiieieiii_ieiidViidii]ii_
_ediebdei[biiibeeVieibiiVeebieibedd^Y^eeeiiRiiTdXdee_e\GieYi
PeW_eYiLW^PP>O^NN_WWYNP]]\c_M`MM[`;PMN_WLRMOLUYMSM[[L^^G[MHc
^MYTRM^[[M^MYL[NVNMLNMWKMJLGMMMM[TMNIXRLTBMCXD@=?KVKMMLLVEOL
DLVQcNPVFVPLI:DCEM\DQAQ?@8EM:@J<NDGFFHDAGG@GRKPGQE?C84OZIF<6
58;<M9D>=MF5IZRA>:656@N7443>@;A94CNC=N<=IK>>8?635D9G5B6:D?GN
SS>87B;5N796A><48=@<;=G56A8?5=345=395;4389F3@653369C:94A5223
58363?4A857>6474
.
frg:64
clr:6,687
}
{RED
iid:1503
eid:1128922867
seq:
GCGATTCTAGAGATTCGTCACATTTCTTAGGAGGGGCATTAAGTTTGACATTGCCTCCTT
GTTGGAAGCCAATGCCATCCTTGATGCCAGGGCGTCTCCCACTATAGAGCATACTTCTAG
CAAATTTAAATTTTTCATTTTCTAAGTTATGCTCGGCAATCTTAGCATCTAGTTTTGCTA
TATGATCATTTTGTTGTTTAATTAAAGTCATGTGATCATGAATAGCATTAACATCAACAT
CTCTACATCTAATACAAATAGAAGTGTGCTCAACGGTAGATGTAGAGGATTTGCAATATT
TTAATTCTACAACCTTAGCATGCAATATATCATTTTTAGTTCTAAGGTCGGAAATAGTAG
CATTGCAAACATCAATATCCTTAGCCTTAGCAAGCAATTTTTCATTCTCAATCCTAAGGC
TAGCAAGAGATATGTTCAATTCTTCAATCTTAGCAAGCAAATCATCATTATTATTCTTAA
GATTGGGAATTGAAATATCACAAACATTTGAATCAACCTTAGCTAATAAATTAGCATTTT
CATTTCTAAGGTTGTCGATTGTCTCATGGCAAGCGCTTATCTCACTAGATAATTTTCACA
TTTTTCAACTTCTAGAGCATAAGCATTTTTAATTTTAACATGCTTTTTGTTTTCCTTGAT
TAGGAAGTCCTCTTGGGAGTCCAAGAGATCATCCTTCTCATGGATGGCACTAATTAATTC
ATTTAATTTCTCCTTTTGTGCATGTTTAAGTTGGCAAAAGAGTGCGCAGTATCTTCTCAT
CACTAGCATTTCATCACTAGAGATTCATATCTAGTGGAGGATTAGATTAACTTCTTCTTT
TTGCG
.
qlt:
8766669;G>9988SbQPB;98<DiZ[RZlNbXlllOSV_e__lll_g[Vlllllll<?>
E=556<:YSGL]dllk[lkgklkgkkkkkllllllllkkkaKJKNG=klllllllllkkl
kllkggglllkkkkkkkkllkkllllkllllllllllllllgkllllllkllkgklllll
lllllllllggklllllllllkklllllllllllllllllllllllllkkllllllllll
llllllllllllkklllllllllllllllllllllllllllllllkkklklllllllllk
\glllklllllllglllllllllllllllllllgllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllbblllllllellllllllll
llllllllllWlllllliiiiiiiieiiiiiiiiiiiieiiiieiieiiieeieiiieii
_iWiiiiidS__iiiei_ieeeiiieiiii[[eiT^i[idiZid^ibiiedWddiediie
dUdieeZ_eJ^UeiUedeTiiXe__UOWWUY\eeeeiSeUeie\_P\J\O^`Occ_\MWP
OcccONFVP\\_JVMcM\NMMcM\NYcccQMLMccSLNIKMYMN^^^U^C^cMLQHGWMC
MNO>TPLGLVLMJGNYOP<GLG<JJY:LIMFMSSGMMLLB?DJ>B^OALRRFK<RDI=HJ
DEcL@?GcIP==NHc\G@<8@OCV>RADJ?EKGI@N\\L;M:=I89>SLC6?P6@G4;9E
J:6<MBIIOZNCADF?;AMBGJ;9AA;;;AFBE@8D286>A>JD8E@I57E5553475FF
L<731
.
frg:64
clr:7,841
}
{RED
iid:1504
eid:1128922868
seq:
TACGATCTAGAGATTCGTCGCATTTTTCTTGAGATTTGTCAGTAGTTTTCTCAAATCCGA
ATTTTGCTGAGCTTCGGCTTCAAGTTTTGCATTGAGATCTTGTTTTTCCCGTTCGAACTG
CTCAGACTGGCGGAGAAGCTTTGTGTTCAGTTCTGATATTTTTGCTTCAGCTTCCGCCAG
TAAACCTTCGGCTGCCTGGAGCTCAAAGTTCTTTTTCTCAAAAGCATCTGATTGCTCCTT
TATTTTGTTTTCCAAATTTCCAATTATAACTTCATGCTTTTTATCTTCAAGATCCTTCTA
TAGTGTCACCTAAATGTCGACGGCCAGGCGGCCGCCAGGCCTACCCACTAGTCAATTCGG
GAGGATCGAAACGGCAGATCGCAAAAAACAGTACATACAGAAGGAGACATGAACATGAAC
ATCAAAAAAATTGTAAAACAAGCCACAGTTCTGACTTTTACGACTGCACTTCTGGCAGGA
GGAGCGACTCAAGCCTTCGCGAAAGAAAATAACCAAAAAGCATACAAAGAAACGTACGGC
GTCTCTCATATTACACGCCATGATATGCTGCAGATCCCTAAACAGCAGCAAAACGAAAAA
TACCAAGTGCCTCAATTCGATCAATCAACGATTAAAAATATTGAGTCTGCAAAAGGACTT
GATGTGTGGGACAGCTGGCCGCTGCAAAACGCTGACGGAACAGTAGCTGAATACACGGCT
ATCACGTTGTGTTTGCTCTTGCGGGAGCCCGAAAGACGCTGATGACCATCATCTACATGT
TTTATCAAAGTCGGCGACACTCAATCGACAGCTGGAAAACGCGGGCCGTGG
.
qlt:
445669J999=>>9KZITeRGNFiiii`Z?=68H8llVQMB[ellllllllVE_gllgY\
Tglll_glllllllll_lllkLlllllllkllllllllllllllllllllllllllllll
llkkklllllllllklllllllllllllklllllllllllllllllllklllllllllkl
klgklllllllllllklllllllllllkkklklllllllklkllllllllllllkkkgkk
lllllllllgllldlllllllglllllgggllldllllllllllllllgllllg\gllll
lllllllgllllllllllllllllllllllllllllllllllllllllllllllllllll
llll_Wllllllllleellllllllllllldellelllbdlllllelldlllelelllll
eiiieiiiieeiieiiiieeeee_]eeeiiieeieeeeeee]ieeieVeeeiiiib]ViY
QiiU_ee[eebNe\S[ee]^diiedi^^[ee][YNdieeb^WeieTdieie^idee^_ie
ideieiZUU\ZUeeUee^CG]i\UY[eXe\XXI\OSe\QQe_YNPOVOWO``\OLY^^^N
NOMREVOJ]EWNMJM_N\CMWW@OMVLMNLTBMTcc^VMTLPTTFNMKTKMY^WK[OJNH
TLI[IYI^TIKDMLLLJN@=DLRLHAPPQLEKMKS@LDHPEKNJM>JJDFQ?LBB9>I?J
LLGGEAFDD7A@\@@>KG8?C;CO9G79B@JKSC9D;BIFCN@ME8:<D<M7;?>>9FN9
TTDD<CGZ?65GA7;=J6M?B=:>;FDD=>CAIABDTII:434>44A7455
.
frg:314
clr:6,290
}
{RED
iid:1505
eid:1127298195
seq:
CAGCATCTGATGAATCAGCTTGATTCGACGAATTCTCTATATATCGCTCATACTGACCAT
TTTACTCCCCCCTCATATAATATAAAATCGCTTACATGGAAAGAAGGACGATGTAACGAG
GACTCCCCCCTAAATGAAATCGAAAAAATTTGGCGACAATCTAGAGATTTTCAGAATTTT
TGAGAGAAGAAGCGAAAATGAGCGGTAATCTACGGGAAATTACTTGCTAGAAGCCGCGAT
TAGCATTCAAAATGGACGCTGATGGCTTGCATGAGCCTGGGAGCGCGATAAAGAGTTTAT
AGACGGGGCTAGGGCGACCGAATCTTGGAAAGCCCGATGCGCCAGACATGATTCTGATCC
TTCAAAAGGTATTGATGCATATGCTTTTCACATGATTTAACAAGCTTAACTGGCTGATGG
AATTAATGCCTCTTTCGACCATCAATTGACTCTCCCACTCCTGACGACGCTTGGTCACTC
CAAAATGAAACCCTTGAGAAAACAGCATAGGAGGTACACTAATAAAAGCCTGATTCATTA
TAAAAATCCATGAAGACTTGCTAGTGATCAAGCACCTGTTGCGTTCCAATATGTTTGTAA
TTGGT
.
qlt:
332444<:68>;74;::9Ki\DRIVI7SD<N;TeeX[G<89_8T[FVXOKE8AWQM?C;T
[C64:9744558<787;8988756>?=:=:;6:;:884447=:5;;987=?@L<:FB=U=
:=8=<@>4=:<<7<;<?:=<<5>7<::;<<86=<F=<<;===:<88=8==8<B<8?7<E=
=BFF?=O<@;<=<:=B=H:MS9;<:B=;?=8:<=<<K;<BB;:<<F<=;=A:E:C=GB?:
===;<H=H=9D;9B:=4=D9:B:<:<<:<9:=:8;<<8D8;:<?B88B85;9;B:;><8<
=:F=8G?J<<P8BH?<F<858:::8;H=;DB?<<=BJ<=AETK98P<<BB5;<:?=K<9=
<96<99;<<8K=<IA9B;;9:<:98:<858896;E:;;8A:;9A<=;<FC?J==ETK:<<
K=<<;F68B<FF?=:>Bk<GP<?I=89:9;:9<:<:<;<<<<GC=BJ<B=;<KB<:9B97
<;=:8<G5:O=B<<8;<KG==;:E;:=>:8;<:D:;:98;C??TH:=8877GD;;C<::;
::?<=A;<;::;I:B::9<66:8>=E9<DA=H=BKS:;=FK;58=<6:::99H;;B@=G:
<BD88
.
frg:65
clr:63,188
}
{RED
iid:1506
eid:1127298196
seq:
GGAAAGTGTCTGATGATATCAGCTTGAATTCGTTCAATCCTGAAAATGCTTCGCAAAATC
TTATTCATTTACCTTTGACTATTCGTAAAAGAACTTTGAAGAGGATTTACAAAAGAATTT
GCAAAAACAAAACATGTGGTGCAAGCGTGGTCCAAAATGTTAAAAATGAAGAAACAATCC
ATGCATATCTTATAAGTATTTATATTGGCTCAATTCCAAGCAACCTTTGCACTTACATTA
TGCAAACTAGTTCAATTATGCACTTCTATATTTGCTTTGGTTTGTGTTGGCATCAATCAC
CAAAAAGGGGGAGATTGAAAGGGAATTAGGCTTACACCTAGTTCCTAAATAATTTTGGTG
GTTGAATTGCCCAACACAAATAATTGGACTAACTAGTTTACTCTAGTGTATAAGTTATAC
AGGTGCCAAAGGTTCACACTTAGCTAATAAAAAGACCAAGAATTGGGTTCAACAAAGGAG
CAAAGGGATAACCGAAGTGTGCCCTGGTCTGGCGCACCAGACTGTCCGGTGTGCCACCGG
ACAGTGTCCGGTGCACCAGGGGACTTCACGCTGAACTCCTCACCTTCGGGAAAATCCAGA
GGCGCTCCGCTATAATTCACCGGACTGTCCGGTGTACACCGGACAGTGTCCGGTGCCCTA
GGGAAGAGCGGCTCTGGAACTCGCCAGCTTCGGGAATTTGCTCCGCTATAATTCATCGGA
CATGTCCGGTGTACACCGGACTGTCCGGTGAGCAGCGGAGCAACGGCTACTTCGCGCCAA
CGGTCACCTGCATGGGCATTTTATTCACGCCAGAAGC
.
qlt:
8557565547777857755875;D::7868:;>>=9:FOE?F<;DIFaVad[H[LH[TS[
SM[]WPDWGL=C=C=B<=<<:=LO==OLLWBaWTd[[NUWGkNUTQaWLWHLGH=SKW[T
UHCGLKBORaVWW[dk\aKMdTO][[VTdOKTPUO]Wakd\kdkYa]kdYFkdk][V\]]
[dkaWkkda]Wd[ddWdkkkkka]ddk]]kkdakkkkWdadadkkaa]dPJ[kklkkkkk
kkkaWkdkdK]dadakkkkd[W[aaY\[kdkllk\kkkk\dkkkdkkkkWOTk[W[dd[W
TKKMN[[kkkdlaldadWWW[kdkkddkWk\kddkakddkQ]dkkkkkdkkkkkkkkdTg
TQ[]d[dkk[dbddddd]]ka[aYdkQd[[[[akkMTkdkadka[S[ldlllldggggdg
ddgagddadddldglggdggggUglggbgbbbb[lgg[UKgTaWlbbgb_Uaa[baUbeO
[[[b]eb__blelbleZblXlbelelW]dde_O]]bXd[Hlbelbee]ePe]e]dbZ]XV
_V]]did]]]dReed__WE]d_Z__edZ_[eedidTdd___VdeeeeVdbiedXVebbNi
Vedeeeb^[eedebdUibUV_XWdWUeZWWWeOeNVQCHRdW[TXX\iUQQU]KdQ[SMQ
DeQ[\NiN\eOHXUXXX_OR`_P_NEX_XM[BTMNA>TM^NNXVKQWRMGMKWRLN]@L`
AKM[ROYBI;YALMMMWPLPDMNLOMBYBT^8;9KJIMO8JJJK<Y@MLLDGMDMNNX==
M<QMOJABCCD<69GA=8@OV8:=6544:69648444
.
frg:66
clr:35,803
}
{RED
iid:1507
eid:1128922869
seq:
CGAGCGTTTTCTAGAGATTCGACATGATTCCTTGCGGTCCTGGCATCTTCAGTATCATGT
AGGTATAGTGCGGGATGGCCATGAATTTGGCTAGCCCCGGCCTTCCGATGATGGTGTTGT
ACCCGCAGTCGAAGTTCGCCACCTCGAACCTCAGGAACTCGGTTCTGTAGTTATCCGGAG
TCTCGAAGGTGACCGGCATGTAAATGTGGCCCAGCGGGTATTCCCCTTCCGTCGGCACGA
TGCCGAAGAAAGGAGTGTCTGACTCGTGGAGCTCTTTGAGGTGAACTCCCAAGCCTTGGA
GCGTACGGGGGAAGGTGACGTTGATGCTGCTCCCCCCGTCCACTAGCACCTTCTTTACCC
GGCTCTCTCGGATCACCGGATCGACGAGGAGCGGGTATTTGCCTGGATGGTCAAAGTTGA
GCCATTGATCCTCCCGAGTGAAAGTGATTGGGTGCTCCGACCACCGGTATGGGGCGGGAG
GGCCGGTGGTCGCCACCAGTATCTGGCGGTCGTTGAGCTTTTGTTGTCTTTTGTTCTCCT
GCGACCCATGTCCGCCGAAGATGACGTTGACCTCCCTGTCAACGCGCGGGAAAGCTCCTC
CTCCTCCTCCCTCCTCCGGCTGATGGGGCTGTCGTGGTTCACCTGGTCCTCCCCTCGCGG
AGGAGGTGGTAGGGGTTGGAAGGGTCGGCCATGCCCGACGGATGCTTGAAATCCCGGCAG
TTGCGAAGAGTGTGCGCATGTCTTATGGTACGGGTACTGGGCGTCGAGGATGTCGTCATC
GTGCGCTCGCCTTCCTCGAGCCTCCTCGGGCCGAGAGTGATGTCGCAGCGTGAACTCTTC
CCAAGCCTCTTCTCCAAGGTTGTCGATGCTGGTTGCTTCCCGTCTGTGCGAG
.
qlt:
44545555:657745668L<8975>eFNbZ^H__e_RVbZ_llWSelllV@bUe_[Mllg
URYSM[F:@A:::87<AJ@UPYYUTddllgl[VYN[Tallklllkkdkdkddkdakddld
]ddddkkkklkggklllllkkllllkllkllka[lkTWkaTTkklllllkkkklkkklll
llllkkkdlkkkakkk[allkdadklklkdkkk[klkkgllllgggglgdddgaggdgdl
llggQgdEgddglldglgllgldgggglblglllllgglYlgllggllggYPOUabbl[g
aggbggblbggllllgllllllbl_llllblleeeeldbe__ellb[b_bbelllleebb
be]llleeebblleX[_WW_ellll]lbllZ_e__beeiii__eibXeiiee]_ee_dbe
N__]_ee_ed^b]]ZNebeiedd_deYVei]WdeZe]eWUKUQeeee]deiebb[e_UeL
^_TdZebiePdV_YNdbNVbUeeeVRMbVVbVVebdGbede^\NddU\SiieeSYZ_RX`
dUOQ>\GCUe_YXPPXAYV>MFU\ORXKMR:\\NSTM]?\OORON`R`OGN_PLQ`WNTQ
NTHDKDDHP\HTOO[IEGODMLM>cYYOKMXESR@M@8<DFLNJ>G9GGMJMNEM?@D>@
WP<JQ?BNGGYIcTABKFI>P>\KRRGBGGAOKGMD9J;>:<5EACL:CcQLHL>:GEOL
?BD=D;>5=67D8S?@:CIH?R<AFLJM@I;K\>9:>GLNA=B685B9C>4:7J66N5ED
8?J=B8C==;<<8D<897@G><<98>558444654675;44;23419:G;9<57:545H7
>86<>7556:635?D4:34<<64<875=246677336659897714144311
.
frg:66
clr:18,805
}
{RED
iid:1508
eid:1127298197
seq:
TGCTTCTGATGAATCAGCTTGATTCGTTCCATCGCGGCGTTTTTCGCCTTTGCATGGATC
ATGATCCACTCAGTAAAAGTTCATTTTGCCGAGCAGGATATTAATGATTTAAAAGAGATT
AGCGCCACCCTTGAACGGGTACTAAATCACCCTGACGAAACGCAAGCCCGACGCTTAATG
ACGCTGGAAGATATCGTCAGTGGTTATTCCAATGTGTTGATTTCCCTGGCAGATAGTCAG
GGTAAAACGGTGTATCACTCCCCCGGTGCGCCGGATATCCGCGAGTTTACGCGTGACGCC
ATACCCGATAAAGACGCTCAGGGTGGCGAGGTGTATCTCCTTTCCGGCCCGACGATGATG
ATGCCAGGCCACGGTCACGGGCATATGGAACACAGCAACTGGCGGATGATTAACTTGCCG
GTTGGCCCGTTGGTGGACGGCAAACCGATTTATACGCTCTACATCGCGCTTTCGATCGAT
TTTCATCTTCATTACATAAATGATTTGATGAATAAACTTATTATGACCGCATCGGTAATC
AGCATCCTGATCGTCTTTATCGTACTGTTGGCGGTACATAAAGGTCACGCGCCGATCCGC
AGCGTCAGCCGTCAAATCCAGAATATTACCTCGAAAGGATCTCGACGTTCGCCTCGACCC
GCAGACCGTGCCCATTGAGCTGGAACAGCTGGTACTGTCGTTCAACCATATGATCGAGCG
TTATTGAGGATGTCTTTACCCGCCAGTCCAATTTCTCAGCGGATATCGCTCACGAAATTC
GCACACCAATTACGAATCTCATAAC
.
qlt:
44444=;BR>E98<><@_lllgSllalllP:lllllllllllllkklllkllllllg\kk
llka[F?==K?<MllklkkllklllllkkllllllllkllllllklkWLLJLRPUkkgkl
lllkklllllkklkllllllllllllllllllllklllllllllllllllllllllllll
lllllkgklkkllllllllllllllllllllklllllllllllllkklllllllllllll
klllllllllllllllkll\gkklllllllllllklllllllllllllllllllllllll
lllllllllllkllkllllllk\gllllllllllllkg\\gkllllllllllllllkgkl
lklllllllkllllllllllllllllllllllllllllllllllllklllllllllllll
llklllllkklllllllllllllllllllllllllllllllllllllllllllllllllg
llllglllllllllllllll_l__llll_lllllllllllllll_lllllllllllll_l
llllllllllllllllZleelU]llll]iiZ[iiVdedeeiiiZTideieieiie_eide
i]iieiZeeiieiVYdeiYRSiYZYKeebiiiV^YYB5=K\eidiWeeeedZedi\XHii
```KYDi\XiLiYMe]i\MNQ\IORPO\NYOUL\ST^L`RM_MLOMQL_MM[MG[>WKMQ
57HLEWMMMMDTIYMcTQMYWYMT>MMMN>MLcYSSQDBNABQCGMMKMMGJMDRcFHEF
@HFKC<=;BPLFJ=P8B;9765675
.
frg:67
clr:5,797
}
{RED
iid:1509
eid:1128922870
seq:
GCGGATCTAGAGATTCGTCACTTTGCCACTGACGTTGCTCCGCCAGCGGTAAGGGTTTCG
ATAAAATCGCCACCTTCGCCGGCGTTGCCAGGTAAGGATGACTTTCCAGCAGAGACGCCA
GTCGCGCCATTAAAGTCTGGCTGACACGCGCATCGCCCTGGAAAGGATAGCGTTGCAGCA
ATAAATCGGCAGCTTCGCGTGACTGCTCGTTCTGCATCAGTTGCCAGGTTAGTTGATCCA
GGCGGGTAAGATTTGCCGGTTCTTGCTGATACAGCAATCGTGCCAGACGCAGAGCTTCAG
CCTTGTTACGGGTCGCCACGCTGACAGCATAACGCTCCTCAAGCATTTCATTGGCGGGGA
GGGTGGCGAGCAGTTTTTGCGCTGCGTCGTACTGACCTTCTTTTAACAGCACCGGTAGCG
TCGCGCCAACAACATACTGGCGGTTGTCGGCAAACTGTACCGTATAATTCGCCAACGCCT
GAACGGGGTTAGCGCTGTATTTAGATAACAGATAGAGCCAACTTTTCTCTTGTGCGTCCG
TGGTAAATAGTGGCTTATTTTCAATGAGATAATGCTGGAGGCGTGCTTTTTCGCCACGAT
AAGCCAGCGCGGTCGCGTAAGTAATATATGACTGAGGATCGGTGAGATCCCCTGTGATTG
CAGTGCCAGGATCCGATCGTCCAGCTGCCCGGCAGAAGCACGTCAAACCACTGACGGCGT
TCTGCGCGCTATGTGTCTGCTGGCGTGCTCATTGATAGCGTATCTGCTGGGACATTGTTC
AGTAGATGCCCGTGCAGCAGATCGTCGCAGCGTTTTTCTTCGGCGATGCAGCAACGTCGC
ATCGTTCAGTTGCGCTTCTG
.
qlt:
87567:9;><;:;8RXVZF>Fiiei_<7RilVQllllllllllVBllll_llll_llllY
llggggllllaOllllllllllllllllkkllllllllklllllllk[lllllllllllk
llllllllkllkllllllllllllllllllllllllllllllllllllllllllllllll
llklllllklllllllllllllllllllllllllllllllllllllllllllllllllll
lllllggllglllllllllllllllllllllllllllllllllllllllllblllgllgb
lllllllllllllllllllllllllllllllllllllUllllblllllllllllllllll
llldlllllllllll_iiiiiiiiiiiieiiiiie_Z_iii_U_iie_iiiiiiiiiiii
iieiie^Q__Wiieiiii_Yei^[iieied]eiiiiiee[Yi]iee_RiebdYNV^deie
ide_ii^^\^ee^de^iXXVi]eUeTPe_XSiNe\iXXYG\UiiiU]_`P]iRXOYWP__
N\\M`cWW\NN\IPPF]LccRM@TM`\^MRMMMWEMV^PGUCMHYLM^^^MSNMWHYM[V
R^KOTMSTMMTYFSLMMHHNLOKMMMLKMMNJLM:=7BEOHT=D@5=ELPPDEV@KMCDM
?HICT<DDD@DF@G>OOOLCACHRLMIEOF@I:T<FL>JEFFBCAPGF=9@CQL9I<=BD
8EA?O7>>=H84Q67G8>J><B>HH>F5O7;?@;39@?MM;E<D<FF<8T9?E8C757<9
5@6@7BFE5L<<G<?G8;;;K?:;3657=5;6@SSH6D7B>=?65;6DC@8?DD9:=;7=
;4479B9=4<:943453443
.
frg:67
clr:7,840
}
{RED
iid:1510
eid:1127298198
seq:
TGGGTCTGATGATATCAGCTTGATTCGTTACAACCCTTAAGTTAGCGCTTATGGGGTCTC
CCCCCTCCTTAGCCCCCGAGGGAGGGTCGGGCTTTGCCGAGGCTAGGCCGACCCTTCCTT
GACGACTAAACTTTGCGCAGGTGCGAGGTATATGGACAACTTGGAAACATCTTAAGGGTA
GAAGCGACGTAGCTGTTTGATGTTCCAAGCGTTGCCGTAGATCTCGCCTTGATTGTTGGC
CAGCTTGTACGTTCCGAGCTTCAGAACTTTGGCGATGATGAATGGCCCTTCCCAGGGGGG
CGTGAGCTTGTGCCTCCCTCGGGCGTGTAACGCCCCGAATTTTTGCAGTTGAATTTTTTC
TTTTCTTTACTCGCCAAAATTCGGGCGTTACCTTTTCTTTTTCTTTTCCCCTCGCTAAAC
CTTGACCTTTTCCAAAGTTTTAGCGGGATTCGGTTTGGAATTCCCGTGTAATGAAAAACC
CTAAATACTTTATGTTGTTTGATGCACCATGCCGAACCTTGCATTTCTTTTGATTGCTTT
GAAAGTGCAAATGCATTCATGTAGAAAGATCGGATTTCGAAAATGAGGAGAAGATCTTTT
CTTTCTTTTTCTCTCTCTTTCTCTCTCCTCTTTTTCTCTCTCTCCCGCGCCGTGGGCCGA
CCCCGGCCGGCCCAGCCGCCCCTTGCGCCCCCTTTTGGGCCCAAAAAGGCCCAACCGCCC
CCCCCCCCCCCCCCACCTCCCCTGTTTTCCCCAATTCTCTCTCGCCTC
.
qlt:
4343488;><B<8:D969?i>D66:iR__CLCLe_bbNUKbb_[[[__g_g_llgggldg
gg[a;88:;@:<GL]STSkklkkklkW]SNTWlkkkdkdl[k]a\Ud]bak]dkdka]]d
kka]l[kdd]kkkkk\Na[Pkklkak[k]a\kkkkkkdkdkkkWd]]YWaS[kkkklkak
[kk[kakdYdgHkllkkkdk[kaa[\[[kdddkkkkkdgOllkkk\akdkkkkklkklkk
kkadkkl]dd[aa]aKkkkkkkVKlddkkkgkaalkkl[ak[akaQda]kdddd]kllll
dkdld[adakakkkddk[kkkkdakYkYadY[[dddadd[d[[ggddY[dYdUUaY[ddd
adddd[ddaddgUdd[gg[abaPagSYUU[aa[baababbabaUgbgbabbgaJUUR[UU
aabg[MP[[[R[TS][SO[[S_F_bebU[[PCTNbZbPbb_dbZVSRbHMMOVO_]__Vd
d[b]WZb]Vb[[W_[NWGLJ[d[ieHKPCO]R[E]bV_]RZKHQQbbVb]]__T__S]__
_^[]VU_VNKb]iZG_bb[W^]U:UULVVV_^RVKRUUFKNOVQeeNbeTWeORHXU_NQ
UNUTXFMPJMeR]NTOSKS]VRYQVPSNLSFCD?MWMPNXR_IP_`Y`QNMD>PCFD[MV
HNMJ@M>VMM8OMHFJMJFWNMMLYKMKKIJJLVLOMOI;?C::;AEHL9JEC9<=C>AE
EADEGHBEA>>=FB9?FE==CLL<DF=;::8?L@5EDBFJJD?6<855
.
frg:68
clr:7,763
}
{RED
iid:1511
eid:1128922871
seq:
TAGCGAATCTAGAGATTCGTCGCCTGAGCAGTGGTTGCAATGCTGACAACCTGGGGGGGG
GGTTTGGTGTGTAGAGCAAGGGTGAGTACACATCAACATACTCATCAAGTATCCTGTTTG
GCTGTAGTGGACTAGCTTTATGTGGGGATAAGTCAAGCAGTTGCTTTTAGTTGGTCAGGT
TATTACTTACTAGTAGAAAGCCAGGTTTTAACATTAACCCAAGTTATTAGCCCAATGTAT
CCTTTCCAAACGGAAAGAATACCACTTACCAATACCATAATCGTAATCAGAACCATCAAT
CTCATCGCCACCTGTACCAAAGTATCTCTGATCAAGTATCACTAATCTCTGGAGCTCCCT
TGGCCGCTCATAACCGCGAGCACGACTGATATATCAGTTTCATAACACTCTGCAGAGGTT
GTGCACTTTACCCACAAGCCGTGATTCCCTCTCTGGCCCGGGCTTGCAAGACCCTTATTC
ACTCCCGAGGTGAATGGCCAGGGATTCACTATGAAGCCTTTACAAAGATTCCCCGGGGCT
GTAGCCACCCGTTAGGTTTCCTAAATGTACCGCACTCCTCCCCAAGGGACAAATCAACCT
TGGCAGAGCGAGCCGCATACACCGAGCCCCATTGACGGCACGACGGCTAAGCGAACTACA
CCCCGGTTCCTCTAATTATTCAGCTAAGGCACCCCATTCCACCCTCATGGTTGCACTGTT
TTCCCGGGCGGTCATCCATTGAACAGGTCCTTACGGAGAGGCACTCGAGAAACGCTCGAG
TCCTCTTAAATGCCACAGTATAATCATCATAAGAATGGGAAAACAGCGTATCATAGATAC
CACATCATGTTCATTGATTAAA
.
qlt:
454468;77;?<B;;:SbERdNbeXiT?KK_XlSSl[JH_llelll[R_lllgglgglll
llla[TLJgYk[k[llklllkllllllllklklkllkkllllkalkkklllllllllkll
lllllllllllllkklllllllllllllllllllllllllllllllllllllllllllll
llgklllllllllllllllllkklllllllllllllklllkkllllllldlkkllllkkk
\gklllkklllllllklllllllllllllllllllkllllllkklllllkllllllllll
lllglldglglgllllllllllllllllllllllllllllgllllllllllllgglgggg
lllglllllllllllllllllllbllllllllllllbllllbllebbbllllllblllll
lllllllllllll_lll_lllelll_eeZlllliii__ee_iiieiee_eeT__eeiei_
Weiee_ei__eiiidi_NdeddYTQiibiiiii_YU__eedebQii^YPe^[Y^diiiei
ibdHVRK_UVbUbeW^R^_d^UdiYeiSXYYeZdeededed\]E[Yi\RRMeUYXMXX]e
Ue\T`Nc>_R^\]RYQNQ\NN\O]\\PYNUM[_WIJM^NMVM`NK_MMM^F^McMLNSMM
YUTMBHNYLNMNEGQLMM>CJFMMNG7<<:LLTKTNQDBJHGKBDJDGNI=:MMCHLVBc
cTBTEE[I;=F9FEMCMJJCHMJK@LFFC;=BG9>=V=VAE?@APR>Q:GR965?HC<QG
JMQ<VCQDN>DQ?=<=M:@MJ>DLMFMIG7CN8AL<MZ:FZZDA=MMM6@:::=@8;5K@
;9;6;7<;E7D9:;:=C??685
.
frg:68
clr:9,858
}
{RED
iid:1512
eid:1127298199
seq:
GAGCGTTCTGATGATATCAGCTTGATTCACGAATTCTCTAGATATCGCTCAATACTGACC
ATTTAAATCAAACCAGACCTCCATAGCAGAAAGTCAAAAGCCTCACCCCCGAAGCGAGAG
ACTTGATGGGTGCGAAACACGCGGCTCATTCGGCCTTGCCGCTTACGCGTACTTTCACCC
GGCCTTGAGGGCCTGTCCCCGACTTACTCGAGAAAGCTTGAAGGACTGCTTCGGTAGGAG
AGCTTCCGAACGTGAAGACTTGTTCGGCCCTCAGAGTCGCTTTATGCGAGCGCGAGTTAC
TTATCGCGCAAGGTGATGAGTGAGGTATCCAGGTCCCGGAGGCGAAAGAGTCCCTCGGCT
CGGTCAGCCTTGGCTGCTTACGTGTACTCCGTCGTTTCCAGGATCCGCTTTCTTAAGTAG
GCAAGAGGCACGAAAGAAATGCTGCTAAAAATAAATCCTTTTTCGAGGAAAAATTCGACG
CAGAGGGGGTCTCCCCCCTTTTAGCCCCCGAGGGAGGGTCGGCCTTTGCCGAGGCTAGGC
CGACCCTTCCTTGGCGACTAAACTTTGCGCAGGTGCGAGGTATATGTACAAGTTGGAAAC
CTCCTAATGGTATAAGCCACGTACCTGTTTTGATGTTCCAAGCGTTGCCGTTATCCCGCC
ATTGATTGTTGGTCAGCTTGTACGTTTCGGGCTTCTGACCTTTTATTTATTTACTAATGG
TTCTTTTCCGTGGGGGGTGTTGAGCTTTGTGCCTCCCGAAGGGCGTATTGTCGCAGCCGA
ACGCACCGGAT
.
qlt:
4233446@979DB5949DGNdiHB98GI5Sd^QZiiieWZ]OeE__[l_`OWeSlll_lV
Mll_EDD;=:@:754?:8;OQk>kQNTBGaGPNFLGC<6<9<8:7:85;65878;;7879
;;=<]UFL:B4B:KKB<=B;===@O8F<:B===:D8JU<=G<B=B:;=A88?<BGB:===
LH=<:MD75A;<9?QJKH==FM<KK<::=M\GJHJ@?<<F<GBTT@BUFICK:B:CKPFI
a=BKHBG:H=<;=B=;=<M=BT>GF=T?EI<J8DEB=H;GBG=<==<BK:<GB=J<?==C
=GCCGC><6B:<TGYOFSNC<MEGI<=HHI:8=?<BCNU?BB=<8;4EJ8=DLCCBB=<B
GK=?H<BQVCKS=<LWCLL==<BG:;EKGG=KNNKLCH=<C<EE=BGBE@F<:;M?=:I;
BNBG=L=B==;TU?HR[;=::BBdB@:<<<<=K:=HCFBHVKIPITGKTCFJMV[N=OG=
TK<UBNSTTFNLWWNKTVWC@=<;?H]WVHLC=7BHNGGQBH;8?;@@<=CYGWISBDH9
<?B<<[LNFFKCS?<<L??<B;BCCBK;9B@6>8THLTMUFL<EFB<E=:<9<<K8EILU
ALKA;9:<OA;=?AO>H<KJF=979>?<GJID<;>C><>CCH>>;IK>@=:9=G<9:;>>
=<;CA=:S<BIA9C879?<?SDC;IGE>9>:8==9:=<A:@CG;7;:>;E?:A8:::EL8
89L9FN=G:957;CC>F<K:KC<9D;;8F8::::E<B=<:96IBFI>:>?68;65:8<>D
A@>?99C<6::
.
frg:69
clr:105,787
}
{RED
iid:1513
eid:1127298200
seq:
CGATTCGCCGGAGGGAAAAGGCTCGTTCCCTGGTTCGCGCCTCTGGACTTCCTGTCTGTG
TATGGAGAACGAGCCCTTATAGTTGTTTCTCGCGGAAGGACAGAAAAGCTTCCGTTTCCC
AGATGCGTGCGAATCCCTCGGCTCATTCGGCCTTGCCGCTAACGCGTACTTTCACCCGCC
CATGAGGCCCTGTCCCCGACTTACTCGAGAAAGCTTGAAGGACTGCTTCGGTAGGAGAGC
TTCCGAACGTGGAGACTTGTTCGGCCCACGGAGTCGCTTTATGCGAGCGGGAGGTACTTA
TCGCACAACGTGATGAGTGAGGTATCCGTATCCCGGAGGCGTAGGAGTCCCTCGGCTCGG
GCAGCCTTGGCTGCTTACGTGTACTCCGTCGTTTCCAGGATCCTCTTTCCGAAGTAGTCA
AGAGGCACGAAAGAAATCCTGCTAAAAAGAGATCCTTTTTCGAGGAAAAATTCGACCCAG
AGGGGGTCTCCCCCCTTTTAGCCCCCGAGGGAGGGTCGGGTTTTGCCGAGGCTAGGCCGA
CCCTTCCTTGACGACTAAACTTTGCGCAGGTGCGAGGTATATGGACAACTTGGAAACTCT
CATTGGTAGAAGCGACGTTTTGTTTGATGTCCAAGCGTTGCCGTATATCTCGCTTGATTG
TTGTTCACTTGTACTTTTCGGTCTTCTGAATCTTTGTTTATGACGATGGTCCCTTCTCTG
GGGGGGCGTGAGCTTGTGTCTCCCCTAGTTGCGTCTTGGTCGTAGCCGAACCCCCCGAT
.
qlt:
1112233544695565459565547794:478577<?G:8:86Y5@9<<9;=<DH>5>66
;86454444455:4546:88=:SZ7:9?B8;68;98544444647577777766:HJ?;B
<A[EbH=<I<<LEELTTTUEKUJY;8@L=E=LBIT?B;;8888<=?6?KBBCG>G<H<CG
<;BLFGU=LLDY<C=BBBMCG?=99C<kBQKL>C>;F<<=TTCCYKOGS@G@@QNE;OBI
TKGB<F?<=<C=@<@L>=UCBHSaHNM=W=BN==<9<BC;=C=<<K<=C?<B;<:<GHKP
OKG<=:H<<UGUUPTaQK[OHP<GCCB<<<FBGNSTHGWLCDO7HU<ADKGHOHOFQUIK
>LBaa[CGSFBW[GGLD?=KN=GCLC=<BB=?SOKF:==8;9767::<KL=[G<KW<CW:
D=WHKHBF:=<<<GCGFSSKdCNBCSMNC]CSOQQIKPT[kNkSWkOSakPVO;DF=LCG
dOTWTNPVR]TNOV[TKKBD;HLaO[LVHH:;IMFBNBF<;KGLG;C=NBUGV<<=7>:C
KKT[[[T[O[HD:LCG:?:HLKCSB=DI9NP[[MYKI@K?H?BBCC=<<;:=8QTK@<>:
8;>?IBB<=?B:NCTA<:<57?;B<E?@>B8GHJNC<75<<B9EL:KdRH;57::?<<ES
?;F9:>:<[OLK?G>=C<;;KBCJDA=<=>;=<?A;<;?KKJ?;::=AK<=D?=;EE;=D
DLRJUI?K>A;=ABBV=H?DCBJB<<>><<G<aOH[QDP<@<9;D>B@FM;JH=JE9<@
.
frg:70
clr:114,777
}
{RED
iid:1514
eid:1128922872
seq:
TGCGATCTAGAGATTCGTAGTATAATGATTTTGAGATTTATATATCTCGTTGGTGTATCA
ATCTTTTTATTGTTGAATAGTGACGAATTCAAGCTTGATATCATTCAGGACGAGCCTCAG
ACTCCAGCGTAACTGGACTGCAATCAACTCACTGGCTCACCTTCACGGGTGGGCCTTTCT
TCGGTAGAAAATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTT
GCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAAC
TCTTTTTCCGAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTTCTTCTAGTG
TAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTG
CTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGAC
TCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACA
CAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGA
GAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGTCG
GAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTG
TCGGGTTTCGCCACCTCTGACTGGAGCATCGATTTTTGTGATGCTCGTCAGGGGGGCGGA
GCTATGGAAAACGCAGCACGCGCGCCACCGACGTGAGCAGTGATATTGGGCCTCAAAACT
CATCGAGCATCAGTGAACTGCATAT
.
qlt:
47756768B=@998NZQGebUH<EE@AC@___EeWSBiKb]dllZlllllll[X_]b_<<
:9>?GOO>FY[_Kbglgg_YlllllllllaUgllgllllT[UC[[GCOlllllllllllk
llllkklklkllllllllllllllllllllllllllllklllllklllllklggggllll
llllllglllllllllllllllllllllgglggg\gglllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllellllllllllblllelllellllll_lllllllliiiiiiiiiiiiiiii
iieiiieieiiiiieeZii[iiieOiiiiiiiiiii_ibdieeieiedieiiiiiiiiei
e_^Y^ieeibdedeVieidbeieeiR^TdViibeiSeiUeie^i_ieeeUieie]iieeU
eU?eNeKMiTe\\eS\R]]UK^c>[N]NNS`P]N_Rc\Q``M^NUcccc^HMWVN]NKPQ
_KMFNCKELMHTJR9YMNOIM[HRMMMLIHMVPCL[YAMLLLOLTNIQMMM^NJQSKKMN
?W^NAGHED:NMTOMITB<LCGcFM>LcGAN?D>PDCEVCLLCLCPACNCMDJB5575@@
9IEJACBQ9G8N<EFJAR:\6G:H@@<JAHS\RE>T@M<7N9EE4<GMBZE:79A@NF8N
8H<T>?Q=B<F=5F9>;;GI9H9556?EGH?FCPNN;735;9H7:>D?I8GTSSN>:<;H
5?79==<<LOG<6I6<:<662114437:A4412495141@6;=A62<7E==>=58DH<5:
:69866884;9@D8C6=69=97>24
.
frg:70
clr:8,81
}
{RED
iid:1515
eid:1127298201
seq:
TGCGTTCTGATGATATCAGCTTGATTCGTGTCTGGACCTTTTCCTAAGAGATAGCCAACA
AACTCCCACGTGATTAGATGGATAACCACGCACGAGATAAGGATAAACATCTGAGTTAAT
CTAATCTCGGGACACGCGGACCCTCCGGGCCCATGGGCCGGACCGTCCGCTCATTTTGGT
GTCCAACATATGCCCCCCTGCCTTTTGGTGGAGCATGACGAACCAAAAGCATTAGCGAAA
ACTTCAGAAACAATTGACCTCATGAGGTTTTTTTCCCGAAGTAAGGACTCAGCTCGATGC
AAGTCATCGGCTCTTGCGATCAGATAATATAAATACTTGATGGGACTTTAATGCACAGAG
GCCGTTTCAGATCGCATCCTCTCCAGCCATGTCTATCTGATCAACCTGTCAATAGGCAAA
AACTTATGGTGCCCCCCAGCCCAAATAAGCAAACGGATTGGGTCAGTAATACAAATTCAT
CGCCGTACCACCCCACACATGAGTAGGACAACACATCGGCGATGGATAGAATGGGACGCA
CCATGCTATCCCTGGAGGAGGATGATAAGGCGATCTTGGTTGTGCTACCCTTTGGGTCCG
TTTAGTCGGCTTTTGCTTTCGCACAGGTCGCCCTTTTGACTTCGTTTGTTTTATTGGCCG
GTTGTGTGGAACGGCCTTCTTCATATATTTGGCAAGCAACTGACCAAAAGTAGGGCCGAC
TCTACTGAGTCGTCTAGACGTCTTAGTAGTGTTTTGTTTCCTAACACTTGTGTTGGAACG
TTGTGGTCCG
.
qlt:
445556G:<U:F>668866[e>F:7>EX_lellllMDllgglllagllllaLlllkVlll
llllkdkVkdSUT[kkllklllklllkkllkllkllklllllkkllllllllllllllll
klllllkllllllllllllklllllllllllllllkllllllllllllllggllgkllll
lllllllllllllk\klk\glllllllllkllllllllllllllllllllllllklllll
llllllkllllllllkllllllllkggllllllkllllllllllklllllllllllllll
lllllllllllllllllllllllklllllllllllllllllllllllllllllllllllk
lllllllllgllllllllllllllllllllllllllllllllllllllllllllglllll
llllllllllllggglllllllllllllllllllllllllllllllllllllllllOMll
lllllllllelllllllllllllllllldlllliiiiiiii^Q_Z_WieieZiiiieeie
eeeiiiieeiiiiiedViiQ_A<_dMiid^_iiiiiiiTPidYieieiieYi^ii^Uedd
diddZeidiUiiiiiOiieeZe\__RiUi\_i\\i^^]LQei\QYi]iK^W]\_\^PDV\
_LO_M^M]_YUM`YL[M__MTML\V_OOc^^^MQPPSQPMY[[H[M^^VOSMLc[L^L^B
QXML[M^MEJVML[RSMMKLLWOLO7@MAAT8ccNVB\PMVDJPACLPHJ?OMC=?6@CH
FGD8ES@P97
.
frg:71
clr:6,787
}
{RED
iid:1516
eid:1128922873
seq:
CGATTCTAGAGATTCGTCATTGTACATATTTTTCCTCTTCTAATGTATTGTGGTGGCAAA
GCTTCATGCCACTTAATTAAAAAAGGATCCTTAGTAACATGCAATGACATCGCATATTAC
TATAGCTCAAGCCATGGACTAATAGTGGTATATTATTATGGACTTAAGCCACAAATCAAT
AGTAATATTGGGGCTATCAATGTTAGCTAATGGCTTGAACCAGCAATGATAGTTCGTTGC
CGGTTCATTACTTCATCTCATAGTGATGTATAGCGAATCATTATCGGTTGTTGGATTGCG
CTAACAGTGATGATTATACTATACAAAACCTCACCCTCTCATTCCTCCTCCCTCCTATAC
CGAGCATACTCATCCAAGGAGGCGTCTTTACCCACCTCTTCATCTATTTTACAGTCATTT
TCTTCCAAAATGCACATAGAAGCTTTTTGTTGGACACCAAAAGAAGCGGACGGTCCGGCC
CATGGGCCCGGACGGTCCGCGTGTCCCGAGATTAGATTAACTCGGATGTTTATCCTTATC
TCGTGCGTGGTTATCCATCTAATCACGTGGGAGTTTGTTGGCTATCTCTTAGGAAAAGGT
CCAGACCTCCTCCCCTATAAATATAAAGGGGTACGGCCGATTGAGAGACCACCGAACACA
TTCCAATCGAACCAATTACCTTATTTACTTTTCCTGCCCTAGAGTAGATGTAGCATAGTT
CTAGTGTAGCTTCGCATATCCACCTCCACCCTAGTCGACTCTACGTCGTCTAGATCGTCT
AGTGCTGCGATCAGACGACCTAGATCTCACCCCTCCGAGGGCAGATCTAGTGTCATCCAG
ACTCTTCCTCGATTGATCTCTTAATTCTA
.
qlt:
84447<;D?:778Q[MUF>?YYQQ@<ddU__ZZ__eiiieLRSeYV^ZlYWl[[l[b:=C
?L<86455@;8al_gll_gllggllll_llllllallgallagQdldYNlllllllllll
lag_lllaalllaalllllllllllgllllllllllllllllllllllllllllllllll
llllglllllllllllllllllllllllllllllllllllllllllllggllllllllll
llllllllllllllglllllllllllllllllllllllllllllllllblllllllllll
llllllllll_llUlllllllllldlllllllllllllllllllllllllllllllllli
iiiiiiiiiieeiie[_OHY_iiiiidiiieieXiiiiiii]iiiieiiieediiieiii
i__iiYNiiiiiVieiii^[ibiiiiR[iViieiVed_N775657Bdd_iGeiGideiNi
XUNYRIYie_edBeiNdeeeeNiUXiiXeNNAQ^JXO`UOX``YNPAc>^OYNVWO[\N_
Q\\A]N`GY`QWMMOIGW`MM[P_LN_N]cTI<K^M^BJUUIMMLSMSLI=;7N[cCGM?
OJKAY<NLKJCM^WTJMLK^IGGELV;NccKAL<JDJEF[?OVK<V<M<CGKFLKLCHG>
ML=F>ALRLRL>HA=FAHD9K8K9\GCAG\\G:H?K:S@@8989GP8NCQANCJM=J6I7
?>A5797N;O:=I48F@F;F:A@8@FM9CRF7M?;F:J:>;AHC=A643C6H;G9I@84=
E846439@4=5I35J:9737958>=5344=KK543=496@=4>4B66:?4?54B8<7=>4
<98<554:46<?DC>:666>:86574633
.
frg:71
clr:5,780
}
{RED
iid:1517
eid:1127298202
seq:
TACGTCTGATGAATCAGCTTGATTCGTTTTTTCTGCCTCTTTTAACAAGTATAAATCATT
TGCTACCAAAGACTCTAAAATATGAAATATTGGGCTTTTTACCAGTTAGGAGTTCATATG
ATGTCTTCTTGAGGATTCGGTGTAAATACAACCGGTTGATGGCGTAGCAGGCGGTGTTGA
CCGCCTCGGCCCAAAACCGATCCGAAGTCTTGTACTCATCAAGCATGGTTCTTGCCATGT
CCAATAGAGTTCTATTTTTCCTCTCCACTACACCATTTTGTTGTGGGGTGTAGGGAGAAG
AGAACTCATGCTTGATGCCCTCCTCCTCAAGGAAGCCTTCAATTTGTGAGTTCTTGAACT
CCGTCCCGTTGTCGCTTCTAATTTTCTTGATCCTTAAGCCGAACTCGTTTTGAGCCCGTC
TCAAAAATCCCTTTAAGGTCTCTTGGGTATGAGATTTTTCCTGCAAAAAGAACACCCAAG
TGAAGCGAGAATAATCATCCATAATAACTAGACAGTACTTACTCCCGCCGATGCTTATGT
AAGCAATCGGGCCGAATAGATCCATGTGTAGGGGCTCCAGTGGCCTGTCGGTCATCATGA
TGTTCTTGTGTGGATGATGGGCACCAACTTGCTTTCCTGCTTGGCATGCGCTACAAACCC
TGTCTTTCTCAAAATGAACATTGGTTAATCCTAAAATGTGTTCTCCCTTTAGGAGCTTAT
GAAGATTCTTCATCCCAACATGTGCTAGTCGGCGATGCCAGAGCCAGCCCATGTTAGTCT
TAGCAATTAAGCCGAGTGTCGAG
.
qlt:
44544<;F_<H:67977AeAE;7?Eaallllllkaallllklkklaakllllllllklll
llklkkaSLLPklllllkklllkllllllllkklllgg\gllkkllllggllllllllll
llllllllllllllkkllllllllllllllllllllllllllllllllllllllllllll
lllllllllllkggllllllllllllllllllllllllllllllllllllllllllllll
llllllklllkgglllllllkkkklllllllllllllllllllllkllllllkllllllk
llkllllllllllllllllgklklllllllklllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllggllllllllllllllllllllllll
lllllllallglllllllgllllllggll_llgllllglgglllllllllllllllllll
lllllllllllllllllllblllllllllllllelllllllllllllllllbiiiiieee
iieieiiii_iiiiiidediebMTeebidiiiiieidieddiibiei]ieNNd[eedd[^
[i_iXVPUHeVddVIeZGdiiYdJYXd]i^eTiidO`ZeU_YWePTXiX`e_YeRe[Ni^
P]P_NZ]P_QM]^]O^X\MMV`[TKOLPMMRFMccMU`GY@OOKM^UPcMC4IU=SEMXM
MMQ>Y=V[@CJLNQ^TEJTJL^MXMLMCJVG^JJ[GQHG=BT9PMCNTcJIHTGCOCLRI
LM9IJLMFBLCJ98:<:LBP@?8
.
frg:72
clr:5,801
}
{RED
iid:1518
eid:1128922874
seq:
ACGATTCTAGAGATTCGTCAGAGATAACCATGGTATCGTTGTGTGGGTAATCTTTGAGCT
GAAGGTCCTCTTGGGAGAAGGTAATAGGAATGTGAGACCATCTTGACTTGATGAAGGGTC
CTTGCACCCCAACATGCTGTACCCTTCTCTGTGCTTCCTTCTTCTGTTTCTTGTTAGCTG
GCTCTGAGGACGAGCCACCTGTGATCGGGAGCACCAGCTTCGGGTCCGAAGCAGCTCCAG
CTTGGTCGTTGAACGAAGCCATCAGCTCAAAAAGTGGAAGTGAGTTCACCCACGGTGGGC
GCCAATGTTGGGGACTTGTTCTCAAATGCTATGAGTTAAGAACAAGGCAACACAAAGAAT
GTTAAACGATAAAGTCCTTCGTCCTTTGAAGCATTATTTCCCTTAGGATATAACGATCTT
CGGACGAAGGTCATGAAGGACGAACCTTCATCATCACAGTATACATTAATGAAAGACGAA
GCATATGAAACATAAAAGATAGCATGAATAATCATATAACATTATCCATTTAACTTTATT
ATATCATCATAGAGAAATAGAAACAATATCGAATTATAAATGTACCTTCGGCTTGGAAGG
AGATGAAAATACAAGCGTGACGCAAAAGCAAACGCCAAGTCAACGTGAACAGTACGGGGT
ACTGTTCACCTATTATAGCACGGGGTACGACCATACAAAATACATGCATGCCCTTTACAT
TTGTGATATTCTATAGCACTCTTATCGAGGTCTAAATGCTTTCATCTTAGTCAGTCGTTT
CTGCAACTGCCGAGCTCTGCTGACGCTCGGGCTGGTCACTTTGATCTTTGAGCTCTCCTT
GGAAGACTCGGCGAAGAAGCTAGA
.
qlt:
67567577?<=87:SdPQW[OeT>7?MbP<llleHVl[Xlll_Xll_bgl_llllllgll
l[LTFRgTglllllllllllk[lllkllllklllllllUNllllllllllllllllllll
llllllllllkllllllllllllkglllllllllllllllllllllllllllllllllll
llllllllllllllllglllllllllllllllllllllllllllllllllllllllglgl
lllllllllllllllllglllllllllllllglllllllllllllllellllllllllll
llllllllllllllllllllllldllllllllllllllieiiiiiiZ_iiiiiiiiiie_
eQiiiiiiieiiiieiU_iieiiieiiiiieiedie_ii___idiQi[Ueee^iiidiei
idie[biRDdLebeiiVIidTbidQQWi^LeeVeeUiXedded^SiW^eeiVYVPdQXii
PeTUeXeee\USe\iRUG\E_O_NOcNKPROO^G\_YIWVMN`OMMTINc_L[MMcVVKM
_MMMSMMSOMTI^P[cQMMLTcOMGKMYLVFIPRWSLOcML^BLMMLMHJGEMMJJ;8?<
A<MARO\MHMLOCINMJ@QGCHLGVcP@MHWOLLJHDDLDNDGGC@IEGKGPFL>W\\C8
CRED6JJ96GJ:8O76468=:ARTB5AH=NLM=A=A=ZZ<>554AMFBBO>Z:4TD?>8C
Z:E3:G5>56:8?7:?;97>;7788=958D5@56N<?<54T?:><:8B;8EC@8<414H<
56;4<K47>873@78934B3C<?474A7A:4767>:<:<7;558=:;G=254:D98>D4:
666<5A<;7:3366115E6A7347
.
frg:72
clr:8,772
}
{RED
iid:1519
eid:1127298203
seq:
CGCGTCTGATGATATCAGCTTGATTCGTAATCTATTTCGCGAAGCTTACTGCGCCGACAG
TCACCCGGACCATTTGCAATGGTGAACAATATGACCGACTTAACCGCGCAAGAACCCGCC
TGGCAGACCCGCGATCATCTTGATGATCCGGAGATTGATGAAATGCCCATCCCACCGTGT
TAACTTGACTTGCCTGTAACGATCCCAAGAGCTGTGGCATCAGAGTGGTTCTTGCCATGG
TCATACTGTACGATTTTGCCTCTCAGCTACTCTATTTTGATGTGGGGAGAGGGGAGAAAA
GAACACATGTTTGATGCCCTCCTCCTCAAGGAAGACTTCAATTTGTGAGTTCTTGAACTC
CGTCCCGTTGTCGCTTCTAATTTTCTTGAAACTTAGGACGAACTCGTTTGGAGTCGGTCT
CAAAAATCCCTTTAAGGTCTCTTGGGTATGACATTTTTCCTGCAAAAAGAACACCCAAGT
GATCCGAGAATAATCATCCATAATAACTAGACAGTACTTACTCCCGCCGATGCTTATGTA
AGCAATCGGGCCGAATATATCCATGTGTAGGAGGCTCCAGTGGGCTGTCGGTCATCAGGA
TGTCCTTGTGCGGATGATGGGCACCGAGGTGCTTTCTTGCTTGGGATGCGCTACAAATCC
CGTCTTTTCTCAAAATGAACATTGGTTAATCGTAAAATGTGTTCTCCCTTTAAGAGGTTA
TGAAGATTCATCATCCCATCTTGTGCTAGTCAGCGATGTCATAACAAGCCTATGTTTTTC
TTAGTTTTTACCGAAGTGTCTACT
.
qlt:
3243488@MHJ<;7>E67LiYi\AiiC_]AZeXReiii?XVRWUbl[U_bbSG[bMW[RX
S[BV:55<:898999<97FTkHDQSHUWWW[[\[adaaGO=<;;<<;<:978<;=BB<BY
dkNSDKd]ddTaT]CO<KYC[aGERTEOLGC;K=9BK77A?=88B<=<===?;<;==;::
;:<;9==:<@:;:B;;:88:<B><:8=:9?=?:I<?:8:<58:;:9B;8:;;=B9;99H8
7FBCC9:@;=@=C=<<>;;;=<<<<<=HC;:=?B<FNEN:BG;M:=;<GC:FG=<6=B=T
<B<;:B<=B:<::8:B6;=;<<:=<B8@:<B:B:<=<>?;==GK=:<==;B=C<GWFBWC
B;BB=G;8:=;C?=SKCKB=HD?<>;<KK:@:BAH<6<KBWE@LK;??L;=778<=@CB=
<=77KK?BGRLK;:<9=5B=?;>JF=<>CGP9D@:DH@KB<K=H<CAG=J=BB<<BAHG=
<D9:88<GLKGCB;D<B=B8HQPKTHHKI8H>585KQL<DCTQKF:9==T<MGDMSNOL=
=<@99;B<;<BE;S@<C:NYOG>968;?L;C:?<@KLCC<DT?:<CPD?CKAF=CIH:JF
FI?=E=<?8L?J>>:EH?G>>>M=C8889<C:>>>99>H98EC=989S<CK:KCEC@778
9:<COLQDKEKC?PKDS>AGLDKLE;APB9=<:@?RR9b:KAK9?<AEGHC<;<S=<=A@
:8:D<_GHN9EC:=:8<=6>6:QBEAE;:<C;::;AH<B758?655=7AA7<AFHE7<E7
<GG@=;AJEA8876=9F@88955:
.
frg:73
clr:7,798
}
{RED
iid:1520
eid:1128922875
seq:
TGCGATCTAGAGATTCGTCATTCCCGCCTCAATTCTTCGCGGAAATATTTGATGGCGCTC
TGTAACGGCTCCACTGCACCAGGTGCGTGGGCACAGAAAGTTTTACCCGGGCCTAAGAAT
CGACACAGTTGCTCAAGTGTTTCGATATCGCCCGGCTGACCTTCACCACGCTCCAGCGCA
CGCAGAATTTTCACGCTCCACGGCAGACCGTCGCGGCACGGCGTACACCAGCCGCAGGAC
TCACGGGCGAAAAACTCTTCCAGGTTACGCACCAGCGACACCATGTTGATCTCATGGTCA
ACCGCCATCGCCAGCGCCGTACCCAGACGGCTGCCCGCTTTACCGATACTTTCGAATTCC
ATCGGCAGATCAAGGTGCGCTTCGGTCAGGAAGTCAGTCCCCGCGCCGCCTGGCTGCCAG
GCTTTAAATTTCAGACCATCACGCATACCACCGGCGTAATCTTCGAGGATCTCGCGTGCG
GTGGTGCCGAACGGCAGTTCCCACAGTCCCGGATTTTTCACCCGACCGGAGAAGCCCATC
AGCTTGGTGCCAGCATCTTTACTTTTCGAGATGTTCTGATACCACTCCACGCCGTTAGCG
AGGATCGCCGGAACGTTACACAGGTTTCGACGTTGTTGACCAGTCGGTTTACCCATGCGC
GGAGTTGCCGGGACTGCTCGAGCGTGGGTAGCACGACGTCTTCAGGAGTGATACGCTGTT
TCTCCCGCAATGTACGCTGCCCGGATGACGACAGTCGATCGACTGTCTATGTTTGGCAGC
GACCGTCGTGCTCGCATGGACGGCAAATACTGCCGCTCGATATCCCACCAGAAATAACCG
TA
.
qlt:
5547767=AIA>?9SbOTF=Tie^NZbllPEJ_llllll_llll[ag[ll_l_l_Yllll
ll_gdggOgll_Plllkllkklllllllllllllklllllllllllllllllllllllll
llllllklllllllkllllllllllllllllllllkllllllllllllllllllllllll
lllllllklgllllllllllllllllllllllllllllllllllllllllllllllgg_l
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllellllllllllll__iiiiiii_iiiiiiie_iieiii__iei_eii_
_iiiieiidZeeiiieieiiiii_iei]XiieeeibeeiiiieiieebeiVPNdiYi_Nd
ieiiWdiediedQHiG\Pee\eee\e]YRQWi]iXeQ_N]]MYWL]V\QD\_`___HcN\
_A^UK_J[I`\N\`MVSN[R`RMNPWMM^MIMPCc^^MMBMWME[FMP[[<POM[[MKMM
OOLTOGH7TETCMLMTSM^OEDO^\CGCYAMAN8?E@KM>HMMFGMRLBLNLGFIFLKPJ
T:B;@JH=:;=CGCE<<AL?K6655ZAH?MAD@=D<=GN44458LD>;R7@RRO=BQ<8H
68GC6;F8<<U844389M99G5569MZC4::M;?;E;;=K74=7?754H9FFD5>G@:5I
7663G6798=6;496495<:F=5633A5;7B37<A83=484@=7;34145>@==46@B33
38<;4;497A3;<84?8B>345783>76D:=D9@74A75884D95834734435634<43
32
.
frg:73
clr:7,719
}
{RED
iid:1521
eid:1127298204
seq:
TGTATCTGATGATATCAGCTTGATTCGTGGTCCGCGCCCTAGGGCCGGACGGTCCGCGAC
CTGGCGACAGGGTCGACTTCCTCCTCCTTGCTGGAATTTAGATCTCGTCCCCTGGGGGAA
AAAGATCTTAAGGTGCTCCGGGTCGACAGGTCACCCGGGGCGGACGAATTCTCTAGATAT
CGCTCAATACTGACCATTTAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCC
GACCGGAGGCTTTTGACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAAT
AAGATCACTACCGGGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAA
AATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGA
TGCTGATTTATATGGGTATAAATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAAT
CTATCGATTGTATGGGAAGCCCGATGCGCCAGAGTTGTTTCTGAAACATGGCAAAGGTAG
CGTTGCCAATGATGTTACAGATGAGATGGTCAGGCTAAACTGGCTGACGGAATTTATGCC
TCTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACTCACCACTGC
GATCCCAGGGAAAACAGCATTCCAGGTATTAGAAGAATATCCTGATTCAGGTGAAAATAT
TGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGATTCCTGTTTGTAATTGTCC
TTTTAACGGCGATCGCGTAT
.
qlt:
44444K;BV<C?88:<66_lllbIll[[lgllakklllllllllllllaVlllllllkkl
lll=HB?G:BKA?lklllllllllllllllllkkllllkR\llg\\d[gk\gkkkkklll
lllllklllllllllllllllllllllllllllllllllllllkllllggllllllllll
llllllllllllllllllllllllllllllkllllllllllllkllllllllllllkggk
lllllllklgggklllllllllllllllllllkkgllg\\klllgggggkllllllkgll
lkgllgglllk\\gkllllllgklllkkllllllllkkkllklklllllllkllllllll
lllllklklllllkkllgkllllkklllllllkllllllklkllllllllg\gllllllk
llllllllllllllllllllllllllllgklklllllllllllllllllllllllllgla
llgglgllllgl_lllllllllllWllgllaglbllllllll_llllblllllllbl[ll
l[ellllRlll[Xldlll]ll]llSWKlZQeZdieeeiiiii_bii_Udiie]i_dXeei
eieeei_i]eVeiX^eed]iide`ei[beeeedVYMLi[HdZW_iiSebdZeHdeXeWdd
VSReieSSiidiiQUU[eQVdXWHSiQUQSYSiiHiXXUI_eXcOCPOF9NR]\^RPNIE
^Q>_LQ>_TM_MTWOMQNcGQW_LYMM[VBQLMOHGHJT>IARM[G^McIMGNMLPYJJM
DccELLMGT?FQFM@JC7>7
.
frg:74
clr:5,162
}
{RED
iid:1522
eid:1128922876
seq:
AGATCTAGAGATTCGTCCGCCCCGGGTGACCTGTCGACCCGGAGCACCTTAAGATCTTTT
TCCCCCAGGGGACGAGATCTAAATTCCAGCAAGGAGGAGGAAGTCGACCCTGTCGCCAGG
TCGCGGACCGTCCGGCCCTAGGGCGCGGACCACGAATTCAAGCTTGATATCATTCAGGAC
GAGCCTCAGACTCCAGCGTAACTGGACTGCAATCAACTCACTGGCTCACCTTCACGGGTG
GGCCTTTCTTCGGTAGAAAATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAAT
CTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGA
GCTACCAACTCTTTTTCCGAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTT
CTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATAC
CTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACC
GGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGT
TCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGT
GAGCTATGAGAAAGCGCCACGCTTCCCGAAAGGGAGAAAGGCGGACAGGTATCCCGGTAA
GCGGCAGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGTATCTT
TATAGTCCTGTCGGGTTTCGCACTCTGACTGAGCATCGATTTTTGTGATGCTCGTCAGGG
GGGCGGAGCCTATGGAAAACGCAGCACGCAGATGGCCACCG
.
qlt:
445:7<D@?99<QXMNQMPA^iR[^ibiH8eZidi]YNilllZOXWWlllllleWe_bIH
HFCCJSEglll_Wlll_llllllgglaTllllllllllllllllllllNdd_Vdlllkll
lllllllllllllllllkkllllllllllllkllllllldlllllllllllllllallll
lllllllllllllllllllllllllgllllllllllllllllllllggggggllllllll
lglllllllllllllllllllllllllllllllllllglllgllgllgllllllllllll
lllllllllllllbUllUOObllllllllllllllllllllllblllllllllR_lllll
llllUM_elllllllllllllllllllllllll]ellelellllXleleidieiiiii_i
iiiiiiiii]ieeiiei__iieid^bee^__ieNiiieeiiiiei_ieeiiiieieXiee
iiieiieiiedeeeiiiiedbUdVeei^diieiiZd[[e^Y_iYZeiWeeXdibeTd_NV
^i^UbiV^NebQd_iPTeUdQdeUR^^^MBeiAiSU_XSeeiM`eiiX_SXeSNiiiiQK
NTXXeNMWK_LYW_YMIN\KQNYD`M\PKS`G^MMMMNWP[[IQ\MBMEMEMMUMHTTWI
YSMMPMMMW;W[TMLMMWAQMMMMNYH:>T<F^BVFYcMGQ:BJQBMMY?DJ<Y;KKAPN
HNAPG79<6:?CEKAAPDQ>X=MBEKGDT:T=L8LRN=NJHcccIKcGLDDDE@59@LC\
@9B?CENOLQ8>>\A<\CD8A8K6:AON;SC;6?>MMBOBTTZ>O8ME<C;AOJFM:FTT
OT==CBQ;FH67:=>ASJA:7F;@785:7496139G?8@64
.
frg:74
clr:5,150
}
{RED
iid:1523
eid:1127298205
seq:
GGGCTCTGATGAATCAGCTTGATTCGTTCGGTTTTCTTTTTCTTTCCACCGGACTCCTTC
TCGGACGCATGATTTTGAAACGGTTTTCATCCAATCAAAATTCGCTTTTCCTAGCAGCCA
CTTTTGACCGGACACTTTTCTTTCTTAATCCTATTTACTCGGGAGCATGCATGAGAGAAT
TTTCCCCTTTATCCTCTCAAGTTTTAACCCGCGAGATTCACTTTTCTCGGTAGCACTTTG
ACCGAGCTCCTCCTTTATCCATGCGTGGGAGTAGGGGTCATGGGCACCAATGGTCGTGAG
GGGCTCCTCGGCACGCGTGAGGCTGCCAACGCGCGATGTGCCTCCAGAGCGTTCGCGCGG
GCACGACCTCTGACGCGTCACAGCTTTGGCCCGGACGTGGGCCTGACAAGGCTCCGGCGT
TGGCACTTCTAGCGCGGCGTGTTGTAGTCCCGGCGCGATGCACGACTGCTGGCACGGCCA
CGACGGCCGTAGCGAGGGATCTGTGTGCCTTCATTGGCCGGCGGAGGTGGCTTTCGAGGG
ACAGTCAGTCGAGAAAATGCTCACTGGATTCTACCAGTGCGGACAGAGCTAGCGGCTTGA
GATCGAGCTGGTCTTAGATGCGGCAGATCGATTTAGAAATTACATACCGCTCAATTGCAT
AGAGAACAGCACCACGACGACATGGCAGTTCATCGCGCATGGATCACAGCTCGTGCACAA
CAACAGATTAAGAACAATAAACATACTGTTCCA
.
qlt:
84454=89D8A866:88<illbKllW_lll_blllllllllllllla?lllkklllllkk
]dOJNGJJBO\TTakkllkkkkkklllkklkkkklkkklkllkkkllllllllkklllkk
ggklllkklllllllllllgglllllkklkkkklllllllllllllllllklllklklll
llllllllllllllllllklllllkgllllkkkkkkkkkkkllkkgklllkkkkklllll
llllllllllklllllkkkkkllllllklllllkllllllllllllllllllllllllll
\gkkkllklkkkkllllllllllllllkllkllllllllllllllklllllkllllllll
llklllllklkllkkklllllllllkkllklllllllllllglllllgllllllllllll
lllglllllllllllllabblbglglbllggggbglglglgbebllllbbl_[ellllle
lbllelellel]lbellbZZllllllllllllbllleei_iiiieZ^eieeii_i[iiie
eZdieieeeieiieeeeYdeedbdeiddTiieedUPebi^^^iReiieiidiei_bd^id
Z[VibieiieiUeeeeK[Ri^eeXeTdQieXKiVQDUKQUSTeT_YeW\_e`MV_i_`P`
`\`P]XNNV`O[`N^O\MLY68C_^M\M``OKV\M]]NML[^KJMHMMNV[[MCYMPYET
VLWVBMP@LJOMcTMLYMJ^TMHMMMGMCL@85
.
frg:75
clr:5,750
}
{RED
iid:1524
eid:1128922877
seq:
CGGAAGCCAGCACGATCTGAGATCGTCCTCCGCCCTTCCATCCTAAGAGAGAGAGAGTTA
AGTTGGTTTCCCATAACCAAGGATGTGATGTGGTTTTTTCAAATTCAACAACCGCCAGAG
CGGGGTGCGGAAAAGGGTTAAAGAGTGAAAGGTTTTCCTTACGGGTACTTTTTTTGAGGA
AAAAAGAACTAACATGTCTTACCAGCGACAGAGGCGGGGTCGAAACAGACCACTGGCTTG
TGATCTGCTTGTTGCGCCCCGCCGGAAAAGCCACTCCATGGTGGATAGGCTTGCTCAGAA
GACTAGGCTCGCTCTGGAGGGGTAGTCAATCGGAGGGGCCTTTGGAGGGATGTTAGCTTT
TGGGGCGCTTTTCCGCTTCCCGCCCCCCTTTTTGGTGTGTGGGGGAAAAAAAACCCCCCG
TTTTTTTGGGTTTCCCCCCCCCGGCAATTCTGTTTCTAAAAAAAAAAAGGGAGGGGTTCT
CCCTGCCGAGGAGGGAAAATAAAAAATAAAATAAAAACCAT
.
qlt:
3333464553459K8I9D5:9;?;>MGC`GMDCD?U^DMDFV8<567>AF9B:D9=5@^8
64444444454445455544478577674464444456554765664;459:7775::9:
4577:?7:875544>88;9575855848B=?67=<8587<B9UE>==<:B>CG=::<=;C
CF=BCCB=B<B<<<;D<=?L=;:99<CF>=H;;?<OOOJKK<<;:=HKKB<98<D:89:=
=LA::;>=B9A9<;:M;G=<<G8:E=5K<S@@=F<>>;=?<::;8U45;9?B?:<=;<=H
?H::9:<D:G;<A?=CRP:SCC?U?LLGI7FBBT[==<>D=<@N:>?S=W=WAL:::GST
\46658;5g\BB9;9?:<=>=CH>PRG@GOWkl96U=D<7DB=<=>=>DGGC?<CLGG<:
<=CCCGL==<BH<AHBBBK@W?G9;>G<=?>;<;<9@HC>APH=B=<88<<;:==;58;:
:=<<8=698<@=:FCD==>><BGB<;<<<;<:=:;698<86
.
frg:75
clr:13,514
}
{RED
iid:1525
eid:1127298206
seq:
AGGTCTGATGAATAAGCTTGAATTCGTGTTTCGAGCATCTGGACTTCCTGTCGGTAATAG
GGATGTTTGTGCGAGCGAGAGTTGCTTCTCGCGGAAGGGACGAGTGAGGTATCCGTATCC
CAGAGGCGTGGGAATCCCTCGGCTCAGTCGGCCTTGCCGCTTACGCGTACTTTCACCCGT
CCATGAGGCCCTGTCCCCGACTTAGTCGAGAAAGCTTGAAGGACTGCTTCGGCAGGAGAG
CTTCCGAACGTGAAGACTTGTTCGGCCCACGGAGTCGCTTTATCCGAGCGCGAGTTACTT
ATCGCAGAAGGTGATGAGTGAGGTATCCGTATCCCGGAGGCGTAGGAGTCCCTCGGCTCG
GTCAGCCTTGGCTGCTTACGTGTACTCCGTCGTTTCCAGGATCCGCTTTCCGAAGTAGTC
AAGAGGCACGAAAGAAATCCTGCTAAAAAGAGATCCTTTTTCGAGGAAAAATTCGACGCA
GAGGGGGTCTCCCCCCTTTTAGCCCCCGAGGGAGGGTCGGGCTTTGCCGAGGCTAGGCCG
ACCCTTCCTTGACGACTAAACTTTGCGCAGGTGCGAGGTATATGGACAACTTGGAAACAT
CTTAAGGGTAGAAGCGACGTAGCTGTTTGATGTTCCAAGCGTTGCCGTAGATCTCGCCTT
GATTGTTGGCCAGCTTGTACGTTCCGGGCTTCAGAACTTTGGCGATGACGAATGGCCCTT
CCCAGGGGGGCGTGAGCTTGTGCCTCCCTCGGGCGTCTTGCCGCAGCCGAAGCACCAGAT
.
qlt:
44448:AR<C868969[eilE;Pll___llllllllglllll[kllllllllllllllll
llkkkkKPNIIM]llllllllllllk\glllllkllkkkkkllllllklkklkkllllll
lkkllllllkllllllg\glllllllllllgglkglllllllllllllllkkllllllll
lllllkkllkgkllkklllllllllllllllllllllllllllllkglllllllllllll
lkllllllllllllklllllllllgklllllllllkklkggkllllllllllllllllkg
glllllklllllllklkklllllllllllllllllllllgglllggglllkkllllllll
llllllllllllllllllllllllllkgllllllkllllllllllllllllllkllllll
lllllllllllllllllllgkllllggglllllllggllllllllggllll_llllllll
bllllggllllgglgllllllllllllll_lAAVllelllllllllllllllllllllll
l]llllllliieeeiiiiieiiiiiieidO__ieii_i]ieeciiei_iiiii_i_Q^]^
iddieYiGUi_^iXd[UWeiiQUicQiiiYQdReVJBeeieXieeieXeI\UUKiVUi]S
^USe[<]^TD_K\U[L[PRPYT_M`WccN__SLI]NW`^UOMEYPPY[NLNLMc[D[ONT
IcMLScccc[MTI^JCMOM^HY@DDLcKING\OMXLRMKVEVLMOENMCIGJMLJO@9=8
.
frg:76
clr:5,778
}
{RED
iid:1526
eid:1128922878
seq:
TGACGTTCTAGATATTCGTCATCTGGATATGAATCTATTGAGAGATGCCAATCTTCCTGT
CAATCTTTGAGCCCCCTTCTTTGTAGTTGGTGGCTCCATCCGAAGTATAGCTTCAATTTT
ACTTGGATTAGCTTCAATTCCCTTTGTTGAAACCAAGCATCCAAGAAATTTCCCCTCCTT
CACTCCGAAGACGCATTTTTCTGGATTTAACTTCAAACCAGCTTGTCTGAAACTGGCGAA
GGTCTCCTGCAGATCAGTAATATGATTCTCCTGCTTCGTGCTTTTTACAATGATGTCATC
AACATAAGTTAGCACATTTCTGCCTATTTGAGATTGGAGAACCTTTGCAGTCATTCGGCT
AAAACTTCCTCCAGCATTTTTGAGGCCCTCAGGCATCCGAAGATAGCAATATGTACCACT
TGGAGTTATGAAGCTAGTCTTCGGCTCATCTTCCTTCTTCATCCAAATTTGGTGATAGCC
TGAATAGCAGTCTAACCAAACTCATGGGCTCTGAAAGAAGCTGCTGCAATCAACTAAAGA
GTCTATCCTTGGGTAGTGGGGAATCGTCCTTCGGGCAGCCCTTGGTTAAGAATCTGTAAA
ACCATAGCAATTCGCCACTTGCCATGGGCCTTTTTTCCCTAACAGGTTACTACCATTTGG
GAATTCATCTCTGAAACTCCGCAGAGAAGTCTTTGAATCTTTGAAGACTTGGCTTATAAT
AGACATTTCCGAACTTGTTCTGGTGGGAAGAGGGTCCATTGAGAGGCTTAAACCTCCTAT
ACCCCAGAATATGTGACATCTAAAA
.
qlt:
54445558:977679USKHB@FHDPT;:?HkUaVLHHLL[kkklV;k[[LkklkkkTUkL
K=<CJGHJOML?C==CBR[KNMaUHCHWd[PkYTdTS?MNOGMB=@BIDJJSW[GO]dUN
TTTVkYddaaall[VKS\a[WYWUUkLllkkkkkkkkkV[[UO[lldkga[a[adglgll
lglllgllg[lgbbllgaaab[glg_bV[abgbVLbbel_llllllllllllllllllll
llllXb_VlWlelllll]eddee_i_Ziiiiiiiiiiieiiii_U_iiWiiiYYiedeii
]eeeee^eiiieiei^iiiiiiVYYee^QQibdLiiii_iiUi^^Yie_eWeVi\eXiUY
WieiWUY\\OKQMYYW_]\QLPPDU:WQNVGI]MUVUWGRVEY@MMMITMPIWFJNOIQ[
MPIM>FJKGMLPKOTRSJVKAJ@PHKMGMLA@8>?C65G?BMBGG[MEZ<IK8GD868GJ
JVFB<MDJLGCD7@L>66798BJ?=9446G<4>>S95=L=OAE@DL898=5;<:;CO534
48B?HCA<95<G75>64>C<5C;:546?43467<45?8>D@45696<@95F8456;4>=?
564535:6425944854446<4516876;97:TK943554;<55346744115935567C
:533464866:49<;544:8731334644439B=33386:43345445554323766668
453139C842365863444344523576331448743233433135334=3313843543
65>C654B84474443448633333
.
frg:76
clr:15,562
}
{RED
iid:1527
eid:1127298207
seq:
GAGAACGGACGGAGAAATAGAGTGGAGACCGGACGAATTCACTTATACCGATCACTACTG
TGGATTGACTCACCTCCCCTCCGTAGTTCCAGTGTAAACCTAAGCATCTGTTCCTTGATC
GGAACCTACAATCTTCCACTTTCACAATAAAGAATAAAGATCTCTACCGGGCCCATTTTG
GGAGTTATGGCGATTTTCGGGAGATAAGGACGCTAAAATGAGCCATATTTAACGGGAAAA
GTCGTGCTCGAGGCCGCGCTTTAATTCGAACATGTGTGCGGAATTTGTGGGCACAAATGG
CGTCGCGATAATGTCGAGCAAGCAGGGGCGACCATCTATCCCTAAGGTGGGAACCCCCAT
GCGCCCAAGTCGCTTCTGAAACGTGACAGATGTTTTTTTTTGCAATGATCAAACTGATCA
GATGGCCAGGCTGAACTGGCTGACGGGATTTTTTGCCAATTTCGAACCCCTAGCAATCTA
TCCCGTGAATCCTGATGAAGAACGGTGACACACAAGATGTGACCCCAGGTAAAGTCCCTT
TCCAAGAATTTAGAAGAAGATCCCTGGATCCGGGGGAAATTAGTGGGTGATACGCTGGCC
ATTTGCCCTTCCCTCCGGGTGCTATTAAATCCTGGGTATGAAAATGTCACAATAAGGGCA
AATC
.
qlt:
753434444776957858:::77575786768:?6HBA:B697747B8<A7<K>9K9?:S
:C>;7446<:444655:9:<<99?85:99867<I:;74447859:47:;4:868:A;CC<
=B9<L;=F9FP9:C=F?:@FMK?;B<:9M:;::8445::N?<@?==B;=<;GG:<::<::
:<C<B;BI;<==ADIB?D9=FF<;:@<:A<;<BBDF<::<==BC=HRB=:9<<@::GBC@
=<<F<KB=?9BBB=G==F:KB<=<BB<BBC?BD<8<<=;;@<;8:=?BLC=:<<==<<NC
<<=H=BKTEK<?D?=@:?B8=9<==B=NIKI=:=CK<?BH:9=@::6:H=:DC:<<?6<=
C>9A<=;J=C>G9<G;<;<<<DA?L;;EF<;8AKGG=B<=<<<<DKTEB;<98:98<;?=
9=<;><GG:F=I?C:>:B9=?:G=;<88<=LC=@BBP<=<L=K8H9<9<B<B=G?8?:=B
===>;=DL;=@::LVA=IG@<<<AB5;G=C?<9:?<H;F<<KH>L<==>:::>><:B=;:
?<:<;B;?G>;D:GK=SBB==<HH@JDCE=9GCW=J=GC;==C<?=<<?;<@><<;=HIW
;:KEB==<=<<<::=>@DAC<H8C>;=HA?@C=?K:<9;?@B=;=<;<I;;<B:C:C;9@
=<:<
.
frg:77
clr:32,113
}
{RED
iid:1528
eid:1128922879
seq:
ACGATCTAGAGATTCGTCCATCGACGTTAACAGGTGGATTTTCCCAGGCACCTTTATCAC
GTTTACAACGGCCAGTGGTACGCCCGTGCGGCACGGCCGTTTCAATCGCCTGACGCAGCT
CTGCCAGGTTTTCAGGCAGGTCTTCCGCCGTTAACGCGGTACGCAGCGCGTTCATTCCAC
AGCCAATATCCACGCCCACCGCCGCCGGAATAATCGCCCCTTTGGTCGGGATCACGCTAC
CAATGGTGGAACCTTTACCCAGGTGTACATCAGGCATTACCGCAATATGTTTGAAAATAA
ACGGCATCTTCGCCGTATTAATAAGTTGCTGACGCGCATCGGCCTCTACCGGCACGCCTT
TGGTCCACATTTTTACCGGGGCATTTTCAGTGGTCAGTAATTCGTAATTCATTTTGTTTT
TCTCTTTTCGTTGTTTGCTGTCCTGATAATTGCAACCGTCGTGCCAGAAAATTAAATAAG
CAGCTTAATTTTTTAATTCATTGTTTTAAAAAAGATTATATCTTTACGTCCGTAACCGGA
GATTTCCCGCAAAGCCAATTTACCGATAATGAAATATCGTCTTTTATAAGGATATCTAAG
ATGCGTAAAACAGTGGCTTTTGGCTTTGTCGGTACCGTACTGGATTATGCCGGGCGCGGC
AGTCAGCGCTGGTCAAAATGGCGTCCGACACTCTGTTTATGCCAGCAAGAATCGTTGGTC
ATCGATCGACTGGAATTGTTGCACGACGCCCGCTCGCGCTCGCTATTTGAAACGCTTAAA
CGCGATATCGCAGCGTTTCGCAGAACAGAGTGGTGAGCGTGAGATGACTGCATACCCGTG
GGATTCGAAGAGGTCTACGCCTGCTGCATGATTCCGCCCTGT
.
qlt:
4445778>;;787OUUQYA9ZeeNPebUPYGDi^]ieKCillUlH>llXZllll_blPHe
eg[SGS<NaglbVVllllllllllllallllllllllglllg_Pllllllllllllllll
llllaallgllllalllllllllllglllllgglllllllllllllllllllllllllgl
lllallllllllllllllllllllllllllllllllllggllllllllglllllllllll
lgllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllllllllUblllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllellllllllliiiiiiiiiieiiiiiiiii
iiiiiiiiiieiiiiiiiiiiiii_ieiiiiiibiiiiiiiiiidUdidi__i_ieeiie
ieeiididdiiiiRbedidRdiiYiib^Q[iii]dMdeZeiiei^bddeiiiZibUieid
VSEie]VYidXXe_W^Ed]iWXXieeXNUO]?KG\``eYX`Yi^UXUNXBUOLPPXPM]@
\E\ONNYcc_NNXNcNM`ccV]CL_^_\LWR^HSBU]NMLMXNKGRSJTEYM[RNMYMVS
SHJSROVMMMMYGVOc^NMPKJMLLP?T7BQVNMYG\@EHMBDHLSGG@EIGOGHCMQ?M
LQQJKQOEHFDEO=A>AQ<EJAAOGM;DDPE;EQRA97=NOK@GO?ZGBK\D@?ABC>\?
@:==Q=?@E<F9E>?:R?M765@Q;46;F46593533749398B=597?I99:G<I=G7@
N=GFKF;JI9D7F6>>;96:J;=G>JA?=@?DC993?C3142
.
frg:77
clr:13,878
}
{RED
iid:1529
eid:1127298208
seq:
TGCGTCTGATGAATCAGCTTGATTCGTTTTACTTTTTATAGTAATGTAAAATGGAAGGTT
TTCTCTGGAACATTATGTTTACTTCAAATGTTTTTGCCACAGATGCCGACCAGGACTCGA
GGACAGGATGCAGCAGGAACTTCTGGGGGACGGGATGCTACCCCAAACCCACCTCCAGTT
CCTCCCACGTTAGCCGAGGCGATTGCCGCCTTGGTGAATGCCACCGCCGATAATACCCGC
TTCCTTAGGGAAATGGCGGGTCAGCAGCAATTCTAGCAGCAGGCGGGAAGAGGTTATCCG
CAGGGTCCCCGTGAGACCACTTATCTGGATTTCTCGGAAACTCGTCCACCTCTATTCGTC
AAGGCAGAAGATCCCTTAGAAGCTGACGAGTGGATTCGGGTTATCGAGCAAAAGTTTGGT
CTTCTCCGATGCTCAGAGACGCAGAAGCCGTTGTTTGCCGCACAACAACTCCGTGGTCCT
GCCAGTACCTGGTGGGGAAATTTTATGGCTATTCAACCTGATAACCATCAAGTCACCTGG
AATGAGTTTAAAGCAGCCTTCCGTGAACACTACATCCCCGAAGGAGTGCTGCATATGAAA
CAAGAGGAGTTTATGAAGTTACAACAAGGTGGAGATACTATTACTCAATACCTCAACAAA
TTCAATCACTTGTCGCAGTATGCTATCGATCAGGTGAATACGGATTTGAAGAAGAAGAAC
TGTTTTATGCGGGGACTGAATGATCGGCTACAAAGGAAAATGGGCACATGCATAGACCCC
CCTATAGGGGAAAGGGCTGTCAGCACCAGCCCTATCT
.
qlt:
44444<=AV>M97<@?HelAE;8@Jalll[[Vllll[kkklkllkllllllkkkkgkkkl
lllkk\\gggkkllllllkgkllkkUllllk\\\gklkklkllllllllllkllklllll
llkllllkklllllllllllllkkllg\gkklllkkllllllggllllllllllllllll
lllllkglllllkkkgg\\gklllll\Pgg\glllllllllkbkk\gk[UUTgkkllkgk
k\\\\\\NgkkkllklllkkkkkakkkklllkgglkkkkkkdgUg\\UUY\Tkdkllk\k
llkllkgkkggkkgYgkkdkkkkggklggkklg\gg[lklkggYkkg\kkg\U\kkgSkg
gklk\gal]GkU[dkU\\Jklak[U\UNkTWkkkkkkUkdkkkdkT\[\kkggYklkgk\
kdkgdkkSldgkkgT=kTYUWkdG\gTkkPdkkkkgPgkkkkkkkkkaggkgYblg[ldY
gdRRTNOgggggUllgN_gTVllgbYllPgbbggOlglbl_SggglUllSlPb_Lbd_ll
l_HKRQ[llWlllbQXll]lblYbleldbleiP@ibiiiSeeKceZdi]ee]]de__]ie
bZcX_@R_QeiedQd_iVZi]dId]WeeiZibiSeV__deVie^ieMXeeTdedOX`SiZ
SiYKSUD9NBU\OePQe>OUM\R\QN`MSWLL:97LYOMLHB@GOcVMOV;R]5^Q6G:?
M]@c^X=FMLQ[UKEGGQLNLYEFLCMDOIGF[K?FMT[RIH^<T@MALS@:AG7@<755
B<:897?=L??D55JJ8?=6>CCK?@6?=BS7B5<66
.
frg:78
clr:5,813
}
{RED
iid:1530
eid:1128922880
seq:
TAGCGATTCTAGAGATCGTTTTTGCGGTTCTGGGCATCCCACAACAAAGTCCATACTAAT
GTCTTCCCATTTCCATGTTGGGATTGGCAAAGATTGTAATGGACCAGCAGTTTTCATGTG
TATGGCCTTGACACGTCTGCAGGTGTCACACTTAGCCACATAGCGTGCAATTTCAATCTT
CATCTTAGTCCACCAGTAATGTTGTTTTAAGTCTTGATACATCTTAGTGCTTCCGGGATG
AATAGAATAGCGACTAAGATGTGCTTCATCAAGAATTTGCTGGCGGAGCTCTTCGGTCTT
TGGCACAACTATGCGGTTTTTAAACCATATCACACCTTGATCGTCTTCTTTGAAACACTT
GGCTACTCCAGCCTTTATCTTTTCTCGAATGTGCTTCATACCCAGATTATCCTTTTGAGC
ATCAATTATTCTTTGCAAAATGATTGACTCAAGCCTTAACTGATTTAGAGTCCCTTGTTG
AATGATCCCCAGGTTTAGCTTTTCCATTTCTTGACACAAAGTGTTCTCGAAGGCCTTCGC
CATAAGACAGTGGCAGGAAGTCTTACGACTCAATGCATCTGCCACCACATTGGCCTTGCC
CGGGTGATAATGGATCTCCAGTTCATAGTCTTTAATGAGCTCAAGCCATCGTCTTTGCCT
CATATTTAACTCTGACTGGGTGAGATGTACTTCAAACTTTATGATCTGTATATATATGAC
AGATATTTCCCAGCAGATAGTGACCCCAAATCTTTAAGGGCATGACCACAGCAGCTAGCT
CAGATCATGATGGGATATGCTCCTCATGCGGGCGCAACTTGCCTTGAAGGTAACGCAAAT
AACTTCGGCCACTTTGGATCAGAACCAGCGAAC
.
qlt:
42435445869:97D:DDDRD^K>8iQ>XXViY^OdZi[R;UHI@G_eddeIBd_eT_N_
SHOJPGC>AWZ@MB>elllleeeVll[WPQbPlWll]lellWeWTCS__belllYPllll
[eel_Vllll_PTleellbl]dlllllbggglllbl_OllllbllglgggllllKgllll
gWlllllRbl_]ll[b_lellbllellWllelllllllllblllllObllllllllbl_l
llllbllelllllllll]lllllllllelllllbIelllllllllll_llllllllelll
llllllellllllllldllldllllleiiicbeeeiiiiZeiieieiieiiii_eeeeei
i__iiiiii_eiiiiiiiiiiiiiiie_Z^i]ieeii]eiei[YbVZie_iiiiiii_P_
eebbbdieYiieiYidYeeididWiiiZiYPbeeiebedbiidRiQ^NeXb^VYeeided
eQReVWeYVYTUedieeSeiiU\PXQeie\X\\MW[`QeiTXeQ]_YXE\T<N:PMVXN\
ULQ``L`KMYNc`MMW`V_MITMGMHL`EMOMRFVHH[[M[JYLMMMQNSL[IBMCIT@W
MIYM>QQ>GHFLB6@LLMQKENRLRGM:KXMYHLTEMA:BMH;OKLNBGLOGD;VOMKEM
H>IA<cV>LKMLIKO>KOVC=DC6?9M?RAHEG>S?BPSJ6@GJ>@:M8D789;7:BBC9
8<Q<I;Q<>UNHJM?8N:F=5?644697N=:L:NK87>Z@<BA@748546F<:9HGA65:
E48F5:8<H323O65348J;=E::9<6754I8:898?;77:9:65564556D98::D96A
7;865:=<;B46353:;774?788545651331
.
frg:78
clr:14,805
}
{RED
iid:1531
eid:1127298209
seq:
TCAGCTGATCGTGCATACGGGAGGTAGAGTCGGAGGTTGCAGGAATCTATTTCTTCAATG
GGACCTTTATGCTGATCAGGAGCGATGAAACTGCAACATGAACTTTTGGAGGACGGGATG
AACCCCAAACCCACCTCCTGTTCCGCCCACGTTAGCCGAGGCGATTGCCCCCTTGATGAA
TGCCGCCGCCGATAATACCCGCTTCCTTAAGGAAATGTTTGGTCCGCAGCTATTCTATCT
TGATGCGGGAAGAGGGTATCCGCACGGTCCCCGTGAGACCACTTATCTGGATTTCTCGGA
AACTCGTCCACCTCTATTCGTCAAGGTCCAAGATCCCTTAGAAATTGACGAGAGGATTCG
GGTTATCTCGCTAAGATTTGGTCTTCTCCAATCCTCAAAGGCCCCTAGGGCGTTATTTGC
CTCACAACAACTCCACGGCCCTGCCATACCTGGTGGGCAAAACTTAATAGCTATTCAACC
TGATCTCCATCAAGATGCCTATGAATGAGTTTAAAGCAGCCTTCTCCGAGCACTACGTGC
CCCAAGGAGTTGTGCGTATGAAAGATGAGGAGGTGATGAAGTTACCGCAACGTGGAGATA
CTATTACTCAATACCTCAACAAATTCAATCCCTTCTCGCAATATGCTATCGATCAAGTCA
ATACTGAGTTCAACCATAAAAACTGTTTTATACGGTGACTCGACCGATCATGTAGCAAGG
AAGATGATGCCTTGCATAAACCCCCGTAAGTCATAGACTGTCACCCAGCGCTCATCT
.
qlt:
A723764464335393447E:<7564445454446965584444444555<A85N<79G;
6749?=B6C7M8755445555758<@DH86<:98=78D8=>>HED?;>G;=>PH?H?;>?
;8;?@?IH=RGK=BG===::<=KA6AC===<;;<8<J;B;=:;<==FBB;67<=:46BFI
JPHK<K<<<<8BB=<<<==AIBFKTMTNF8H<DB?;B;:;<==O<?M=BWDLCTT=C;>B
;K<<W<UBBG=KOCG<<E<OB=B<<FCH]>=C<:<E;GBF<CBB==JBFBN<>><=>K=Q
@CLDR<?<<;=DGFG=@=B;<C<==H;;9F<<PCCNB=K?=DC<;G9TS<TW=Q<BIPJ<
=;=CL>L:B=:<<<=>@GDGGG]KGK;DG<D@;LI@=:C;;98<>=KC=;B=DD=;=C<<
K<N<::<:<7>=B?8<C=<QGHOBE;:8CGIL8<?;;?LI=C;>K;@A<;<RF:?J;;;>
;?:9;BII<:C;::>9:;;B>?@<D:>>88E;=<99>:88;;D<:9>:<>>:>FE=8:9D
9>BK<KKD889A=8<=AAGA@@=<98F@78E98@:<@?K;@;B8:76L98EF9C>=@EG<
Q@<<9;AJD78;;8:8E>EZ=L]=PS66A@8:EG=GF6GG6:99:D>CDD@9VDC68968
A9>94:9:C;9;85588I88@<<:GBKKK;=9<5579>BEA:>8;E>:@9<A>;:96D<@
B?;H>E>9:FC58@@57:57:HA68>:<>>:98;F@;7=6B>7C59887<9D8:567
.
frg:79
clr:50,763
}
{RED
iid:1532
eid:1128922881
seq:
GCGATCTAGAGATTCGTCCTTGGAGGCTTTCGTCGCACTTTTTTGCAAGGGGACCAGCCT
TTCTCGGTTGCATTTCGTTCCGGTGGGTGCGCGCGAGCGCACCCGCCGGGTGTAGCCCCC
GAGGCCTCGGAAGAGTGGTTACACTCCTTCGAGGTCTTAATACCTTGCGTAATGCTTCGG
CTGGTCTGGTCGTTCCCTTATGCGAACTGGCCGTAGCCCGGGTGCACGGTCGGGGCCCAA
GCTCTCGGGCTGGTATGTTGACGCTGTCAACGGTTCGGCCGGAGCCGGTTTTTGCGAGAG
CAGCCCCCGAGCCTCTGCACAGGGCGAGAGGACGATCAGGGACAGACTCGGCTTTTTACA
TACGCCCCTACGTCGCCTTTCCGCAAGGAGGAGGGGGGAGTGCGCCATGTTACCCTCGAT
GGGCACCGAACATGGTGTCTCCGGTGAGCTGCAAGCGGGTAATCCGAGTGGACGTCCGTG
CCCCGTTCGTTGGGGGTCGGCTAGGGGCCCAGAGGCACGCCCAAAAGTACCTGCGGGTGA
TTTGCCGGACCCGGTCCCCTGGCGACGGGGTCCGAGGGCTCGATGCCTCCCTCCGATGGG
ATTCCGTTACACGATCGTTCCCGCTGGTCTCGGAAATGTCCTAGGGTACCTCGGGAGCGC
AGCCCGAGCCTCGGTTATGTATCGAACGTACCCTGTCATCCCTCGCTCGGTGTCTGAGCG
ACTGTGACCCTTCGGGGCAGCTTCGACCCCTGATCAGTATGGGCGCGGAGCCGAGTAGCT
GAGCGCATGAACTTCGGGGCTGCTCGACCCTGACAGTATGGTGTCGGCCACGCGATCTGA
GCGACTGTTGAA
.
qlt:
7756:7@B>C;=:QZKPQN^_eVTMT=eillV[l[OZXlllUUl[EBFglll_Y[Vlllg
ggglggggllgalllllllllllllkkklllllllllllllllllllllllllkllllll
llllllllllU\\lllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllll\\glllllllllllllllllllllllllllllllllllglg\gll
llllllllllllgglllllllllllllllllllllllllllllgllllgOOUllllllll
lldlbUUbllbbUllllllllllllllllQll_llllllllZllllllllli_UUZ_eed
iiieii_iiiieiiei_i__eieeieUOIRiiNiiiiiibiiedeibeiiedU__iiedd
i[[de_iei[eeeiY^ieeeeYdiZiiLiiiWVddiii_WXVW^iWiUUiUdQWe]ieZi
T\QWXX[UUS\QiiiUSXW\SWPP^^\O_UNHV=\WNPX_]ON`^NMMMKNM]FU^NKTG
<^WKAXMMT>WMM^NMYWI>:=7>MKM[[^JTNA^BcWNV[ITOMEEMSODJJO?TLScJ
CBP@PMPMLMDMGVRRLTONTJCFLHEAA8;B<Q\<ANKIKJCHZ8<DM<>>AcDA;E;F
LFLJ<>V?L=KOBGG?H=<9<?DFGB>POENG9<G8LCNDV<=<G>;:G75:;E?B=987
MBC@56M9@=6;;JZQ<466B5<=9G6A=7=IEH>8?;J8GK445499J5;<5947@5A>
G9?5436:G6483=66HNA5843666A7<:@C=76:784=<4:9DD=:>454<::88<D@
K44945:7?685
.
frg:79
clr:6,841
}
{RED
iid:1533
eid:1127298210
seq:
GAGGTATGATGAATCACGCGAGATTCGACGATTCTCTACACTCGCTCATTCTCCCGATTT
TGAGCCCTTCTAAATGATACAATGGCTATATGCTTAAGGGCTTTCTTGACGGGATTGTCA
GCATGAGGATTGCTTCTCATTAAAACATAAGAAAATGGACTTTGGTTAATTTGTAGGCGT
AGTCCCGAAGGGGCTGCCTCATCGAAAGCAATTGCGCGCAACATTGACCTGCAGCGATGT
GCTCGGCTTCGGGGGTGGAAACAGCGACCGAATTTTGCTTCTTTGAAGCCCAAGACACCA
AGGATCTTCCCAAGAACTGGCAAGTCCCCAATGTGCTCTTGCTATTGATTTTGCACCCCG
CCCAATCGGCACCCGAATAACCAATCAAATCAAAAGTGTATCCCCGAGGGAACCACAGCC
CAAATTTAGGTGGAAAAACCAAATATCTCAAGATTCCTTTTACCACGTAAGGTGGGATTC
CTTAGAGACGGATTGGAATCTTGCCCACGTGCACACAGAAAACATAATGTCCCAGGCGAG
ATGCACATAAATAGAGCAATGAACCAGTCATTGACCGGTATACCTTTTGATCCACGGACT
TACCTTCCTCTGTCGAGGGTCTAGATGCCCATTTGTTCCATGGATGGTTTTTTATGGGGT
TTGGCATCCTTCATTCCAAATAAACTTATGATGTCTTGAGTGTATTCATTTGAGCTGAAA
AAGGGTGTTGTCCTGGGAGTTGTTTTACTTAAAAACCCTAAAAAAATACTTTTGTCTTCC
CTCGTAAAGTATCT
.
qlt:
111244746:5546457954456\UK@>I887ACHGB:565777BPK>8=>N>8><8GHD
65445554469857?98A96495;96:A?9E<<74494494478<8<<E<=A=<JAE;<;
;8>;<H;BB?CH:;;F===B:B:>?>?8@>BH@<<9;;HC=?BHH=<:97::=67579:=
=:DUF=G?;<QO<T@[GHBCGCCODCG<<GG=>L>;B<KLAF=:=MKGD>T<:;CB=:LH
KCCOEHBGG[G<;<H=H<G<G<N=ICC??=R>@=<;<<?PJ?BC<DC;BHAB<;J?=J=C
<<P[TWCQRHK<D:;9;G;9;<<K8B<;97=::7<BCGMU??<KHQTH;G:<C<;?IKF<
JKLTEHUL@<G:DBCTK=[QHQQQ=D:=@=<:::66<89@B=LLK:TBGC<KBH===<?B
<;967=<9?G:F<H;=:65:;B?:=8F8B<==XGOV;:B=<T>8475>OC8B:LB<U@CL
K;CH9B?@<<GL<BD9F?=L;<EA:E?<<=LA:?;C<TA:F?=A?H==F=@L=<B9@9UH
V>C?JJHG<PFCCEP@A<>;VG>>:?;<::=9;7:<88:G>B<<=C>UVCVbC8;C?MP>
BB>D<BE<8?8RGD:K=SWLC8Q:I7BC>?BAHO[LAPB>:8;9;9=GOK<:>9A;9<88
:<E9?A?>COHIFEE?<>HAE9:79IA>7SOGCCMFOBEA=A89>@8:G>GEA<;?>AC:
;C8><886:8::DD?HHF8>FG8HH<>C@I>GHH<:>;;@77:6:A>?7<=;>6<5AEH=
<;>68755487O79
.
frg:80
clr:23,782
}
{RED
iid:1534
eid:1127298211
seq:
GAAAGTTCTGATGATATCAGCTTGATTCGACGAATTCTCTAGATATCGCTCAATACTGAC
CATTTAAATCAAACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTT
GACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGG
GCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTC
AACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATG
GGTATAAATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATG
GGAAGCCCGATGCGCCAGAGTTGTTTCTGAAACATGGCAAAGGAAGCGTTGCCAATGATG
TTACGGATGAGATGGTCGGGCTAAGCTGGATGACGAAATTTATGCCTCTTCCAACCATCA
GACATTTTATCCGTACTCAGAGGAGGGAGGAGGTCACGCAGCTGTGCTACCCAAGAAAAA
AACAATAAAACGGATAAAAAAAAAAATAAGGAGGATTCAGGAAAAAATGTGGATGAGGTG
GTGTTGTTGCTCCTGAGGATGGCAACGTTGACATGAATGTACCA
.
qlt:
431221165587:67:7968M[=A:8;ENIGXNNJeeW^RTZLTNSiddeTH_dbddiU[
IN]_HHE:78865558?=:;OPN@MCbU_Vlblde_bbUHLabUUbU>;>9866979KKG
UY[dddWdadgd[dd[dTLlOd[gll[adggd[Sadaad[akkdddddNkkd[dkkdkkk
kkkdkdkkkkdadS[]lkkWkdkkkkkk[UlkYadWWKka]WddVTMW[kkTklkklkkk
addkkakkdkd]kdkldkkdkdlkkkkdkkkkaakkk]WRUJSkWaklkkkkdkkkkdkk
kUUa][aa\kdddkkdWOdRW[WkLOGYQLNHNPJBdLakWk]OWWaVW]\NV]dkMW]k
d<WLKKLVGVKk]NW]]GkGPWWNVY\OLPGB==BO<<=HKUWD=:?GDBMTOBEFTGBK
EBCI<=K==D<K=L?;G=GOB;H>9EDOB<BFB>=<B:?B<G=<LC??DFTE>JCLC<@=
:;=HITKNPPLCC<<JC=<C<C:99=9<=G=LG;9:H:L;::;:<G<9;?R=G=KM;JK<
K]<9<89CHK<G=CGGG;UG=a\BKI<?<;=:;CD;==:=><CRK@AGC==Q<@C@?<@@
<=<?;?8K>;:G>6<C>C;<E=<;:;8:?=:<;;B8:;L:5:>;
.
frg:81
clr:499,639
}
{RED
iid:1535
eid:1127298212
seq:
GAGGTCTGATGAATCAGCTTGATTCGTACATCAGGCAAGACTAGGACAGGCGCTGTTGTC
AATTTGTCACGCGCTTCAAAGGCCTCTTGGCATTTCTGGGTCAAAAGAACTCAACCTTGT
TGCCTAGCAACGCTGTCATTGGTTTCGCAATCTTCGAGAACCCTTCAATGAATCGTCGAT
AATATCCGGCCATTCCAATGAAACTCTTGATTCCTCGAGCATCAGTTGGCGCTTTCCAGT
TCAGAATGACTGCCAGTTTCTTCGGATCCGAGAGCGATCCCTCATTGCTGAATGTGATGA
GTGAGGACAGGGGTCCCGGAGGCCTAAGATCCCCTTGGCTCGGTCAGCCTTGGCTGCTGA
CGTGTATTCCGTCGTTTGTAGGATCCGCTTTCCGAAGTTTCTTTAGGCACGAAAGATTCC
TGCTAAAATGAAATCCTTTTTCGAGGAAAAATTCCACGCAGAGGGGGTCTCCCCCCTTTG
AGCCCCCGAGGGGAGGGACGTGTTTTGCCGAGGTTGGCCGACCCTTCCTTGATAATTTAT
CTTTGATCAGGAGCCAGGAATATGGACAACTTTGAAAACATCTTTTTTGTGTATTTAGCG
ACGTATCCTGTTTGATTTTTTTAGCGTTTG
.
qlt:
311137:DSBB77:@9ASiei^RiiV]ZUD^NTee[TLK?8PXllQGQlleleelOalG_
@<8;666444:;aRkkkU=RGLBVlllllkadllkWRkLK<4748;97:;;8:<PYkllU
dk]kkl]kkklkkkl[kWdd[F=JCHTOWLL[PMUBTCWNKMT]aWLIPaT?K<;B>:JB
=COOTFKHN=\<GGF?BGSPD=GGKGBBHB@GGCGPGT>B=BF<\=PY<:F=B=9;<<B;
<;:;<<=<;;<==H<<;BBP<====A:B9<FFC?G<KBFD=SHDK>T=<GU<<PNKI?KT
:?H=<B;9<;8:8B<==HGI=BE==GFBP;:=G<F9>F:?BD=9;8><N<<S=;?TBI:=
=B<>:?<A:=<?==B=A<:=E8L?KBGJOWLGA=Q98=<<:<BDFBEG=8:J8<JF:=BG
TkCWI=KA=;N:KO====DMH[WaKLaG=TNDUO8FK@GB=SDGNINHHNNOGOOWLSG=
C>>CMHKGTS\B=KFIC=B;B<<HRLK:<BN<D<=B@;;CI>=KJTLLG=PC<<?;;<<B
<>BBL@;?=<E9L?=W<B:<>C?<<C>=C<?B;<9CH@=?;9<<=>A><;=====:H:?>
<=;L<@@;;LCT?H;=<<C;<;;;=99=;:
.
frg:82
clr:6,628
}
{RED
iid:1536
eid:1128922882
seq:
AGGATCTAGAGATTCGTAGCTGCTGGAGGAGACCCAGACGACGAAGGTGGCGACGACAGC
TCGAGCCACGACACCGACTTCTCTGCTGACCATGAGCCGGAAGGATGGGTTGTTCGACCC
ATCACTCGCGACGCTGCTCGCGGGTGTCACTTCCACGATGCGCTCGACACCCTGCTACGT
CGGGCACTTAACCGGCATACTTGGTCCATCGAGTATCGCTGTGTGGTCTACCAGCACAGT
CGCGGGGTCTACCCGGACCGCTGGGAGGCGACCTGCTTGGTGCGCCGTCCGGAGAACAAT
CTCCAGGGTGTAGAGGCCTGCTCAGAGCACTATTCTATCTCTGAGCGGGACTCAGCTGAG
GCAGCCATGCAAGATGCTGCACGGCGTGCGCTTTCGCACTACTGCTCGGTTCTCGGTGGG
GTAGCTGACGGTCTTGACCTGAAGTATTACCCCCACCGTCCATCTGGCAGCACAGGAGGC
GTGATTGTCTCACCTGTCGGTGAGGGCAATCCTAGGTTGAGCAGCACAGTCAACCTAGCC
CGCCGGTGTTAAACGCCGGAAGCTGGAACATGCATTAAACCAACCTGAATAAGGCTTGGG
GTTAAAATCGCCCCGTGCGGGCTTAACCCCCGAAAAGCCTCACCCTGGGAGTAGGGTTCC
CCGCTCCCCGCGGGAATTAAGCCCCTATAGGGTCTCTCTGGGGGGGGACCCCGCCTTAGG
GATATTCCCCAGTGCGACCCCAGATATCTTCACACACAAGCGCTGAGAGTGCGCTGTGGT
ATTCACAAATATATTTAAAACCTCTCTAAGT
.
qlt:
5558:7A>:=;8;WVLZeS]l_KllgVH_gBM?lS?ladgldlllgaLlaVllklllEkF
B=<<==;Slllkklllllllllllllllll[kllllllllldYgPPgkklllllllllll
kgkllllllllllllllllllllllllllllll_alllllllllllllllllllllllll
llllllllllllllllllllllllllM_llllllllllllllllllllllllllllllll
llllliiiiiiiiiii^__iiiiiiZ_iiieeiiiiiiiiiiiiiieiiii_IHiddeii
iiiieiY[iieiiii^Uiiiiiideiiie^iiiYiYViiieieiHeii^RLeYQT`i`i>
iXYYeiH\e`RYMTL`T`^POR\cP_K_MQWVZ]MKMRSMNMM_LYWS_HMMMMJW<W^W
WHOJSYRYCP^LMPRVNFMLODPDLIJMJGTNNJ>MKGMLJ@MOLHO>JCH>KKLHH?V>
G<BGH><78:585HA=8I=@99=8VI67CD@97COD::97759<768<LDM9>:FMM9?I
77555=677:IL@555665697688Q:8D59@>8?<557436H59E6@B>>5KM:?5345
2466<94:77CD7464334322365964344569>6454354:=85;67746;85:99<A
I:3318>:3457D6486433135@54335643444646448<7;B:8679644455334:
325444:=334735563136433;66854113654231344344354384;678447445
2411452823334484215132121141112
.
frg:82
clr:6,595
}
{RED
iid:1537
eid:1127298213
seq:
TGTTTCTGATGAATCAGCTTGAATTCGTTCCAATCCCGGTAGTTTCGTGCCCTCTGTGGC
TATATAAAACCGCACCCCCTGCGCCGTTCACCATGTCACGGGGCTTTGCACCACCACAAT
GATATAGGGAGGCGGAGTGCGCCGCTGGGGGCCGCCTCCATGGAAGCCTCGCTTGCGAAA
CCATTTGGGTCAAAAGGACCGGCCATGATGGCTCACGGATTCCCTTGGGTGGTGTCCATG
GCCTCATCGAGGGATTCAGATGAGTAATCCATCGATGATTGCTCGCCAGTGTTGGGTCAC
GACCGTGTGGCCACGGAGCACCGTGGCTAGGAAAATTTGTGCCACAAAACCTGGTAAGAA
CCCTCCTCACATGTTCATTGTTGGATGATCATCATTTGGCATCGTGTTGATTAGAGTTTG
GCCGTCAGGTCGGGGTGCTGGTGTGCTATGGCAAATTGATCCTACTACTGATACCCTGGC
GATCCAAACAAAGGATAAATAAGATTCATGACACCCCAAAAGTATAGCCAAGAATAGAGA
TTGGGGGGTATTAGAAATTTATTCAGATTCCGTGACAAGATAGTTAATCCTCTGGCAGAG
TTCATTTGTCGACTGCATCGTTTCTTGTTTGCATGGTACCATATACAGCATCACGCAATT
TTCTCTCGCTCAAGCTCAATCAGGAATGACTAATAGAGATGAAAGGTTGAAGTGATTTCA
TTGCTAGGGGGATTTGCTAGTGGATTTGATTTTTGTTTTTGTATATTTATGTCTTTATA
.
qlt:
11313C9<TAD:7877?Uc^Q<:Fii>YYY:8;OYi^iQD_ei_e_e__iielllll_Yl
lele9<<8;;776E?GOUlllgglllgl_gl__lllklllkkkkkW]BG?B><?Ekkdkl
kkllllllllllllkllllllllllllllllllllllllllllllkllllllllllllll
llklll\\klllllllllllllklkllkllllllllllkllllllllkklllklkkkkll
lkldkadkVlklkkkkld[lkklYkkkklkkkkdkkllkkldkkd]d[aYk]dkRQOULV
[kTW\GXKkkK[LVKSH=C=BLWLk[R]dVTdWWWOVWWCWRK=KGYVWPTPYKCWLH[T
QWWYYUQVHWW[dKMS]WTa=JLTdTakWTBTKGGHFO=BBDG;;9H@GG@MK<LD<KPU
E;=84<==<<B7;B<8:85<<8=<65===C;<9D;;LL=:=9=::>;G;==;<?=G;I<;
<;=F=<;99<CFH=:98FG?:BD:;=B<<;:;;?C=FFB?:>;H=C;:9<:7==:K9:;=
?@@:69<9L>=CI=G=?:98:;::B=:<9848:@C;A:>:==?;<?;889:9B<:=:8;;
<;;B9:<<<;9E9==;;:?;;=<<8=B<?;9=67I<=;;:;:=99<A:;CE=:9::=A99
::==;?A<;LEE=<<>D=<===<AG@GJV<<<<<=;:;?9:9C;=<:95DM:CCC=L>=<
;7957?86@I=9:>;989D8647>7899<:<<=:<E<;E:=AF@9=>=:?9D=UEC77;
.
frg:83
clr:5,775
}
{RED
iid:1538
eid:1128922883
seq:
TGACGATCTAGAGATTCGTCAGCTATATAAATTAACTAACGTAACCAATTTCTAAATTGA
GACTACAAACTTATTAATATGAACAACGGGATTAGCGCGCATAGGACACGAGGGGGGGGG
GGGGAGCAGCCGGCAAAGACCACAGTGCCTGCCGGCCAACCCTACTCACACGAAGCCGAC
CTCCCTTCGCCCCACTCACCCTACGCTTCGCAACCGCCCTTCGCCGCCGGCGCCCGGTGC
TAGGACCAGGCACATCTTCTGTGTCCGCGGCGGGCGGAGAACCCTCCGCCGCAGCCACAT
CCAAGGCCACGCAGTAATCTACGTCATCCTCCGACGACTCCTCAGTTCACTCGACCGATC
TCCCAAAGCCGGCAAAGTTAGAAAACTCAGATGCTGACCATTCACATTCATTACCACCTT
CCATGGTCGATTCCAGCAAAAATTTAGTATTGGCGGTTCTGAAGGGAACATCCGTGCCTG
CAGCTAATTTTTGAACCGAACGACCTAAATAAAATTAATTACTAAGAGCGTGAGCTAAGA
ATACGACTACCCCCAAGAGGAGAGTGGGGTAGACGGCAACTAGCAGTTTAGGAGCGT
.
qlt:
41147875;@?<877BMBPB=XXNNEGOW^FUXT^GVPD@@PXZeQEeei__LXiZ^ill
D=;64447644478>SV]]YWgaTTgglgl____llllggg?F=:9;:89DBI?TT[TCI
CFF<8;=><@GGG<?E>8PC<C=::<=;<=L>C=B=?:CFSDUPGKPALAE;C945:9D8
<=B=<CCG<=JHCHLKO<<BFBKKP;CC<<;C?G<F<BFBGB8=CK=CFJ=CGTLLK?TG
KF:MNC=J<<<RB<JKHLOO[H]G=<<?<=B==K;9=?OTJ6HFGC:7BFBAK;<K;>:?
<BCEBS?G;<87<>GN;F?;<;==>=BF=B=<<U;;UMBKNGLS9<??9KKNBC<CC=:=
:9=B:<G7;:;=<N8BF=AG??;;<?K=<<K<GGG<T9DB<LC<K=LJd@WLGG@@<946
B:?CNN<;;?;98:;:===C::HFHHP?S;=H=88F:=<<?E<99<B<;:48869FF:88
:<<:;87;=99:A9E9;9<8;GT<BGN:=:::=D976?>;9<:;:@<?;=<?7=:=:=;G
<<:<<:<:6=;<;99B69845<88868<B;5=::=;:<<=;;=>6><=<8DG54584
.
frg:83
clr:8,592
}
{RED
iid:1539
eid:1514872996
seq:
CCTTCCGCTTTGTCGATTTACTATGCTTTCTAAGAAATAGGTTTCTAAAAAGGCTCCAAA
TTTTAACAAGTGCTCACTTTATGATAACAAGTCTTTCCAAGAATTTCCATGATTTTTGGT
GCTCAACTCTGATTTCAAAAATTCCAATAATCCTTCCAAAGACACCTTTGATTCACTTAA
AATTTGCTAACTGATCTAAAAATCCTAAAACCATTCTTATCTGAGATCTCATGAATTTAG
ACATCCAACAAAATTGATCTCACTATTTTTGGATTTTTCTACAATTTCTAGCACAATTTA
TAAGTTCTCTGTTAAAGAAAATACCAAAATATGAACAGCATTGGGCCCAAACTAGACCAC
ACCGCCCAAGTTGTGCAGAGCCGACCCATGGCTGACAGCTCGCACCCACGCCGTGCGCGC
TTTGCAAAAAGAACCTCGTTGCCCAGACAAATCCAAACGAGCCCGAGCCACTGTTAATTG
GTGTCACTGACAGTTTCGCTTAGATCCCTCGACTTCATCTCTTTTGCACAAACTCAGTCG
CGACACCGTCGTGCTCAACCCCGGCGGTCAGACGTCCGATCCGCCACGGTGGTGTGACCT
AGTCAACGACGACGGCACCATCACGATCCCTAGGCAACGGTGGACTCCAACCTGTGTTCA
ATCGACCGCGGGGACACTAAGACCTAACTACCGATGGCGGCGGCGACAAACCCAGTTCAG
TGGGCTCAATTCTATGGGACGGTCTGCAGCGGCGCGACCCTGTACTGGTCAACACAAGAC
GGAGAACTGAAATACCAATGGGAAAACCTTCACCTGAACCTTCAAAGAACGTGGAACGAG
GGTCCATGCGGGCTGGTCACTCCCTAGAGACGTCTTGGACC
.
qlt:
34445444565785C?;:>;8689BAG?AGOLBKBC?5_eH=KIPQIb@KH[USbbUFQV
Nb=<=;;96556=<>:EUaVYglggdaaVaggddggdM?dgldglaaSBSTSLdkkklkk
kkllkkkllkllkkkkddlkllllkklllkllkkkkaUllllllllllllllllkllllk
kkllggkkkkkklllkklkkkllklkllllllkllllllkkdkkklllklkklkkkkkkk
lllllllllllllllllllllllllllllgglllllllllllglllllglgglllgllll
lllglllllllglllllllglglggllllll_lllllllllllgggllglglllblllll
gllllllllllll_llggllglellllellelllll_elll_llllldlellebllelde
eeelebllelel[[leleell]l_dZldZlllllde_leleedd]lW_^bbeieeeWb__
TPebe__deZedeeiee]eedbHOLeieeiieeeeeSiiiie]_P_ZSeZiiiidRedib
dee]ZeeibbZR_ZbbKUW__ed[]ieUeeKe][]bYedRS[VN^LXbeZiUWXEeWUdY
bNedXXdUbRbiXbebSeeZbeRbQQJUidOXDUVORXU^CdUIGTU_HUVWTiNK6A\N
ORWQX?FUXX\RNGKHSXO\DeBU>:E9QQSMUVNPPEPROQRMNN=HMFBNL>KJIMNO
F[OO6BLDEMMKDKEPTCMLOM>LL[CHNQMM<BKJMKMKB=;5C5DLEL::9D>>JGJ6
778ATRC:TNMCcAHN<A6JN9V[NQCW@NJ8<@;F9A8B6;578=8FTM95@ELP;<MC
YA;FF=8655>@ADFC9H68>A@665JE875:<IAA?A585
.
frg:83
clr:14,877
}
{RED
iid:1540
eid:1127298214
seq:
TCCGGACTCTTTTATATCCTGCGTGAGTCGCGATACTCTTCTCAGTTGGGTCATATGTGA
AGGTTTTTTATGACCCTTATTTACTTCAATGGATTGCCCTGAGAAATATTCAGAGACAAG
ATGCAACATGAACTTTTGGGGGACGGGATGCTACATCAAACCCACCTCCAGTTCCTCCCA
CGTTACCCAAGGCGATTGCCGCCTTGGTGAATGCCACCGCCGATAATACCCGCTTCCTTA
GGGAAATGGCGGGTCGGCAGCAATTCTAGCTTGAGGCGGGAAGAGGTTATCCGCGGGGTC
CCCGTGAGACCACTTATCTGGATTTCTCGGAAACTCGTCCACCTCTATTCGTCAAGGCAG
AAGATCCCTTAGAACCTGACGAGTGGATTCGGGTTATCGAGCTTAAGTTTGGTCTTCTCC
GATGCTCAGAGACCCAGAGGCCGTTGTTTGCCGCACAACAACTCCGTGGTCCTGCCATAC
CTGGTGGGGAAATTTTATGGCTATTCAACCTGATAACCATCAAATCACCTGGAATGAGTT
TAAAGCAGCCTTCCGTGAACACTACGTCCCCCAAGGAGTGGTGCATATGAAACAAGAGGA
GTTTATGAAGTTAGCACAAGGGTGGAGATACTATTACTCAATACCTCAACAAATTCATCT
CTTTGTCTCAATATGCTATCGGTCAGGTGAATACGGGTTTGACAAGAATAAGTGTTTTAT
GCGGGGACTGAATGATCAGCTACCAAGGAAAAAGGCACATGGCTAGACCCCCGTTAGGTA
AGGGCTGTCCGCCAGCCCATAATTG
.
qlt:
42234444476745:7:755=::@=75<A:558:8:?E>8>6>55B6<8J:88599C?<=
BHDA==A9954444644647:;8:79447CA7558@E@64<44644858=<586<LB?;?
B?KB?::<<<FHLHL@CGQ@GBV@?<8F;C<<;849;:7;<=BG>CB=<>B>CBFB=<=<
<B<B78=N;aGUKCLCCR>G<CH=AK<<HKK=\JF<B=C===VLCHG?KGIVBPHG=B=<
>L?KG=EUNBFMF=K=BB<LR?CL[YNLHC=<M<<\<GB@B==W[QHGPHHCCB=<QMCT
=?D<<GO=KGG<==C?<OLTKNGCL=BCKHL@=CTWGDC?:=C[LQ?HG?8<C@<BGGB8
SC=[HBMNRQC;C=:;BBNG=QL?a=ML[[CIB=LQCC=;;98<<:9?LQaQGdWW[QVV
HaGVLRJ?5E<H;9C;8@B=<QK?GG@GNS;SGS<;:=<<FCHGG:<[L?TVVdUT@D8S
[[a=<G=<8;6;;NK?<PLQJTTNSO<:=LCTTC:?LGA<;665<?:?C<E<AI;PTLT[
HD<8;IA=JVPS=;<BCC?BBJJPI9>BC?C<@??E?99CC>:99:U[OC>>>;8JK@EK
;8?IOMPM<D98897798:>G[>[bHCNMDPOHC@H?KI:8:CB<?D:BMEOVKV?7E::
;=MWCKA<:=:A:AEGO@RK@:>>>6BKIHD==C45?:AHCQ:H@6I@8H=9AQDZQR>D
FKD:ACMF@KC>GN@BB6=:HCE:7@KON>:>9D8?7N8<B887<:6B>@76LC86767=
DA8@=HC=BE;@=:6=<:58:>875
.
frg:84
clr:114,796
}
{RED
iid:1541
eid:1127298215
seq:
GGGTGGCCGAATAAAAACACGCGTGACTCGATTTACTTTCTATTGTTAAGTCAAATGAAA
GGTTTTCTCCCCTAATATTTCGTTTACATCAATGGATGGTGTAACACAAGGATTAAAAGG
TGCTGACAAAATAAGGAGCTACCCCAAACCCACCTCGGTTCCTCCCACGTTACCCAAAGC
GATTGCCGCCCGGTTGAATGCCACCGCCGATAATACCCGCTTCCTTAAGGAAATGGCGGG
TCAGCAGCAATTCTACCTCGAGGCGGGAAGAGGTTATCCGCAGGGTCCCCGTGAGACCAC
GTATCTGGATTTCTCGGAAACCCGTCCACCTCTATTCGTCAAGGTCTAAGATCCCTTAGA
ACCTGACGAGCGAATTCGGGTTATCGCGCGAAAGTTTGGTCTTCTCCGATGCTCAGAGAC
CCATAGGCTTTTGTTTGCCGCACAACAACTCCATGGTCCTGCCAGTACCTGGTGGGGAAA
TTTTATGGCTATTCACCTGATAACCATCAAGTCGCCTGTGAATGAGTTTAAAGCAGCCTT
CCGTGAACACTACCTCCCCCCAAGGAGTGGTGGATATGAAACAAGAGGAGTTTATGAAGT
TACCACAGGTGGAGATTCTATTACTCAATACCTCGCAATTCAATACTTGGTCGCAGATGC
TATCGATCAGGGAATACGGATTTTGAAGAAGAAGAACTGTTTTATGCGGGACGGAATGAT
CGGCTACCAAGGAAAAGAGCCCCTGGCTAAACTCCCGTTAGTGTAGACTTGTCGCCCTCT
GCTTATAT
.
qlt:
4334448757756;:75747:756;847:8689;::<AAHE87:56776C8;:886F898
HDCBA;;8466657777:9:9;9876A7D45@:>8:7496465744675:;4<;56E6;:
8544=4=5885659<:B:BGB=CDEC@:=BCCBKB=669==;9=<=?>=<<:::95;:89
;EKCO:F:=I98:87;;<=O<B9BCBCB=a=<<CG==;D:BHJGGDF8G=MF>;KE<<CC
=KGGBDKGKG=WWILBB<8B><M:M==GC>[VSBGP;LCDC=;URGK?CKB=OTMTTJ=G
=C==H?HCQ=@FC=DJCC<<<:D;BBH=CCNGN<CGK9=@=<CC?<8M?9]LQ]RLRC:K
B<==CTH@PC9\=L@LQ<GLCKKGG:<F:=B?;:>CCUBS\LRQCLG<GLVWLIA:TFMB
8:<:<:;=;5<7KCGKU;T?L=D9=?:=?HTG58RG<MFKaNSH@G;DHHT><HBB:ACH
?ELGEE[aPVSQOB:@B=ON==BEL>=E;CC;C<KL@?88CN:GLJR[ULLJ?MAFAPLF
<A=:JGFFFE8C?:?<B@<ODRJFSP;:B:>>>:9DEPC>C855EUBET9;EEK>?E88;
>8K<C@7;K?SOA>AL@D@:KHKMLH@7?G@=AA:==HAKW988869HLH:NGFD889:H
DPGLA>AAA8AA>NEHL6;:9@N::IK@?@8@@:H>@>L9FLN>EBA<IEA89=L<?UHP
H8><><<7><>NDDCKH68?<B85@F<8:87C><6:<8:8?:89A;5@<=78<:=8@8:8
;B=D>K6<
.
frg:85
clr:134,785
}
{RED
iid:1542
eid:1127298216
seq:
TAGTTCTGATGATATCAGCTTGAATTCGTTGTTAATGTAAGACATCTCGATATCTCCCTT
TTGTTGGTGATCCCTAAGAAAATGATACCGAATGGCTATGTGCTTAGTGCGGCTATGCTC
GACGGGATTGTCGGCCATTTTGATTGCACTCTCATTATCACATAGCAAAGGGACTTTGGT
TAATTTGTAACCGTAGTCCCGCAGGGTCTGCCTCATCCAAAGCAATTGCGCGCAACAATG
ACCTGCGGCAATGTACTCGGCTTCGGCGGTGGAAAGAGCGACCGAATTTTGCTTCTTTGA
AGCCCAAGACACCAAGGATCTTCCCAAGAACTGGCAAGTCCCCGATGTGCTCTTCCTATT
GATTTTGCACCCCGCCCAATCGGCATCCGAATAACCAATCAAATCAAAAGTGGATCCCCG
AGGGTACCAAAGCCCAAACTTAGGTGTATAAGCCAAATATCTCAAGATTCGTTTTACGGT
CGTAAGGTGGGATTCCTTAGGGTCGGATTGGAATCTTGCACACATGCAAACGGAAAGCAT
AATGTCCGGTCGAGATGCACATAAATAGAGCAATGAACCAATCATCGACCGGTATACCTT
TTGATCCACGGACTTACCTTCCGTGTCGAGGTCGAGATGCCCATTTGTCCCCATGGGTGG
TTTTGATGGGCTTGGCATCCTTCATTCCAAACTTGCTTAGATGTCTTGAGTGTACTTCGT
TTGGGCTGATGAAGGTGCCCTCTTGGAGTTGCTTTACTTGAAATCCTAGAAAATACTTCA
ACTCCCCCATCATAGAACATCT
.
qlt:
455448;AXBGB8<?=68[lllHIVll_lllladlaallllk[llllllkllklllllll
llllJW<:GDK=BKkllklkllkkllllllllllllllllllllllTdkY[d]kklllll
llllllkllllllllkklllllllllllllggklllllllllllllllllllllllllkl
llklllllllllllllllllllllllllllllkkllllllllllllllkkllllllllll
llllgglllllllllllggllllllllllllllllllllklllllklllllllkglllll
lllllllllllllllllklllggllllllllllllllllkkllkkkkllllkggklllll
kglllkkllllllklllllllklllllllllllllllllkllkkllllllllllgkllkk
k\gllklllllkllkkllkkg\YllllkgklklllllllllgggkklkkkRdglgglg_a
ladglg_[llllalllllldl_glll_Vlllllglllllglglglllglllllllllell
ll_ldllllllelelVllelllllZlllllieeeiiidediiibiii_Xiec]]X]biei
_iib]d[]diiUZU_[YY_[dZZAibeVeZdXeWiZdLibi^NNiiWVE\iVGUWiR9?M
Tii?DJL^iXReLeUUUX``U``NVcV[LcNCMNH?]L668W`U`O`VMO`NALVS[[MM
cRMU8FMYWFMMQLMDJAcNMTNKMNY?[YLK9J=KMCONVcMMMMLV>^^^YBJ:7?EA
FMSMcccOFLLH<C:DC?9F>8
.
frg:86
clr:31,800
}
{RED
iid:1543
eid:1128922884
seq:
AGATCTAGAGATTCGTCCGCCTAAGAGAGATTCCTAATGCATCAAATGATCATGCCATTT
CAATTAAAACTTTTGATGCATCTTATGTGCTTACTAGCAAATCCGGCAAGGTAGTTGCCA
AATTTGTTGGGGGCAAACACAAGGGCTCCAAGACTTGTGTTTGGGTACCCAAAGTTCTTG
TTTCTAATGCCAAAGGACCCAAAACCGTTTGGGTACCTAAAGTCAAGAACTAAAATTGTT
TTGTAGGTTTATGCATCCGGGGGCTCAAGTTGGATACTCGACAGCGGGTGCACAAACCAC
ATGACCGGGGAGAAAAGGATGTTCTCCTCATATGAGAAAAACCAAGATCCCCAACGAGCT
ATCACATTCGGGGATGGAAATCAAGGTTTGGTCAAAGGACTTGGTAAAATTGCTATATCT
CCTGACCATTCTATTTCCAATGTTTTTCTTGTTGATTCTTTAGATTACAACTTGCTTTCT
GTTTCCCAATTATGTCAAATGGGCTACAACTGTCTTTTTACTGATGTAGGTGTCACTGTC
TTTAGAAGAAGTGATGATTCAATAGCATTTAAAGGGTGTGTTAGAGGGTCAGCTATACTT
AGTAGATTTTGATAGAGCTGAACTTGACACATGCTTAATTGCTAGACTACATGGGCTGGC
TCTGGCACCGCCGACTAGTCATGTGGGATGAAGATCTTCATAGCTTCTAAAGGGAGAACA
CATTTAGATTAACAAATGTTCATTTGAAAGACAGATCTGTACGCATGCCAGCAGGACTAG
TGATCATCTCATCGAGACTTCATGCGACTGACGGCGCTTGACATCTCCCATGGATCATGT
GGCCGAATG
.
qlt:
434897;;=898CMEIIMFJ\RGCEN6@46:D^]]eiUYVI[TRZe^^]SOQ^^Z79:54
54444=?;HO_blell[[dQllllllllllbUll[_CF><C[JFCl[bggllllllllS[
llllllllllllllllllllglllllllgFggllllllllllllllllll]lllllllll
llllllllll_SlglllllllggllllgOglllllllllllllllllllllllellllll
llllllllllllllllllllllllll_llllllllllllellllllllllllldllllll
lllllllllll_lllllllVlellllllleeiiii_iiiiedeXedceii_ediieiiii
eieeii^iiiiiiZViiiiieeeiiibiii_ee]iieiiZ__iYei^^ddiie[e_eeie
i__iYKKVdiebeeiieVJ^eie[iieediiUebdKeeeideGeUedeMebddibeiX\U
iLiY]i]MeeZeXi_YUeiTU<CeYeVSie_iX^i^ii]XUXeXN`LP>_O]M`KUN]K`
K]WO@`[7^Q@NTQHR`BT_QAMYMMMNcM<Y<Q^KJ^@^OKN=^Acc@RVRTMKLGLFP
D8H[9RG^YPKLLL9^GTMGEI=CPQOIAOFL[LOMCCP@SLEJ6A>JW9BHMVJ5P;IA
ECAHL?JFP;@F>NCRI4345=:86ZCFFJHE<S:A8F969=4@M8:;FM;FQ=@6>O:9
E;NUG98979=?<5ZB7A9M;8>6<35493C745<A6<@436:D5>H>H5G;8@>634>4
F84333547?65@6D6B6764445>36?54A4==7347;9684867>D@57:7?999546
3><C;;;:7
.
frg:86
clr:6,774
}
{RED
iid:1544
eid:1127298217
seq:
CGCCGCCATGAAAGAAACCTCGTGAATTCGTTGCTTCTGCACTTTTCTGGCATAAAGCCG
TTAGATAGAGACCCCAACATATAATTTCGACGGGCAAGATGCTTCTGATGCTAAAAGCGA
CGGGATTGTCCCCCCGAGGCCCAAAACGGCCATTAACACATAGATAAGGGACGGTGGTTA
ATTTGAAGATGTAGTCCCGCCGGGACTGCCTCCTCGCAACCAATTGCCCGCAGAATGACC
TGCTGGAGGTGCTCGGCTTCGGTGGTGGAAAGAGCGACCGAATTTTGCTTCTTTGAAGCC
CAATACACAGAAGATCTTCCCCAGAACTGGCAAGCCCCCAATGTGCTCTTCCTATTGAAT
TTGCCCCCCCCCCAATCGGCATCCGAATAACCAATCAAATCAAAATTGAATCCCCGAGGG
TACCAAAGCCCAAACTTAGGTGTATAAGCCAAATACCTCAGGATTCGTTTTACTGTCGTA
AAGTGGCATTCCTTACAGACGGATTGGAATCTTGCGCACGTGCAAACGGAAAGCATAATG
TGCGGTCGAGATGCACATAAATAGAGCAACGAACCAAGCTTCGACCGGCGAACCTTTTGA
TCCACAGACTCACCTTCCGAGTCGAGGTCTAGATGCTCCTTTGTCCCACAGAGGGGTGTC
TTATGCGCTTGGCATCCTTCATACAAAAATTAACTGATGATAGACTTGAGTGTTCCTCTT
TTGTTCTTGATTATCGTCTCGTTCTTGGATTCTTTTTTTCTTATTATCTTATATAATTTA
TTTATTTTTCTTCTTATTGATTTCTC
.
qlt:
13334347446::55:55958::;778<><8@G7>8>>II9;687:7788;<>88;<78A
A8=>89<<98447746747849::FFE9:9::D<8BF;B<<;;74474567656497;::
==;:?;<B=:>;=:<<9;=<<<=A?=;=9=:=;::==:<=<85;65::;=C=:::?C<<C
?;B==:7@;<;<<98B===<99HKBIHMJ=BC<<@K;=>=9==<=H>=B=K<<<:8@<<;
:E=8F<6:D<<<<=;<;==G;=<BK:E=G<=>K=<<9:<;<==;===@;<<<<<:@=;=C
<K=9K==:8<749K==CCKKB=K<WC>LQC><<LCONOG=G@K=CC:NMG<K;HLGWIG=
@===<CGTHBJGGB8<J<<;H;B??QB?HG=D@B;?:<<<?9:<B<BG8MB>===;\KQK
<NGKC@KGCICHAAHG>C;A7@<G=:;<:=<BG>C;I=H==G[@=MCBA>:D:8@:B9;@
B6T?[T;a==BB;;874:?HKBD<;J7D9:F@@TQ<MB=<KUK=<>8;IG<C=D?;::?C
:<<:H88899?<P>;;<=;NG<;<D:<::5E>B=@A<<?;::::<?BA8:;C?;;C==RG
Sa;:<=<@I@<::??DK<9:TKK:B==;C8B<KJ>=99>=;<I<<CB:9<>9>9>:?7@8
78>;?:>8EGGGGCDEAGO><9998<G>D=><9:A?>8>C>?D?C8F><;888=96H;8=
AB<::<<GA>?=:98><6<<78>G8>>;;<88;9=@GC<>@D7>=>@>?>C6::<8@:J:
T?D8>A=:978866<7>:8:=9C689
.
frg:87
clr:27,786
}
{RED
iid:1545
eid:1127298218
seq:
TGCGTCTGATGAATCAGCTTGATTCGTTAGATTGATGGTTCTGATTACGATTATGGTATT
GGTAAGTGGTATTCTTTCCGTTTGGAAAGGATACATTGGGCTAATAACTTGGGTTAATGT
TAAAACCTGGCTTTCTACTAGTAAGTAATAACCTGACCAACTAAAAGCAACTGCTTGACT
TATCCCCACATAAAGCTAGTCCACTACAGCCAAACAGGATACTTGATGAGTATGTTGATG
TGTACTCACCCTTGCTCTACACACCAAACCCCCCCCCCAGGTTGTCAGCATTGCAACCAC
TGCTCAGGCGAAGATGAAGCTGTGGAAGGAGACTTCCAGGAGTTCCAAGACTACGACGAG
TTCTAGGTGTGGGTTAGCGGCAACCCCCCAGTCGGCTGCCTGTGAAGGCCGCGTTATCTA
CGTTTCTTTTCCGCACTTTGATTTATTGTAAGAACTATATGGACGTCTTAGACGTATGAT
GTAATCGACTATTTCCCTTATTAATACTATTTTGAGCACTGTGTGATGATGTCCATATTA
TGTAACTGCTGTGTACGTGAATAACTGATCCTGGCACGTACATGGTTCGCATTCGGTTTG
CCTTCTAAAACCGGGTGTGACAGGGCGTCTTGCCGCAGCCGAAGCACCAGATCGCCCACC
TGGAGGTCTTGGGACCGGACCCCTCGGGCGTGGTAGCGTCGCAGGGACTGCTGGTACCGC
GCCGAGTGTAGTAAGGCCCTGTCCCGAGCCTCCTCCAGCTGGTCCAGCGATTCTTCTCGG
CTAGCTTGGTTGCC
.
qlt:
33545H;:\?L<88<8?^ii^lQllelVee[HllVVllllllllgalklllklkllklll
ll@B=;=B8<<k\klllllggklllgglllkkllllllllllk[][WLTTgkkllkklll
llllllllllllllllllllllllllllllllllllllllllllklllllllllllllll
lllllllllllllllllllllllklllllkklllllllklllllllllllllklllllll
llllkllllllkllllllllllllllllkggg\\gggglllllllllllllllllllkll
lllllllllklg\llllllllllllllllllllllkllllllllllllllllllkllkll
lllllllllllllllllllllllllkklllllllllllllllllklllllllllllllll
lllllllllllllllllllllllllllllllllllllllllllllllglgglllllllll
lllllllllllllllllllllllllllllllllllllllllellll_ll__lllllllll
[llllllllllllllllllllei_iiieeiiiiieeeiiiii^ieeiieeieiiiV]iid
_idiidYiii_iiideYRiPQdeiieieieiibideeTiiUieNdTVeUXeVeQTiWT]d
ideRMPQe`ii^eODePiJH^cc^]Oc]]\TWB5A=\FGcKNM8RKTKN^[`OTMKJYJX
MTcB[BMYGMLLKVM^DcYMYMMc^GYLRPMQ[MRNLHNLDLGKQNSYJKDQGEMNLMBD
DCOFDQDD>PG=55
.
frg:88
clr:5,791
}
{RED
iid:1546
eid:1128922885
seq:
AGATCTAGAGATTCGTCCTCTTGCGCTTGGATTGCTTCTTTTCTTTCTACTTACTCTTGA
TATAAAACTCCATTGTAATCAAGGCGAGAGGCACCAATTGTGTGGTGGCCCTTGCGGGGA
AGTTTTGTTCCTGGCTTTGATTTGAGAAGAGAAGCTCACTCGATCCGTGGATCGTTTGAG
AGAGGGAAGGGTTGAAAGAGACCCGGCCTTTGTGGCCTCCTCAACGGGGAGTAGGTTTGC
AAGAACCGAACCTCGGTAAAACAAATCTCTGTGTCTCACTTACTTATTCGCTTGGGATTT
GTTTTGCGCCCTCTCTTGCGGACTCGTTCCTTATTACTAACGCTAACCCCGGCTTGTAGT
TGTGTTCATATTTGGGACGGCAGGTTTCGTTTTTTTTCCTACCCTCTATGCGACTATTTT
ATAGGAGTCGGGCTCAAGCCTGATATTTGTGTCTTCGGAGGGCCGGCGGCACGCGCCCTG
TGTTTATCGTGTCACAGAGAGGTGCAGAGACACCTAGTAGACGAGGTCTGTGATATCCGT
CCACGTCACTATCGTGGCAGAGGGTGCGCACATGGCGGGTTGTTTTGTGTTATCAAGATA
GCACATCACCACGAGAATCTGACTAGGAATACGCTTGTGATGCTTCTGCTTCTCTGGCTA
GGCCTCCGCGACTTAG
.
qlt:
5457>?@9?78<Q\ABQVTeUYNHFR_iiQB7_O>iiidiilldl_@=9=C[llOE<8:5
::7799QUal[ClllllllaTlllllllllllll_NM[Y[S[S[gkllkglllllllkgl
llllllllllllllklllllklllldllaldlllllllllllllllllllkllllllllk
lkllllllklkkllllggldk]aa]]LdddkkakaVkkkkdk[S[[OKNkTVdQaUaWd[
QNTkQ[dT[LO]V[TCRLNGTSSd[T[T[TdVa[d[[HL[SOLVVLOOTGRTTdCIUTLT
dC[daldKSaYL[GWTYU>HLUJLdLLLYRITHBAIEKFHILLTIJUUGMHI;:=G=B;:
:K:U@CHC>;B?<C<?::::>:E7=B;99;;>;>@:=>98>B:;999;=8:9SIDC?<79
=:789?;;>;8A=>EAELH@7HH<ED>H<88877@E>=588=8?98<:=>>@9;8@A==:
D<FOJBIC<=CIID8KF:89:=88>=>86<847:887997A>BO<<8D:88789977D99
@E:C8:<EJ8DAB>@A=8568=;98?::;88:;87<V>H9=:8<;AH7@<867=>H8>:8
8:K;?<OCG;H;E<5<>9D65A;7>:<5;5H<:7><><96H::7G=<;7@>@=;96D;:8
:;96>>;6:8<68575
.
frg:88
clr:4,666
}
{RED
iid:1547
eid:1127298219
seq:
TGTTCTGATGATATCAGCTTGAATTCGACGAATTCTCTAGATATCGCTCAATACTGACCA
TTTAAATCAAACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTGA
CTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGGC
GTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTCAA
CGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGG
TATAAATGGGCTCGCGATTATGTCGGGCAATTTTGTGCGACCGGCTATCGATTGTTTGGA
AAATGCCAGCCGATTTAAATGGGTATGAAGGTGGGCTGAGGATGTTTTTTTTTGAGGTAA
CAGAAGATATCGATTGGAT
.
qlt:
21448>?NGG?8<AA:9\eiiIBNiiPYQie[UiiiilllWW[[llll_]lllllgMgLS
llllR=<;<;899BLC=Kkkkkkklkkklllllllllllll[[ULB=C=<<;=@QJJP\k
dlllkkkkkaklkdkd]lklklllklllllk[adTYadklkklkk]\lkd]llllllllk
ldkkkkklkkgk]dTd\M[YkklaaTIBNYML[BHBT\WWWaMPGOdkdKWaKVTTMUC?
@<<;=aaaW[d]dk\adW]NYM\TTK\U]a[[aWa[LTUTLaNNKkWWU\W[W[WLWWWH
CORONNSkTPGNI===E<<<:H:FFK?=G<=;C<N=TEKLB85;9;=HT:=@BT<>GK:4
7;6=:<:D@:8J=8@4S8FAG<;:9<;9:>=:A:;<5<:?A6:CC8=77=;:<;79H<:<
:86B8:?9E=::<<=B:;>
.
frg:89
clr:363,437
}
{RED
iid:1548
eid:1127298220
seq:
AGTTCTGATGATATCAGCTTGATTCGTAATGGGTTCATGCTCACCAACCTTTTACAAGAT
GGATTCACCATAATTTTAATGACATCCTCAAAAATCATAATAAAAAGTGTTCTCTATAAA
TTGAGAAATAACTATCATGATAATCAAAAAAATTAGCCATCAAAATGATTAAAAGCTACA
AAATTAAAAGAGTTACCAATATCAAATTAAGCAAGAAGATAATGCCCATTTATGAAAATC
TAAAAGTGTTGACACCTTTTCGGAGGCGCCAATCACTCAAAAGAACCAGCGGCGGTGCTC
TCTGGTCAGGCGCGGACGGTCCGCGGCACAGGGCCGGACGGTCCGCGACCTGGCACGAGG
CTAGGGTTTCCTGCCTGACGGCCGGACGGTCCGCGCCCTAGGGCCGGACGGTCCGCGACC
TGGCGACAGGGTCGACTTCCTCCTCCTTGCTGGAATTTAGATCTCGTCCCCTGGGGGAAA
AAGATCTTAAGGTGCTCCGGGTCGACAGGTCACCCGGGGCGTCCCCAGATGACGTGGAGT
CGCCTAGGAATTAAGAGATCAAATCGAGGAAGAGGTCTTGGATGGACAACTAGATCTTGC
CCCGCGAGAGGGGTGAGATCCTAGGGTCCCTGTTCGGACC
.
qlt:
44448<;Y@MA8;>969diilQ:bll]ld_lllll[Xlllla[lallllgklklkQklkk
llaGGK:FC:JGB\glllllllllllllkllllllklllllllllkkklkggklllllll
llllklllllllllllllllllllllllllllllllllglllllllllllllklllllll
llllllllllllllllllllllllllllllllllkkllllllllkkkklkgklllllllg
\klllllllllllkll\\kkllllllllllklllllllkllllllklklllllllllllk
kkllllllllllllllllllkllllllllllkVMkaklllllkkllllllllllllllll
lllllllllllllllllllllllllllllkllllllllllkllllllllllkllllllll
lllllllllllllllllllllllllllllbglgggglggallleldblellelbbedlle
le]l_dbedbbl_ldeeZS]OL]K[VK_^D__]dee__^_e]ee_dVPebei^_XeN_W]
dGNe_YGP]NQUUL>[NWGVVYb]SLF8>P;9UNG<TNNY@L@IDKB<A?C9:BAF?;S>
F@<8=858LNHDC<UQAU@D8:B5@>6>:87755559F66
.
frg:90
clr:5,625
}
{RED
iid:1549
eid:1128922886
seq:
TACGATCTAGAGATTCGTTTGGAAGCGAAACTGAACCAAAATGTCGCTTTTTCACATGGA
CCCTCTTACACAATAGAGTGCTAACTGCTGACAACCTACAGAAAAGGGGATGGCCATGCA
ATCGGGTTTGTTGTCTTTGCAACTCGTCACATGAGACGGTGGCTCACTTATGCAAGGATT
GCCCCTTCACCGGTGATGTATGGGGCAAAATATTGACATGGGCTAATCTATCCTTCATGA
GTGGTGCTTGTAATTTAGGATCTCTATACGATTGGTGGAGAATACTGAGAAGCCTCTGCA
ACAAAGAGTCAAGGAAAATTTTTGACGGCCTTTTGATTCAATTCTGGTGGCACATTTGGC
TGGAAAGGAATCTGAGGGTGTTCTAGGGAAAGCACAGATATGCATAATAGGTTACGCTAT
CTGTGAAAGATCTTTTCGGATGGTGATTATTCTATTGACACGGGCGGTTGGCTCAGGGCG
ACCTATTTCTGGAGGCATCTATAGTTGGCCTCTTGGCTCGGCCTTGTGGTTTGCTGAAGT
CTTTTTGTTTTCTCCCATATCTATGCGGTTGTTCTCTCTGTCATCTTATTTCCTGTAGAC
AGCTGATGGTCTACTTTTCCAGGTTTTTGTTTTTTCTAACCTTCTTGCTTTCTGGTCCTT
GCCGGATATTGTACATATTTTTCCTCTTCTAATGTATTGTGGTGGCAAAGCTTTTGCCAC
TTAATTAAAAAAGGATCCTTAGTAACATGCAATGACATCGCATATACTATAGCTCAGCCA
TGACTATAGTGTATATTATTATGGACTTAGCCACAAATCATAGTATATTGGGGCTTATCA
TTGTTAGCTAATGGCTTGGA
.
qlt:
4555:55;<9<;=:P[QWieA8889;Q==8L_l_leP;llg_[_l_lllllla<VKllgD
TYLNNSXWaVkallklllllllklllllllllVkklllkkklllkkllllklllkkllll
llllllkkkllllllgkllllllllllllllllllllllllllllllllllllllklkll
lllllllllllllllkllllllklllllllllllllllllllllllkgklllklllllll
llklllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllgglllllllglllllllllllllllglllllllllgllllllllllllllllllll
lgglllllllllllllllllllllllllllblllllllllllllllllllllllllllll
lllllllllldlllllliiiViibic_iieiiiiiiiiibiiiiiieiiieeiie[iiie
i[_ieiiiiiiiiK^eeeieiiiieiiYViiieeideiieVVideeeiRWieiVi_iiQe
eeYRiiXHii^eeVJSQ_ede]eeeeedHeiK_eeeee\iU_Re_eUeTi]UWR^M_D_O
M`[_]RIccM_NRM[^^^MNIMYOccc`TAc^^^MYMJYM[KPNNNXL[cMNL[^LYVR[
XJ[LIVCJBPWFMMGVOM^ZTMKOGNGOMJGHGY9MHJT>KIBMJ<EcPGLSc\POB;?L
KL;BAGH\cccLM>HCHG?CN8DMAJBLRL?BFLEE<CGGLLL<\8GLICBCK@<>9;BG
D=38?83;:LE379;:J>A5=:9AJG>:86H=;G?PGHFI9>:>K856AHTTB8=66>;B
85<5FC;G@?C;GA8ED945
.
frg:90
clr:7,856
}
{RED
iid:1550
eid:1127298221
seq:
TGCTTCTGATGAATCAGCTTGAATTCGTTACCTTAAGCCGAAATTGCATCCTTCAGCGCT
TTACGCAGACGAATTCTCTAGATATCGCTCAATACTGACCATTTAAATCATACCTGACCT
CCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTGACTTGATCGGCACGTAAGAG
GTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGGCGTATTTTTTGAGTTATCGA
GATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTCAACGGGAAACGTCTTGCTCGA
GGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGGTATAAATGGGCTCGCGATA
ATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCCCGATGCGCCAGAGT
TGTTTCTGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCAGGC
TAAACTGGCTGACGGAATTTATGCCTCTTCCGACCATCAAGCATTTTATCCGTACTCCTG
ATGATGCATGGTTACTCACCACTGCGATCCCAGGGAAAACAGCATTCCAGGTATTAGAAG
AATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGC
ATTCGATTCCTGTTTGTAATTGTCCTTTTAACGGCGATCGCGTATTTCGTCTCGCTCAGG
CGCAATCACGAATGAATAACGGTTTGGTTGGTGCGAGTGATTTTGATGACGAGCGTAATG
GCTGGGCCTGTTGAACAAGTCTGGA
.
qlt:
45444748D:B:67766_lll>=NllYl_VVll_llllllllkklllllllllkklllll
lkkVKO=;IB<JDk\gklllllllkllkgklllllllllkklllkkkkkd\Ukkkgklll
kllllllllllllllllllllllllllllllllllgklllllllllllllllllllllll
llllllllklllllllllkllllllllkllllllllllllklllllllllllllllllkl
llllllllllllllllllllllllllllllllklllllllllllllllllllllllllll
llllllllllllllllllllllllklllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllkllllllllkllllllllllllllllllll
llllgllllllllllllllllllllllllglllllllllllllllllllll_llllllll
lllllllllllllllllllll_lbbllllllllllellllllllllllllllllllliii
e_iiWeieeiiiiiiie]iieiiiiieeiie]ii_iii_ediiddiidViieeV^d_ii[
iOY__iddi[RedQV^WeiYYWde`i[QiedMdUYdeiiX`d_iPUe`ei_\eeU^T`iY
SeeeRRN_N`X^J^UcNMNLc]NYVMcc`L`YYcUMOLQ\_OMMMc[[MS[V[NMNMD5M
HM[JFMNLYJWWN[JOMMVQLYLc^[MLIIPGYN@OGFMLEccOKYHKQJ<P>MVHFI==
=LDAZ:KEALBJIGJL?JJJNA;85
.
frg:91
clr:8,67
}
{RED
iid:1551
eid:1127298222
seq:
GGATAACCCCTGATAATTAATCTTGTTTTCTTACTTCTTTACGTACATAGGGTATTGCAG
ATCAAAATTAGGAGGCTCCACGGTACCTCAAACTATGGTCATGAAGGGGAAAAGAAGAGT
CGATGGAGTGTTAGCAAGTGCTTGGATGCTTTCCCTGAAGCAGAATCACTACTCGGCATC
TTCTCTTGAGTTCCTTTCATTTGCACCTGCTAAGGAGGCTAAAATGAATCGTATTCAACG
CGAAACGTCTTGCTCCACGCCCCCATTAAATTCCAAGATGGATGCCCCATTTATATGGGT
ATAAATGGGCTCGCGATAATGTCCGGCAATCTGGTGCGACAATCCGTCAATTATGTGGTA
TGCCACATGCGCATCAGCTTTTTCTGACCCCTGAAGAAGGGGGCGGGGGCCCTGATGATA
CAGATGATATGGCCACGCTAAACTGGCTGACCGAAATTATGCCTCTTCCCACCCTCAAGC
ATTTTATCCGTACTCCTGATGACGCTTGGTTACTCGACACTGCGATCCCAGCGAAAACAG
GATTCCAGGTATTCCAACAATATCCTGATTCACGAGAAAATATTCGTGATGCGCTGGGGA
GAGTACCCTCCCCCCCGTCACCCTTCGATTCCTGTTTGTAACTGGCCTGTTCTTCGGATT
CGTCGCCGCGCTTGTTTCTCTGCGCATCTCCTATATAAAACACTCTAGGGTGAGCCCAT
.
qlt:
E33335337854666754:95:9;677D;9:<8:=DFB;AF<A888<9><<=>89::897
:@:<8E>9:9667444444468899:;8789768:8E775=7967:56998885:678::
:<EBCBC<;=<;=7;FFH?GDHA@=><=E===B<:<;<99;<===8;:9=CC=@?<:;<?
GQ=W=C<G<:;B=:<B<:<;K;?@<>A?=<<:;IC;<8D<===;CG??<>:GCG<?9B<<
BBB<=:9;<=BK??K<K<D:K=B<;<;<<:FFB==@B<:D;=@;=<G<>?=:;==>CB8=
<B;IGHUB=CB@E<B?L::FKEN8<B<:<<<:=C=?<<K:<;A;?:==:<@@<:;=H8<>
;;TDD;G=;G<D?;9A<=C=<=:=?=?:;A>JD=9BB<B=<G<=;B=E:MC<BG;;?=;B
GHDSJJN8E<=F=CR?><C=:;;=GF:KGPB::B::GBL<9EC=F:;=AGUGGC@HC<8B
CDC<<F=CF?HCIH?C=BCHD?C<<8?LC@?<?K?A<LP?VN88GG:KP@OBBDB=GKG<
9BOOBOLHT=GDG<:FM9]GNWWVKG[QCKPGA[=VLA9<;;:<==9BT<FB<;DC??:G
G>?<::C=>=G===G<=BA?>C;;F;::BLHGBL<;9BGL>FCH<<:<>;;AA<:;9B<9
;>BV=====?@;==>=:;=<=9=9=KP=?VC>;C?==@@==<<:I<>B><;?B;;>;=9
.
frg:92
clr:652,717
}
{RED
iid:1552
eid:1127298223
seq:
TGTTCTGATGATATCAGCTTGAATTCGTTAAAAGGTGTACAGAGGGTCATGGGGTGCCTC
GCGGCCCTGAGCCGCTTCATCTCGCGCCTCGGCGAAAGAGGTCTGCCTCTGTACCGCCTC
TTAAGGAAGGCCGAGTGTTTCGCTTGGACCCCTGAGGCTGAGGAAGCCCTCGGCAACCTG
AAGGCGCTCCTTACAAAGGCGCCTGTCTTGGTGCCCCCGGCGGATGGAGAAGCCCTCTTG
GTCTACGTCGCCGCGACCACTCAGGTGGTTAGCGCCGCGATCGTGGTCGAGAGGCAAGAG
GAAGGGCATGCATTGCCCGTTCAGAGGCCGGTCTACTTCGTCAGCGAAGTGCTGTCCGAG
ACCAAGATCCGCTTCCCACAAGTTCAAAAGCTGCTGTATGCTGTGATCCTGACAAGGCGG
AAGCTGCGACACTACTTCGAGTCTCACCCGGTAACTGTGGTGTCATCCTTCCCCCTGGGG
GAGATCATCCAGTGCCGAGAAGCCTCGGGCAGGATCGCAAAGTGGGCGGTGGAAATCATG
GGCGAAACGATCTCGTTCGCCCCTCGGAAGGCCATCAAGTCCCAGGTGTTGGCGGACTTC
GTGGCCGAATGGGTCGACACCCAGTTGCCGACGGCTCCGATCCAACCGGAGCTCTGGACC
ATGTTTTTCGACGGGTCGCTGATGAAGACAGGAGCCGGCGCGGGCCTGCTCTTCATCTCG
CCCCTCGGGAAGCACTTGCGCTACGTGCTGCGCCTCCATTTCCCGGCGTCCAACAATGTG
GCCGAGTACAATCTCTG
.
qlt:
31447;;OBC:89B=67^iiiFEUilXl[_llll_Lllgb_lllllllllllggllllll
lllkdWMKFD;Blllllkklllllllllllllllllkkllllllllllkklkkkllllll
lllllllllklllllllllllllllllllllllllllllllklllllllgklllllllll
klllllllllllkkkllklllllllllllllllllllllllllkgkllllllllllllll
lllkllllllllllllllllllllllllllklllllllllllllllllllllllklkkkl
llllllllllllllllkklllllllllllllllklllllllllllllkllllllllllll
lllllllllllllllllllllllllllllllllllllllklkllllllllllllllllgl
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllglllllglllllllllllllllllllllllllllllllllllell[llllllllll
leeellellllllldlllWVe__eeeeieRZR__eePZeiieeddiii]ii_Xeei[eei
beiY_e]iV_i__eibi]PYed]]eiibe]eUGe]eeeDdQedTYbee^_KeieeeeOHV
GeiSieddeQXOVeU\iPQ_XOIQJD?\KOX\XGMXXPIOO_HPAOL\O_OUPPKN^MNJ
PU\TROWC@RNIRMMFFNMDMMJBEM[MMP>;DC<7:8?IKENE=>CJKIFMNJ:<:C7G
MEOAO9A=8676CMM;9
.
frg:93
clr:30,795
}
{RED
iid:1553
eid:1128922887
seq:
TACGATCTAGAGATTCGTCTGTTCTTTTGTATTAAATATGTGGATGTATGTATGTTTGCG
CTCGCATAGAGAACGATCCGGTCGAAGAGCCCGAGGAATTCGCAGGAGAAGCCCCTGAGC
AGCAGTCGGTTGGTGGAGGCAAGTGTCCTTTGACCTATCTCTGTCCTAATCATTCTTTAA
TTCACCTCCCGCATCACACATTTATACCTAAGGATTGACTAGCTTTTTGTTATCCATGTC
CTTGTTTACCTATTTGGGTCGGATTATTACTGCTTAGTTTGATGCTATTGCTCAACTTTA
ATCAATGAACATGATGTGGTTATCTATGATACGCTGTTTTCCCATTCTTATTGATGATTA
TACTTGTGGCATTTAAGGGGACTCGAGCGGTTTCTCGAGTGCCTCTCCGTAAGGACCTGT
TCAATGGATGACCGCCCGGGAAAACAGTGCAACCATGAGGGTGGAATGGGGTGCCCTTAG
CTGAATAATTAGAGGAACCGGGGTGTAGTTCGCTTAGCCGTCGTGCCGTCAATGGGGCTC
GGTGTATGCGGCTCGCTCTGCCAAGGTTGATTTGTCCCTTGGGGAGGAGTGCGGTACATT
TAGGAACCTAACGGGTGGCTACAGCCCCGGGGAATCTTTGTAAAGGCTTCATAGTGAATC
CCTGGCCATTCACTCGGGAGTGAATAAGGTCTTGCAGCCCGGGCAGAGAGGGATCACGGC
TGTGGGTAAGTGCACACTTCTGCAGAGTGTTATGAACTGATTATCAGTCCTGCTCGCGTT
ATGACGGCAGAGCTCAGAGATATGATACTGATCAAGATACTTGGTACAGTGGCGATGAGA
TGATGGTCGA
.
qlt:
44776:78>?>;;9PWNWddZGedWillQJINWbOQbe[T[llWV_lb__lgaalggaaa
YdaQLC[alllllllllllllllllllllllllllllllllklllllllllllllllkll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llkkllllllllllllllllllkllllllllllllllllllklllllllllllllllllk
gllllkkkllllllkglllllllllllllllllllgglllllllllllllllllllllll
lllglllllllllllllUlllllllllllllllllllllllb_lllllllllllllllll
lllllliiieiiiii_ii__iiiiiiiiiediiiiiiiiei__iiieiedibdi[G_iie
id]^ei_eYii_ie^QQdi^deed^Veei_YUV^NiidJiRTi^i^WiY^VV^UVVV]eH
eeUiBXNSSe`KeUKiLJ\YQOGNcE\L]]NPP\OXA]\NT`OM_@WMO[ISMX^^_NTM
MVG_LQMMMGPLMPQMTMMX@M?LNTHMNSFcJOLSYDEMT^^MXAQVCMMDJMGKDAMc
NBH:E87EMDFDLcO;EPDSLO?JNTG@EVcEJJ?=:L?JKIcFEDCECD<JL9ONBCIC
N<>J>;<=NKN7<5FCWCQCJOL@F7<668?<DC7M=AJG>N:389G575I744@8:;C<
OE57QKAFA;9M;>4A?654>M=65@44;8H;=>HJ8AHG868DG>9;;87A5;:44E8:
;544377C4434;CB55J;8F93;666>K>@C99:4535?9=7B98=4A3<B46=9484B
=;:49=:533
.
frg:93
clr:8,811
}
{RED
iid:1554
eid:1127298224
seq:
AGTTCTGATGAATCAGCTTGATTCGTTGAATTCTCTAGATATCGCTCAATACTGACCATT
TAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTGACT
TGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGGCGT
ATTTTTTGAGTTATCGAGATTTTCCGGGGCTGAGGAAACTTGAATGAGATTCATTCAACG
ACAACCTGCTTGATCCCGGGATTAAATTCCATCATGGATGCATATTTATTGGGTATAAAT
GGACTCGCGAGCGATAATAAAATCCTGGGCCACAATCTATCATTTGTATGGGAAGCCCGA
TCCGACAGAGTTGGTTCTGAAAGGGCTCCAGATAGTGTTGGCAATTATGTTGCAGATGAA
AGGGTCAGATTAAATGGACCGACAGAATTCAGACCTCTTCCTACAACCAAGCATTTTATC
CTTACTCCTGATGATGGAAGTACTCACATTGCGCGATCACTCGAACAGCGCATTCCATGT
ATTACAACAATCTCCAGACTCTGAGAAATACTGGAGATGCGGTATGGTATCGCTGCAGCG
CTATCCTAGTGTCTATATCGTATCGTCTATAAGACGACTATGCTGAGTCGGCTCACACAC
TACAGAATGATGAGTAGTGCTTAGGCGCAGCTACTGATGAGATTACGCTTGCTGGGCGGC
CTATGACTCGAATGGAAGATTGCGTGATCTGTCTCGCTCAAACTCGACTGACTAT
.
qlt:
43448==S@D;6:<68__lll_ll_lllVI_llllaalkldkllllkkllllllklkkll
klB?DK8G===T\RNkllkTlklkklllllllkllllklkaadkFWWHFA[Gka]]\kkk
kkkllkka[kkklk]l]k[dddLLTba]dJd]STMUWk]TSa\S=QUGCNUSOTSPKKWL
T\PKKHHHFBGK<==:<<?GM==948<8;<@:66CBB:;B<<?9BBB9<:<;BBC?:=<=
9<G=?<?NBB>K:=C<===;<=<<IFF==<<<=>=C<KKT?:<<::<F><7B;B<<<=<8
KB89<;:>=>=9:<<;;55<<B=F<=GHVGBKG=>;C=C<;::;=>;ONHRCOH==<9;G
;9CGH?<=[=<<TO=?H@<PP;<<D:;C==G?99:;<::=;;;<;=@8?;C:F@AF<;<:
=<@<<H?;;<DB>9;AB<;9;;:;:I;<<889>G;<B>::;:B>D<7=A8>>:@;:;<;A
;>8D:>H;DBE>AK;K>@CD<@A9<<=<66:A>9L:@<=C:<C5788@<88T=ASRH>HB
A::C8;G8:JC>9>=CGH::85:99N?:9ETIEHNPZAF@E99<789==9AAL<H@58<D
?@A;B@>CC;<<>86654=>78C>F;7A:89>7AI9<66BE<>6@G:<M9@F?9I7G=@5
6988<BM8CM<7M9B95;H57:>=M<K;9755L886D<=75<=>K:75:@F77:>:<BG=
@D>AGT;78AI@>>7<>5>9G6C>QC>?R<<978<FAIDGA7:7:6J58>78;@8
.
frg:94
clr:582,767
}
{RED
iid:1555
eid:1127298225
seq:
AGGTCTGATGAATCAGCTTGATTCGTGTTCTCTTCGCGAATCAGTCCTTAGGTTACTATT
CACATGAGTCACTGGCATTACAGAAAACCCCTCGGGTTCTACAAATCCTAACCCGAGGTC
CTTCTTCTACCTTAAACAGTAGCCGCGGCGAAGAAAAGGGCGGAGGGGCTTACCGGCGGC
GAGACTGTTTCGGTGAAGTGGTCGAGGATGAAGGGGAGGTCGCGGGGATCACAACGGTGT
GCGGAACGCCGTCGGAGATGGCCGGAGTCGGTCGGTCCACGCGCGCAGGCGGGGATGCTC
GTCGGCGGCGAGGAGACCGGCCTGGTCACGGCGAGATAGTTCAATCAAATGGGTCAGGGA
GGTCCACGGGATGCCAGAGAAGTTATGAGCGAAGGGAATTGGGCGGAGACTCACTGGATA
GCTCGGCCCACGCGCGGCGGCGGAAGACCGAAGTCCGGTGAGGTCGATCTCGGGCCTCCG
GTGAAGTCCGGTCGGGTCCGAGGGCTTGGCGAGCTTCACGGGCTACTGGCGGAGCTAGCC
GAAGCACTGGCCTGCCCAGAGGATGGCTGGAGGGGGCTGGCCACGGTGGCCGAAGCTCTG
GCGGCAATGGCGGGCGGAAATGAGCTCGCCGGAGCTAAAGGAAAGTGGCTGGCCGGTGAG
GGTGAGTGCGGGGGCGAAGTGGGGCGCGCCCTGGGGAGGGCTTTTATAGGCATGGCGCGG
TGCACGGGGCGGTCGTGGGAACCGGCGAGTGCAACGCGG
.
qlt:
4444798K>K:68<8:[ediiPll_[llllellllgll_gglVlllllllllkllkllll
kUkakkkYlkklllkklllllkllllllllllllllllllllllllllllllllllllll
ggkkggkllllllklllkllllllllllklllkllkkkllllllllllllllllllllll
llkkllllllklllllllllllllllgkkllg\klllllllllllllklkllllllllll
lllllllllllllllllklllllllllllllllllllkllllllllllllllllkkllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllklkllllllllkkllllllllllllklllllllllllllllllllllllall
llgglllllllllllllllllllllllllllllllgllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllllblllllllllllllllellllei
iiieiiiii_iieie_eeeideZEiZeiiidXiii_Vii^]iXeeied[diei^eiiiii
i]iieXeeiVYiQYeiiiiVViiWiiidWiXiiEi[BieXieiiQUieXiccRiXXNIAD
ii_e^MUF6Hccc[_\`^L[^^^GNHCMC]MLM^^KP=^]MMcZEMQMMcYHM^^MYTMN
E[FHPLccWMMQI[97WT57:7<>N>=MDMYA87ADQBH
.
frg:95
clr:7,757
}
{RED
iid:1556
eid:1128922888
seq:
TACGATTCTAGAGATTCGTCTCCGTGATGCGTGGACTGCTGATCTCGCGCGCGGTCTTCG
TTTAGCTCAATGTGATTTTGGTATCCATGCTGTCGTCGGCACGGTCTGCATCACTGTGGG
AAACACCTGTAGGGCGGCCAAAAAATGAACACTTCCCTTCAATTGAGATAAAGCAACTGC
TCAAACCATTAATACATCAGCGAACGAGTGATCTTATAATTACAAAACGTTCCTAATACT
CACATGAGACCAACACAACAAACGGATCGCAAATCGGACACCAAAAAATCCAAAACAGTC
CAATATAGTATCGTCAACAAGAGTCGTTTTCAGCAGTACAAAATTCTGTTTTTTAATTCA
AAACTGAACCAAACAAACTCCGATTGAGATGAAATTTTACACACACCTAAGCAAATATGT
TTTCAAGACCTCTCCAAATTTTGAGCTCAATCCGACTTGTGAATCACCCGCTGATTTAAA
AATACAACCAGAAATTGGGGTTTTCTAGAATAAGTTCAAACTGATTTTTTTCTCAAATCG
CGACCAAAATCTGCAACAACTAAGTGTATGTAGTGTTCCAAAGAGTGCAACTCACCACCA
ATCAATCCCCAAACCAAATCCTCTCAAAGGAATCAAAGGTTTTTCACCCACAACACAAGA
TCGGAAAAAGGGGGAAACCAATACTATAAAACTTCAGAAATTTCAGCAAGGGTACAAACT
GAGATTTGAAGACAAAGAGCCCTGTGGGCCGGACCGGCGACCCTTCTTCTGATTAAACTT
GAAAATCAGACACAGTCGAAGTACAAAATCACTGCGAATCCTCGGCTCAACTGGTGGAGA
.
qlt:
44475778<@?;7>:KOLW_OG;IRi@>VEII[S<:di_QiXTe_ideeiii_l]lee<8
468666:575:F;eXXllUblllllTJlllllllb[gag;=?9:?99@EAQSPUllllgg
lllllllgl_lllllllllllllggllllllllgllggggRO\llgllllllllllllll
lllllllalglllllllllllllllllllllllllllllllllllgllllglllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllbllllllllllllllellllllllllll_lllllllellllllllVZlllllllll[
llllllllllellleiiiiiiieiiiie_Hiiie_iiiie]ieieiiiiieieiiieeei
iiieNiii_U_iiieLeie_iiiieiidLeiiieieieieiiiei]^iieie^YFi_bii
iieeeRiidVeii]_^iddUOiiddWeUi^UeiUeeULieeeieNiiiddeddVGiV^e]
i_UBFGQOVdeX\YK_XU\_SJiU_iTiTiTeYUcE^SIH`\H^KP]NW[^c[MOYM\PB
^R]KW]M]NPM__JNE]]PM_]\`MIcYKNTXMQLc[HY>cccMSDMWPBUFKMMUHI@M
LQFUMc^^GA^c^LT^MGM@GBLLLMMMccIKRYK>AccJJ\IMFKMF=GcKDOFCcEHM
VM6MGcDHIO=M<Ec=;OCFNAGP@OOJB>B>R;E?LD9O>F:C;;H5<GKH=GA\FG=?
NK\T7B?D;I5;ADIJR=RMEOO;BOT?MD9<GQ4445466=A;69GI>;<DMN569867
.
frg:95
clr:8,834
}
{RED
iid:1557
eid:1127298226
seq:
TGCGTCTGATGAATCAGCTTGATTCGTTTGAGAAGGTGGCAAATGGCCCAAACAGCACTA
CGCGTTTACCGTCCAGAACGCGGGTATCGATATGCGGAACCGACATCGGTGGACGAATTC
TCTAGATATCGCTCAATACTGACCATTTAAATCATACCTGACCTCCATAGCAGAAAGTCA
AAAGCCTCCGACCGGAGGCTTTTGACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCA
TAATGAAATAAGATCACTACCGGGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAA
GGAAGCTAAAATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTC
CAACATGGATGCTGATTTATATGGGTATAAATGGGCTCGCGATAATGTCGGGCAATCAGG
TGCGACAATCTATCGATTGTATGGGAAGCCCGATGCGCCAGAGTTGTTTCTGAAACATGG
CAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCAGGCTAAACTGGCTGACGGA
ATTTATGCCTCTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACT
CACCACTGCGATCCCAGGGAAAACAGCATTCCAGGTATTAGAAGAATATCCTGATTCAGG
TGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGATTCCTGTTTG
TAATTGTCCT
.
qlt:
444447;@P;H8:8868EiiiiWll[lllll[_gN_Kl_alglllgllgdlllkllllll
kklCC;9<;8<<TT[klllllllllgkllllllllllllllldR?HH;:GH=RNLgdkll
llkllllllllllllklllllkllllllllllllllllllllllllkllllldlgllllk
llkklllllllllllkllllkkggkkkklkllklkllllkkklklllllkllllllkllk
llllllkkllkklllkllllklllklklllllllkggkklllkklllllllkdllkllkk
\kkkkllkk\klllkllgkllllkllllllllllllllllllklllllllklllgkklll
llllllllkllllllllllllllllgllgllllllllllgglgggllglddd[aa]llll
llllllll[lllllgllllabglgglllllUllllllllllllllllllllllUUlllll
llllblWlllllllll^llllZllliieee_ii]^Xi^Xeieiiiii_iiieeiieXeii
ediieYdeiiiiiiidiVd]id]eeeediiiedii_diiiii^i^QiiQdZddiiUdeee
dDed_eiie\VPYiWQeec^ii__X\eWYee[O`eXNMPVGccH^_NVPc^P^RH]YD8N
Q]__]_N_M^WD_MTG[MMUTWWOT[M[JC9EM[MMYNMYCNNLJ^PYF^NO^TE^JCHO
HMcMPTGQ96
.
frg:96
clr:6,111
}
{RED
iid:1558
eid:1128922889
seq:
TGAGCGATCTAGAGATTCGTCCACCGATGTCGGTTCCGCATATCGATACCCGCGTTCTGG
ACGGAAAACGCGTAGTGCTGTTTGGGCCATTTGCCACCTTCTCAAACGAATTCAAGCTTG
ATATCATTCAGGACGAGCCTCAGACTCCAGCGTAACTGGACTGCAATCAACTCACTGGCT
CACCTTCACGGGTGGGCCTTTCTTCGGTAGAAAATCAAAGGATCTTCTTGAGATCCTTTT
TTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGT
TTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAGGTAACTGGCTTCAGCAGAGCGCAGA
TACCAAATACTGTTCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAG
CACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATA
AGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGG
GCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGA
GATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAAGGGAGAAAGGCGGAC
AGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGA
AACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCATCGATTT
TTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAACGGCCAGCAACGCAG
.
qlt:
534364579:A<:7=>OWWYWE8Q]NOUiZe^=@eUTQVLUO`eeZbVdiieieibd_iL
:86445566F;?;>HKlelllbOQlllWSlllllWTlll[;9?77997;aOOPHblllll
llll__ll__llllllllllgllllllaalllalllllllllllggllglllllgllggl
allllllllllllllllllg\llllllllllllllllllllllllllllllllllgglll
lllllgglllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllgglllllllllllllllllllllllllellllllbl
lllllllllllllllllllllllllelllllelllllllb_llllll]llllllllllll
lllllllllllllll_iiiiiiiiieiiiiiiiiiee_eeiiiiiiiieeeeeieeeiZe
ieie_bieeedidiiiieei_ieidUeed_eibediebd^^edN^iUdWeeeZeeYeiei
ieieieediViiededebi_U_SeX\eiVTS_eWVCiLeTdWOMeSi__XNeeYQ[Q\\\
LXMX^^T\eL_eXX^^P_XPOY^JUQ^Q`WM]KVUIKKL^_AD^BN^E^H[c_L_FNMTI
MMcKLSV^L[HS^FWM[LMI^N=TBTFOM;H>[B^FMBMLML[GcII=MMVLOKOccYQQ
^JMIKOACG>EMSHVJHGHIILHLYGS?^PCTGQ@>T86NCDHLK>CALLGRJOQGQMcc
cJE:<LGL?KMAAN6ERSWUMAJ8I7I?67;HEM\OK>86LM6BL;>K@886
.
frg:96
clr:9,104
}
{RED
iid:1559
eid:1127298227
seq:
TGCGTCTGATGAATCAGCTTGAATTCGTTCAGCTTTATGCTGATGGGGTTTACCAGCTGA
GAATTAGGCGTCTTGAGGGTACCCCTAATTATGGTCCCCGACAGTAGCCCCCGAGCCTCG
AAGGGAGTGTTAGCACTCGCTTGGAGGCTTTCGTCGCACTTTTTTGCAAGGGGACCAGCC
TTTCTCGGTTGCATTTCGTTCCGGTGGGTGCGCGCGAGCGCACCCGCCGGGTATAGCCCC
CGAGGCCTCGGAGGAGTGGTTACACTCCTTCGAGGTCTTAATACCTTGCGTAATGCTTCG
GCTGGTCTGGTCGTTCCCTCATGCGAACTGGCCGTAGCCCGGGTGCACGGTCGGGGCCCA
AGCTCTCGGGCTGGTATGTTGACGCTGTCAACGGTTCGGCCGGAGCCGGTTTTTGCGAGA
GCAGCCCCCGAGCCTCTGCACAGGGCGAGAGGACGATCAGGGACAGACTCGGCTTTTTAC
ATACGCCCCTACGTCGCCTTTCCGCAAGGAGGAGGGGGGGAGTGCGCCATGTTACCCTCG
ATGGGCACCGAACATGGTGTCTCCAGTGAGCTGCAAGCGGGTAATCCGAGTGGACGTCCG
TGCCCCGTTCGTTGGGGGTCGGCTAGGGGCCCAGAGGCACGCCCAAAAGTACCTGCGGGT
GATTTGCCGGACCCGGTCCCCTGGCGACAGGGTCCGAGGGCTCGATGCCTCCCTCCGATG
GGATTCCGTTACAAGATCGTTCCCGCTGGTCTCGGAAATGTCCTAGGGTACCTCGGGAGC
GCAGCCCGAGCCTCGGGTATG
.
qlt:
445449<@d=M?88=@HllllEATllgllTCllllkkkllllkkllllllklkkkllllk
kklklkOSNSkklllllllkkkkklllllllklllggkllllllklklllggklllllll
lllklllllllllllllllllllllllllllllllkllkg\\\\\glllllllklllllg
\glkgllllllllk\gLNlllgllllllllllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllllllllllllklllkkkkklkllll
llllllllklllllllllllllllllllllllllllllllllllllllllkllllllkkl
llllllllllllklklllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllglgllllllllllllllgllllllggll
llllgllllllllllelllllllllllllllllXlllllllldlllllllllllllllie
edi__b__e]iieeiieei_ieiePeeiieiiiebeeiiiddiebiieieeiiiVVdiid
dibddieeiedUddiiidbeYdXeeTiidWi_UXVCi]U\_\i_RQ@iQXUUQU^_O^P`
`VM^^RNRLO\Hc[\^MMc^]Q]_XMNMLYc^S[YN^L[[MV^NMLVHRPMYYVMWB[GT
^TL=PGQMMTHMEKIOHMHOMO\PMNMYXHYANEJPVMLVHVOLN:cTELDNBIENL@;N
?NG?RSL=I>@J=I6K448=6
.
frg:97
clr:6,796
}
{RED
iid:1560
eid:1128922890
seq:
AGAATCTAGAGATTCGTCCTATTACCGACAGGAAGTCCAGATGCTCGAAACAAGAGGAAA
AAAGACGCAGCTTCGCAAGCACGGCGAGAGTGTGTTTTCTGGCCTCGGCGGCCGCAGAAG
GCACACGCTACAAGACGATCTGATTCTGCAGGCTCGAGTCTTCACGCTGAAGGGAGCCGT
AGCACCCTCGGCATCGACGGCTTCTTCAGCAAAGTCCAACCCAGCCTCGGACGGCGACGC
GGTCCAGGGACTCCTCCGGGAATCCGGCCCGAGCAGGCGGCTCGGCCGATTACCCCTGGG
GCCTCGGCCAGCCGGCTTCCAAGGGCGCCAGCCCGACCCGAGGCCTCGGCTGATCGACTT
TGGCGTCGGCTCTGCTGACGGACGACACGGCTAGGCTCCGGCCAACCAGGTTCCCATTCT
CGAGCCAACTCCGCCTCTGTTCATACTGATATCGCTACCCCTGACCTCGGCTCATCGAAG
GGCGGCCGAGGGGTCTCTTTAACTAAGCTAGGGGAGCCCCAGACAACAAGGTCGAACGGG
CCGAGGGATTCCTACGCCTCCGGGATACGGATACCTCACTCGTCACCTTGACACGGGGCG
ACTCATGCTGGCAAAGCGGTCCAGATATCACAGGCGAGACTGTGCTCGAAAATGAGAAAA
AACACGGCTCCGTGCCGAATACATACATGTCAGGCCCGACAGCACATGACAAAAAACACT
GCATCGAGATGCATACACGGACTCGTCCCTCCGCAGACGACATCCTCCCTAAGAGGGAGG
GCTCTGCGAATAACAAAAAACAATGAGCGTCGCTGCGCCGTTCCACCAGAAGAAACCACC
CCGCCTGAGGAATTGT
.
qlt:
5656977=C8776557:<A88;99;>adV<glX_DakVBL==7:<?kkgkLP:;==FGkk
kL:9:<9=P<<<<:<CHBKUKTSHCC=<4:;=<:8=F@B588;Bllllklkkkl]OKMKG
KGHllllllklRTJS=@=<:9DMPKMAGODLWW[kdkkkdllkVlGG>FBCBJBBKSQkd
kk[[[U[YYgggggddYYSTU[ddgg_UdlllgllllgbgggVRTNYPICFMMS[[ggag
gblgl_]_bNPKBH[bbddb_llSSQPKSbbbWROHHQRllllllJNMH@MKU_JND;FI
__iiie^_iei__iii_UZ_MO_ZP]ii_Piiiii^Piii[VidiiedY^ii^ei_i]ii
id[ZebeY^Tie^VUeieXdiRIeiSXe^i^e_VYWe^^QVIVEdZdM_UUiX\WNe\\e
\JeTXNE\]eQYNY^^_M_N]PP\Y`Q]PON`YXNXLN]][M_PEU]`MO;MMRY[RQW5
^TJQOKOK;=Q^GMRVNMZMBGDM>KEIMMVccJPCMWWXICYBCFMD;JJIMBPNLM^O
EMBSLcFFBGBJILM@DEM=<=ZBE>I;C9LA@IB8CJELRLIL>G?I>LLI9CNOPJ=I
R@BA:AVBc=I6:VP>B@OFJQ?:K69;BO;9M666D786N84<=?<?L\R>LL89<\\\
U<>:;<I;87O9<<6F9IE=6<696>=G=E99I<MNJ<A:;>M5348G@45ZTCZ647FA
D68K<965@?DI8<5244:8<15>6@IB9DGG9?9>A:9J7<5742668588G5:K4B:H
56355:49779=858EH8HD8:743@45<38444594@A6B::7=4867:644833734=
C<887353348=1113
.
frg:97
clr:16,759
}
{RED
iid:1561
eid:1127298228
seq:
GGAGGTCTGATGTTCAGCTTGATTCGTTCGATTGACTCGCGGACGCTCGCGACCGGCCCA
TGTACTCCAAACCTACCTCTTAACATGAACTGAGCTGAAAATAAAGAAGGGTTGAACAGC
CCTTCACTGACTTCTTTGATTTTGGCGGCATCGTGGATAAAAAACAAGAAATTATTCATT
AGTGCATCAAAAATGACATAATACTTAAAATATAAACCGATGAAATAACAAAACAACTTT
ACTTGTTAAATATCATCAAAATCAGGATCTATTTGTTCTTTTCTATGCAGAGGTCGCCAT
GGAACTTTTCTCCTAACCGGTTGTCTTCTCCGTCTCTCGGGAAAAGTTAAGTCGTTAACG
TCTACAACTAGTGAATCTAATGCCGGTGCAGGATCAATATGAAGATTAGTTGGCAACTCT
TCTTGAAACACGTCAGCAACCTGGTCAAGGTGACCAATTTGATATTCGTCCTCACCAGGA
GTGTATATGCATTCGGGGGGATTGACCTTGTGCGAACCCTCCATTTGGACGATTTTTGCA
TGAATAAATCCAGAAATAAACTTGAACGGCTTGATGGGCGGGATATTATGTGTCGCGCGC
TTGATGCGTTTTCGCGGGAGTAGATCTGGGTACTCCGGAATTCCAGCGCTATACGACGCT
CGCATGCCTCACTTGACACGGCGAAACGGGTTGAGCGGAAGTGATTCTTTTTTCGATTAG
GCTGCTGTAGTGTGTTTATTCCTGTTCAGAGAGGGATAATCCCCCATGCCTTTCCGGTGA
ATATGAGTTTCTAAGGTT
.
qlt:
A4133376GC9<77767CKKQKHMVM><KKG9FK<C@Q;9;97<E:8F:=C8:999885>
8>76<94447466:999;;>9:>989:89<A:=;<:9<444486476654:?=@;?CHDH
GLCI=C?DDB=??I@CC=C=CCC=?;;?;;GA=HMC=<=C=<H?=G<:T==;BB<=;:CB
?:<N=QVNFHGEFPYWGGTCG=K=CHBCLWKKHKL=>9<==HF<CGC=E==<<:<=O=C=
=??W\BFK==FGEB=KJLAA<B=B<SaWKJTWDLM=CR[]]aWLRWV@<DkGUCF<;B9G
[@==CLTTYWNSI<RH>;<=<GI=KL[Q<><<=>LLC==B=OBB@?HNELBAG=<?;BCG
<FCBH9?HVP:E]dTKWEPKGN<<B=;RCK<HNLI<9HGK=KC<NBRR==DKB<GC<KS=
KOCGQFL=I=D@====;=BGLCU:GC<;KB=B;;;<=@L=WVGEHOUB9BFBL?GLCLBV
HGT<@B<HL<;BEF<=OS;AC@B==;9BF@:<<9<8BC<GLOL;C<9=<77:CLKBK??9
K=9:7:=<978B=C??;>B;:?IE<:C<I<<=:B9>98;:8EE;A=;A<?;?=;F<?<?;
<<AA<;>9:B<<J=;;<9:<B;9<><;7:>9>8<9;;B<<?BAD=<:>BE>>F=<?KE:?
<:9999:9898A9=>:89?<;74F:887<@9<>HF9M=ICE9K<<<9:>::99>AG>C<E
888>><G;8:9;<<98;98?8;;:>EA8D;:<BKA<58H8?>:>?88<:87@CJ=A=E=B
E:A85<98=B:9<<<;98
.
frg:98
clr:8,795
}
{RED
iid:1562
eid:1128922891
seq:
AGATCTAGAGATTCGTCTCATCCCTGCACAATGAGGCTAGAAGAACAGTAGTAGCTTGTG
CATTCTTATGGATTTGCTCATTAATGAATATAGGACTATCCGAACTATTAAAGTGCATTC
CACTATCTGCAATCTCCCATATGCTGGGATGGAGAGAAAATAGGTGACTACGCATTTTGT
GGCTCCAAAATCCGTAGTCCTCCCCATCAAAGTGTGGGGGCTTGCCGAGTGGAATAGAGA
GCAAATGTGAATTTGAACTTTGCGGAATACGAGAGTAGTCAAAAGAAAAGTTAGAATTAA
CCGGTTTCCTTTGTTTGTCGTGGTCGTCGTCCTTTTGGGAAGAAGAGGACTCATCGCTGT
CGTAGTAGACGATCTCCTTGATGCGTCTTGTCTTCTTCTTCTTCCCATCTCTTCGCTTGT
GGCCCGAGCCCGAGTCATTAGACTTGTCATCCCTTGGCTCGTTGACGAAGGACTCCTTCT
CCTTGTCGTTGATCACAATTCCCTTCCCCTTAGGATCCATCTCTTCGGGCGGTTAGTCCC
TTTCTTGAAGAGAACGGCTCTGATACCAATTGAGAGCACCTAGAGGGGGGGGGGTGAAAT
AGGTGATCCTGTAAAACTTCAAAACTTAAGCCACAAAAACTTGTTAAGAGTTAGCACAAG
TATGGCCAAGTGGCTAGAGATGAGTCAAAACACATAACCACAGAAAGCAATCACAGAGTT
GACACGGTGGTATCCCGTGGTTCGGCCAAGTACAAAACTTGCTACTCACGTGTGCGTCCA
ACGGACGAGAGTGCACTCACTCCTCTCAGTGATCATGATCACTGAATACCACGAATTTCT
TCTTGATCTTCCTGTTGCGAAGAATCTC
.
qlt:
445:7=C::79=OUNUdZA8SiYRiiHAKGBeieiYSb_eZlZl]LElel_l_llllb@J
E:gg8>>HFgYg_lllll_Hlalllllllll_lllllllgTHRCCUUl_gglllllllll
aalaalllllllllllllklllllllllllllllllllllllllllllllllllllllll
llllllVlllllglllllllllggllllglllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllllllllllgllllllllllllllll
lllllllllllbllllllllllllllllllllllllllbllllllllll[llllllllll
llllbllellllllli__ii^[iiiiiiiiiiiiiiiiiiiiiiie]iiiiiiieiiiii
i^diiiidiiiii]ieedii]idiiiidbi_Q_eiideiiibeiYSRi_GidUieediie
eeedideV_ee_ObdeXeei^^^e^^ii^i]^D^dQXeMeeeee]eQi^WiVCWeY[U]\
]\i]\[[OeEiUeQK\]Ne_]]TINONAMPc^YKcNONN]W]N`M^^^^^ccc]JT>cKM
SIRIPMHBMM^LMccNMM[SMccNNMTJOHONEML^ccMLMMY>JGNEYEGGMHMMMLNJ
LLL[T<E?MH?IJ:MRFJEGHMN>LLCTVHEA@PBCFEEAET>KVLGICAIR?H>CR>LC
CMA>?G>=?A44:=I>A54749JFG?>ANGFMO9\\FBBBB<;EADN5<9E<<M8><GN6
:@>@@98?585M?;@AH9G6@:A459;J?;E<8C86?>C8H8G@=89898663134PB77
64334897:4248C4;85674;9D;945
.
frg:98
clr:5,824
}
{RED
iid:1563
eid:1127298229
seq:
TGGTCTGATGAATCAGCTTGAATTCGTTAGATATGTTACCTCATCTCCATGTACCGCGCT
CAACAGCTCTCGACGTCTGCTGCTGCTCGAAGAACTGCCCTGAAAAAGGCCCAGGCCCTT
GAACAAGCCCTTCACTGACTTCTTTGATTTTGGCGGCATCCTGCATAAAAAATAAGAAAT
TATTCATTAGTGCATCAAAAATGACATAATACTTAAAATATAAACAAATGAAATAACAAA
ACAACTTTACTTGTTAAATATCATCAAAATCAGGATCTATTTGTTCTTTTCTATGCAGAG
GTCGCCATGTAACTTTTCTCCTAACCGGTTGTCTTCTCCGTCTCTCGGGAAAAGTTAAGT
CGTTAACGTCTACAACTAGTGAATCTAATGCCGGTGCAGGATCAATATGAAAATTAGTTG
GCAACTCTTCTTGAAACACCTCATCAACCTGCTCAAGGTGACCAATTTGATATTCGTCCT
CACCAGGAGTGTATATGCGTTCGCGGGGATTTACATTGTACACAACCCTCCATTTAGACA
ACTTTTTGCATGGATATGTCGAGAAATAAACTTGGTCTGCTTGATGGGCAAGGATATACG
TGTCGTGTCCTTGAAGCAATTTCTCAGGTTGGATCTGTGTCATCCCAAATTCGGTCCTAT
AATACTTCGGGTCATACCATTTACACTCAAAGAAAACTAGCGCTAAAGGCTTATTTCCAG
CAAATGTAATCTCGATTATATTTTTGATTTTCCCGTAATAGCAGCTTCGTGTCCTTCCCA
TGTCGGTTGCCCTAGTAACGA
.
qlt:
43448:A\>CA8<?98_eil@AKllW_[lg[OgK_lllglg_lllllkVllkllllllll
kkl<<<FMCJB<Ta[kllllllllllllllllllllllllllkkW]aVgT[kXTkkllll
lkllllllggllllllllllllllllllllllllllllllllllllkllllllllkllll
lllllllllkllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllkkkldl\Rggggkkklkggkgggllgklk[lk
lllllllllllllllllggllllllllllkkllllkgllllllllllllkllklllllkl
lllllllllllllllllllllllllllllllggllllllllllllllalllllllgglll
llllllllllllllllllllllllllllllllllllllglllllllllllelllllllll
lllllllllllllll[l[[elll_llllWGllleblllell]lHUiiiiiebiiii^ieV
iiiiiiiWKeiiiZVeWieibieiidUiiieiiiSVieibeiidOiY^[diUi^PQ?d__
eibid_idieZiibiZdPRRTLeXeU@iU`\dXMeZcRiX`U`eieHiY\eYRiT``N\H
\_N_R_c`E^^R`MN\MMK[c`WMM`cVH]UM^cc[MMYJ[YMTKcTFWHMM[E^WKQHQ
YLYNL^>GHM[VYGV@QOHHMcccTFO>ccMMcMM?LP;MCN569HLL>JVFMD:?@MH?
CPHSGMBAN?\L?N8=NK?98
.
frg:99
clr:5,798
}
{RED
iid:1564
eid:1128922892
seq:
AGATTCTAGAGATTCGTTATGAGAAGATTGATGTTTGCCAAGACAATTGTATGCTTTTTT
GGAAGGAACATGACAGAGAACAAAAATGCTTAAAATGTGGGAAGTCGAGGTACGTGGAGC
TTGTAAATGAAGATGGGGAGAAGGTGGTAACAAAGGTTGCACATAAACAGCTTCGGTACA
TGCCTCTCACTCCTAGAGTGAAACGTTTGTTTCTCTCGAGGAAGACCGCTATGCACATGA
GGTGGCATAAAGATTGTACGGACAGACAAGATGGGTTAATGGTGCACCCGTCAGATGGTG
ATGCATGGAAGGCTCTTGACAAATTTGATCCAGATTTTGCCAGCGATGCAAGAAACGTTC
GTATCGGCTTGGCAACTGATGGTTTCACGCCGTTCAATATGACCGCTACGTCGTATTCAT
GTTGGCCTGTCATTTCCATACCGTACAACCTTCCACCTGCTCTTTGCATGAAATATGAGT
TTATGTTCCTATGTCTTGTTATACCTGGGCCTGAGCATCCTGGCGTACGCCTCAATGTGA
TGCTTCAACCACTGATTGAAGAGTTAAAGAAGCTATGGCAAGGTGTGGAAGCCTATGACT
GCTTCAAGAAGCAGAAATTCAATCTTCGTGTTGCATATCTGTTCTCGGTTCATGATTTTA
TGGCGTATGGTATTTTCTCTGGATGGAGCGTGCATGGTAGATTGACGTGTCCTTATTGTG
CTAAAGATACAGATTGTTTTCGTCTTAGTGCTGGTGGCAGATATGTACTTTGATGTCATA
GATGTTTCTACCCTTCATCACCCTCAGCGCAGAGAAGATTTAGAGGCACATCGTCCGAGG
ACGCCCAGCGACGTATGGGATAGAAAT
.
qlt:
45579::B>;79:NUJRKDAXeLG=<:6_RFAOIiiVOI:LllWKllllle__lllglB@
=8777888QUdgggalllllgdllllllllllllllkklkV[TPLLGallllllllllll
lllllllllllllllllllllkkgkllllllladdUkkllllllllllklllllllllll
llllllllllllllllllllllllllkkllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllll\gglllllllllll
l_lllllllllllllllllllllllgglllglbllgglllllllllllllllllllllll
lllllllllllllllllb_lllllblllllllllllllllllllllllllllllllllbl
iiii___iiiieiiiie]iiiiiiiiee_Z_iiedeiiiiiiiiiieeiiiieiiYiidi
ieidd_iiieiiiiii^i[Ydeei[ii[[eeeidEedeeieiV^ebiebiiieW_eibiV
SddiVVAXV^Ueei[UVVUeLiN^_UiiSeiKee\\iiNUX\^QeViO\`MN\O_O_^NP
^N\YWGQMc`E]QCccQM^MDON^MMYMM^IYMMQWVW[VcC^MMMM^KNLNM[QN^^[M
QY[KMLMMMWHMVccVVMTLQQKHTQM@MMAXDMOJMAWCQAGMHDGKXIF@9E@AFXAH
JOC\;8ACLRI?M@DT9M\FRFLM9LA8>KCQKMBFI=N7M9A:NC5>G\C=CN@8GACK
:QBC6ZJ<<A>T?>=?N<N7EOC63734147684L>564SD64=BB9;K9HI98EJ>C;>
>A79>=B6==@>;D95KK>87538H=7
.
frg:99
clr:5,858
}
{RED
iid:1565
eid:1127298230
seq:
TGCTTCTGATGAATCAGCTTGATTCGTCAGAACCTGGCAGCCGCAGCGATGCTCCTCCGC
GCGATGCCGGAGCCATCAACCACCGAGGGTCGGCGAATCTAGGGAGAGCTCAAGAATCTC
CTGGAAGGCGCTGCGGCCCGACGGGCCGAGAGCACTGCCTCCCGAAGGCAAGGATACCCC
TCGGAACCTCACGCCGCGACTTCCCGATTCATGCGGGAAGCCTCGGTCTACACCGGGCGC
ACGCGCAACACCGCGCCTGCGGCCCCGGGCCACCTCGGCAACGAGCACCATCGACGCGAC
CGTCGGGCTCACCTCGACGAAAGGGTGCGCCGAGGCTACCACCCCAGGCGTGGGGGGCGC
TACGACAGCGGGGAGGATCGGAGTCCCTCGCCCGAACCACCCGGTCCGCAGGCCTTCAGT
CGGGCCATCCGACGGGCGCCATTCCCGACCCGGTTCCGACCCCCGACTACTATCACGAAG
TACTCGGGGGAAACGAGACCGGAACTGTGGCTCGCGGACTACCGCCTTGCCTGCCAACTG
GGTGGGACGGACGATGACAACCTCATCATCCGTAACCTCCCCCTGTTCCTCTCCGACACT
GCCCGCGCCTGGTTGGAGCACCTGCCTCCGGGGCAGATCTCCAACTGGGACGACTTGGTC
CAGGCTTTCGCTGGCAATTTCCAGGGCACATACGTGCGCCCCGGGAATTCCTGGGACCTT
CGAAGCTGCCGGCAACAGCCGGGGGAGTCGCTCC
.
qlt:
4444487:I:I<69>=:P_>D:8;l_eVC_lGWlllbWllllllllll_lllgllllkkk
daPLJJGJBJ[HkkVlllllkklllgUgllllllgkllllkklllklkgkkkkkllllll
lll\gkgllllllllllllllllllllllllllllllllllllllklllllkkkllllll
llllllllllllllkkllllllllllllllllkggllllllllllllllllllllllkll
llllllllllllllllllllllllllkgllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllklllll
lllllllllllllllllllllllllgglllllllllllllllllgllllllllllgllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllle
lllllllllllllllllllliiiieiiii^eiiidieediiiiieiiiibiiid[]iiii
iieiiei_iiiVeiOiieZiiiiibiibiiiidi^eiii^V^iiieeeieeediXiZUei
ieiiieeei\ieUeiie]eP`c]^]]_\_P^c\UXNUL`^V]E^MOUQUPMV`KY^^MRY
[LM^MccYMMMY^^LKMQcYNMLYc^QOMGTOXLMXNXMTTMMcXOMGIAXLY\NF>OCN
M:HNIMSVJRDVKECEFSMEJZ\\IG>LI?I>87
.
frg:100
clr:7,751
}
{RED
iid:1566
eid:1128922893
seq:
AGATTCTAGAGATTCGTCGTCAGGCAAGGTATAACTGTATTCAGTAATACTAAATAAACG
CTATTTGGTTCGTTTATGATTTGTTTACCTTTAATACTTTATACTTTATGTTATTTTATA
CAATCCATTAAAATACAATTACGAAGATTTAATCTTCGTAATTATACTGTAATCAACCTT
CGTCCGAGGTCCATTAAACCCCAAGGGAATAATGCTTCATTGGACGAAGGACATTAACAT
TTAATATTTTATGTTGCCTTGTTCTTGATTCATAGCATTTGAGAACAAGTCCCCAACAGC
GACGTAGACCAAGAGGGCTTCTCCATCCGCCGGGGGCACCAAGACAGGCGCCTTTGTAAG
GAGCGCCTTCAGGTTGCCGAGGGCTTCCTCAGCCTCAGGGGTCCAAGCGAAACACTCGGC
CTTCCTTAAGAGGCGGTACAGAGGCAGACCTCTTTCGCCGAGGCGCGAGATGAAGCGGCT
CAGGGCCGCGAGGCACCCCATGACCCTCTGTACACCTTTTAAGTCCTTGATGGATCCCAT
GCTGGTGATGGCCGCGATCTTCTCCGGGTTGGCTTCGATGCCTCGCTCGGAGGCGATGAA
CCCTAGGAGCATGCCTCGGGGCACCCCGAAGACACACTTCTCAGGATTGAGCTTGACTCC
TTTCGCCTTGAGACATCGGAATGTCACTTCAAGGTTGGAGAGGAGGTCGGAAGCCTTCCT
TGTCTTGACTACGATGTCATCGACGTAGGCCTCGACTGTGCGACCGATGTGTTCGCCGAA
CACATGGTTCATGCACCGCTGGTACGTCGCGGCCCGCATTCCTCAAACCGAACGGCATGG
TGA
.
qlt:
46577?=A;777;QOMNeXUZeNK>78;B:DF___ZZedZiG8Zelbelllllll@@979
654576:FUaalll_llllllllllUlllllalHJUOFLC?E<CDK_gglllllllalll
_alll__llllgglllllllllllllllllllllllldRggglllllllllllldlllll
lllllllllllllllllllllllllgglllllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllll[lllllllllgllllllllllblllllll
llllllblllllllllllllllllllllllllbbblllllellllllllllllllllllS
lllllllllllllllldllllllllllllieeiiiie_iieii_`iiiiiieeieiieei
iiieiieei_iTe]ii_eeeeiZieeeiT_iii_iieeiedTieiii[YdWii_\iid_i
eeCiieieeeY_i^ddiiebdiYSiiiieieedQdiiiiR_dbeeebeiRLiVRQii^Ue
ie\iiUidOi^NieeedUed^]XXZ_idVdi^TiUeHeKd\e__YXe`_Y\:\QQeLYcU
UiiUe=i\OUNM^L]UQ]^^]PNQc^]N``LYKV`OPX^_NMGA_TBMM\LMNM`UMMM`
H^MRQNVLQQQLQMLVVL<JID[EYGM[[M?=GWCSUHO?B>QP@IDVOCAJ?LLSNLNG
>T@REDNMKJOM9VCWAK?RRLRLMLAD@MFNN>MGDX<MJ<PAFEPCRGR<@OFLT<VL
DAAAOH:77GJCQ<=<@:AQFMC;AG8D9;587C99>CRI?>?<FSJ==FLG<;B5=GQM
675
.
frg:100
clr:5,839
}
{RED
iid:1567
eid:1127298231
seq:
TAGTTCTGATGAATCAGCTTGATTCGTTGTGCCCCCCAGCCCAAATAAGCAAACGGATTG
GGTCAGTAATACAAATTCATCGCCGTACCACCCCACACATGAGTAGGACAACACATCGGC
GATGGATAGAATGGGACGCACCATGCTATCCCTGGAGGAGGATGATAAGGCGATCTTGGT
TGTGCTACCCTTTGGGTCCGTTTAGTCGGCTTTTGCTTTTGCACAGGTCGCCCTTTTGGC
TTCGATTGTTTTCTTAGATGGCCGGATTCGGTCGGTCCGCGCGCTCAGGCGGGGATGCTC
GTCGGCGGCGAGGAGACCGGCCTGGTCACGCGAAGATAGTTCAATCAAATGGGTCAGGGA
GGTCCACGGGATGCCTGATAATTTATGAGCGAAGGGAATTGGGCGGAGACTCACTGGATA
GCTCGGCCCACGCGCGGCGGCGGAAGACCTAAGTCCGGTGAGGTCGATCTCGGGCCTCCG
GTGAAGTCCGGTCGGGCCCGATGGCTTGGCGAGCTTCACGGGCTACTGGCGGAGCTAGCC
GAAGCACTGGCCTGCCCAGAGGATGGCTGGAGGGGGCTGGCTACGGTGGCCGAAGCTCTG
GCGGCAATGGCGGGCGGAAATGATCTCGCCGGAGCTAAAGGAAAGTGGCTGGTCGGTGAG
GGTGAGTGCGGGGCGAATTGAGACGCGCCCTGGGAGGGCTTTAATAGGCATGGCGCGATG
CACGGGCGGTCGTGCACCCGGCGAAGTGTACTCT
.
qlt:
411346:;L<?85:967Uiii[EiiW[iiiZWiiii_XlllWMlelelllllllll__ll
lll>>@:;>B<?LKKkkkklllllllllkkllllkllllllk]kgK\TWHJJHdUggkll
lllllllllllklkllllllllllllllllllllllllllllllllllllllllllllll
llklkkaadkgklkkklkkkklkY=GP=@BaTTYKHBFC?;<;QE<IBH<=WT\\P=<;B
GCL==G=K=BBIB::G=C9BG<C<<B=<G;9:<=H9:<<EB;<<GBB;G;?JB@[PB=<;
9;><:;=?:<K<<B7@G;B=9<<P:<G;=??<8HBK=BBGCBCFBF==GJSPO<<?<T:D
;?<EC<GBC<F:UG>:JT;GU:NTGDK[W[[TKEYPTKHLYGLLK=P8OJSKGRHdBN?N
=CaT[[TUTTTKMIMTS:GC;BDTQUkCLBTS<LVTKPSYkO[G[=QUGII=GCGHN??;
J:U[OBTWNTCCLAE>:NTTd;WJLULdTA;WLBCCHMCFH>@HPHKTCJYDbFGMOECU
G[S:EGJIM@;@C[EOEB;[HSWAPHBL[G=7OGIPPPS:99=C:KCW@AE?H@ALZ[]d
UWNHDF=HVDF:<9E@8I9CNNL9DLE?8@8DW;HN9VMCKAAJDBEA=UHK<F<VLFU:
@=?BGALW=@C58<8GP6@C5;7?>??:HPQPDFP:N<KA>B?>F>NFC>STB:8KN;?H
DLCB<8>8@;R7??66:>?K<<4GDC=E88>@95
.
frg:101
clr:6,751
}
{RED
iid:1568
eid:1128922894
seq:
AGATTCTAGAGATTCGTCCTTCACCGGTGATGTATGGGGCAAAATATTGACATGGGCTAA
TCTATCCTTCATGAGTGGTGCTTGTAATTTAGGATCTCTATACGATTGGTGGAGAATACT
GAGAAGCCTCTGCAACAAAGAGTCAAGGAAAATTTTTGACGGCCTTTTGATTCAATTCTG
GTGGCACATTTGGCTGGAAAGGAATCTGAGGGTGTTCTAGGGAAAGCACAGATATGCATA
ATAGGTTACGCTATCTGTGAAAGATCTTTTCGGATGGTGATTATTCTATTGACACGGGCG
GTTGGCTCAGGGCGACCTATTTCTGGAGGCATCTATAGTTGGCCTCTTGGCTCGGCCTTG
TGGTTTGCTGAAGTCTTTTTGTTTTCTCCCATATCTATGCGGTTGTTCTCTCTGTCATCT
TATTTCCTGTAGACAGCTGATGGTCTACTTTTCCAGGTTTTTGTTTTTTCTAACCTTCTT
GCTTTCTGGTCCTTGCCGGATATTGTACATATTTTTCCTCTTCTAATGTATTGTGGTGGC
AAAGCTTTTGCCACTTAATTAAAAAAGGATCCTTAGTAACATGCAATGACATCGCATATT
ACTATAGCTCAAGCCATGGACTAATAGTGGTATATTATTATGGACTTAAGCCACAAATCA
ATAGTAATATTGGGGCTATCAATGTTAGCTAATGGCTTGAACCAGCAATGATAGTTCGTT
GCCGGTTCATTACTTCATCTCATAGTGATGTATAGCGAATCATTATCGGTTGTTGGATTG
CGCTAACAGTGATGATTATACTATACAAAACTTCATCTCTA
.
qlt:
445779<C7<7<9KXDXNN^iC8R_eZeiE:OQZOllllRd[l[blXl_lSKlllgggHL
[gOYbllllaTlllllllllllllkklllkklllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllllllllllllllkllllkdllllll
llllllllllllllllklllllllllllllllllllllllllllllllllllllllllll
lllkkllllkklllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllllgllllllllllllllllg\lllllllggllllllllllllllll
llllllllllllllllllblllllllllblllllllllllllllllllllllllllelll
lllllllllll_lldlllll_llllllllllll_Wlliiii_ibiiiiiiee_V__iiii
iei_iiiii^iiiiiiii__Xe[ii]iebi_SRi__eieeeie]_ieiVe_ii[iRWiVb
eiibeiiii_VVTbYYWVV^UQHQQVUe_OVYUeeDTiVYTdiVNX_idXRe`US_TeUW
\XYieeXeeQHQNODIQ\WTNNP_O_TPYIN[VNMW[HM_MM]RMMOLQIYMH_M]MNSG
HM[QRSOPPPNUZ^MMMMMLLJJYCLMEMMGIEKH;ON[KOADHFNJIHSRKYIQIRKKD
MGI=K=;MAGIKLCMJGRQNN<@H?RSGDMGMGL@MIC?INERCC@@GDD=HBBF=<9CK
?;LMN?<@=<NNADND>ILROEOC?==ZQ?55;A4364741
.
frg:101
clr:6,814
}
{RED
iid:1569
eid:1128922895
seq:
AGACGATCTAGAGATTCGTCTTCTTGTTCGGGGTCGGCGTGTCGCGGGGGGACGGCGCTT
GCCACCGGCTTGAACGCGAGGTCGACGTCCGGCGTGCCTTCCGTCGGGGCGTCGGGGGCG
TCGATTCGCTCGACGGCCAACGAAGCGCGGCCTCCCGCCTGGCCTTGATGGCCCCGCCTC
CTCCTCCGTTGGCGGGGGAGAGAACGGAGCGAGCTCGAATGTTGCTCTTCCACCACGCGG
GGAAGATGTCGTCGATTCCGCCGCCGGCGGGCGGGCTGTCGGCCGCCATTGTCGTCGTCG
CGCGGCGGTGGAAGAAGTATCATGTCGTAGCTGCCGTCGAAGGACATGAACTCAAGAGTC
CCGAAGCGAAGCACCGCCCCGGGCCGGAGAGGTTGCTGGAGACTGCCCATCTGGAGCTTG
ACGGGGAGCTGTTCGTCAGCACGCAGCAGGCCCCTACCTGGCGCGCCAACTGTCGGCGTT
TCGAGACAGGGGGGTCCCTAAGCCGACGAGTGAGTGTGCTGCGTGCCCCAGCCCAGATGG
GGTCGAGCGCGTGGGCGAGCGCGAAGGGGGAGAGGCGAGGTAGCCGGAGTCCAGCGTGAA
AAAGTGGGAATCCCGCGGCTTCGTGGTCCTCCCGCGCCCAGGTCAGGGGCCCTGCGTAAG
GGGGGTTCAAACGTCCCCCCCGGTTAAGGAGGCAACGGGCCCAAGAGAGGCCGTCCGTCT
CGGTCCGGGGGCCACTTCTAAAAGCGCGTCTCTCTCTTTTAACCTAGGAGGATCTCGTGT
CACGGGGGAGCAGAGTCTACGTCTACGAGAAAGAGAAATGGCTCGGCATGATCTTT
.
qlt:
555566::>:@=;;>UVHS]]d]PeZQ]b[_K_LWHQ?SWlQbVWlllllUMCllgggaA
A=:97876878F>=JVVUdggdg[lggggglldlCL?<:78=;676::<@aNYJdllggl
gldlgggadgddddVgUNPR[abggggggaVbbbbbaag[gaE[UUlggllagggggggg
gglgllllbllleebbbb_PW[[[[[e__lellllbGQQZlbbeelllllZWll_l_le_
____WZU_]lZ_eL__ee__eeeeieiddeebee___iiiR_W_b]dVeiiebXQdR]ie
ii_ieeddUieee_dddbbddbiieeUdYGeeeeebUJ>KNHRKNLWebUYedOU_XQee
ee]^]Ud_ddNUTQYSQWVW]eeXeW\J;MJSN[_OT_]PKRPN_\W\G_NO\QKMVYHW
NMH_]GMIMMM:KMDMN?WN>NMMIDNDAWDQQHGA=CFWMGCFCBD9:GMGFMAOCMRL
DCACJMF<MTJKPLFLJA7768TE>H=6E>DI<<AE7>CFG?G9CBRQL<:JVQ:5676P
P5@L8E?8>AA;9>555D6H68497<IIH;<5954448;<:=4?C=?:5=@7:496;>97
<99D6@A5<:9>J:74744864559675363;<4635>8776679?<86475=8643347
D<DD534854576539596546423444213421113348@:44376:575433335668
73553321583338733135;719511573869363244433133473313788444335
4555HH?7334A46576732386:44665743134553133875521454444431
.
frg:315
clr:6,612
}
{RED
iid:1570
eid:1127298232
seq:
TGTTCTGATGATATCAGCTTGATTCGTTCACCTTTTTGGTATGCACAGCACACTGTACTG
TTATTTTAAATTTATGAAGCTAACATTATGGATGTACTCACATTATGACTCAGCAAGGTC
GCAAGGCGGGCACGTTCCGCGTTCTGGTGGTGCTCTCGTTACATTTGCCAAGCTCAATCA
TTGATTATTGAACCGGTAGCCGAAGCCAAGAATATAAAACCCTGCAGCCTGCACGCCTAG
CCTCAGAGCCCAGCGTCCGTCTCTTGCTCATCAGCATCAGCTAGCCACCCGACCAGGCTT
CAGAAAACAAAAAAATGAAGCTCTCGGCGGCAGTCCTCTGCGCGCTTGTGGCTGATCAGG
AGGAGGGGATTCTCGCCAGCTTGGAGATTATTTATGAAACAGGGGTTTTTTTTTATTCAC
AATTACTGGCTCAGAATTTATGAGCTTGAAAAAACGCCGTTATTGACCTCTCCCGCCCCC
AACGATCAAACGATTAATGCGAACACTAAAAACCACGCACGAAAAATACTTTAAATTTAT
TTGTATCAGACTG
.
qlt:
3131498TEK@7:D>7AU^^^UAii[diG:I^YiiiiiY_]SdiZi_iZeid^eYSllll
bYl<976<:7575;7<=8PlllllllllllllalglllklkklllAD@>B9:;DJGJWdl
lllllllllllllllllklllllllllkllkllkllllklllkllklllkkkkklkdkl[
adkkakllllkkkkkk\kaklkgkakldkQkd]kd[dakdka\kT]GdldkdWd]kk\kK
YkdkaFkTVddaCkkWddaRdakWTkKM\K]]WKVUT][TY\dPWkW]\aWkTdTTWWa\
dQ=kTTWYLRRQLWOWdkWWa\d[aQN[dVTTW=WOBTG\TFSTTUUaBJ==HU;JK=<G
<J:<HB8PPGTP8P@@B:8B=>>;I9B<;<8:<C<<<:;:;<@=<;CPGGH=C?B=;<:D
<B88<=<B<;<H;=:4688<<?<<<=<KSG;Q;L;B<E89:===9@H:>L<8F<:B<:D6
L=A=:<HWWE=89<<:BG<D>=;CD<=FT=HD<<=<:=?6;8:=>>>=>><:?GFD>:?;
<=8<@;<:=;::8
.
frg:102
clr:7,549
}
{RED
iid:1571
eid:1128922896
seq:
ACGATTCTAGAGATTCGTCCCACCTAGCCACCGTGAATCGCTAGCAATCGTGCACCAGTG
CGCTTGAATTTCGGTTTTCCCCCAAATCAAATTTCCGCCACCCGAAATCAACCTCACCGC
GGCCAGCCCTCCACAGGTCCGCTCATACCCTCCTTGTTCCTGTTCTAGCATCTGTGCATG
TTAGTGATGCTTGCCGACCCATGTAAGTGAGCTAGGAACTCTCTGGTCGCCGGGAACACG
GCGATCTTGCCGCTCTGCTCTTGGTCACCGTGGCCAGAGTTCGGGGGTTGGTTATTTGTG
CAATTAAGTTAGGGAAAGTACTCTTTAGGTCACGAATCCGGTTTAATCCGAAGCTGAGCA
TCGGTCTCGATCTTCCCCGGCAAGTCTAACTCGCCGGAGTTGTGCCGCCCATGCGGAGCA
CCGTCGTGGACCCCGTCGCGCGAAAGAATAGAAGACCGAGGGTCTTTTTGCAAGTTGTCA
GTGACTGAGAAACACAGTAAATAAACCTGCTTCAAATTAACCAAAACCCCATGGTCCCCT
GTGCAAAGCCGCCAGGGCGCGGCCGCGCGCGGGCGCGCTTTCCCTCTGGACCTGGGCCGC
CTGTGCTGGATTCGGCCCAGTACTGTTTAAATGTTTTTCTTTTTCTTTTATCCCTAGAGC
CAAAACAATTATAGAAAAATGTAGAAAATGCTAAAATTGTGAAACTAATTTTCCTAGGTT
TGTATTTTCATAGTATTTAATAAAAATAAGTTGGTGATTTTAGTGAAAGTAGAATTTTAG
GTATTTAAGTAGTAAAAGTCTGTTATAGATTTAGAAATATGATAGTCTAAATGCCCAAAT
TTTTATATGAGTGTTATATAATATTTAGAAGCCTGG
.
qlt:
544565;?D:6687UUL>=868=eVY_eA7_bed^>;NiW__XlN]llllllZWlLMlll
elebgg>Cggggg_[lllllll_KlllaYllllllgglaallllllllgdllllalllll
lllaallllllallallllllllllllllllllllllllgllllllallllllgglllll
lllgglllllllllllllllllllllllllllllllllllllgllllllllllllgglll
llllllllllllllllllllllllllllllgllllllllllllgllllllllllllllll
llllllllllllbllllllllllllllllllllllllllllllllllllllllllllell
lllllllllllllll_llllellliiii_Z_iiiiii__iiiei_Ziiiieiiiiii_ie
__ieiieieePiiiiiieiiieiiibi]`iUiiPiHiiiViieieiiiiid]eeiiY[iV
edidViiiHiieeeedebiidei^_ei^idiiUGi__ee\^WUeeeeYV^UQiiWe^VVS
iZeXOi_XSiXeeSecRXe_i_ReeT^^c_UKC\___U^]_K\U[XM^M`LMNP]WMR_N
VM^M]LUO_OIMMIQHcMMNFMLPcJcJH^LP^@c^^MSLc^cQVM^^IMLLcTLMHcLO
HDYYKND?NPLMMMccccNJW?M>cccP=RGSOc\DFFR>LL\IGTE@I\cQDC=@@:@\
DD>:?\\H<7BQCGNC\HI6AF\\\I<8I=G=JA;?>ATTC;6=J9TBA<E4=64TT<44
:8;9I<476:K:C5FKA=?<H>35;645>ETI<6>T:4:<7:5F8;E=BH88D6C5FN;9
INH<545>8424=:7@5669;145B@517@4B7C:9
.
frg:102
clr:6,843
}
{RED
iid:1572
eid:1127298233
seq:
GACAGGGTCTGATGAATCAGCTTGAATTCGTTTGACGCGCTTGCCGCCATATAGCAGGTT
TACGATGGCACGCGTACCGACAATCGCGGTAAACATCGACGTCGCCACACCGATACCGGT
AGTAATCGCGAACCCTTTAATTGCCCCGGTACCCACTGCGTACAGGATGATGACTTTAAT
CAGCGTGGTGATGTTCGCATCGAAGATAGAACTGAATGCGCCACGATAACCTTCATCAAT
TGCCTGTTGAACACTACGTCCGTTGCTCAACTCTTCTTTAATAGACCAATTCTCTACATA
TCGCTCAATACTGACCATTTAAATCAAACCTGACCTCCATACCACAAAGTCAAAAGCCTC
CGACCGGAGGCTTTTGACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAA
TAATATCACTACCGGGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAAGAAGCTA
AAATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGG
ATGCTGATTTATATGGGTATAAATGGGCTCGCGATAATGTCGGGCAATCATGTGCGACAA
TCTATCTATTGTATGGGAAGCTCGATGCGCCAGAGTTGTTTCTGATACATGGGATATGTA
GCGTTGCCAATGATGTTACAGATGAGATGGTCAAGCTAAACTGGCTGACAGAATTTATGC
CTCTTCCGACCATCAAGCATATTATCCGTACTCCTGATGATGCATGGCTACTCAACACTG
CGATCCCAGAGAAAACAACATTCCAGGT
.
qlt:
6447544498@N>E=7:>=AblglB@PlldlgglV?dlkllllllklkVlllldllklll
klkklkl=<<F;@@<=dd[Yk]kklkllklllkkkllkllkkbG=?=B:=CKLLHYTklk
kkkllllklklllllllllkllkllllllklllllllllkllllllkkkkklllggllll
llkllllllllklllllllllkllkkllkllllllllllkllllllllllllllllllll
llllklW[RWRRDCLL[@WLLLHHWGKN[RL]aWPLCFFCHLWGWL=dOUHMKG=C<[RB
SJFO][W=KRYUldWTHKMKG[G=B:;G@QQNYGLCLM=TK<BT;[===<DCLVGBGOGL
GK[CTT[[BUIR====B=CSKEKG<?<<RADHL<a<LAILLDH<H?DFIPKPF@AJ[FFA
HC?;[UCBECC>I@EC;C;COOUGIC[aGGSQFOPP@SM[IHPM>bd?OGG@<KHA:GQH
H:PGLPCGV:C?=AGCWKJD>G?@@;KIAEO=ERDN<HACBB:H?HHP:PVJFF>D>>C?
KDPHLRLGDNLMFFGD99A<:><G]LHKZdGRLE>@?>H9@6EDE@EIN>:[NPKLIKTV
KTKHGI7>>DO@C=::5HD:=8H=LAA>;FH=AK9DIN>NIQGUO5DQALKCGM6D8H<>
9>:><::>9AELNFR>LINL;PMSM6B=G;5>M9MCML@>LBN;:HFI=A>BJKMKMH>;
ILLLMLM?QE:5JM9:L?GE6KGGJE>ADG:@F=>E<;FD:;AJRK?>NLJD:7587<AF
;7::;HI:4787;987<=64;IOP==>7
.
frg:103
clr:10,283
}
{RED
iid:1573
eid:1128922897
seq:
ACGATCTAGAGATTCGTCTATTAAGAAGAGTTGAGCAGCGGACGTACTGTTCACAGGCGA
TTGATGAAGGTTATCGTGGCGCATTCAGTTCTATCTTCGATGCGAACATCACCACGCTGA
TTAAAGTCATCATCCTGTACGCAGTGGGTACCGGGGCAATTAAAGGGTTCGCGATTACTA
CCGGTATCGGTGTGGCAACGTCGATGTTTACCGCGATTGTCGGTACCCGTGCCATCGTAA
ACCTGCTATATGGCGGCAAGCGCGTCAAACGAATTCAAGCTTGATATCATTCAGGACAAG
CCTCATACTCCAGCGTAACTGGACTGCAATCAACTCACTGGCTCACCTTCACGGGTGGGC
CTTTCTTCGGTATAAAATCATAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTG
CTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAACT
ACCATCTCTTCTTCCGAGGTAACTGGCTTCATCATAGCGCACATACCAAATACTGTTCTT
CTAGTGTATTCGTAATTACGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTC
GCTCTGCTAATCCTGTTACCAGTGACTGCTGTCAGTGGCGATAAGTCGTGTCATAACGGG
TTGGACTCAAGACGATAGTTACCGGATGAGCGGCAGCGGTCGGGCCTGAACGCGAGGTTC
GTGCACACACCTAGCTTGAGCGAACGACTACACGAACTGAATTACTACGCGTGACTTATG
AAAAGCGACAGCTACGAATGCAGAAGCGAAGTATCAGTAGCAGCAGTCGAACTGAACGCA
AACGCACTTTCATGGGAACCGCTGACT
.
qlt:
7767:8>B:<98:TYGI^DNH[LVAl[<lEH__l<H>8>C>GBCFIIIP=;:9;BCW>C?
LVTDHHG@B][LHLLCKTG<CABDGCLLLd[LHQQLIR>GBPD;LQHDWL?WL<V<=<?L
RKHK<===:CW;MMHKaKLH?LH:=kkTNLWBBH==<GB[QIB@[[LVQQKKUVHKLLKS
KLCH?CHLCGG[L[BB=QPNKTG[[VQTOLLLCO<OKMTDO<>ADE8F=OTHJALLLL[Y
UULLaLPURVHJC<<<RBHHP>JP;GH;I>9L>EFEM:;<>=OJIIA;7C>IE>SSI<S9
>EBC=8QG>@C:8@>MLGMPbHHCFOF::KSF=@KG8=BLEGOKIMHLKH:@AM::L@=I
CECDD?HH888@8GN<LRJ78;:CEKAAMHAAEV8QQGTNGEPKEOKHI?8HJOZLGOGH
HHQKHKL=B:AA:D?:?>:=A<AB>>D@G:97:<<;N?=?IZHKBD@=;>TZOE::QC@G
D<:89<C>;;58:TNFeNMAGB<=A8<HNUL<A;7G58AJE>RFCBA<E>MHJNN<JLLK
LJH=CNCI;=M>=JEAIC<B9LMADNN@MP:B=MI>KQIRME5A;DBD>D9HL8J>;@CL
>@@LGMGLGELHLFM<IJBG<7<A5<L?>GO6J:6DA9<DOQ?<8=G68=:G><<997;<
FC;:=<<:;=6==?N9@?C<?A=8AA;6:<:9C:=7:97:F=?G757=@<<45<9BI=J7
65;B956484;7M:A87>534:AM=6?I=DG5:98>=D<LC:97N6796448>95@;765
<PP558858585D442474<;;;=637822336:H;GAC9<57?6A55<7C943673555
3;4B8@8667=347;:@;?;4C5:325
.
frg:103
clr:6,267
}
{RED
iid:1574
eid:1127298234
seq:
TACGTCTGATGATATCAGCTTGAATTCGTTCATCAAACAGCTACGTCGCTTCTACCCTTA
AGATGTTTCCAAGTTGTCCATATACCTCGCACCTGCGCAAAGTTTAGTCGTCAAGGAAGG
GTCGGCCTAGCCTCGGCAAAGCCCGACCCTCCCTCGGGGGCTAAAAGGGGGGAGACCCCC
TCTGCGTCGAATTTTTCCTCGAAAAAGGATCTCTTTTTAGCAGGATTTCTTTCGTGCCTC
TTGACTACTTCGGAAAGCGGATCCTGGAAACGACGGAGTACACGTAAGCAGCCAAGGCTG
ACCGAGCCGAGGGACTCCTACGCCTCCGGGATACGGATACCTCACTCATCACCTTCTGCG
ATAAGTAACTCGCGCTCGGATAAAGCGACTCCGTGGGCCGAACAAGTCTTCACGTTCGGA
AGCTCTCCTGCCGAAGCAGTCCTTCAAGCTTTCTCGACTAAGTCGGGGACAGGGCCTCAT
GGACGGGTGAAAGTACGCGTAAGCGGCAAGGCCGACTGAGCCGAGGGATTCCCACGCCTC
TGGGATACGGATACCTCACTCGTCCCTTCCGCGAGAAGCAACTCTCGCTCGCACAAACAT
CCCTATTACCGACAGGAAGTCCAGATGCTCGAAACAAGAGGAAAAAAGACGCAGCTTCGC
AAGCACGGCGAGGGTGTGTTTTCTGGCCTCGGCGGCCGCAGAACGCACACGCTACAAGAA
GATCTGATTCTGCAGGCTCGAGTCTTCACGCTGAAAGGAGCCGCAGCACCCTCGACATCG
ACGGCTTCTTCAGCAAAGTCCAACCTAGCCTCTGACGGCGA
.
qlt:
43444C>FQEK:88==67[illEEPllW_lVDl_dllgallallllllllllklllklll
kkkkkW]]PI<FHHNlklkklllllllllklllllllklllkllllkllkkkdkllllll
lllllklklWlllllllkllklllllklllllllllllllllkgklklkkkklkkkkdkb
bkllllkkalllllkllkllkklkd]WkXk]kkkkkkkkT]][kkkkkkkkddWakdddk
dklk]]daadkWdkkkkkkdkkdddldk[[]TkT\kl[dkdUk]adddkaaW[WadlTkl
lddakT]d]kbkkkW[a\PTaWdaada[k[kdddYkkddkkkdW]Y\LYTQRkkkkak]]
kddk]dkadkkdakaaaa]kddWOUSPddd[akTkda[dkkdd]da[daddQ[aYdd[dk
kkkllgddggTTK[[TddQT[Yada[dgdddddalglgggd[bbbg[U_URaga[gbbRa
ga[[UaFIb[SUUSU[UlPOUHELQSIBFMWGSE[HO[S<[bNeXbb[UbbebWWVb]]V
Q__R_MOMAKQRblll[OOSZVOd]bVVPLKTM[N]]MLLNN]bReRZVPPK]RNNVVN]
PMPV]UWVDEKVKCP]TVNVUV[]dKiO][QTTKXNNGeOO^UUUUbT^_ERHKTbQWAV
NKTUMeUXALeUMFEXDUHHIHXQeODUNWIJ?OQPUYXH5\H6P<PFB:8::;;8?9L:
;MFFBCD<EDEMCABM=EMLSLGWJHT7>CDDM[J9Y<O:B7:5<4:CAD@A=5557A<8
MJ:EDM[B>E;55><9<97<A?97<:8:>CDC:;87?>5:7
.
frg:104
clr:31,817
}
{RED
iid:1575
eid:1128922898
seq:
ACGAACTAGAGATTCGTCCGGTCCCTGGCGACAGGGTCCGAGGGCTCGATGCCTCCCTCC
GATGGGATTCCGTTACAAGATCGTTCCCGCTGGTCTCGGAAATGTCCTAGGGTACCTCGG
GAGCGCAGCCCGAGCCTCGGTTATGTATCGAACGTACCCCTGGTCATCCCTCGCTCGGTG
TCTGAGGCGACTGTGAACCCTTCGGGGGCCAGCCTTCGAACCCCTGATCAGTAATGGGCG
CGGAGCCCGAGTAGCCTGAGGCGGCCATGGAACCCTTCGGGGGGCTGGCCTTCGAACCCC
TGACCAGTAGTGGTTGTCGGGCCCACGCGATCTGAGGCGACTGTTGAACCCTTCGGAGGG
CCAGTCTTCGAACCCCTGATCAATAGGGGGGGGGCTCGGAGCCCGGTTCCTTCGCGGAGA
AAGGTCCTTTTTGGGGTATCCCCCTTTCCCGGTCCCTGTTGCAAGAGATAGAGAAAGAGG
AAAAAGGAAAAGGATATGAAATCGAACGACGTGGCGTACCTCTTTTTGACGCGGGTTATT
ACGGTGAAAGGCGAAGCGTCGCGCGCTCCTCCCGCCAGAGGCGCCGCGTGTCCCGCCGCG
GAGTTAATGCGACGGGGCGTGTAGTTGGCGGGCGGCCGTTGCGCGTGCGCGATCCGTCGA
GGACGGGTCACGGTGCACCGTCTTCACGCCGTGAGAAGAGCTCTTCTTGTTGTCCAGATG
AACTGAGCTGCTGACGACTGACTGCTGCCCCGGCCGCTCACCGCATACTGCGCCATTCGT
CATGACCGACGCAGCTGGGCGTTGTCGCTCAGTCTGCTAAGTCCGCACGAAGCCACGTGC
ACATGC
.
qlt:
:555568DA@<:9JQETWTiH8868Al_dlSM=l_lllllllllgllllllllkglllll
lllk\\kklllllkllkllllllllllllllllllllllllllllllllkllllllllll
lllllllllkllllllllllllllkllllllllllllllllllllkllggllllllllll
llllllllllllllllllklllllllllllkklggglgllllllllllllllllllllll
lllllllllllglglgllllllllllllllllllllllllUUllllll_llllellllbl
llllllllllll_llllll_llZU_lllllliiiieeiiiiiiiiiieeiiiiieiieie
Wi]eiiiiibeeV___iiRY_S_eidiiiiiiiieiiieiX^QY^[Ueb[YiebeiYiHi
YQedL^U^iYiVYYYWUX\Uee^VeiiU^S^iQXe\NiS]eTQNeiUQNUUiNei`W_PY
\cccVUWMc^XN^NHHPX_cM\ML`MOL\PMM_UMMKMHPUJNW^^NFMGII;[<QAPMN
MMP[EJ;c<QL;>OP?NMKOHLMKYFMAHMHMHMDGE>CDM>MGMLMQ>TAKTOMAEKAA
AF6EN?CJM:6L>GcVD6>ENFH5ICCI=NVDC=>D@;D:LA6@CD?:6A6PRDBBRA?I
8EO9BPB7==9MF4AB;;FC>E9M99>@9F:5@8587G8@994454>B=95;BMN>;7:;
:858@;489?4?;I76E54<H;?I9>949N454F>><@46;79G8E478?<4373467B:
3135<873576:5B47>22=6639474?5223667A4465;33854855BD;875564A5
44;483
.
frg:104
clr:7,765
}
{RED
iid:1576
eid:1127298235
seq:
GGGGCCTCTGATGAATCAGCTTGATGACGATTCTCTCGATATCTCTCTCTACTGACACTT
TATATAGAAAACCCATCCCTAGATCTTAGTTCAAATGACTCCCATCGGAAAAAGAAGTTT
GATCGCTGCCAGGAGGTTCCAACTTTCACCGTACTGAAAATCCATCGCTACCGGGCGTAT
TTTTTGGGTTATCGAGATTTTCGGGAGCTAAGGAATCAAAGATGACTTGTATTCAAGGGG
AAACGTCGTGCTCGATCTTGACTTGAATTCCAGCATGTGCGCTGATTTAGTGGTACCCTT
CGGGCTCGCGATTCTTTTGTTTCTTGTTAGGTGACTCTGAGGACAAGCCACCTGAGATCG
GGAGCACCAGCTTTGGGTCCGAACCAGCTCCAGCTTGGTCGTTGAATGATGTCATCAACT
CAAAAAGTGGAAGTGAGTTCGCCGAAGGAGGGCGCCCCTGTTGGGGACTTGTTCTCAAAT
GCTATGAATCAAGATCAAGGCAGCATAAAATATTAAATGTTAATGTCCTTCGTCCAATGA
AGCATTATTCCCTTGGGGTTTAGTGGACCTCGGACGATTGTTGAATACGGTATAATTACG
AAGATTCAATCTTCGTAATTGTATTTTTAATGGATTGTATAAAATAACATCAAGCATATA
GTACTACACGTAAACAAATCATAAACGAACCATATTGCTTTTATTGAGTATTACTGATTA
CAGTTATACCTTTGCCTTGACGGATATTGGGTTTCCGAATGAAACGATTGCGGATACGGG
ATTCCGTGGACAGTAAAGGAATACTAC
.
qlt:
944354488789G<:<=578=:<;A@78879:KAD?@8@B;A97=9?=A9>:8@787877
:87998547777575479><;9:;<@AA9<G9=<D<BG<::=:<;<;?64954875969<
<:9<9;=K<<<N9Q<G<<B<;CC<9>B<=??=I;B=8?B;<<88GB<BMKFF=B=>?<;?
BCC<<<:<9<<=B:<;?B=<;<88GB:B;;9:@>=9::=;?;BHD6<<<:<=<=:<<<<9
;<<:<<;7>BA?=:<9<<<<<=98:<9=<=<<:<<<<==:;A==??>=:=8AK<=;<=:=
<?956:=:;:9<;:869<=AC;=<BG<<<::=AB<:<8;B:<B9887:;:;==G<G@=>:
<:<89<=C=99=>JK<::BB<Q<<8<:<=CR>==H=H9:B=<<8GB=?H@=:D=C?8:BB
A9<D:<<?C9=9:?=G==;;;CCG<@:E@LC<D;OOP;DH?B=;?<H?C<D::FCA<:B?
K::><ETGKTK=OV<?T=JP<=A@?HE<;A<??A<<<@T<CCJ>MIC?<CE:CHPHHRRG
F::=<<?;=:<:?:@97<;>9><>E9>=><@97L<8E89F9>:::E>B9?BWHCECQ?B8
<68K:@:8;ISZKV8D>CGEH7=>BB=:;;KWLOMNO=AC>>88C=BNGN>7>98ELF9L
FEC=D=:=;K7>=CG>:DFUMXQEA>9XBCC>N]SIR><KKEACD:@99?87HF][B6WZ
@::=FN:9=ALbRb?VMFWHD68B8GDRQN=BZSSVFXSIYB9<9<XDAGF@=L8AE7@C
G7HQM::::NRM<<MNF>HN@AMR;>6
.
frg:105
clr:313,805
}
{RED
iid:1577
eid:1127298236
seq:
TGCGTCTGATGAATCAGCTTGATTCGTTCGAATTCTCTAGATATCGCTCAATACTGACCA
TTTAAATAAAACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGAAGGAGGCTTTTGAC
TTGATCGGCACGTAAGAGGTTCCACTTTCACCATAATGAAATAAGATCACTACCGGGCCT
TTATTGATGGAGTTTATCGAGATTTTTCAGGAAGCGAAGGGAAGCTAAATTGACCCATAT
TCCAACGGGAAACCGCCTTGCTCGAGGCCGCGATAAATTTCCACATGGATGGGGATTTAA
ATGGGGATAAATGGGCTCGCGATTAAGGCGGGGCTTTTTTTTGCGACAAGCTATCCATTG
GATGGGAAACCCAATGCCCCAAAATTGTTTCAGAGTTTTGACCAAAGAGTTTGGTTTTTT
GATTTTACGGATGAAATCGTCTTTTTGGGGGGGGTAAAAAGAACTTAATCATCTTATGAC
CCTC
.
qlt:
31313=?HMDH878>7:U\iiYGiiS[iieYidiiiiU_iSd]Zi_^eZblllllbYl_V
lbG;@:77899:;;LCOYll_Xlllklllllldl]lklklWB?=C<;9;:;::;;;<RGB
=[kYddddUTakWkkJlWkSCL=>HPJOLGP\KKOHJaUFBBHKB\KKHJOTOLT]>:<:
=<5:5<76BF:8;CHCCG:?>B=CCC=G<<H?NCA@W;;=GB9<DC?GC<<AH:==:9:<
=BNHCKF=PGMI=JH?;;<B;:9;6;;GA<:89;87:;L;I;;<<9HG<>B><<B89:==
B==KB=JK<B;BEG;<FF7B58<:;=;:;<<F=8:BMJPL=8BF:F;>B8B=FBF:DAJ<
;=;BH8:<<<=;<I8:A=FH=?K:<99;<9<89H;;><:G;99:C?B588;846=<;TGG
<<<:B8AF8:A<FO<E?=F==<BBG;9=>GCGB8:<GPTS<WLDIMSB;=<::;LI8?K<
=9<8
.
frg:106
clr:395,482
}
{RED
iid:1578
eid:1127298237
seq:
TGCGTCTGATGATATCAGCTTGATTCGTGACGAATTCTCTAGATATCGCTCAATACTGAC
CATTTAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTT
GACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGG
GCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATTC
AACGGGAAACGTCTTGCTCGAGGCCGCTATTAAATTCCAGCATGGTTGCTGATTTATAGG
GGGAAAAATGGGCTCGCGAAAATGGGAAGCGAATAGGGGGCGAGCAAGCCTGGATTAGAA
AGGGAATCCCGGGTTGTGGGGAAAGTGCTGGACTCGTGCAAAGGGTTTTTTTACTGATAC
GAAATCGAGCGCGTGGATGGGATGGGGGGAAGGGAGATACACAGATCAGAGACACGAGAT
CGGAAACACTTACGTACAAGTGGCGAAGAAAATGATGG
.
qlt:
11334678KBJB8:>>79\]iQQ?iiORiBA_^e[iiidXXeXZNZi_eeWH]ldlll[l
WKl[<@<89:79<:;;CCglgg__lllalklllllllllllCD<<:>>C:;;:;G<BBBG
[lllllkklkkkdkkdkkalklkllldlkkddkUdk]kdakl]OPOJH=kkkWkkkkkgS
LRJKOTaabddW]GWaOkYISTkkkkddMBadNTTOWLWT]L]aG<<BGOL=KU?MONHP
;<BFFGaT\TPJTW[dODKFFKM=HFF<NLG==<KTG;<;<AAG<=HKBGLW=BH;C?=<
<=;=BE=<JUKTB:K9?=I<=B<IBG:N;9K=:<<@;H<?=<=H;H<G:::=G=<=;:M<
IFJQGB>C=<KB9:<B;<9?><B=<:<<:M==<8;8:M==<dFWI;C====8;8;=<9<:
==B7:F::KI;C:<YF;<==?K<<CGG8@KAFKBN<:9M:;:F:?:=C?EGC<HCQ9IK<
=;OP<K:<?9;;<;;=<;6L9PM:<O;FA?BAEa=<FD
.
frg:107
clr:372,516
}
{RED
iid:1579
eid:1127298238
seq:
TGCTTCTGATGATATCAGCTTGAATTCGTTCTTTGTAAAGGCTACATAGTGATGCCCTGC
TGGGTCACCTTGGTAGTGATCAATGGAGAGTCATGATCTGCGGGCAGAAAGGGAATCACG
ACTTGTGGGTAAAGTGCACAACCTCATAAATCAGAGACAACCTCATAAATCAGAGACACT
TGTGGGTAAAACTGATATATCAGCCGTGCTCGCGGTTATGAGCGTCCAAGGGAGCTTCAG
TGATTAGTGGTACTTGATCAGAGACACTTTGCTTTTCAGGTGGCAATGAGACTGATGGTT
TTGGTTATGACTATGGTGCTGGTAAGTGGTATTCTTTTCGTTTGGAAAGGGTACATCGGG
CTAATAACTTGGGTTAATGCTAAAACCTGGCTTTCTATTAGTAAATAATAATCTGACCAA
CTAAAAGCAACTGCTTGACTTATCCCCACATAAAGCTAGTCCACTACACCCAAACAGGAT
ACTTGCTGAGTATGTTGATTTGTACTCACCCTTGCTCTACACACCAAACCCCCCCATCCC
CAGGTTGTCAGCATTGCAACCACTGCTCAGGAGAAGATGAAGCCGTGGAAGGAGACTTCC
AGGAGTTCCAAGACTATGACGAGTTCTAGGCGTGGGTTAGCGGCAACCCCCAGTCGGCTG
CCTGTGAAGGCCGCAGTTATCTATGTTTCTTTTCCGCACTTTGATTTATTGTAAGGACTA
TATGGACGTCTCAGACATATGATGTAATCGACTATTATTTCCCTTTTTAATACTATTTTG
AGCACTGTGTGATGATGTCCATGTTATGTAACTGTTGTGTACGTGA
.
qlt:
44444657C:FC89<966deel9?QllTdllllllXdlllaglllgllkllkklllllll
llllllkkk\\g\dk\klkkkllllkklllllllllllllllllllllllllllllllll
lllllllllllllllllllllllkSgllllllkkllllllllllllllllllklllllll
llJ[;FFGlklllllllllllllllllllllllllllllllllllllllllllllgglll
llllllllllllllllllllllllllkglllkklllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllggklklllllllkgllllllllllllll
llkllllllllllllllllllllllllllllllgllllllgglllllllllllgglllll
lllllgglllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllblll[lllllllllllllllllllllllllllllllllliiiiiiieeii__
_eiiiiie__iieiiiieiiieiiiiieeTdiXii]dNiii]didbieieSii]d]died
[eiiTi^[_JieiQeebidTbibZiebbTdWdZiYVeUeQiiY\Sd^YQQVUXUeN[X`e
Xe_iX\QXK\Mi\X`M[^PN_\PX_\c``P^^_TWMNMMTc]MKIc_MM^^LM[M_MKQY
MMT[[SLQV[VMB7WHJYMMNSI^KKKM[DVMQOMMOM^TK^NRc\cIHOAMMLMQc\NM
YOQMJGD:LFMHCMLFVIMJDHMML=@F?DPPAEBDMBN?JOB@=7
.
frg:108
clr:31,824
}
{RED
iid:1580
eid:1128922899
seq:
GAACGGTTCTAGAGATTCGTCTACATATTATATGTTCAAATTCAAAATAAAAACTAATAG
TTTTTCTTAATGACATGGACATGTCTTGGATGGTTGTGGAGAATGTAGGTGGTCACAAAT
GCAACCCCAATGGCATCCTTGGCATTTTGGTCAGGGAACACTTTTCTGGGATTGTAGAGT
ACGGTGGACATGTTGGTCCCTTGCTTTTGATTACTGGATCATAAGACAAGGCAACACAAT
CGCTAAATGTTAAGGACCTTCGCCATTCGAAGCGGTGGGCGCCAATGTTGGTCTCTTGCT
TTTGATTACTGGATCATAAAACAAGGCAACACAACCGTTAACGTTAAGGACCTTCGTCCT
TCGAAGCATTATCTCCTTTTGGGCATAATGAACTTCGAACGAAGGTCATGAAGAACAAGT
CTTCGTCATTCAAAAAATATAGTTACAGATGTAACATTATGATGATTATTCATTTCATAT
CAAATGTTAAATAATATTAAAAATTCATCACATATCGACAAAGTTATACACAACGTATAT
TACATTGGTACCTTCGTCTTGCTTGAAGGCAAAAGCGAGGGTGCAATTCCAATCCCGCCT
CCATAGTACAAGGGTATTATTCATCTATTATAGGCAAGAGACGCAGCCCAAGCAAAAGTA
CATTTATGACCCTAACATATACACATAATCCTAATACAAAACATCAGGATTAAGTAGTCT
TTTCTTCTTTGGTCAACATCATGTTTGACTTTCATAACCACCTTAAGCGAAATGCATCCT
TCAGCGCTTTACGCATGCTTGTTGTAGCTTCGACATTCAGTCTTGTTGTTTATAGACAAT
TCTCTGTCTGAGACTTCGGCGAGAAGAGACCCATAGAACTCTTCCCGCTATCTTGACTAC
AAAG
.
qlt:
:7;5557549D:;98:A@68?@<K8eZ[[bS[VQWbJ;NlllVFggldgdggllglglUU
kkaaakTTPCLPPYHdlkkkallkllllklkllklkkllldllklkkdllllklllklll
llklllllllklllllllllllkllllllllllllllllkggkllgllllllllllklll
lllkklklkklllllldkkgkkllllllllllllllllllllllklllllllllllllll
lkklkllllllllklllkklldkkklllkllllllkllklllllllllllllllllllll
llllgggllllgllllllllllllllllllllllllllllllllllllllgllllbdlll
llellelllllllllbllllllllllllllllllllellll_lllellllllllllllli
iiiieiieeiediiiiiiiiiiiiiieiiiieiiiee_iiieYiiTdidiiZiiiiWeie
i]iiidZieieeiieiYdeLQieeidQid^eeieiieeeUiiiieebdiXeXie^Wiedd
_^^UidVR\X_\We]OOee_]UeXeX`G\HQic\NRN`J^\N\NNW`PNNAYN]QGOTWM
NNAMMMLMMFKQ^MIMOM`CFMOWYMMFL[SMM[HOPM[CMKLYLO[YTEFFMMcc[JIM
MJTcWMMM[ATOMIJ9:HKHJMBMERLF@LRRKPLTLHcVPEHOR6:A57ECMGJOJDSM
c\EGQ7C?cLBG9QAHJCLL@AG:S>BI<H\:;>I?ABF>>G>G>;>O8CR:44>GE<>:
=M;69<EGNF?FBMH@Q<D6D>9E6E6@=9D:F?:FEC?A9H;>@58E7J66466<:;<D
<46<6846C5449B5?:6:3143=<4B6AAE<536569459373H64349<;4=497873
4544
.
frg:108
clr:10,829
}
{RED
iid:1581
eid:1127298239
seq:
TGCGTCTGATGAATCAGCTTGAATTCGTATCCAAAAGGTCATCCTTTTCATGAATAGCAC
TAACCAATTCATTTAATTTTTCCTTTTGAGCTATGTTAAGGTTGGCAAAAAGGGAACGCA
AATTGTCTTCCTCATCACTAGCATTGTCATCACTAGAGGATTCATATTTAGTGGAGGAGT
TAGATTTAACCTTTTTCTTTTTGCCGTCCTTTGCCATGAGGCACTTGTGGCCGACGTTGG
GGAAGAGAAGTCCCTTGGTGACGGCGATGTTGGCGGCGTCCTCGTCGTTGGAGGAGTCGC
TTGAGCTCTCGTCGGAGTCCCACTCGCGACAAACATGGGCATCGCCGCCCTTCTTCTTGT
AATACCTCTTCTTTTCCTTTCGTCTCCCCTTCTTGTCGTCACCTCGGTCACTGTCACTAG
ATATAGGACATTTAGCAATAAAATGACCGGGCTTACCACACTTGTAGCAAACCTTCTTGG
AGCGGGACTTGTAGTCTTTCCCCCTCCTTTGTTTGAGGATTTGGCGGAAGCTCTTGATGA
CAAGCGCCATTTCCTCATTGTCGAGCTTGGAGGCGTCGATTGGTTGTCGACTTGGTGTAG
CCTCCTCCTTCTTCTCCTCCGTTGCCTTGAATGCAACGGGTTGGGCTTCGGATGAGTCGC
CAAGCTCGTTGATTTTCCTCGATCCTTCTATCATGCACTCAAAACTTACAAAATGCCCGA
TAACTTCCTCGGGGGTCATTTTTGTATATCTAGGATTACCACGAATCAATTGAACTTGAG
TGGGATTAAGAAAAATGAGAGATCTTAATAC
.
qlt:
43445A7>M?I<9:966Ci__??LiiH_YNlQ:_lll[W_blllllllVHlllglallll
llllk<A=<;<<<FKFLY\ggllllllllllllllllllllLHPL<>D@<>B=;LJGJJD
]kllllklllkkllllllllklllllllllllllkggglkllk[d[[ddlllllllllll
kkSgkkllllllllllgkllllllkklllkklllllllllllllllllllllglllllll
llklklklllllllllllllllllllllllllllllllllllllllllllkllkglllll
llllllllllllllllklllllllllllllllkllllllllllllllkllllllllllll
llllllllllllggllllllllllllllllllllllllllllllllllllllllglllll
lllllllllllllllllllllllllllllllllllllellllllllllllllllllllll
lllllllllllellllellllllUliiiiiiXiiiiei_ViiiediiiieiiiiiieYii
dQiiiied]iiieiiiUdiibiVideiii_iSdUieiZ[ViiTOidOiVe[eiiYZiViS
iieiieeiUieMee_ee_eidUeeU^SieUUOiQS\e_ieY`iUi\`c`NN\I``B]_PP
`H^O]^\_VY\O;ccYMPM]FNWMOL`[MMMQLM^MMV[VAc^WMNNMNLccMLY<^^IX
GIJLMPJMMSRccc^FLNMcccRO=MMKQSGLLTDAMLCPLSJIIFOCDTLOBIJMLGH?
?PcJHGN?IAS\\\HCJM=I>DFLNC45631
.
frg:109
clr:5,806
}
{RED
iid:1582
eid:1128922900
seq:
GGCGAATCTAGAGATTCGTAGCAGCGCACCGAGCTGCCCAACATCACCGACTCGGATGTC
ATCAGCGCGTTCCTCGCCGGCACCACTTGCCGCGACCTGGTGAGCAAGCTGGGTCGCAAG
ACCCCCACCAGGGCGAGCGAGCTGATGGACATCGCCACCAAGTTCGCCTCTGGCCAGGAG
GCGGTCGAGGCTATCTTCCGAAAGGACAAGCAGCCCCAGGGCCGCCCATCGGAAGAGGCT
CCCGAGGCGTCTGCTCCGCGCGGCGCCAAGAAGAAAGGCAAGAAGAAGTCGCAATCGAAA
CGCGACGCTGCTGACGCGGACCTTGTCGCCGCCGCTGAGTACAAGAACCCTCGGAAGCCC
CCCGGAGGTGCAAACCTCTTCGACAAGATGCTCAAGGAGCCGTGCCCTTACCATCAGGGG
CCCGTCAAGCACACCCTCGAGGAGTGCGTTATGCTTCGGCGTCACTTCCACAGGGCCGGG
CCACCCGCCGAGGGTGGCAGGACCCGCGACGACGACAAGAACGAAGATCACCAAGCAGGA
GAGTTCCCCGAGGTCCGCAACTGCTTCATGATCTATGGAGGGCATGCGGCGAATGCCTCG
GCTCGGCATCGCAAGCAAGAGCGCCGGGAGGTCTGCTCGGTGAAGGTGGCGGCGCCAGTC
TACCTAGACTGGTTCGACAGCCCATCACTTCGACAGGCCGACCACCCCGACATGTGCGAG
CCCGGGAAATACCCGCTCGTCGTCGACCCTGTTGTCGCATGTCAGCTCACCAAGTCTGAT
GATGGCAGCTGCTCAAATCATTTAGCCGAGACCTAGTCTGCGTTGATCTTCTTCGTCAAA
GGCTGACCTCCAGGACTTCCGGAAGCG
.
qlt:
744666:8=C=;9;:KUOOA9RHZVYILTeiU_eicZeQALBKlQElllllllll[Wl[S
=[C98:::@IJLIa[bbgllgglWVllllgllgllllllaglggd[[ddglgllllllgl
lllllllla_llllllllllllllllllllgllglldlagglllllllllllll_Xllll
lllllllllllllllllglgllllllllllgbbglglggllglllllgllgblldlllel
llbellllllllllllllllllldeelTlbllbllllllellleWle]leVed_ll]e^_
lelellll__ii__eeied__eeiiiebeeeeiiii__[iee[ibi[___eeeiieee__
__eiiYPieiedeeiiiiiiidi]Nie[UiiidZbeiieiieeibQYe^[^d_ieU_idi
eeieeeUbieeeb^QQeibdPidIdiTeedddiUed_OVXedZSdei\XKYQOiiY\Y`X
UeNU]]_UWS`Wc_Pc]MWN]UI]\P]PONN\PP`MO`S^MNF``>TOYQXUEQKN?I@]
H^NHPMYUWK[H[GJXEMHMMNYFTNLGLNMLMMMMQNMHYW@EMTGMWLKPML[@@GHF
MGFLELFNRQB?FFMJEN<^9MMD:ERB@;ICLLR@LA>C=JCB847=G?I7887=7FJF
;?EEOMCQGAOM97I8N7HBDN>BLB484;?:DE8:F=E9Q;>?@NA=7;E58;43A4A<
:M7GZAGZJGADK>D99879<65:8J8J<:K9:99AJ;B7I;@4:6;979?44<5A9AG:
C33=>3798C;>95=45;55967:5B73?798866535663744495233;868@;3337
>6851134B563?9>34359>>7=344
.
frg:109
clr:8,780
}
{RED
iid:1583
eid:1127298240
seq:
AGATACGACTGATGCAACTTGTTTCTTTGTTTTGCGGGCGCTCTGATTGAGGCGAGTGCA
ACCTAAAGAAATTTCCTATGCGGTCGCCTTGGGACCGGCTGACGGACGTCTCAACGTACG
GGCCCTCTGGGTCCGAGGAAGATGACGATCCCAGCATCTGTTAGGATTTCTCCGGACTTG
GCAACCCCAGTGCCGTGCGGGACTTCATGACCGCATGTGACTACTGCCTCTCCGACTGTT
CCGACGGAAGCCGCAGCCTTGGCGACGAGAGCTGCGGCCCAAGCCGCGAATGTTTCCACA
TCGAGCTGGGGGATCCCTCCGAAGGCAACCATCTCGGCATGCCGGAGGACGGTGATCTTC
CTAGGCCGGTGCCTCGCGCCGACACCCCACGGGAGCTAGCTGTGGTCCCCGCTCCGGCGG
GGGGTTACGACCCACAACTCGAGCAAGTCCGCGAGGCGCAGGTCAGGCTCAACGAGGGAA
CAGGAGCGCTTGAGCCGATCCGTCGGGACGTCGGACAGGCATGGGCGGGCCAACCCTTGG
CCGGAGAAATACGTCACCTGCCCCAAGGTCTCCAGCACCGCGTCGCCAACGATGTCAGGG
TCAGGCCGCCGCCCGCATCCAGCGGGGGTTGGTCAGAACCTGGCAGCCGCAGCGATGCTC
CTCCGCGCGATGCCGGAGCCATCAACCACCGAGGGTCGGCGAATCTAGGGAGAGCTCAAG
ATCTCCTGGAAAGCGCTGCGGCCCGACGGGCCGAGAGCATTGCCTCCCGAAAGGAAAGAT
ACCCCGTCGGGACCTTCACGCCGCGACTTCTCGATTTTTGGGGG
.
qlt:
41233314776785475778:77?::EH?AEAACB67786:?>:?6>EHH;?=:C8>V>>
H<:4447;84446689=H>??9?HOEIU@Ua<;U[bHJ?95889=997:88878<;9<@=
ddaddTa[dUSTSPBdLHa[LaVOaS;[aT[S;=QGQ[[L<<<=<aV]aa[a]Q]]VVQV
LC<=GKGGGQWdPUNQdQFM=PLLUTCTUNCG=CFLYWYaPTOWKdOOW]WWTLaVWdKP
]TRd[Ldd==JJADI=FNLdkd]WkaFkNdKLW[RF[WWWGC?MTGI=LQWd[WW[aad]
LG=BB=YddNNW[aLYY[[V@[SCkQO[NUH[TTQQLUKYdSSS[kLd[KSk[kkkadkk
d[[LdQ[[[[kkd[dGUW[dTkYBkkkaV[V[a[L[UOLR[WOaVQ[TSTTUXa[LTGNU
XaddY[[VKdTPUBLLHTWULLYYPJUYdaTaLU[aH<OTHY[[UCgSaYFIJCUF[bY[
VICYa8ab[aV[U:[a[Xb[[FGa>a[WSO[bLggaWCB98EUUJUUaR[_U[[bSS[JK
I[[SSCLHGS[[K[[OEIHPADVWEFK[MHMKD>>ORUWKPJV[@>bC;QW[LR@>9<KA
AWQPbH[OVWZW]PPK<HD<58>IFLLLPKeP9RH8OIPV<_ESEKKDARXCGPTQPPVS
QNTTbV[VOJAbSVVPU58L<PR86@CPLSAV<[TITEKH6YAIbUJSG@U]eTTWP<:7
88:UHZZC8PD8d@HDHMAMEEUHGMI;UIG;BV?N7C86558:TQVNMHA<B@8<B]><
9=@C?7F99>7@7<::95D8=:5;?H<FK>7B:I5?N:879767
.
frg:110
clr:23,817
}
{RED
iid:1584
eid:1127298241
seq:
AGGTCTGATGATATCAGCTTGAATTCGTTGTTTTGGCGGGCGCTCTCATTGAGGCGAGTG
CAACCCCACTGGGGTTTCGTATGCGGTCGCCTTGGGACCGGCTGACGGACGTCTCGACCT
ACGGGCCCTCTGGGTCCGAGGAAGATGACGATCCCAGCATCTGTTAGGATTTCTCCGGAC
TTGGCAACCCCAGTGCCGTGCGGGACTTCATGACCGCATGTGACTACTGCCTCTCCGACT
GTTCCGACGGAAGCCGCAGCCTTGGCGACGAGAGCTGCGGCCCAAGCCGCGAATGTTTCC
ACATCGAGCTGGGGGATCCCTCCGAAGGCAACCATCTCGGCATGCCGGAGGACGGTGATC
TTCCTAGGCCGGTGCCTCGCGCCGACACCCCACGGGAGCTAGCTGTGGTCCCCGCTCCGG
CGGGGGGTTACGACCCACAACTCGAGCAAGTCCGCGAGGCGCAGGTCAGGCTCAACGAGG
GAACAGGAGCGCTTGAGCCGATCCGTCGGGACGTCGGACAGGCATGGGCGGGCCAACCCT
TGGCCGGAGAAATACGTCACCTGCCCCAAGGTCTCCAGCACCGCGTCGCCAACGATGTCA
GGGTCAGGCCGCCGCCCGCATCCAGGCGGGGGTTGGTCAGAACCTGGCAGCCGCAGCGAT
GCTCCTCCGCGCGATGCCGGAGCCATCAACCACCGAGGGTCGGCGAATCTAGGGAGAGCT
CAAGATTCTCCTGGAAGGGCGCTGCGGGCCCGACGGGCCGAGAGCACGGCCTCCCGAAAG
GCAAGGATACCCCTCGGAACCTCCACGCCGCGACTTCCCGATATTCTTGCGG
.
qlt:
4444=:;TFI>:;H?8>eiilE=KllW_lllllll[Vllldlgllgl[llllklklllll
kkllkkl\kkkkklllllklllllllklkllkllllkkllllllkklllkkllllkllll
kllllllkkkkllllllklS\Rk[kalladlklll]llklkklkkUNggkll\\kldkgS
kkllkkllllldklldkkkldlkk\Uklgakllklklklldlkkkklkl\\\lklldldl
ldlllklkkllldllkll]llllllkllakl]ll[akSTdklld[kkkkklla]kT\L\l
]d]kgTkdak\gbkkkgTddlggklkklakllk]kkkkkkkLdgN[PgUFkUN\gP\PUd
lkggkdak\[gkSg[TT\dllllkkkdlllkkllg\gdlkkdkllkllllkkkkkkggdk
]klllklklkk[ldkkdklllllklkllllggaPXEYdaQNY[[ldgd[lgggdaggldg
glglgdllllllllllgllllglllllglll_llllllllllbgllllllllllblllQl
llllllllSlOIdllllllllllllll_lll^llliLeieeiiii_iM_Y:Ye_Z__We_
iiiei_i_W_VV_id_iQ@>FVT6<@KNiiiZdZei]e]DMSWieiOed\ii_eeXied_
iQVVV^iV]eeeiOTiVeYVeHXeCYO;PQeXee``U^iS`NOKH^]Q^RNKcY`N_PT_
MDKC_7ANMMLII7KN>S`A>BCNMF[MJcVJMLFcYN[M[ANL>;867<VMM^N?HcDO
M@IEQIMGLGc\QMQDNLK=;B;FCLSON?=A=:GLGN77G68G;575?583
.
frg:111
clr:30,824
}
{RED
iid:1585
eid:1128922901
seq:
GGGATCTAGAGATTCGTCAGCCTTCCTTGTCTTGACTACGATGTCATCGACGTAGGCCTC
GACTGTGCGACCGATGTGTTCGCCGAACACATGGTTCATGCACCGCTGGTACGTCGCGCC
CGCATTCCTCAAACCGAACGGCATGGTGACGTAGCAGTACATGCCGAACGGCGTGATGAA
GGAAGTCGCAAGCTGGTCGGACTCCTTCATCCGGATCTGGTGATACCCTGAGTAGGCATC
GAGGAAGGACAGGGTTTCGCACCCAGCGGTGGAATCCACGATTTGATCGATGCGAGGCAG
AGGGTAGGGAACCTTCGGACATGCTTTGTTGAGACCAGTGTAGTCTACACACATCCGCCA
TTTCCCCCCTTTCTTCCTCACAAGCACAGGGTTGGCAAGCCATTCGGGATGGAATACCTC
TTTGATGAACCCTGCTGCCATTAGCTTGTGGATCTCTTCGCCAATCACTCTGCGCTTCTC
CTCGTCGAATCGGCGCAGAGGCTGCCTGACGGGTCGGGCTCCGGCCCGAATATCCAGCGA
GTGCTCGGCGACATCCCTCGGTATGCCGGGCATGTCCGAGGGACTCCACGCAAAGACGTC
GGCGTTTGCGCAGAGAAAGTCGACGAGCACTGCTTCCTATTTGGGGTCGAGCCCGGAACC
GATCCGGATCTGCTTGGTGGTGTCGCCACTGGGGTCAGAGGGACGGCCTTACCGTCTCGC
TGGCTCGAGTGCGGCATGCGCTTCACGTCTGCACTCTTGGAGAGGTCTCAGTCGGCGATG
AGGCTCGACTCGGCGAGGCTCGGCGTACTCACGCACTCCACGTCGCATCGACCTGTTTTG
TACTGGGCCGACGTGATGACCCCGTTGAC
.
qlt:
875779@CE>>?:SZQZKB]e_diY_[lllX_llLPZWlllllgV>lllllllllallll
g_dg\Tgllllllllllllllllllllkklklllkkkkllllllllllllllllllllll
lllllll\gllllllllllllllllllllllllklllllllllllllllllllllllllk
gggllllllllllllllllllllg\glldllgllllllllllllllggllllllllllll
lllgggllllllllllllllllllllllllllllllllllllllllllllllllllllle
lllllllllllEU_ll^llieiiiiiiiiiiieiee_iiiiiiiiiiieiiieiiiiiee
iiii_QJJJ__ii__eieibebiiieeeiiY^ei^eeei[QddiiiiidOiQ^ebdGV^i
eieidO^Y^biiUieeiUVHidZXeeYVHYFUVdeeW^WXiO=Qe`Teeeeii_XWW_XQ
\]\UN_Hc_NX\]W]\`Y`B\LR`K]N^_MLc]MOM^]MTHTK]F]UMQPUMQKOAMMMO
NAW=MMDNMGTCAYIWNMLHWHLLT=PM^^GLM[FLT=RAZ8:AVKQEMLMLYI9LHGI:
>=?L?cD@;:HF=^6GcO=BLARA9[>KA@GTJH@>RMJ9I9Ccc>8LGVG=G>9<=B>C
HMQAF>8;>E>M:9?RL5:>7;986;N;?AQWS@:@N<D:\K>:ED?<E;N58?<BHS89
:9I@E@8M;F8=7:@A@G64<AB@=DMHH9R5<QA333AC@5;:<=87<9K599:75C?C
E6H@97KC9?57874>8?345749GDH?=K7?9559>F:55<D@55=D:4A42255KE8:
8?76KN5454<4B35867B<BCA:73412
.
frg:111
clr:6,845
}
{RED
iid:1586
eid:1127298242
seq:
AGTATCTGATGAATCAGCTTGAATTCGTTGTCTTCCTCCGAAGCCACAGAGAGGATGTGT
AGCATCATGAATCTTATCTTCTGGCTCTTGCATTTGTCTGAAGGCCTTAGCAAATATGAT
GTCAGCTGCACTGCCTGTATCAACCAAAACATTGTGGACTAGAAATCCTTTGATAACACA
AGAGATAACCATGGCATCGTTGTGTGGGTAATCTTTGAGCTGAAGGTCCTCTTGGGAGAA
GGTAATAGGAATGTGAGACCATCTTGACTTGATGAAGGGTCCTTGCACCCCAACATGCTG
TACCCTTCTCTGTGCTTCCTTCTTTTGTTTCTTGTTAGCTGGCTCTGAGGACGAGCCACC
TGTGATCGGGAGCACCAGCTTTGGGTCCGAAGCAGCTCCAGCTTGGTCGTTGAACGAAGC
CATCAGCTCAAAAAGTGGAAGTGAGTTCACCGGAGGTGGGCGCCAATGTTGGGGACTTGT
TCTCAAATGCTATGAATCAAGAACAAGGCAACATAAAATATTAAATGTTAATGTCCTTCG
TCCAATGAAGCATTATTCCCTTGGGGTTTAATGGACCTCGGACGAAGGTTGATTACAGTA
TAATTACGAAGATTAAATCTTCGTAATTGTATTTTAATGGATTGTATAAAATAACATAAA
GTATAAAGTATTAAAGGTAAACAAATCATAAACGAACCATATTGCATTTATTTAGTATTA
CTGAATACAGTTATACCTTTGCCTTGACAAAGATTGGTTTCCGAATGATACGATTGCGGA
TACAGGAATCCGTGAACAGTAAAGGAATACTA
.
qlt:
47444O=AK:><88878WeelGAPllP_l_lllllllllgaldlk[lllklkllaCkklk
kllllkkkkSUkkkkkllllllllllllllllllllllllllllllllkdllklllkllk
klkkllllllllllllllllllllllllllllllllkkllldllllllklllllllllll
lkllkllllllllllllllllllllllllllllllllllllllllllllllllllkllll
lllllllkllllllllllllllllllllllllllllllllllllllllllllllllllll
lllkllllllllllllllllklllllllllllllllllllllllllllkkllllllllll
llllkllllllllllllllllllllllgglllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllgllllllllllllllllllllllll
lllllllllllllllllllllllllllbllllllllllllllllllZllll_^Xiieiie
eiXRiiii_iii_ii`iiiiiiiiiebieeeYidieiiieid]eiV>YNiidPdedbiee
dd__ie^Li[H[F_bieeiiiid\eU_iiVXQiiW]]eiVRDViTd_SiiUSY]iXeQie
\``UYi\eYSK]URY\UF]^]_K^]_`S_\^_`S^GM`K[NM][MM_cMTMcYMMLTHMT
MO[NPRM[PXGQMYMTJO^WTGKLMMOGLcRMPBDWILZQKP>OIM[MHMSGYNIYLPFR
DLMIPRFGPMVLKPIJDKLGOcOCFH?8=HI8
.
frg:112
clr:5,810
}
{RED
iid:1587
eid:1128922902
seq:
TGCGATCTAGAGATTCGTCATTTCGGCACGGAGCCGTGTTTTTTCCTCATTTTCGAGCAC
CAAGTCTCGCCTGTTGATTATCTGGACCGCTTTGCCAAGCATGAGTCGCCCCGTGTCAAG
GTGACGAGTGAGGTATCCGTATCCCGGAGGCGTAGGAATCCCTCGGCCCGTTCGACCTTG
TTGTCTGGGGCTCCCCTAGCTTAGTTAAAGAGACCCCTCGGCCGCCCTTCGATGAGCCGA
GGTCAGGGGTAGCGATATCAGTATGAACAGAGGCGGAGTTGGCTCGAGAATGGGAACCTG
GTTGGCCGGAGCCTAGCCGTGTCGTCCGTCAGCAGAGCCGACGCCAAAGTCGATCAGCCG
AGGCCTCGGGTCGGGCTGGCGCCCTTGGAAGCCGGCTGGCCGAGGCCCCAGGGGTAATCG
GCCGAGCCGCCTGCTCGGGCCGGATTCCCGGAGGAGTCCCTGGACCGCGTCGCCGTCCGA
GGCTGGGTTGGACTTTGCTGAAGAAGCCGTCGATGCCGAGGGTGCTACGGCTCCCTTCAG
CGTGAAGACTCGAGCCTGCAGAATCAGATCGTCTTGTAGCGTGTGCCTTCTGCGGCCGCC
GAGGCCAGAAAACACACCCTCGCCGTGCTTGCGAAGCTGCGTCTTTTTTCCTCTTGTTTC
GAGCATCTGGACTTCCTGTCGGTAATAGGGATGTTTGTGCGAGCGAGAGTTGCTTCTCGC
GAGGACGAGTGAGTATCCGTATCCCAGAGGCGTGGGATCCTCGGCTCAGTCGGCTGCGCT
ACGCGTACTTTCACCGTCATGAGCCTGTCCCGACTAGTCGAGAAGCTGAGACTGCTCGCA
GGAGAGCTCGACGTGAAACTG
.
qlt:
5759687?A@A9:<TSLLD>TllllKCCWllVKlllblllllllllla<lllllakladl
XHkkkklllkkgkkllllkllllklllllllllllkLllllllllllllllllkllldll
lllllllllklllllllllllllllllllllllllllllllgllllllllllllllllll
lllllllllllllg\klllllllllkllklllllllkllllllllggkllllllllllll
lllllllllllllllllllllllllllllk\kllllllllllllllllllllllllllll
llllllllllgllllbllllllllllgllllllllllllllllllgllllllllllllll
llllbllllllllllllllllllllllllllllllllllelll[llllleeZZ_eiieii
^_iiieiiieiiiiiieiibiii__iiiei__Xiedee__ididdiieiii]eieeeiii
_ieeei^dei[^Si[^eei^ieRieNdiebebXVieibeNiVSi]eUeTiU^SQVYdYBU
deUiMeQ\Q_\UYYe\UiRXUi\U\UiV^N_R`O]^M`K_\N^O_LVNOXQ^M_]BWUIH
M`H[B_PN_^^MMMUMNWMYMLMMM@YLMIUHFNTILMMLLMQTc^ZZMKKCKBDYEcLL
DLHHDMJLNPGKMIEMETCR@PCHFJA@Z:>CVAVGT;JB>V?LKV<BBI=CCT<?FO>9
56654;GN8<M447>LDD;?DLLSI::J=98<>KU9>;KB89AF8MFJBHGB=?66634M
9;7?=>H?CT=847B88I;DG<B779:=D:<7J<J;;>C5E85A35GD>57:?E6G9645
=77345=A:5B9D=8C84573
.
frg:112
clr:7,835
}
{RED
iid:1588
eid:1127298243
seq:
AGGGTCTGATGAATCAGCTTGATTCGTTAATGTGTTTTCAAGTCCATTTCAAACCAAGCC
ATATGTATATTGAAAGGGAATTGGAGTCTTCGGCGAAGACAAAGGCTTCCACTCCGTAAC
TCGTACTTCGCCATCACTCCAAGCAACTCTCTATTCCTTGGGGAGAAATAAGCATCAAGG
AAAAGGACTTCGTCTTTGGTATAATCTTAACTCATTTACTTATGACCAAAGGGGAGGATA
GTTATTCGAGGGCTCTTATGATTCCGTTTTTGGCGATTCATGCCAAAAAGGGGGAGAAAG
GAGCCCAAAGCAAAAGGACCGCACCACCACCAAATTCAAAAACTTAGTGCTTTCCAAAAG
TATTTATCATTTGGTATCCTATTGTGTTCAAAAGGGGGAGAAAGTAGTATTTCAAAAATG
GTATATCAAAACCCTCTTGAACACTAAGAGGTGGATCTCTTTTAAGGGGAGTTTTGTTTA
GTCGAAAGAAAAGCAATTGAAACAGGGGGAGAAAACTACACAATCTTGATACTGCTTTGC
CAAATCTTATTCCTTCCCCAATGACTATTTGAGAAAAGAGTTCTGAAAGGATTTCCATAA
GAGGTTGCGTAAACTAAAAATGAGCTCGACGCATCTAACCAAAAAATGCTATGTACAGAA
GGAACAGTTCCATGCC
.
qlt:
41133599O>K<9<:8?Yie^YEid[dRRY[ddiiiiiX>IieiVTillVOlll[Wlll_
PllBH89>=A<l[TMbllllalllllllllllallllkkkklllk[a[aGCLYgklklll
gkkklllllllllllllllkllllllll\\llllllllllllllllllllllllllllll
llllllllllllllllllkglllllllllllllllllllllllllllllkgllllllkll
llllllllllllllllllllllllkklllllllklllllklllllllllllllllkllkk
kkddllkkkkklkllklllllkkllklllllkkklllkklllllll]klllllllkllkk
klllllkkkkkklkkkllllllllklkklkkklkllllllllllkldkllkkkY]kaddl
kdkkkkk][kdklkklkkllkkdkklkkldkklkllldlkkkkd[Nk[Tk[dkkkkdkk[
=AK7:I7FC=>CC<C<BIBB??==?G<;;N:?=?@<;9<:7<E<C?FDF=;::J<?LJOF
==TC?VH=MB;C9>?F<;;99=?O:8B=I<N<::C;;<@8:9;DD<:<7:I8KFDB:>::
9E888CBH;;>9G:<@<==BAHAC7@:<A89@A:9F99>@<8R<M=AK>9?>FAB887?E
8<>88:8@::66BK8<
.
frg:113
clr:8,673
}
{RED
iid:1589
eid:1128922903
seq:
AAACGAATCTAGAGATTCGTGTTGAGGTCGTTGTAGATCCGAGGCTTGAGCCCTTGTAGA
ATCATGCCGTTGGCACGCTCTACTTGCCCATTCGACATGGGATGAGCCACGGCGGCCCAG
TCCACCCTGATATGGTGATCTTCGCAAAAATCCAAGAATTTTTTGCCGGTGAACTGGGTA
CCGTTGTCGGTGATGATGGAGTTCGGGACCCCGAAGCGATGGATGATGTTGGTGAAGAAC
GCCACCGCCTGCTCGGACCTGATGCTGCTCAGAGGTCGGACCTCGATCCACTTGGAGAAT
TTGTCGATGGCGACCAGCAGGTGTGTGTAGCCCCCGGGCGCCTTCTGCAAGGGACCGACG
AGGTCTAGACCCCATACAGCGAAGGGCCAGGTGATGGGTATTGTCTGCAGAGCCTGAGCG
GGCAGGTGGGTCTGCTTCGCATAGAATTGGCACCCTTCGCAGGTGCGGACAATTCTAGTG
GCGTCAGCCACCGCCGTTGGCCAGTAGAAGCCTTGTCGGAAAGCATTCCCGACAAGGGCT
CGGGGTGCTGTGTGATGGCCGCAAGCCCCCGAGTGTATTTCTTGCAGCAGTTCCCGACCT
TCGGCGATGGAGATGCATCGCTGGAGGATGCCCGAGGGGCTGCGATGGTAGAGCTCCTCT
TCATCGCCCAGCAAGACGAACGACTTGGCGCGTCGCGCTACCCGCCGAGCCTCGACTTGG
TCGGGGGTAGCTCTCTTCGGCGAAGATACTGCATGTACGGGTCTGCCAATCTCGATCTGG
CGTGACCCGCTCTGCTCTTCTTCGACGTCCAGTGCCTCGCCCTCGGGGGCC
.
qlt:
4455:8:9::E>@;<;RKAGVRQQSMT>QA9COBO:OPDJEPLdRb[bOKOS[[[_HF<U
CCH9EO;AFUaaaPPddYgk[V[[akO[SFT[S<OH@Yd]d[]kaT[aQ[]aT[]LTVL=
Vd[V]kkkka[[ak]Wdkkl[a[BNLWddW]aVNKKkYdk[kadkWd]kTkdY]dkdWad
dddTddWaRa[dU\adddad]kkdTPVaWSLLGV[GaW[UaYYUdkak]ad][dkaLkWV
[]TG[]STdaldkkablkkkkkdkadk[ddTBkTkTdY[kda[aKUa[aOTadldaTda[
a[aQaIbdddLMaPUTCROAdUdTddg[PFPaUaUV[UUU[a[a[RaUCC[bU_[b[_aU
lUb[gabK_ggbdVb[[EOSSS[CbOESGBTSdWWbVQVXdeeelll]OOlWbbblXBOQ
KD]ZR^Wlb[]dbldb__F_]bbLb[[eeRLNZ]Z__bL]VG_VebTP_VLZbe]_PZ]e
NWee_RZV]VTbZ]_UJVWWGRQHZW<_bL_eb^^RUKReTZXXMT_UPQLdVGWV_QNU
bTIRWPeU_eZeUdeKXSKTOSL`_dTUQXTdUPeQLe_MXPS_KA:FK<DQMNUHeFUP
WK:CCI[N\GTIDBOXI\PMM]PEM9R`J_LTI>Y;OJGM\MY>^MNMBM?WBMYLIRMM
KF<MQHAND>6MKBHMC>SRLAMAHGB78?MMGGCDFLRGTNVHDG;P6PGKK>KEJDDC
7<?TTYP>D8OLGLV968=LJ7VD6TC>LCPAMGM<>NOPH5E896@8KL?<?FQJBEOB
:75;4:?9<@IC>N<:?>BC5>B9QE6548D=5=;=>=7?J:893BB<;54
.
frg:113
clr:8,828
}
{RED
iid:1590
eid:1127298244
seq:
TGGATCTGATGATATCAGCTTGATTCGTTGACTCGAGCGGTTTCTCGAGTGCCTCTCCGT
AAGGACCTGTTCAATGGATGACCGCCCGGGAAAACAGTGCAACCATGAGGGTGGAATGGG
GTGCCCTTAGCTGAATAATTAGAGGAACCGGGGTGTAGTTCGCTTAGCCGTCGTGCCGTC
AATGGGGCTCGGTGTATGCGGCTCGCTCTGCCAAGGTTGATTTGTCCCTTGGGGAGGAGT
GCGGTACATTTAGGAAACCTAACGGGTGGCTACAGCCCCGGGGAATCTTTGTAAAGGCTT
CATAGTGAATCCCTGGCCATTCACCTCGGGAGTGAATAAGGGTCTTGCAAGCCCGGGCCA
GAGAGGGAATCACGGCTTGTGGGTAAAGTGCACAACCTCTGCAGAGTGTTATGAAACTGA
TATATCAGTCGTGCTCGCGGTTATGAGCGGCCAAGGGAGCTCCAGAGATTAGTGATACTT
GATCAGAGATACTTTGGTACAGGTGGCGATGAGATTGATGGTTCTGATTACGATTATGGT
ATTGGTAAGTGGTATTCTTTCCGTTTGGAAAGGATACATTGGGCTAATAACTTGGGTTAA
TGTTAAAACCTGGCTTTCTACTAGTAAGTAATAACCTGACCAACTAAAAGCAACTGCTTG
ACTTATCCCCACATAAAGCTAGTCCACTACAGCCAAACAGGATACTTGATGAGTATGTTG
ATGTGTACTCACCCTTGCTCTACACACCAAACCCCCCCCCCCAGGTTGTCAGCATTGCAA
CCACTGCTCAGCGAAGATG
.
qlt:
44545D69647988;87?_lllbOll_lllJ?lllallllllllllllllllllllllll
llllka]NULNTLN[kkkkllllllllllkkg\glkllllllllllllllllllggklll
llllllkklllllllllllllklklllllllllllllllkklllklllllllklllllll
klllllkklllllllllllllllllllllllllllllllllllllllllllllllllkll
llllllllllllllllllllllllllllllkllkllllklllgSklllllllllllllll
lllllllllllllllllllllkllllllllllllllllllllllllllllllllllllll
llklllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllllllgglllllllllllllllllll
lllllellllllblllllllllllllllllllllllllZlllllllllllllllii_i^e
iiii_eiiieicee_ii__iiiieiii_eii_i[QiiediiiiiieieiiiiiiiYddde
_iVdeiiddiiiddiYQV_beddZZei\XeeXi_dieiRQXTi__SRRiTXLW]ei_ee`
YO_]\P\Q^\N]M_Pc^Y__MNQ__MTWQ_K`cVEc[OMO^TMYNM[YOMM^GMJH[M^M
RFWMXLLM[YGYcNLMNLMYLLKCNHMMJcXHcccTZTccTLKMNIISOVOLMIMGFFCC
NMAOELLNN4569NQ8797
.
frg:114
clr:17,795
}
{RED
iid:1591
eid:1128922904
seq:
AGATCTAGAGATTCGTCCTCCTCACGGGGAGTAGGTTTGCAAGAACCGAACCTCGGCAAA
AGGCTCTGTGTCTCACTTACTTATTCGCTTGGGATTCGTCTTTGCGCCCTCTCTTGCGGA
CTCGTTCCTTATTACTAACGCTAACCCCGGCTTGTAGTTGTGTTTATATTTGTGAATTTC
AGTTTCGCCCTATTCACCCCCCCTCTAGGCGACTATCAGAAAGGAGTCAAGCTCAATCCT
GAGAAGTGTGTCTTCGGGGTGCCCCGAGGCATGCTCCTAGGGTTCATCGTCTCCGAGCGA
GGCATCGAAGCCAACCCGGAGAAGATCGCGGCCATCACCAGCATGGGACCCATCAAGGAC
TTAAAAGGTGTACAGAGGGTCATGGGGTGCCTCGCGGCCCTGAGCCGCTTCATCTCGCGC
CTCGGCGAAAGAGGTCTGCCTCTGTACCGCCTCTTAAGGAAGGCCGAGTGTTTCGCTTGG
ACCCCTGAGGCTGAGGAAGCCCTCGGCAACCTGAAGGCGCTCCTTACAAAGGCGCCTGTC
TTGGTGCCCCCGGCGGATGGAGAAGCCCTCTTGGGTCTACGTCGCCGCGACCACTCAGGT
GGTTAGCGCCGCGATCGTGGTCGAGAGGCACGAGGAATCATGCATTGGCTCGTTCGAGGC
CGTCCTACTTCGTCAGCGAGTGCTGTCGAAACAGATCCGCTTCCCCAAGTTCAAAGCTGC
TGATGTAGATCGACAGGCA
.
qlt:
4567<DDA=;;>Qb8=77;<_WPBHiillRJLeeQ@ll[QMO_ledllllggll>::485
6588;?CbPllllaUlllllllllllllllgg<@<:98:899;ICJLUadllllllllll
llllg\lllllllllllllll_lllllllllllllllllllllllllllgOgglllllll
WllllllelllllllSlUOOUbllllllllllllllllellbllllll[llllllellll
lldllllllllllllllllli^i__ic]ieeiieiieei[ieeie_iiiiiieiei]iii
]ii]eiiii]i_@ie__ii^HiiSYVi_dii_iZiiUYYVe_eeii_YSY^Vieb_ii[[
^iSY[ee[HiNdbbidQiiQeXeiYYdZiP^eVd_^bPiebi[G^ieUieVKeeeiedeR
ReWQVUPeiPXd>YIi]dTiRdQeUQU[XU\U^WSSXMYQ`K\9\S`BL\:^ONMOWO?9
6<\\ULYQ6]F]RW9TNYO_][MML[KM_MTN]M_I]DMPWNEIMM>CUQL[>FESJYFM
M;?J;UI^WTFEW>I:M9CIF=PO<9TMM?:DAT5<LKRLEEL<I?ELMIGH>DQH<;;9
MC=>R?FJTC=M?ROOB<MG7D?V:V=JAE56L:854446<HOCMG?>B6;PBF;7L8J8
AC>;954;EFFD>A55;3635A=M>5313<<745=5@675;54559>>;:B5?N;;;>F>
DG658337G5>5;6C<G87
.
frg:114
clr:4,721
}
{RED
iid:1592
eid:1127298245
seq:
TGCTTCTGATGAATCAGCTTGATTCGTTGCAAGTAGAGCGTGCCAACGGCATGATTCTAC
AAGGGTTCAAGCCTCGGATCTACAACGACCTCAACAAGTTCGGCAAGCGGTGGATGAAGG
AACTCCCCTCGGTGGTCTGGAGCCTAAGGACGACGCCGAGTCGTGCCACGGGTTTCACGC
CGTTTTTCCTGTTCTACGGGGCTGAAGCTATCTTGCCCACTGACCTGGAATACGGCTCCC
CGAGGACGAGGGCCTACACCGATCAAAGCAACCAAGCTAGCCGAGAAGAATCGCTGGACC
AGCTGGAGGAGGCTCGGGACAGGGCCTTACTACACTCGGCGCGGTACCAGCAGTCCCTAC
GATGCTACCACGCCCGAGGGGTCCAATCCCGAGACCTCCAGGTGGGCGATCTGGTGCTTC
GGCTGCGGCAAGACGCCCGAGGGAGGCACAAGCTCACGCCCCCCTGGGAAGGGCCATTCA
AGGTCGACAAAGTTCTGAAGCCCGGAACGAACAAGGTGGCCAACAAACAAGGGGAGATCT
GCGGGAACGCTTGGAACGACGAGAAGCTAAATCGTGCAAAGCTTGGGGGGGATAGAGTTG
ACAAGACCTTTCGACCATGGCCAGGTAATGAAACGAGACCAGGAGCGGCATAGATGACGA
AGCACTGGAAGACCTCATCCGTTCTTTTACAAATGACTGGACACGGACACGGGTGTTGAG
TGAAAGAGTATTTTGGGTTGTAGTAAGTTA
.
qlt:
44544:5=XBH97><67KilllUll[_ll_S[llllllallll_kllllklllkklllll
lkggUTJKHFKK\\gklklllllllllllllkllklllllkklllklllkklkk\gkkll
llllgklklllllllllkllllllllllgklllllllllllllllllllllllkgkklll
lllllllkkklllllllllllllllllllllklllllllllllllllkkllllkllllll
llllkklklklklllllkllllllkkkkklllllgglllllldlkkkYllllllllllkl
lkkllllkkgkkkkllllkllllllllllllllklllklllllllkkldakgkkllgkkk
WlklklkkkkkkkllklklkWMSOBOkkdd\kRkdddkaCLNGdWGKGUKGdkd[kadad
FUO[kKadWRYJk[G\a\\kWdWMHK:67HB=KT]WENMUWLGGMU<?K::CUGM4=UI;
<<;9=BE<9??DGGGG=?99:GGH>BB;MF:<BK=C:@GI;9B9<=<;:;<=<<<;<;;B
@;:=N:?<H<==D8<:89@9;9?=C54<8;:;B<9B::<9?IG=9:=C<9:<8<7<UPUL
E:E@@R;??==<:;;:===D<<C;>8:H<B=<C9F:><999FLJ>:>;989H=::MJ6EH
<B8E79D8Q;PH68<<@B:9:@>B>G>>:::?77:U8?PO79C79:;7E;=@>>GO98:@
8;BHK6J:79=8:=K876785767=7::O6
.
frg:115
clr:7,734
}
{RED
iid:1593
eid:1128922905
seq:
GCGATCTAGAGATTCGTCCTTTCGTCGCACTTTTTTGCAAGGGGACCAGCCTTTCTCGGT
TGCATTTCGTTCCGGTGGGTGCGCGCGAGCGCACCCGCCGGGTATAGCCCCCGAGGCCTC
GGAGGAGTGGTTACACTCCTTCGAGGTCTTAATACCTTGCGTAATGCTTCGGCTGGTCTG
GTCGTTCCCTCATGCGAACTGGCCGTAGCCCGGGTGCACGGTCGGGGCCCAAGCTCTCGG
GCTGGTATGTTGACGCTGTCAACGGTTCGGCCGGAGCCGGTTTTTGCGAGAGCAGCCCCC
GAGCCTCTGCACAGGGCGAGAGGACGATCAGGGACAGACTCGGCTTTTTACATACGCCCC
TACGTCGCCTTTCCGCAAGGAGGAGGGGGGGAGTGCGCCATGTTACCCTCGATGGGCACC
GAACATGGTGTCTCCAGTGAGCTGCAAGCGGGTAATCCGAGTGGACGTCCGTGCCCCGTT
CGTTGGGGGTCGGCTAGGGGCCCAGAGGCACGCCCAAAAGTACCTGCGGGTGATTTGCCG
GACCCGGTCCCCTGGCGACAGGGTCCGAGGGCTCGATGCCTCCCTCCGATGGGATTCCGT
TACAAGATCGTTCCCGCTGGTCTCGGAAATGTCCTAGGGTACCTCGGGAGCGCAGCCCGA
GCCTCGGTTATGTATCGAACGTACCCCTGGTCATCCCTCGCTCGTGTCTGAGCGACTGTG
ACCCTTCGGGGCAGCTTCGACCCTGATCAGTAATGGGCGCGGAGCCGAGTAGCTGAGCGC
ATGACCTCGGGGCTGCTCGACCCTGACAGTATGTGCCGCCCCGATCTGAGGGACTGTGAC
CTCGAGGCAGTCTCGATCCTGATCAAT
.
qlt:
6766:7;>:;:::OVHUYSWidiH[iSHKQllllllQEDJllll[LSHlllllgllllll
llgUllllglllgllllgggllllllllllllll\\llllllkllkllllllllllllll
llllkllkllllllllllklllllllllllllllllllllllllllllllllllllllll
llllllllkllllllklllllllglllllgglllllllllllllllllllllllllllll
llllgglllllllllllllllllllllllllllllglgllggglllllllllllglllll
lllllllllllllllllllllllllllllllll[llllllllllllbUllllllllllll
llllllllllllllllllli^_ieRiii__iiiiieieieiiiieei_iieeeiiieiei
eiieeiiiiiiii_YTieiieiiie]eeiiieeibeiiei]eiieYeeeiedi^QQ[eee
bbbdiYiieUde\Uee_iiVVV^TXiHiW\ddei_U^EVUXXV^\iOSi\SeM@ii\TiU
YY8WU\\MN]WR[YKPNRNKP^[MN]HcEc]M`MLMMTIFUM_MWNWH`HYcMKDMDWMM
MMLDJ>NMRMINLYCQLSM^MRQLGGP^GL[DHML@;J?>MIDILH\?B>MCGLGRT;DY
CD@JMHBI6BFMB>CDJMJLORILLJA?GJ5>GQO\?CD@9JAL6ECHBG=7:=RGJI;=
;4C9=G>CB@6466:4<A7A6G=>MMMGMFHG?BGT?<55=8H5<;4C5?F7G?C<B5:7
9=EE74444FSA47:4444B8>78@CD9C<76=3535>33234C765>@@8358:<<9A=
7F;B<8=96>:5K:6F4AA:@666332
.
frg:115
clr:6,861
}
{RED
iid:1594
eid:1127298246
seq:
GAGGTGGGTTTTGGTGATTTATCCTTGATTTTCGTTCATTTGATGTCTATAGGATTTGGA
CATTGATTGTTCTAAGCTTCACCTTGCTTGTTTGAAGGTTGAATTCTAACTACTTTTTGA
CCTTCTTTCCGTAATGCAGCAGCTTCTTCTGAGCTCATAAAGCACTTTACTGAGGTCCGC
TATCTCTTGATTTGGATGATGGGGAAGATGAGCCTAAGACGACATCCTTACCTCCATGTG
CCACATGTTGTTATCTTCGGATGCCTGATGGGCTCGATGCGCGGGAGGAATTTTCAGCCG
AATGACTGCCAAGGTTCTCCAATCTCAAATATTGAGAAACGTGCTAACTTATGTGGATGA
CATCCATGTCAAAAACACGAACCAGGAGAATCATATTGCTGATCTGCCCGAGACCTTCAC
CGGTTTCAGGCGACGGGCTTGAAGTTAAATCCAAAAAAAACCGTCTTCGAAGAGAAAAAA
TGAAAATTTCGTGCATGCTTGGTTTGGGCTCTTGACATCGAAGCTCCCCAGCCTAACATT
GAAACCATAGTTTGGATGAATCCACAAACTTACGAAGGAATGGTCGGAAATAGTGACGAG
GAGGATGGCCCTCTCGCACGCCATTGATACCGGGATCAGCAGACACTACTAACCAGCCTG
TCAAAGCGCTGAAGTCCTCTGAGCTATTCCATGGTGTAGCTATTCGTAGGAGGCGCTTGA
AGATCTCAAATCATATTATGTAGGTCTCTCCTCGTTGACTTCGCCAATGCAGGTAGCTCC
TCTGTTTGTAGATGTCCCAGCTTCGTTCCCGGCCGTCACGCTA
.
qlt:
:54446777744746:7654755=@8:88878899@>98>86:8@CC8D=9:976898?E
6;?::9;<<;8=54489<8;<<==<G@==B<<B=;?9?<;==>>;=9<;=<<:6<<B<<9
::==<<=<?:<A:B?<=<:;:<=BBQ=H=;8=>=>I=<>>?@:6<CC9??DM;=B<D;C=
=<=::C=BB;;;<=:<;<:;<;;=<HBG<;<9:D>=NBK=?K9<B:;;B<=CCKB<;BCK
99B@C?<J>=;=>=BB><<:=<=<>HOH;==;EB?;<8GB>?L<BBCAJ@;B=CC;;==<
K=;B==;B;8?>PFK<HC=B::=B??>;?<68;<9;=>=C=DTKG=<BB<CGO=@=FI=M
J;=K:=GO=W=<CG;>:>HC:8K?;B?8?HHG;D=<<H:?>E<:8?8>=TW>LKKGVG8M
O<WCC=C;<T<@><;G8@=9:<::DCCCCCGGH:P===<9<B>;I??K<?C<BCVK:B;=
<C@LV@H@C<;?B;;BK<=KC:<;<<?;B=C<<?::C:;8;:;?;;A;G;;<>=E@9C=G
HB>AJ979<?:?;:9>=B<<=RH?B?;>>I=D=CL?>ME>9A79><@8:?9<<;::=;CB
@::CD<;A><:889E;OD::8=C98=9><<@;?@@::<:>8>>:>:97:@=;B>9>=:8=
88<A>@<A8:8<:788=8::9<89:9?;6<8:86<78L;9A=>:CA<=@9G>G7889BD<
EDKE?I:::?:<9>BIAGCDA@<<;A@8<;5=6@QJK@G;6A:8>88:<787;:8;58:9
=7:D8=9885878=FD=@:IHBLDA5=;8=:6<9:<:H@G657
.
frg:116
clr:35,819
}
{RED
iid:1595
eid:1127298247
seq:
ACGATTCTGATGAATCATGCTTGATTCGTACCAAACCCCCCCCCCAGGTTGTCAGCATTG
CAACCACTGATCAGGCAAATATGAAGCTGAGATGGGACACTTCGAGGCCTCCCATAAATG
ACTCGCCCTCTGGAACGAGTAGATGACTATCCGACATCTGTTTGGAATTCTCCGGACTTT
TCTCCCCAGTGTATGCAGGACTTCATGACCGCATGTAACAACCGCCTCTCCGACTGTCCG
ATTGATTTTCCACCCTTGGACACTAGAGCTGGGCCCAAGCCTTCAATGTTTCCACATCGA
GCTGGAGGATCCCTCGCTATGCAATCGTCTCGGCATGCCTGAGGTATGTGATCTTCCTAA
GCCGAGCCTCTCTCCGACACCCCACGGGATCTAGCTGTGGTCCCCTCTCCGATGAGAGGG
TACGACCCGGTCTCGAACTAAACCGCAGACCCTACCGCTCCCTACGCCAACGAACAAGCT
GCTATCATGATCCGTATGGACTTCTGACAGGCCTGGGCGGGCCACCTTTGGTCGCAAGAA
TACATACTTATCCCGTGTCTCGAGATCCGATTCGCTAACATTGTCCGGGTCTCGGCTGCG
CCCGCTTCCTGCGAGGTTTTGTAAAATCAGGGTGGATCAGCTATTTTTCCCCGCTCTAGG
TCTATCTGCTGATTACAGGGTCATTAATCTAGGGATATCTCATGACATCTTAATTAGATA
CCGTTTTACCGTCCGTTAAAATATCACCCGATGGAAAGAATCTCCTAGAGAATTCCCCCA
TACTTGTGATTTTTTCTT
.
qlt:
4433747EBLQO95;:86HTebKEJQdHZSI?<=EZ]e___]ZVWISP_dbAIHEOR[bb
D@DRV@==95575997667=LDFC<=kkkV:58<<<T8FF9==:=DP:4466;;76968;
8;A:H=DBBHB=<768<H4;8<?:9B857=8<5=:<<BB==<6::L:B<J<<9;<H;<<:
F<=<=<=<;<;<88==<=::?=CG=<HD>=8=:;=<;=<=<?:IBBLGGCG;P@<;8D<=
J<;TD<;<<88G=<KBLG=:8@<8A:?;<8<;:9:<=:8=;;=58;:=>:6<==<<;B<<
;==BJ<:GAL<IB=D;<;848<;8:<89;;<;:<<B<<B9>K;898;B<KEP?>KGC;@7
PKB:B6BKBA>?:?E<K?9ECD?;9<BLD><989CGB=BBJ<<=:68=KC8B?B::;<G:
B;=;=B<F;<<ICBB==B<>9;HC>C=<:88<=<==8@;9<959<<=;??;<E8879<7;
7;:8:88B:9?B<;=<:CCGC;?GLWO;H;8<8<D<D?:<;><<@@FH<@7;?;:A9;DB
K?<<:8;:B<=<<8=4=C9<LJF?KD;=><?EK:9=?559:?TG=98@85;99E:A8DR=
??A;;<9;<<SB<9<;;;<999999=:<>GO769BC@>99;;F@H?>;998;PA:;>><>
7D;>?88:78:;9?8B8CC6C@=7=B=QLE=8=5>=E;>NIOML@67KG:C87>88758:
9BA6;><87889DD>>@=9>>>8AG8H<:@@FA>C<:BC:<<9:=B;<==G=;66>>:A7
;:8B?:?8>SbGA><9C9
.
frg:117
clr:7,796
}
{RED
iid:1596
eid:1128922906
seq:
GCGATTCTAGAGATTCGTCATCGAGCAGACGCCTCCAGCCAACGGTCAAGTTTGGTGGTT
GGCCTATAAGTACTGCAAACAACCCACTGGGTGTGTTTTCTAGTGGGTGGTTCTCCGAAG
GCAAAATATCAAGACTATCGGTTTGTGCCTTTTCTAGTATGGCCCGCCGGGGAAACGAAT
CACACTCGCCAGCGAAGGCTACCTAGGCTAAGTCTGACCCCTCCCCTTTGGAGACGTTTG
GAGGCGACGGCCCTGCACCCGACTGGAGAAATTAGTGTGGCTGATGTTGAAACCGGCGTC
GGTAGCGCGCGTGGAGGCCTGTCACCCCGACTAAGTTCTCGGCTCATCGATTTTGCTATC
AGTTAACGCGTGACAGGCCAGGCTGGGCGCCCTAACCGGTAGGACCTATTATCGAGACTA
TTCCTGCTCGATTCCCCTTATTGTTGCACGGGCGGATCGCGCGACACCACCCGCTCCGCG
GATAAGACCTAAAACCAACTGAGGTGAAGTCCCCCACACCAAGGACGATAAGACAGTTTC
ATCAATGAACACGGGGGGACGGGAATGCTTAGGTACGCCCTGTGCCGAGGGGGAGATATG
CTAGCGAAAAATGGACGAGGAAACTGCGGGATAATCGTAGTCCTGTCAGAACCGGCAACC
GCTTAGCCCCCGCTCTGGTATCGCCGAAGTAGTAGAGGGCCCCGCCGGACTCTCGAAAAC
AAAACTAAAGAAATCCGGATGGCCAAACGTAGGA
.
qlt:
65566@>9<:=:=9=LH[J<UibeZKMEQ<WllllA9llTE[lllgVI_lllllaalaGl
l:9<59=844<7:BG<<;9C;BC:6:;:<<58=BH<:F;84;<;;:8:<@?KG;<=<9:=
G:<78::F7>=I==;:;LD;;;CGBC=9<=C=E99=;==9;99<:<<>:<<<<=;>C=WB
BH>E<BC<BB:9??<?;<<<:<:;;:;<;9:A8;=B>>=<;9==<B8:<<::;::<=;=7
::6=5D<::=<9<<=?88::9:<;<<G:<7:<=:;==;;9<<<@;9;=<:=<:7:;:98<
::5<;9;;:<<:?9<<;<<AC:=86==9;F?<78<::R@G=9B@:=DC;:;:=GL=;88H
8;;C?;9B<<==::<C:@<@=K<=B;GF<8==>==F>;88:;B<?;?E:;?:;==<;<:B
88=;>@AA@=:;:9:;;@<;9:=<==>:=B>:=<C;CFDEH;?=<;;;:;;:>;CS>H;=
>>68:;?=CBI8EGP=:EAHGF9;=98<<98F<?>><::E:?9:;<:@>A9:8;6I9=@8
>;;:?8A;:C:::@?:88;:>AC8:8:A>;>=:98888:@8>;=@>:B<?8::D877677
D=L86K?CAAN998C98C;8C:9@:698<<>I<89:5::<GDIFA:J<A=76;9>=OF>9
76768<8:67<86=8577AAT=>7::9:5?57=?66HGG98@>996<::98=;68E=K:7
9?K@9B8LA<6<<F?>:D>998=59?=8;55A<9
.
frg:117
clr:5,746
}
{RED
iid:1597
eid:1127298248
seq:
TGTTTTCTGATGATATCAGCTTGAATTCGTACGAATTCTCTAGATATCGCTCAATACTGA
CCATTTAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTT
TGACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCG
GGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATATT
CAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATAT
GGGTATAAATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTAT
GGGAAGCCCGATGCGCCAGAGTTGTTTCAGAAACATGGCAAAGGTAGCGTTGCCAATGAT
GTTACAGATGAGATGGTAAGGGAATGCTGGGAAAGAGATTTTATGCGTCGTCGAACCGTC
CACATTGTAACCAATCACGAGGAAGGGCATGTAAAATATTAAATGTTAATGTCATAAAAG
CAATGAAGCAATATTATAAAAATATTGAGTGGACCTAGGAAAAAGGGTGATTAGGGTATA
AGTTACGAACATGAAATCTTCGTAATTGAATTTTGATGGATTGTATAAATAACATAGAGT
ATAAGTATTAAAGGTAAACAAATCATAAAGGAAGCATATTGCGTTTATTGAGTATTACTG
ATTACGACTATACCTTTGCCTGGAGAAAGATTGAGATCCGAATGATACGATTGCGGATAC
AGGATCCGTGAACAGTAAAGGAATACTAT
.
qlt:
44444464=TLD<:8A@67SieiH:HllPl__ll[_llllllladlallllkdlllllll
lkalkga]L\KFNLT]lkllkklkTlklkkllllllllllllk\klllllklkkklllll
lkgllkkkllkkklllkkkdlllllllkkllllldklkkkllllllllk[llkdllllk\
glllllllllllklklkdkgTkkllllll[aklkld]\Jkdkklkkk[kkllalldkkdd
kHK]k\YkkkkWdg[kkkklkkdkklkkdkkkkd]kllkVakTkkakkkkkkkklk]a[d
kdkkk[[]T\kdkkbkWd[k[[[[kK\HaKOLLTaWRTG]N=[d?GL\HTKUCLLT]KK\
[UWdTGW[WKWHW]FVVPGaBLWWLCDF@=G:>B:GK:;<<@=V=LGT[A=<=@9;8H<E
LGCLC;;T<=T:HBFD8;B<=<D;;?JBCC=;BB=CL=<@?<=;<;?B=<=<;H=<<D=:
=<>@=GB<===CC<;AB?FL<>=<<>:;:;<EF?>>;;9:999<H89:C<K9<=;;:;;;
=>>>MHIB>=;?G?;E9<>8:898888?:AP;<999<@8@;CD:@A55==:9>8:88>;8
>A9:B==D99@7<?:>>9EC>>ILBKCD6:?:88<:9MHC<7HHHHDG<CE>8A<L6DG9
L?<@>:LC>?8<8@586@68=<=@@<CA:G>YA=<NBN<9R8F<988658??6@9=P:SU
d5<Q=>B5CX?:758H=X=>ABE855586O8;N8>:<:;HONFMD9`:>N6EO=B8M9:<
89=Q:H:;5<?MAF><>5;7@HH:I5785
.
frg:118
clr:493,805
}
{RED
iid:1598
eid:1127298249
seq:
GGGCGTCTTGATGAATCAGCTTGATTCGTAGGACTATGATGAGGATGAGGTGGCCCAAAT
CGAGCACTTCAACTCTCAAGCAACAACAATACTCCTCGCCTCTCTAAGTAAAGAGGAGTA
TAACAAAGTACAAGGGTTGAAGAGCGCCAAGGAGATTTGGGATGTACTCAAAACCGCGCA
CGAGGGAGACGAGCTCACCAAGATCACCAAGCGGGAGACGATCGAGGGGGAGCTCGGCCG
GTTCCGGCTTCATAGGGAGAGGACCCTCTACACATGCATAACGGGCTCGGAACTTTGGTG
AAATAGGTGTGCTCCCGAGGGAGCCAGACATGCGGGGACCACAATCTACCAAATGTAAGT
TTAACATCACTCGTTTTAGTGATGGCATGATAGTGCAATGGAATCGTGGGCAACGGACTC
ATGATTGAGATCGTCCCGCTAAAGTGGCTACCAGAATTTATGCCATTTCTGACGTATTGG
CGATTTTGCGGTGCTCTGGTCATTCCTGATGACTTGGGCTGGTCACCCTTTAATACCAAT
CCCCGAAAGTTCAAATTCCCGGAGTTGTGCAAGTTCGCTACGCTGTGACCCTTCAACGGG
CCGGTTGTCTAGTTCCATTTATCAGAGTTATTTTGAAGTGACCGATGAGCTGGCAG
.
qlt:
543444844697@::==68GW\QQ;idQXiOi?8PVdYBU_^U_@>i_OY_iZ_l_H]ee
_MbS9<:68768?UFF>A:bV_ggddadggllllllllllllkkk[=<<=;::B=JPJGF
]OYdkkgkkkkkkkllllllkkldkkdkKY[kkNkkkkkd]kkkaddkkVT]dkkddaa\
\U]CYGT?KJB\TMbYNTWTY]kk\W[[KKYKUUkkCWLD[JMHWCkT\KTKIMPKG;GF
?8PKWKO=KBB66<=BC<<H<MP?<L:F=EB:==TO====;;<=8=?BB=MBBLGJG<BS
?<CC;?=La=>B=<:G<<=<BLMBH?B=A?=[?:<::B@=NG=J8DBB<B6BBMaK:;?=
:<G?=G:<==;D8::;;H:8=;:<:8<:A8:CBBMC<H<=GD@<B>9FH<B9;:B98<=:
88:<9BK<=<:;B;K=@<<9;<;:;K=<=?9:<GJ<;GDB=<CV=9<88<=A<><=:<B9
=>98:>8?::B==:;;;<6::;9;949C;49<<:;<@78:A=7=CBBB=;;8:;8::46:
A=?9;:<99<C>:?B=<<=:?:>=888;C9<;88<;<B8G<:=<=8:G<<5<<77B99C=
@:;8988@889::>:<8;9=C;7<?::67<:<:;:<<<98<B559=;;9=:C<<J>
.
frg:119
clr:12,425
}
{RED
iid:1599
eid:1128922907
seq:
TGCGATCTAGAGATTCGTCCATACAAACAAGTCATTTTCAAGAGTTTTAGTAAAGAGTGT
AGGATCGGCCTTGCCGACTTTGAAGCCACTAGCAATAAGGAAGTCTCTAAGGCATTCATA
CCATGCTCTTGGGGCTTGCTTGAGCCCATAAAGCGCCTTAGAGAGCCTATAAACATGGTT
AGGATACTCACTGTCTTCAAAGCCGGGAGGTTGCTCAACATAGACCTCTTCCTTGATCGG
TCCGTTGAGGAAGGCACTTTTCACGTCCATTTGATAGAGCTTAAAGCCATGGTAAGTAGC
ATAGGCCAATAATATGCGAATTGACTCAAGCCTAGCTACGGGTGCATAGGTTTCACCGAA
ATCCAAACCTTCGACTTGTGAATACCCTTTGGCCATGAGTCGAGCTTTGTTCCTTGTCAC
CACACCATGCTCATCTTGCTTGTTGCGGAAGACCCATTTGGTTCCTACAACATTTTGGTT
AGGACGTGGAACCAAGTGCCATACCTTATTCCGCGTGAAGTTGTTGAGCTCCTCTTGCAT
CGCCACCACCCAATCCGAATCTTGGAGAGCTTCCTCTACCCTGTGAGGCTCAATAGAGGA
AACAAAAGAGTAATGTTCACAAAAATGAGCAACCCGAGATCGAGTAGTTACCCCCTTATG
AATGTCGCCGAGGATGGTGTCGACGGGGTGATCTCGTTGTATTGCTTGGTGGACTCTTGG
GTGTGCGGCCTGGTCTCTCATCCTCCTTTTCTGATATTTCATCTCCCCTTGATTATTCCA
TTATCTGTGGTGCTCATCTTCTTGATTTGCTCTTCATCA
.
qlt:
4455677;??=9<>QUOUTD9bNR<YiD:Y_iHKZlllK=JZl_]lbU[_bel_WlW__R
lglg_ll_YgllllllllllllllllaVlaalaklllllllllllllkllllllllkkll
lkklllllllkgkllllllllllklllkllllllllllllkllllllllllllllllkgk
kllllllllllllllllllllllllll_llllllllllllllWllllllllgglllllll
glglllllllllllggllllllglggllglllllllblglllllggllglllllllllgl
lllglllllgllllllllllllllllllbllllldllllbllllllllllllllllllll
elbMebbbbbllVlllllllllllBJZlllll_lellllllelllll_leleeeiiiiee
eeieeeeiiiiieiiiiiiieiiiiii_ieX^JUSbeiii__eeeeee[e_eiii_iV_e
i_iiP_ei[i_[_N_eei[[]eeYY^ei_^e^_di]iie][QiPieiW^iWVee^VVVVe
bUddLd^P^^VMdee^Gi^U\X]Y@iTeRV\UMUeVSYHY\UeYe\H\NeXUO\`K_NO]
^ONN]^]D^FSQPPW>OONQM_^ZQTQ`LNLTMNJHW@MNLF[BPVGNOMMGJK<@MMKR
CIM[KOLB?>c8IFFQYLWCLCM?J^cI>NMLGGLDHBYEMBDTFOJAH6DKD?RLE@Qc
Q@V@J8=@A8J<>56?>5B@KNLBAHFWN><=6CSM?\NBAKNRV\\H;=KF99@KN;BA
>>KDCM64E;476@FG@98G@8=:@BZG78734GA@F;7
.
frg:119
clr:7,817
}
{RED
iid:1600
eid:1127298250
seq:
TGTTCTGATGATATCAGCTTGAATTCGTTCATTTGAGCTCTATACCGAGTCTGAAATTTA
GTGTTAAAGGCTCCACTTTGGGGCTTTGTAACTTTCAAATTATAGGGTTTTTGCCCTAGG
TCACCACATCAAGTTTGTAGCTCAATCATAGGAGAACAACTTTGTTTAAGGAAGTGAGCA
AAGTTGTTAAGAGAATATGGGAGATAATTAAGCCTGAAGATTGGCTGTCAGGCTGATTCA
GTTAGAAGTTCAGAAGTTCAGTGCAACAGAGCTAACTTTGGACTTGAATTAAACCTTGAT
CCAGTGCTTAAATAGGTTTAATCCCTATAGTTGATTTGTAGCAGGTAAGTAGCATTACAA
CTTTGATGCAGAGCTTGGGTTAAGTTACCATTCAAAATTGAGAGAGAAAGTGGCTCCAAT
GTGCTTTGTCAGGCGACTGAATCAGGTTTTCACCATGGTACAGTAGTTCCAAACTGAAGA
AGATCGCAGGTTCACCCCCCCTGCTCGCCGCCGGTGTCCATCACCGTTGATCTCTGCTCG
TCGTGATTCGTGCGTCGTGGTCATTGGTTATGCACAACTCGGTAAAGATCCTTACCGCCG
GTGAGCTGGCCACCACTCCGACGACCCCCTCTCCTGTCTTCCTTTCAGCTTTGCGGCTGG
CACGATAAGTTCGCCATCGATTGCCGCGTCCAGACCGTGCGCCGCGAGGCCTAGACCATT
TACAGCGTCTTCATGACACCTACTACCTTGACTTCGCCACGGAGGAGCTGCTACGTATTA
ACGTGAAGCACGGAACAAGCGTCACGCA
.
qlt:
41445:9TFOD8:=<8>^iiiH>EiideiB<ZiiiiilllZlllllll__lllllllll_
llllUY[GKGE[dkkllkkkgklllllllllllllkTlllllllgkllkgklllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllklllllllllklllllllllllllllkkllklllllllllllllkkl
llllgkllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllllllllllllgklllllllllklllllllllllllllllllllllll
llllllklllklllkllllllllllllllllklllllllkg]lklkllllkllllllkll
llllllllklllllllklllkkllklkllllkllllllklllldl[gllldglgllllal
lUlagddgdldgg[ggggggbblabggglggla[IbUUggllglelWbllebbebe[bb[
MbQWlXSZXKIXKGHMHDbH>RON]dKKWZOVKNDJMHWVNKKR_e][LAKMP[DF[9@:
><DbBNZ]ZLP?<KBAIG?:V>AdZ]>::@GBLM;O7@8>G>@?KA7KHNIIRH9>8?LC
9>I;H9LE;HOK8><85;5>57<E>78;8<B@KQ:H<8<9><8:8>;D;<I?<E689=;B
H99>@@B@;95;@>GM?9>958<>IE==G=>@7;H7<::8=5:55>;6B>>;EE;5@98;
;47<A?76;8C8;<8<66756><=9::6
.
frg:120
clr:30,793
}
{RED
iid:1601
eid:1128922908
seq:
TGCGATCTAGAGATTCGTCAACCAGGGAGGCACAAACTCCTCCCGAGAAGACAAAAGCAA
AAGATCCTAGGTGGAGGACCGAGTCCTCCCGCACATCAGTCTTGATTTTCTTCTTTTGGA
ACCACCTTGGCACAGAAGCAGCAAAAGTCTGCTACTTCCGCACCTAAAAACAACGAAGGG
ATAAACCCTGAGTATGGAATACTCAGCAAGTCTTACCCGACTAAAGAAAAGACTCTCAAG
GGTATGCTGGTTATATGGGAGTCAAGGTAAGGCTTTTCAATATTCAAAGACTCTATTTTG
CAGAAATGCTTACTAAAGTGGATCCTTAAAAATCCAGTTTTAATTTGTCAAGTTAAGTAA
AATTACCTGCACTAGAGTTCTTTCTACCCTAGTTCAATCACTGGTCCTGCACTAGCCAAT
TTTTTTACAAAAGCCCATTGTCTTTAGTGGAATGCTACGTGTAGGGCAGTGACCAAGTCT
TCATAACCGCGAAGGTACGGCGATCCGAATCGATTATACTCAGCTGAGGATCTCCAATCA
CACGACATATGTAGCACTTAACCCTTGCATATGTCAACCCGCCACCGGGGTTCTTAAGAC
CGGATCAGGTTCACGCAAACCGAGAGCACAGCTACACCACCGTCCAGCCTCTTGCCACGG
AGGGTACACGCTACTCTCGCACGCTCCACGCCCATTTCGTGTTATCTTATTCCGGCCTTA
GTCTGCCCGAGCAGCTTACCCATGACGAGGCATGGTGACAGTAAGGTCTCGATCATCAGC
TACTCGGACGTCCTATCGAATCGACGGAAACCTACCCGAACTCTCTTCTCTCGAGTCCCC
GCCGGTCTCAGCTTATCATTTCACCAAGTGAC
.
qlt:
5747677@?:<898M]ILJH_PM>iYJGG[>OWPllelllllllglg_l[gKVllllggl
ggYgNMTTRLOMllllllPllllllllllllllkklkkllllllllllllllllllllll
lllklllllklllklkkkllllllllllllllllllll\gllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllglllllllllllllllllllllllUUllbllllllbllllllllllllll
llbllelllllllllllllllldlllllllliiieciiiieiiiiiiieeiiiiiiiiii
iiiiiiiiiiiiii_iiiiiiiiieieiiiieiiddiiidiiiieiiiiidiiieiYQid
ii[[i^^eIiiieYQC_ieieeeiVbdbiN^WTiWee^d\iZeFYiQeZdiXS\HeYeeY
eeR_`\YYe_Re[EiLPYN^NX^NI]J\]N_MNHP_NNN^TKMMPMW=_RHM\VNJTM`M
NMYL^MLYNM^R[PMNMORMTMWMMNWFKLML[LVGJMVMMHPHOLSccPGLLGLBM<[<
B@ACGL;?=FGLDHLMH[RIJJPCMLLJJLIKQJL=BKC=DJ@EHQ<G9:=9@E;@ADJC
Q=\G6OA<@ORJRJOB8<46796775B:B@ARA<?ZA<=:F8C:8:>BM>:4:;A7;=AM
=@J=Q:Z=9D=7442>AF<H8<DIH94C;G;7:=84:=B99D8>;=7C5;?GD?;<8J=A
=E34964:6A7?6BA5A8>5444<46<95<8=D@6494983846568563113B555388
89<6=4858:<6K774869F@95338533313
.
frg:120
clr:7,781
}
{RED
iid:1602
eid:1127298251
seq:
TGTTCTGATGAATCAGCTTGATTCGTTAAAAGGCCAATGGCAAGTGGCGAATGTGCATCG
ATTTTACAGATCTTAACAAAGCTTGCCCGAAGGATGAATTCCCACTACCAAGGATAGATT
CTTTAGTTGATGCAGCAGCTTCTTCAGAGCTCATGAGTCTGTTAGACTGTTATTCAGGCT
ATCACCAAATTTGGATGAAGAAGGAAGATGAGCCGAAGACTAGCTTCATAACTCCAAGTG
GCACATATTGCTATCTTCGGATGCCTGAGGGGCTCAAAAACGCTGGAGGAAGTTTCAGCC
GAATGACTGCGAAGGTTCTCCAATCTCAAATAGGCAGAAACGTGCTAACTTATGTTGATG
ACATCATTGTCAAAAGCACGAAGCAGGAGAATCATATTGCTGATCTGCAGGAGACCTTCG
CCAGTTTCAGGCAAGCTGGCTTGAAGTTAAATCCAGAAAAATGCGTCTTCGGAGTGAAGA
AGGGGAAATTTCTTGGATGCTTGGTTTCAACAAAGGGGATTGAAGCTAATCCAAGTAAAA
TTGAAGCTATACTTCGGATGGAGCCACCAACTACAAAGAAGGGGGCTCAAAGATTGACAG
GAAGATTGGCATCTCTCAATAGATTCATATCCAGATCAGCAGAGAGAAACTTACCATTCT
TCGAAGTGCTGAAGTCAGCCGAAGTCTTTCAATGGGGACCAATCCAACAGAAGGCCTTTG
AAGAGCTAAACAGTATTTAATAGATCTAACAACATTGACTCCACCAATGCCAGGGGCTCC
TTTGTTATTATATGTGGCAGCTTCGCACTTCAGCGGTAAGTGC
.
qlt:
4444;:JU>E97:966[lllbHllV__lllllaLk[llllllllllkllllkllllllll
l]]\KGN=GLNKllllkllllllllllllllllkklllllllllllkkkkkkk\glllll
llllllllllkllllllllllllllllllllllllllllllllllllllllllllkgkll
llllllllkklllklkllllllllllllkklllkkllllllllllkklllllllllllll
lllllllllllllllllllllllllkgggklllk\\[klllkkgkllkggllllllkklg
gldkggkk\\[kkklkk\\\\kkkg\U[klllkkg[klkkkg[\\ggkkkgkklkkg\g\
\\kkkgkkl\k[gkkkgkkdkldkk]l\NkkU\N\kgkllkkkgkklklWkkSkklkkkk
llklkllkgklkllllllkkklllldkkkkllllkkllllk\llkklklgM[kGSkgkdl
l]llklllklkllllllklglll_YlllallglllllllallllgllgllllSlllllll
ll_llMJbVV[lblb]llMllldll]elGlb[RQHllZllPlllWB_eZei]T<iiXKXb
ibi]_Dii_V]eeiiedZeee]YPeeMbeeedFe[ZYW_edYiJidiY_WVidMRAdddX
e_DF]U`iTeXeiRTXNYYi>G<;A\TieWBRMQ=>OVDPLWVPYL`TMI[Q`cH[Qc_`
SPIcMSVKZHNMQM[Nc[MVMM<MLYVOPJGOEFMPTTLNHQHE>?EB^@MGX\\TANDL
G\87=CC=89=CLVKVTILMRNIH:=GN<5=?ALMR<:>=;E8
.
frg:121
clr:4,821
}
{RED
iid:1603
eid:1128922909
seq:
GCGATCTAGAGATTCGTACGATGAGATGATTATCCTACATATGCCTAGATGAATGTTTAT
GAATGCAAATGCGATGATGTAATGTGATGTGCAAATGAATGGCCAAACACGTATCCGAAG
CCATATTCATAGCCATTATTTTCTTAAAAACAATCACACCTCAGCTCTGCATTCCCTTAG
GAACGACTTTGGAGCTTCTTCGCCTTTACTTTTGGCGGAATCAGCGTTGACTTTTCGCTG
TAAGCTCTGCATTCCCTTAGGAACGTCTTTGGAGCTTCTTCGCCTTTACTTTTGGCGGAA
TCAGCGTTGACTTTTCGCTGTAAGCTCTGCATTCCCTTAGGAACGTCTTTGGAGCTTCGT
TTTTTCTTTTTGGCACTCGATGGTGCATTCTCAGCTTTTACATTTACATTCTTTGGGGGA
TTTTTCTCTTATAGAACTAAAAAAGAAAATTACACGTGATGGCCCCATTAAAAACCTTTC
TCCCCCTTCGGAAAGGAAAAGGGTGCCATGCAAGAAGAAATAAAAAATAAAAAATATGAA
AAATTACATCGAATTATACATAATATCGCCGAAGCTCATCCGCATTCCAAGATCTAGGAA
TGTCATTGCCGTCCATATCTTTCAATCTGTATGAACCGGGTCTTGACGAGATGCTACTAA
GAAAGGCCTGTCCCATTTCAACTGCATTTGCCACTGTTTCGGTGCCACCCTCCGAAGCAC
AGTGCCTGCTCATATTTTTAGCGAACTTCTATCGCATACTGTTCAGCTGAACTTATGAAT
TTCCACGCTGCACTGATCTTCAGCATCTTTTTCTAGAATAAGCAGCCTCGGAATCTGATC
GGCGAAGCTACTATCCTTATTATCG
.
qlt:
57677B=D?;879PTPFUDQ_BiI7?8WP;_]VllelUHlllllll_ll_lll_[Olala
alll_lS\\lllkllllklllllllllkllllllkklllllllkYlllllllllllllll
lkkllllkklkllkkllllkllllllklllllllllllllllllllllllllllllllll
lklllllllllllllllllllklllllllllkllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllllllllllgllllllllllllllllll
llllllllllllbUllllllllbllllllllllll_lll_KUlllliiiiiiieiiiiii
iiiiiieiiiiiieeiiiieiieViiediiiidiiiiiie_diiieeQiiiei^idii^Y
<iiiieeedUeXeWiiXbZiYYiiQYRYQV]^eXee\iRRiYUQQQMi]X^eeSeUUi]\
QXe\QWMWOIN_^WP`P^^PO^^N^AG@M^JMNL`XK^^cY]^^^^WIM^^ccPNMMVMc
^^MM^MMA[VKWMBVMKMNIMKPGOKSLA?:MJ:JSQGLFP=JGSRDJ<BFMDRO@@9EG
>T:LED:N<FJEDHGLLLLGcQNF?CLIP8IC?@G;=DOC??9JN?@9M5D7LLOLGGQL
=S\BGHAG=P;CN=?BWGI=8?FM:E6T9KF@7?BD5Q;544444334O:45F<HG=<56
45:=:E?D4=:A45:NTNB@5E4E>IDFE;>6A5E56358A6B<;>AH=34<<47<K@@C
834:43@6B<7545D;5=3:463::459HMH83254CD6=A6;8656:75558583:553
3486A6345353694@5534436:3
.
frg:121
clr:5,779
}
{RED
iid:1604
eid:1127298252
seq:
ACAACTCTGATGAATCAGCTTGATTCCGAATTCTCTAGATATCGCTCGTACTGACCATTT
AATCACAGGCCTCCTTAGCTGAAGCTTGGGACACTGAGAGGCCTCCACCTAAGGGCCCTC
TGGACAGAGGAAGATGAGATTCCATCATCTGGAAGAAATTCTCCGGACCTTTCGAAGGGG
GTGTGTAGACGGGACTTGAAGAACGCGTAAAGAGTACTGCCTCTCCTACTGTTCGGACAA
GAGCGGCACGCTTGGAAACGAGAACTGCGGCCCCACCCTTTTTATGTTTCCACATCGAGC
TGGAGGATCCCTCCCAATGATATTTTTCTCGGCATGGCGGAGGAAAGTGATCTTCCAAAG
CCGGAGCCTCTCGCCGACATGCCAGAGGAACTAGCTGTGTTTCTTTGCTCCGACGAGGGG
GTACGACCCAATACTCGGGGGGTATCCGAAACCCCCACGTAAGGCTCAACGATGGAATAG
GAACGCTGGAGAGGATTGGGTAGGGACGTCGGACAAGGGTGGGCGGACCAACCCTTGGCC
AGAGAAATACGTCACCTACCCCGAGGTCACGAGCACCGAGGCGCAACAATGTCAGAGTCA
CGCCCGCGCCCGCATACAGGGGGGTTGGG
.
qlt:
311131469>>754556:?@QTN^[ADMN6N^L_NU8>8X8KJMEVC4:@Fbb<@@;__Y
><4;44448556876?78887785559@666744694464644776787899:=>?JH<C
=?=95=<SJ:THBVC<A:B@:;;<9;G==<887779Y<EBTGIB?:<:;:B<:<<;CC=C
=;<C;9B:::9:====??;<PH<B=??;=<<;G;CD=:B<:B=<<?6PC<H;>ABBPC:<
<<<8DDBM8BFCLC:@:P>9H>P:C=GC;;9<C=;CLC?TNGG<B?=B9?<@=><<<<<:
<GK<<HNG;==@A=5:=888<DBA=<C?=<<<<=CG=<<>VE;>=:B:GHCBG=GB878D
:=@DF7=I?=<;<=F=G<=;<=@I;CELW??=B?9=:<BBNI8==;99<CA:76<BC=EU
8>B<<=:<;=;9:><;==<B;<:B;<<;=<?:;<8999<?=<;;:89=?<;C=<B<=:<<
=K<=K;C;<<:;==GB:=;<;88KGA<<BTBbY?U<<::BQHIH<=5=<<<<C?A=B88>
;=E;FG=GWB9G=:<<<<;<=;?@??;=?HHC@<L=A?<<;G:<7C<6=GO:=;==>;WS
9URH<HVFFCL=;C?:B<I8B=?8BCCCC
.
frg:122
clr:84,627
}
{RED
iid:1605
eid:1127298253
seq:
GAGTTCTGATGAATCAGCTTGATTCGTGGATGCTTGGTTTCAACAAAGGGGATTGAAGCT
AATCCAAGTAAAATTGAAGCTATACTTCGGATGGAGCCACCAACTACAAAGAAGGGGGCT
CAAAGATTGACAGGAAGATTGGCATCTCTCAATAGATTCATATCCAGATCAGCAGAGAGA
AACTTACCATTCTTCGAAGTGCTGAAGTCAGCCGAAGTCTTTCAATGGGGACCAATCCAA
CAGAAGGCCTTTGAAGAGCTAAAACAGTATTTAATAGATCTAACAACATTGACTCCACCA
ATGCCAGGGGCTCCTTTGTTATTATATGTGGCAGCTTCGCACTCAGCGGTAAGTGCAGCG
CTTGTCCAGGAGAAGCTTGATGGTCAAGTCAAGAGACAGGCCCCAATATATTTTGTATCT
GAGGTTCTTAGTTTGTCAAAGAAAAATTATACAGAACTGGAGAAGGTATTGTATGCTGTC
TTGATGGCCTCCAGGAAGCTTCGACACTATTTCCAAGCTTACAACATAATTGTTCCTTCA
TCACAACCTCTGAAGGATATTATGAGGAATCGAGAAGCTACTGGAAGGATTGGAAAATGG
GCTGCAGAGCTCAATGAATTTTGTATTGAATATGTTCATAGATCTTCGATTCAGTCACAG
GCGCTGGCAGACTTTATTGCTAATTGGACGCCAGGGGCTCAGGAGGAGGAAACGAATAAA
GACAACGAAGCCTGACAGTGTTTTGTGATGGATCTTGGGGAACCTTCGGAGCAGAGCGGC
TGCTGTGTTGGTTTCACC
.
qlt:
4213465>?7E=89:66HiU^[J_^GUiiD8ZZee__]iVY>XlQelllllOCllllgl_
gll;8<>:7;<=<>?FC:[lgllllkgkkgkllkllllkgK><<:9;AAA=<;<g[kgkl
llklllllllllllllkllllllllllglllklllllllllk[[U@J[dlllllklklll
llllllklllk\gkklllllllllllkllkklllllllllllllllllllllglllllll
lllllllllllllllllllllllllllllllklllllllllllkllklllllllllllll
lkllllllllllllllllllllllllllllllllllllglllllgglllllgglllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llL_lllllllllblllllllllllellllllllllllllllllllbllll]llllllll
llll_lllllllbellieiii_iiieiiiiiiiXZiiiiiie]iieiieeicXiiZ_iiV
iibediiiiiiii_Ji[KWUeiYdi]didZieieiiVdeeeeiVQJViYGiiR^iYeRii
bdeibbNiN^ieTdeii_ZiiidS[YiYMX\_XYPe[UeeXYSWY]eLYM_`IYXeTXUY
c`^^P\\NWN[GY^]PVT\JNLPL]]N_FMORIVcc_M\MN6WT?\YCVY^QM>WTSMcN
CNKFMNM^^AUVR86;FXHYMccTWHOSI[NBKMMMY^cMMPCNMNMLHO9M9?G:NMVI
ELSDMCTMHPPNcJL<55
.
frg:123
clr:7,795
}
{RED
iid:1606
eid:1128922910
seq:
CCGATCTAGAGATTCGTCATTGGAATTTGGAAACAAAATAAAGGAGCAATCAGATGCTTT
TGAGAAAAAGAACTTTGAGCTCCAGGCAGCCGAAGGTTTACTGGCGGAAGCTGAAGCAAA
AATATCAGAACTGAACACAAAGCTTCTCCGCCAGTCTGAGCAGTTCGAACGGGAAAAACA
AGATCTCAATGCAAAACTTGAAGCCGAAGCTCAGCAAAATTCGGATTTGAGAAAACTACT
GACAAATCTTCAAGAAAAATGCCTGGAATTTAGCAACAAGTGCATTCAACGACTAAGAAA
GATTTTTTACTCGGTTGGAGCCAGTAGTGGAAAATTTACCCCCTCAGCTGAAGATCTGCC
AAAAACCTTCGAACATATTGAGGGGGAGATTGACGAGCTCGACGAAGTCATAGCTGGGCA
TGGTGACTTCTTTGCCTGGGTGGCTTCTCGAGGCACTGCTGCGGCTTTCCTGAAGGCTGG
CTGCGAGCATGGAAGGATTGTGAATAGGCCAAATTTCACTTTGTCGCCATCAATCCTGGA
CGACATTCCTGATCTTGCCCGAAGTATCTCGAATAGATTCATAAAAATGATATGGACAAA
AGGTGGGCGAGAAAAGGTAGGAGACGAAGCTCGTAGCCACCTTGAACCAGTAAGAAACCA
TACCTTGTGTTTACCTTTTCTTGTAAGCTCGATTTTGACTTACAACGATCTTATTCATGT
AGATGACGAGCCGAGCTATGATCAAAATAACGCCGAGCGAGCTCTTGAGATTAGATAGTA
GACTGCAGACAGTACTGAAAAACTTTGAGATACTTTTTGTAATGTAACAAAACTGTTTTA
TGATGCTGTCATACTGAATATAT
.
qlt:
446677==F?<?:TXQVL__ii_lDKl[lOB=RPIllglll_llglllllaa_lalllll
lkkklllllkllllllllllllkPllllllllllllkklllkllllllklllllllllgg
kglllkkllllllllllllllll\\lllllllllllllllllllllllllllkg\\gkll
lllllklllllllkllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllllg\\lllllgllllggglllllllllllllllllllllllllgglll
ll_g\gllllllllllllllllllggglggllbblbbllbUUblllllllllllllllll
bllbllblllelllllllllllllllllllllllllllllllllllllieiiiiiiiiii
ii_ei____ii__ie_ii__eiiiiiiiiiieiediiiiiiid^_iii__iii^Uddiii
biieei[iediii[JiOKiiUi[S_iei[\WRL^iidV^iiVideTY^FedFeeedWiQe
TKeNTiVW^XidNWeY^UUQQe\VUUYeieUN[XeRUN\VH_N^^^K``\QOO\N\NG]\
\N[Gc]UPM]A^ccMQUC_=N_GOEE^cNMMMNN[AMWENGJM[IODDHNMJI<YOWE@<
VVMCCJ^IY<^MMJAOY^MMF?T>KFERMJLOIc\OLRJHOGMEEMMTRIDIJCHP>JVC
567>MGEAA6:GB>59?A8MAKFN\\M>;>LJB;:H877M8L<I69A37M>OB9?>AD:=
9MFFQ?67D84AGD:MI@ZZZMGJTE;?7:5I>>SSL8H5=?;I7DA:8PT@9E>7IK<4
3<34CD:B8747<A444366144
.
frg:123
clr:6,847
}
{RED
iid:1607
eid:1127298254
seq:
TGCATCTGATGAATCAGCTTGATTCGTGACGAATTCTCTAGATATCGCTCAATACTGACC
ATTTAAATCAAACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTTTTG
ACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACCGGG
CGTATTTTTTGAGTTATCGAGATTTTCAGGAACTAAGGAAGCTAAAATGAGCCATATTCA
ACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGG
GTATAAATGGGCTCGCGATAATGTCAGGCAATCTTGAGCCAACAACTATCGATTGACTCG
CAAGCCCAAAGCAAGGACTTAAATCTGAACCTAGTTATGGGACCTGTTTTCTTTGAATTA
CTATCGATTGTATATGACCCACTAGACGCCATACTTGATGCAAATTCATACAATAAATCT
TTTTACCATTGATGTTGCTTTGCACAGTTACTGGCCACTTGGGAATGACAGAATAAATGC
ATTCCAAAAACCACCAAA
.
qlt:
31224>7:;:A:89:78W[^WQ?^iENi;;^^]MYiiiVVePUUPiYddUWeieeeiZiW
Tii;@;796669<::C<LMbl_Mllg__lllllglglllgglggg@:>=><:<I<B==CL
lllllkkkkkk[kd[dTQl]k]klldkkkkkkLadVkaYakddWdaNHk[TH\dkakkkO
CGHJKNWYUTV]LMUW[bMaWkdkkRQ@=MK<HHLHLW[WHWWWG=MTdaWWaWWdWaTP
L[W]Wd]daSL[R]kWR[L[L[L]NWQdMTTKS]daWOTOKKTBNGTHR[WDWPT?BITM
BAHK;CHETL<=AB;<?E:<<;P=BIJC@:<NK<:I?GF:G<@?CBCD<D6::8>9::;=
=BK@<E<>8::<::==K9?<:<=<C;?=9=9=:B??<@G:NGI;@=CKC?B;BA<AG9:<
9??:;8B8<GH;F=:?;;<?;F<;;?=@==9<T=:?===<F8=H:;G<<==<P=;=;=?9
<=<:::?<BCG?H::I;:<:???F:B;:89;<:==;?;=;<=:;;C=KC;;K;AH:>@<;
C=B<=;<:;C88:<@@CB
.
frg:124
clr:368,556
}
{RED
iid:1608
eid:1127298255
seq:
TTCGTCTGCTATTCCAAATTAGATTATTCGAAATTCTCATGACTCGGTCATACTGACGAT
TGTGGAACCCCAAACCGTAGCTCATAAACGAATGCAAATTTTTTGACTTGATCAGCACGT
AAAAGGTTCCCCCTTTCACCATCCCTTAAAAAATCACTACCGGGCTTATTTTTTGAGATA
TCTGGATCTTCTCGAGCTGAGAAGCTAAAATGAGCCCTATTCTACGGGAAATGCCTTGCT
CAACGGCGCGAGAAAATTCCACCATGGATGCTGATTTATATGGGGATAAAAGGGGTCGCC
ATACTGTCTGGCAATCTGGCGCCACAAACTATCTCTAGCATGGGAATACCGATGCCTGGG
AGATGTTATTGAGAAACGGGAACCTGATTTTCGCCAACGATGTTACAAATGACATGCTGT
GGATAATCTGGCTGACGGAATTTCTGCCGCCTCCAACCAGCATTCATTTTTTCCGTACTC
ATGAGGAAGCATGGATACTCACCCCTGCAATCCCCCGAAATGAGCATTGCATGTGATATT
TGAATATCCTGAGCCCCGGGATGATATTGTTGAGGCGATCGCTCTGTTCCTGGCCCCGGT
TGCAATCGATTCCGGGATCTGCTTTGCTGATTACGCACTGAATCGATCACTTCCCTCTCT
CTCCTGCTCACTGACCAATGAGACACCGGGCTTTGGGGCGAAAGAGTGATATTGTTATGA
TAAAGTTGCTGGATGGGCAGGCCGCCGCTCGATAAGCTGCTGCATGTCATCGAAATGTTG
ACTATTCGCGTCTCG
.
qlt:
521344855>7<957545H@455C?87A96<8:57?7D885676775787=:::=@::C=
87787647657<:8:77=6;9:=N<F:=<7654=8447:84=?C@C?@<=<H=:<GET<<
=G9K9BC=BB>;BJ=CJ@HDC::;=:5459:;IG;HK=B=<<:;=45;;;<<B@8BKBC=
C?;::;;;GF?:<IHFAH==E::<<B:<==9<=<?D;?HI=G:=:8=@F=QB=G<<<G==
B9BBBE<=K=GCLG=B:=KI:7:<;F<G9B===?BC<K=BTTF=?=<<B<@LBB9CB<C<
BE<=CKBB=GG<KI=N<OC:<<==8:==C:<H=@:8DM:<LGBGP:<88<;::<9:<<:;
O<=B?9<<@<<I:B=;<K=B9:>::88=5:;<BFBGH=K?;VDB=W=;K==M<QBH<===
=YG9;S;;9F:=BOG<<;<B===@CHTD<O<>JBCKBD8?DK8;PFPD<;=L?G::<;8<
;:<<:<==?:=AH<::<C?G;?;9?=C;8;99>:<89<9:77:88<=?;;G>K<;:::=<
;AH<:>HGG?T<;:9;9N:IE9APAdCUb[CAJ9C<>H<>;H9H:Q9>>@>LO=:?@E;:
;=><;;B9?>>KE8IF;:>96;FEIE<G=;8??@8H7=A>:=;:BA78EB:QL@<;>KNR
9LF@89B88>;G>988:78<9:D8G;LDAG9:;:868;A@<AD?UAE89>8<D9776>;E
C<8<<DK:87==BFW]G<@8DE?9<A69AA86B6<H9:=56756;>H:>7<55@BF=FE?
>:>EIHI8<<;6>88
.
frg:125
clr:614,790
}
{RED
iid:1609
eid:1127298256
seq:
TGTTCTGATGATATCAGCTTGAATTCGTTACAAAGAATCACGGAGCAAGGGAGGGATTAG
CAACTCACACACGACACAAAGATCACAGCGAATACGCACACACAAAACCCAGACTTGAGC
TCAAGAGACTAGCACACTAGAACGGAGCTCAAATCACTAGAATGTCGAACACGTGCGCAA
GAATGTAGTGTGAGTGATCAACAATGCTCAAAGGATGCTTGGTGTGCTCCTCCATGCGCC
TAGGGGTCCCTTTTATAGCCCCAAGGCAGCTAGGAGCCGTTGAGCACAAATCTGGAAAGC
CATTCTTGCCTTTGGTCATCGGGGGCACCGGACAGTCCGGTGCACACCGGACACTGTCCG
GTGCCTGATTTCCTTCCTTAAATAGCGAAGCCGACCGTTGGCAGACTTGGAGCCGTTGGC
GCACCGGACATGTCCGGTGCACACCGGACAGTCCGGTGCCATCTTCTAGCCGTTGGCTCA
ACCACGTGTCTCGCGCATATTGCGCGGCCGACCGTTGGCCCGGCCGACCGTTGGCTCACC
GGACAGTCCGGTGCACACCGGACAGTCCGGTGAATTTTAGCCGTACGTCGCCGGTGAATT
CCCGAGAGCGGCCACTTCGCTCGAGCCAGCCTGGCGCACCGGACACTGTCCGGTGCACCA
CCGGACAGTCAGGTGCTCCAGACCGAACAGCCTTTTTGGCTGTACACAGACCTCTCATCT
CTGACTCTATTCCTACTGGTTGACGCACTTAGACAGAATACACTAGTCTTCAAAACAATG
TACTAAGGCTTAAAATCAAAC
.
qlt:
435497;K>MB89FA>Yeill@8Kllll_S[>lllaYalgallkklllllkkllk\\kkl
llklUIGG@E?G<UgklklllkkkllklgllllllllllllklWdabakkULSkklllll
llllkkklllllllllllllllllllllllklllllllllllllllllllllllllllll
lllllllkllllkllllllllllllllllllllllkllllllllllllkgglllllllll
lllllllllgkllllllllllllllllllllllllllllllkgkllllllllllllllll
lglllklll<<<6<77H;glllllldlklllldkkkkkllllkkkkklkklkkkllkklk
lklklllllllllllkkkkkddkkdkklldlkklllldklkddkllkkkagaglgdggld
lllglgglaadg[[ddgagdddaddddldababgglalblgllglbUaJV[UGUa[Ug[O
OMSORRabUUU[MHSSN6KT[_OSSdb[bPeOVQMZZ_PbdbUUb]lMVWOW]TH_SROW
WVlWRWOJKWXEZKMNMN]OTZAE@?COPW?Z_]S]LMNKILLDLQQVXGQ]J[O]W]V]
QGJDWK]HQGGDD>DEKG<JOTNZSIONHBUNbHAHKLEEBDUK?AGQE@@=L<ZKBCKB
>KGKSHBIB@=<H>XI\NK?>Q:>GHXMCL9D?AA:=D@>DN9=B><79>:=88855BEA
BNKJ;HH@MMC6DO=<:J;OK9M99M6<><C6EA;59;:B>95>D7799;:A<CBC@<6M
DHBJ9LEM:<685688<G967
.
frg:126
clr:30,789
}
{RED
iid:1610
eid:1128922911
seq:
TACGATCTAGAGATTCGTCCTGTTGACGTGGCGGACCTGTGCCCTAGGCAGGGCGACGTG
GGGGCTCCTCCGAAGTCGAGGTCGAGTCTGCCTTCCGTTGCCGAGGCCGAGCCCGAGCCC
CCGGGTCGGGCGAGGCGGAGATCGTTTGGCCGAGGCTAGGGCGGAGTCCGAGCCCTGGGG
TCGGGCGAGGCGGAGATTCGCCGTCTTCCGGGTCTTAGCCCGAGTCCGAGCCCTGGGGTC
GGGCAGAGCGGAGTTCGCCGTCTTCCGGGTCTTAGCCCGAGTCCGAGCCCTGGGGTCGGG
CGGAGCGGAGTTCGCCGTCTTCCGGGTCTTAGCCCGAGTCCGAGCCCTAGGGTCGGGCGG
AGCGGAGTTCGCCGTCTTCCGGGTCTTAGCCCGAGTCCGAGCCCTGGGGTCGGGCGGAGC
GGAGTTCGCCGTCTTCCGGGTCTTAGCCCGAGTCCGAGCCCTGGGGTCGGGCGGAGCGGA
GTTCGCCGTCTTCCGGGTCTTAGCCCGAGTCCGAGCCCTGGGGTCGGGCGGAGCGGAGTT
CGCCGTCTTCCGGGTCTTAGCCCGAGTCCGAGCCCTGGGGTCGGGCGGAGCGGAGTTTCC
CATGGCGCCTTTGGCAGGCCCGACTGCCTGTCAGACTCACTCTGTCAAGTGCACTGCAGT
CGGAGGGCGCAGGCGGCGCTGTCCTTCTGTCAGACTGGTCAGTGGAGCGGTGGAGTGACG
CGTCACTTCGGCTCTGTCGGGGGGCGCGCGTCAGATAACGTGTCAGCACTCGCGTAAATG
CTCTGCACTGTCAGTCGTTGCGATTAGTCAGTGCTTTGACGAGCCAGTCTCGGCACCGGA
TG
.
qlt:
4546677==>877;RWIVSV_iN__@@WWll_eeV>ellllell[lblVSlllag_addg
UMTRTddglllklkklkakklkkdkkllllklgkkkkkllllllllllllllllllklll
llllgglllgkllllklllkklllllllkdlkldlklkkllklllklllllllllllkll
klllllllllllkl[kklldklkakkkkdkkllllllklllllllllgllllllllllgl
gllgddlgglglllllllllllllllllllllllUgllglllllllgglllllllellll
llll_llll[llllllllebbbbblllllllPdeeeelllllldlllllellllllleii
^_ei_iRiiiieiieiiiiiiiieieeePeieeeeiiibi]eiiii_iebeeiebdedWe
iedHieedViedeiieeeiibee[]SeeeedRVbeViVeiebY?Iibe]eeWeedTeeH^
KeeWVVeeUeeeP_Yi]SXLXYUWie_`QXQcM`SV]OPOO]\NXO\\OP_QB`^NR=VU
QMQWDM`MTM`W^^HNMML<GYWM[LME[AYFMWMNO[^YLSHcYMVSV?MJFN>O^KJM
MELJC8CJEMcPKYD6967TIEQOLNCLGYJN>:N>SQCGH?BMCJD?O886<=JLC>DC
8<5<55557?:B@5@86@KMG>I;?:<8@DG;<VCOFM;LA854?=7:@F7KH@5;M=4A
8@6FB@?:9CD<I>7;=7BORQD8:7647<8?5935?J9J5:;H57444436;762J;?H
9:E4?;J?GD5B=C=7531558><=54;D5633=@645767A4>:A@5;79;83327333
33
.
frg:126
clr:7,794
}
{RED
iid:1611
eid:1128922912
seq:
TACGATCTAGAGATGCGGCAACAAAATAAGCATTTTAGGGTTTTGCTTTACACGAGATCT
AAAGCCAAAACCCGCTATAACTTTGGAAAAGATCAAGGTTTAGCGAGGGGGAAAGGGAAA
AGGAAAGGGTAACGCCTAAATTTGGTGAGAGAAAAGAAGAAAAAATTCTACCCCCAAATT
CAGGGCGTTACACCAGCTAAGGCTCCTTCTTTGTCGTGTGCCATTTTAAACACTTGGCAC
AGAAACTGCGTTGGGGCCCATTAGAGCTCCCTTTACCGAGGGCGTGCTGGCCTGACATTC
TTTAAAGGCTTCGTCACCATCTCTTATCACCGTTATGACGACTTTTTTACTTAGTGTCAG
CTGGCACTCGGCAAAGACTTTGCCCAGTGCCCGACATAAAGTACTCAGCAAAGAAGGCTA
CACTGTCACGCTCGAATTTAAGGGCAAACTCGAACGCGAATCAAATGTGTGCTAGGATCA
AGTCTCACACATATGATGACTCATGGTATAGAAACAAATGTCACATCTTTACTATATAAT
AGGAGTTCTATACAAAATAACTAAATAATTGCACCATATGAAGACAACGATCCTCTGTAA
CCAAAGTTGACTGGGAGACGATGGCCTAGACCTCTCACGAACTCATCGCAGCATCCTTCA
TGCTCCACATCTTGTTGTACCTGCTCTTGACCTAGGGTGAGTACAACAAGGGTGAGCTCA
CATATGTCATCGCTCACAGGTGTGGGCAATAATGTGCATGAGCTCACTACGATGGGAGCT
CATGTGAAGTGTAAGTTACAGAGATGTAGATGAGCATGCTTTTAACAGCTGTCAATTTTA
TAGCAGTACTAGTTAGTACAAACCAGCCAT
.
qlt:
4745688><:;988PBWDEWJ?D>HKP=8:BPT]]PTV_MHb][WNbbPEW=eN_SUWOL
GBCMSE>ICIGM[OCGHQBUUaa[[S[SYd[gaaTT[gUYNUBRYddgdddgdaddUaTT
YdlgddglgYdaYY[dUgdLad[dWdgg[gdgddd[ldWlgdgdadddaaQ[YYYLTggg
YHGg[Ubb[[[Sa[VJagYbUlJ[aaUaaUaaaMaJPgVga_[bgllUJUSO[b[bJLUT
UJgaabagbaaab]][Tb][bWH;O[]ddbbd[[SLQOe]e_[bWbZZbWK^bllb][Zb
SZW_V]d_bdbeWbdO_eW^^_e_eld]OW]ZT[]]]_ZKell^__bbddbUW@PeR_KD
VZZVHNVZbVLW_]eV_ZZ]]b___[ZVeb_ieie]ebZ]XV_]b`dV[dbe_iiWeP^_
]N_beV_Nd]RTP?DG]bTUZG_Z]QV[]ee>VQPU]L_]bb^ANVdUYRe[_^J_YQYN
X]]]W[SdUTPXUVX[Oe^VWXCTeXLb\WC_UU`PQTVeUUXSReeX]T_\XeUZ]VWK
S:FUNK]YUY\TKLS__YXO]SGUP\UQNP^KLO\LW_N\^\NRICHPIVNGP\ML`LM\
ETC`QRLOMM@MN^NY@MIC[BMOFHLO5BEMMIMMCH=NFCOLBVOGGH9MLRLMLFHG
L[OOLOLJHSQIKQDEM<GEMFSCLM<<NLILM96GMFLO?>FFAHHGE8J=??P9DTA?
R?GJE7:5:LNA=AJE45;7S>BBQIKC>;9A=O<GCCD>N<JO?:7N8@<N9NO8D;@?
=?B>7BA?4:<6@=533<M:5D5D54554284=7A9@8@>JC<657?>98839<8CLN;5
A77E8;J:?:G65438;9474459>37A?3
.
frg:316
clr:7,850
}
{RED
iid:1612
eid:1127298257
seq:
TGCGTCTGATGATATCAGCTTGAATTCGTTAGAAGGCACACGCTACAAGACGATCTGATT
CTGCAGGCTCGAGTCTTCACGCTGAAGGGAGCCGTAGCACCCTCGGCATCGACGGCTTCT
TCAGCAAAGTCCAACCCAGCCTCGGACGGCGACGCGGTCCAAGGACTCCTCCGGGAGTCC
GGTCTTAGCAGGCGTCTCGATCGACTAGAGCTGGGGAATCTGAGCTGAATTGAATTCAAC
GCGAAATGCCTTGCCCCGCGCCGCGATTAAATACTGGATGGGAAGCTGAATTGTTTGGAA
ATCAATGGGCATGCTGTCTCATTAGGGTAGTCTTACGTGATACCCAATGGATGGGATGGC
CCTTGCGCGGCACCTGTTTCTTATCATGTCAAAAGAAAGGTTCCCAATGATGTGATGTAA
GAAATGGTAGGGCCAACCTGGGTGACTGAAATGAGGGCTCGCCCGACCAACCATCATTCT
TCCTGACTCGTGATAAGATTCGGGTAGTCTGCACTGCTAATGTAAACGACACAACACTAC
AGGAATTATTTAAAATCCTGATTGTGCGAAAGAATATTGATGGGCTCGGGGAGTGTCCGC
GCACGCTGCCTTCGATACCTGTTTGTATGTGACCGTTTAAAGGACATCGCCATTTTCGCC
TCGCTCAGGCGCAATCATAAACGAACATAGTGTGTTTGGTGGGGATACTGATTAGAATAA
GCCTTGTGGGTGGTGTTGTTGGACTCCTAATGAAAGGAATGCCGAAACCTTTATCCGTTC
CCACCAGAGTCTACCCCT
.
qlt:
31333@9<MLL>=9BI8>ei^L78Ti\HdX]UZeVOdEiLlblYZlBll[_elllllW_l
llllL?@g;<<789<<C@BdSlldUOMkWlklllklSlklllklY\:?<J;8;:;;B=BB
GkPTkTTdaklkVUkgkVkkggldakkdd][kkUbSJHKK=<=?GNTTTNaWLB<:<@LH
;:9=;=<<<FDB=J=FHJG<9;CH<::=G:IHI==QGH8:<:E:<:D=;:<<====N;E;
<=BDF<BT=CBJW<<F;HHB<I===G<KS<F==:=B=<<;<:B<:ABAC<=:;?89<KH=
99:<9==:699;9;;<B88;699:8;8:;::994B<B:;HBB=<=<:9?=CB<B<E?=:=
<;==G<:B8@CJ:FBB<=B886D6<88968<858=@:85788865:;:::78<<9:<<H8
BK;K;E=:<<=C@<=C;>GH99DE<=:=DD>9GS<B:B98:=B:>B:E=B><<9<<=6:7
;<=<G9A8;:;<@=??<@=;:TG?>?:<??<;8;<=C9<;<<<8:78=;<B;@=:89;=<
BD<@BBC>>?96=B>B;=9C=;;89J4777C:A@<:=@AJ;;?C<J;=E@;;=:::<<=9
=D?8:8=H><KBU:<B<;?>C::>B;A:B<N:;=?:>E@:8:;<<F>C8889<<=;<><F
J>88:=G8=99=DA<PH7FNH;CM;8:9;=7D;IA99H=8<998@6=:=9>>?E86=9><
>>6@<<:D799<=>?97<9BFC=9><8:=;8>:V]E8C==H:E?H>PCA68::9NO:C<K
9@DAA97N<>::<AAB69
.
frg:127
clr:31,233
}
{RED
iid:1613
eid:1128922913
seq:
GGACGAATCTAGAGATTCGTCACCTTTGCGTTAATGCTCCTGCAACTTGGTCAGTCGGTG
TGGCGATTTAGTCAGGGTTGCTTCTGAGCGAAGCCAAGGTCTCGGGCGAGCCGGTGATGT
GTCTGCCGTAAAAAAGGGGGGCCTCGGGCGAGACGGAAGTCTCTCGAGGTCGGCTGCCCT
TGGCCGAGGCTAGGCTCGGGTGAAGCGTGATCGAGTCACTTGTGTGGACCGATCCCTGAC
TTAATCGTACCCATCAGGCCTTTGCAGCTTTATGCTGATGGGGTTTACCAGCTGAGAATT
AGGCGTCTTGAGGGTACCCCTAATTATGGTCCCCGACAGTAGCCCCCGAGCCTCGAAGGG
AGTGTTAGCACTCGCTTGGAGGCTTTCGTCGCACTTTTTTGCAAGGGGACCAGCCTTTCT
CGGTTGCATTTCGTTCCGGTGGGTGCGCGCGAGCGCACCCGCCGGGTATAGCCCCCGAGG
CCTCGGAGGAGTGGTTACACTCCTTCGAGGTCTTAATACCTTGCGTAATGCTTCGGCTGG
TCTGGTCGTTCCCTCATGCGAACTGGCCGTAGCCCGGGTGCACGGTCGGGGCCCAAGCTC
TCGGGCTGGTATGTTGACGCTGTCAACGGTTCGGCCGGAGCCGGTTTTTGCGAGAGCAGC
CCCCGAGCCTCTGCACAGGGCGAGAGGACGATCAGGGACAGACTCGGCTTTTTACATACG
CCCCTACGTCGCCTTTCCGCAAGGAGAGGGGGGGAGTGCGCATGTTACCCTCGATGGGCA
CCGAACATGTGTCTCCAGTGAGCTGCAGCGGGTATCGAGTGACGTCCGTGCCTCGTCGTT
GGGGTCGCTAGGGGCCAGAGGCACGTCA
.
qlt:
74487:9:8=B?A;::BUGVJ<KY_ieiePIE88ATPlllllXV[llll_lSGllll_gl
gg>?LOYb_[[lWallllllllllllllllllllaPllllllllllllllllllllkkll
llllllllkllllggllllllllllllllllllllgglllllllllllllllllllllll
lllllllllllllllllllgglllllllllllllllllllllllllllllllllllllll
llllllllllllllllgllllllllllllllllllllllllbllllllllellll_llll
ldllllblllllllllllllllllllll_llllllllllll_llllllllllllllllll
lliidiieiiiiieiiiiii_e_ZUO_eii]eeeiiii_iieeeiiii_TedZ__eeiii
ii_eiiediiiideieeeiViiieiiiieiiidiiibdi^eedYiiebeed^[[[Y_dbe
[QVeVUV>ViEeiGN_beSeii__edNdXiSe_deYdddUe_iedZe^WiSieeUVQXii
ReXieP_T``S]\UXR\eTLiXXU^IF]NM^JX]\N]^K^NNO\cO[K^_[MWKGUMN`W
YTM]UHN`_INMV@PJTKGNV[JSFMMHYHMVLMDKLMQ=MHC^Lcc^TLKB^G[EMMKS
TKKEIT=OCIKKMFCCJEVC9D[DY?NL=;NLL@BM:MIDGRCOGFA?NcccJELCQMNF
ILL=8CIF?ICKCLcPGDALIGLEA656OZ\TQ7N8=PF<A7CN9G@=I;=DCJDET>;H
@G=MBI@<F4=7547DBHGM@9DNF:N7=6RG:@751325937C@;F::9:H7D897;E:
JPNG<<D5<H?OO34398H:<33333;4
.
frg:127
clr:9,852
}
{RED
iid:1614
eid:1127298258
seq:
TGTTCTGATGATATCAGCTTGATTCGTTAGAACATAATGTATTTGCTCGAAAGAAAAGGT
ACCATGATGATGAACGAGAGATGCCTCCTTGTAGTGATCTTTTGATTTTTCAGACAAACG
GCAAAGCCGTTGGTCCACCCAAGGCATATCACCTCAGTATGGAAGAACAGAAGTTTACTT
TACTGTACATGTTCACGAATATGCCTGAGGTGGAGAAATATTTTGTGTAAGACTTATTTT
CTTAAACTGTTCATATGTGAATTAGTTTATGTTATCAAATATCTCATGTCACACAATAAT
ATTTGACAGCGAGTTTGATGAACAAAACATGAGGTGTCTCGGTAGGCCAACAGCGAGAGA
CATAGACAAATTGCGATGCGATGGTATGCATGGGCGACCTAGTTTCATTATGTGGCTTCG
GGACCGTGTAAGTCTTAATTATGTGGCTCCGAGAGCTAATTTCAGTTAACTAATATTATA
GAATTTGCTAATGCTTTGTGGCATAATTGACAGTTTGGGGAGGAAATGAATTTGAATGAT
GACTTACGTCAGTTATCTATTGGAAGCGTAACTGCCAAAAGCTATGGACGTTACGACGTC
AATGGATATCGCTTTCGTTCAAGCATTTTCGAATCAAGTCATCCTATGGCCGCCACTCAA
AATAGTGGAGTCGTTACTAGGGCAACTGACATGGAAGGACACGAAGCCTGCTATTACGGG
AAAATCAAAAATATAATCGAGATTACAGTTGCTAGAAATAAGCCTTT
.
qlt:
43448;>PCM>89FC=B_iii_FllUl[le_[[Sllllllg_llllllllllllllllkk
lllkBG8;<777gYYkllllkklllllllllllllllklkllllkkkTUkUPLllkllll
llllllllllllllllllllllgllllllgkllkkllllllllkgllllkllllllllll
llllllllllllllkkkllllllllkllgkllllllllllkllllllllkglllllllkg
ggllllllllllllllllllllllllllllllllllllklllllllllllllllllllll
lllllllllllllllllllllllllkkllllllllllkkkklllllllllllllllglll
llllllllllllllllllllllllllklllllkllllllllllllkllllllllllllll
lllllllllllllllllllllalllllllllllll_llllllllllllllllllllllll
llllllllllllllllll`llel_ll[llllll[lllllllllUl_N_llWlllli_^e_
ee_iieiieibeeieeiieeiidii_ddbibiiie[Wi__eiiediidKedeeieiebed
EeeiiRZZXedeiieed`edLee`MViiiiDc\UeYXe_^ReiiViY^[OcX]\O\^^Ec
c_PNO`cM]NM`V__QYMT\c^MMUMTRNILT[H^[?cTSVTGWYLWWM^HMOTMNMAWM
^cTQGMATc^YMRHMKOXG^MG<NJHALCORMLNAWcEGIT9=N9>8
.
frg:128
clr:5,765
}
{RED
iid:1615
eid:1128922914
seq:
GGCGATCTAGAGATTCGTCAATATCATCACGTTAAATGCAAATATCAAAAAGTATACAAG
TTTATAAATTAATGGAGAGTTATCAAACGTACCCTATCTCCAGGTGCAGGTATATGTGTC
GGAGGGGTGGTGAACTGTGGTGGTGGAACTGGTGTGTTTGCAAATTGGCTCCATTGTGGT
GGCGGTGGAAAATTTGTTGTCATGCCCTTTTGCTGCATTAACTGTTAAACACATATGTGT
TACTACCGAAGATGTTGTATTGAAATATAATAATTTAGAGTTCGGATTATGCGTACTCAC
TTGATACATCGCTTGGTTATGTGCATTGCAAGCCTACATAAATTCGCGTTGTTGTCTCAT
CTCTTCACGCATCCTCATAATCTCCAACTCCTGCTCGTTCGGTCGATGAGAGCATGAGCT
ACGGGAAGATGAACCCGTCCTCTGAGATCTCACCGACGACGAGTCAATGAATCCGTCGAA
GAGTGTGTATCTATAAGTGATTCAAAAAATGTGATTACTATATAATCAATTTAGTGTCAA
CCATATAATTTCATAAGTTAGAGCTTACCGTCCATGCGCTTTGCCACCACCACTTGCGTA
CACCACCGAGGGATCCACCGGTTCATGGCTCCAGTCGAAGTCAGGCCATGGCGACGAACC
ATCTCCTCCCCATATGCCTCCTATACATCATTCACAACCTTACAAATGCAGGAATTTATA
TACTTGACGTTTGACTTTTGAGCCAAACTCACAGCGATCTGTGCTGTCTGCTGCAAGCTG
TCAGATGTCGGGTCTGTCTTTGTGCCTCCTGTAGACTCAATGTCACTAGCTTTGGCCACT
CGTAG
.
qlt:
65467:78=9?;?8TVG<@78:>ADDWMAlll_lbb[[aRllll[VYlllladgllaa_l
llkklkgkllllkllllllllllk[lllllllllllllllkVlllllkllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllklllllll
llllllllllkkllllllllllllllgklllllllllllllllllllkllllllllllll
llllllllllllllllllllllllggglllllllggggllllllllllllllllllllll
lllllllllllllllllllllllllllllllllglllllllllbllllllllllllllll
llllllelllllllllllllllll_elllllllllllllllleiiiiiidieiiiii_ii
ieeiZUZe^ViieeeieeeeeiiieWediiibdieieeieeiVieb__ii^ee^eeibii
Nibei[ieeeieeebibiidOidPYiiYVdiRidVeeedieeeieedSiei\dRUiUXLX
WNO_ee\UMieXR`e[PPO[PcNP]Q\F]]N_WK\]N\V_^UWL[LSVMMVMTTV]]MPY
MHMYMQ[MM@^LEKQYJPNLXMMMHONNCNLNAMCMAYQDLL6876;=LLB8AQHCWKBL
NYMNEGCGNIGDJF?DCID@ILRBGLDVLCFLK>DCGG>9@F<CSABVC9G:B?F\CQA?
AJC<<8F4?DT@@M:@TTB<G>C>ENK<F<<9J9@>MAAB<5@4994<5K8EHB345D@@
3;443458;6N75@5K9A>D5;5646>6=>A3=6=D9;6<8D9D=98:A:ENE5<84335
@=8<4
.
frg:128
clr:8,832
}
{RED
iid:1616
eid:1127298259
seq:
TGTGCCGTCTGATGAATCAGCTTGATTCGTTCAGGCTGGCTGTGGCTGGAAAGAACCTGC
TGTGGATGAAGTTGACCTGGGACCCACGTGACCTGAGTGAAAAGAGCTATGGGTTTGCAG
GGGACACCGGTGCCCTGCTGCAGGTGGTTCTAGAGCTAGGTATCCTGCATCGTGACTTGA
GCAAGTCATGAACCCACTCTGAGCCTCAGTTTCCCACTCTGTTTTTGGTGTTTGGTTTGG
TTTGGTTTTGAGACAGGGTCTCACCCTGTTGACGAATTCTCTAGATATCGCTCAATACTG
ACCATTTAAATCATACCTGACCTCCATAGCAGAAAGTCAAAAGCCTCCGACCGGAGGCTT
TTGACTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAATAAGATCACTACC
GGGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGAGCCATAT
TCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATA
TGGGTATAAATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTA
TGGGAAGCCCGATGCGCCAGAGTTGTTTCTGAAACATGGCAAAGGTAGCGTTGCCAATGA
TGTTACAGATGAGATGGTCAGGCTAAACTGGCTGACGGATTTTATGCCTCTTCCGACCAT
CAAGCATTTTATCCGTACTCCTGATGATGCATG
.
qlt:
344566458789>I;7:C:8;>AF:JddQUUQ>L_beeXXeeWWWW_lbP_bWeWPbblb
gU<I97977789:<UTUW[I\NTkkSdkkkkllllkdklkTWWTkY[YBFHGBGBGk]kd
llkklklllkkllllllllllkalklkkklkkdlkllkkkkklkkklkdkkkklllkllk
akadadkaklkdkklkkllkklkllkkkYklkkkkkkkllllkkkkkkklkkklkkllll
klllkklkkkldlkadkddkkkddkkkkdkkkkKldkllklkkTkddkkaklkdadkkkk
kaa]addkkdkkddkdddklkllld[dkW]aPldkkkkkkllklllllklkklkldlkkk
kkkkddkkdkkddYUUTSSTKk[k[k[aV[[ddddYdgdddYabaaTdagdllggggdad
ddddgdgagddddgg_bggbgbbbgabbbVPCabHbggaObbaUbgblab[ggKaX[]b_
SSEFIMbUbbbTM[][b_WdbWd=HDJAMWddb]VS_bWQHRdbel_ll_WWV_RVZ]]]
_b_KUTV]b[_ePVbdeSVQUNLLVdFZEPVTHNTZJ9IQb]LdLOPV]ZZ_VN]][_ZM
QUNLb]LVSPNVQb]QY_N8N:MSRHQXZPOdHQP@JSKE>@L5KGQBC>>DMDG7BKSQ
FO>@DQ@BUMY\=BAYUNQN<UMPFORMPNLNKMNB>=O;MKFNMMFIMSMNPQ@OEEEJ
D888>97<5==8DM>9JMLKBBMQCAD7DIM;7
.
frg:129
clr:12,270
}
{RED
iid:1617
eid:1128922915
seq:
TACGATCTAGAGATTCGTCACAGGGTGAGACCCTGTCTCAAACCAAACCAAACCAAACAC
CAAATGCAAAGTGGGAAACTGAGGCTCAGAGTGGGTTCATGACTTGCTCAAGTCACGATG
CAGGATACCTAGCTCTAGAACCACCTGCAGCAGGGCACCGGTGTCCCCTGCAAACCCATA
GCTCTTTTCACTCAGGTCACGTGGGTCCCAGGTCAACTTCATCCACAGCAGGTTCTTTCC
AGCCACAGCCAGCCTGAACGAATTCAAGCTTGATATCATTCAGGACGAGCCTCAGACTCC
AGCGTAACTGGACTGCAATCAACTCACTGGCTCACCTTCACGGGTGGGCCTTTCTTCGGT
AGAAAATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAA
CAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTT
TTCCGAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTTCTTCTAGTGTAGCC
GTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAAT
CCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAG
ACGATAGTTACCGGATAACGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCC
CAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGAGAAAG
CGCTACGCTTCCCGAAGGAGAAAGGCGGACAGGTATCCGGTAAGCGCAGGGTCGGAACAG
AAAA
.
qlt:
5333447:99779:JMOSMcA9\NNeiddP;QSQQRUeNAFPOK>id[NAid_@Di]J=7
95555555568=eZed]eWell_ldlSVellllbL=<=88=88?K86?8?BHH_Slllll
llellellllllllllllllll_llll_lllllllllllbR>_[llllll_ebebb_[ll
lllllllUMUlll_lllllllllllllllllllldllllllllUXlellllUlllllll_
Well[llllllllllllllllllllOllllllllllllllllelllllllllllblllll
lllllllllllllllllliiiiiiedeii_iiebeiiiieiiiieii__iiiiiiiie^_
iiiiiedibiiii_Uiiiiiiiieieiiiiiiiiiii_edeeei_iieieii_iiiddii
eeiii__[[^beY^edeiPVeiiiV^^eieibi[i_ieiiNeUediWeeeeWTe^ieeii
e^VVHiHiTedbdii_ie_Q\e`SiEee\eBdQXW]Q`i_d_YiMe`WXeQQXXiReHei
_XeL[]SNYMUO`YQ_eiSA[Rc]N^`]^P`NXNP\M\]NPNK_MURW\_X\QN`NIFQM
YNMc>NNGNMOFT_MM\SRNJ\LSR`MMBVIMOILMMD[JOGHMHMMVWD@MMQCYM=JA
[DC[KPHHLMLJPLWBK=4=>FLLCMLNAMJ^DLOLKPML^Yc^O>CKJCMA@LCMAHHT
DEARKM?J76ONOJOGS=KRNF?AOHMI:LRJ6?AEI@<IH>FLMEOC?LRIADL6IOCC
?;?448>GA@;IB:J958J:<\8D:=;LB<=>LC>7>;<@ALE>96696OJ:<>:M<943
:>95
.
frg:129
clr:13,256
}
{RED
iid:1618
eid:1127298260
seq:
TGGTTCTGATGAATCAGCTTGATTCGTTCATGTCAGGGTACTCCGACCCCACACATGACA
ACCGTCCCCATCGATTCCCCGTTCGCGTCCAGGCCTCACCGCCTTGGCATACAATGCTCC
ACTGACCCCGGCTGCCGCCGTGTAGTGACCGCACTTGTACCCACCATAGCTAGCATGGGA
GACCCAGTCTCAGGTCGCATGAGGGATAAAGTCCGCGCCCGGCTTCACTCAGGTACTAGG
TTTACCGGTTACCATTTTTCCCGGCATGTGCTTAGTACGTTCAAAAGCTTGACTCAGGTA
TCCACACATTAATCCTTAATTCCTTTTCCCGTCTCATGGACAAGGCATCCTCCCTGGATC
CAAATCCATAGACTAACATCTATCCCGTTATCAAGATGAATACAATCAATTCCTGACCTC
GCGCGAGTGCTAGAAAATCACTCGACTTCTACCGAGATCCTGATTAGCAAGCAGCTACTC
GACCTAGCATACTAGTATTCATCTCAAAAAGGAATCCTAAGTTCATGCAACTAGAGGTTT
CAAGCAACTCCTACACTTAAGTGCACATTGCAATCCTACAAGCATTAAGTGTAGTAAAGT
AGCATATAATAATACGGTTATGCATAAAACCGGGGCTTGCCTTCAATTGCTGGGGCTGCG
GGGAGATCCTCAATAGCAGCCTCTGAAGCCTGCTCCTGGTCCTCCTCTTGGATAGGTCCT
TGCTCGGGGGTGAGCACGTAC
.
qlt:
3231369>V?F<7::68VeiiQ?iiO[iF9N_iTTei_ZXPllllM_ll_Xldl_ll_g_
gl;;:8;:69:;=K=Qllllllllkllllkkllllllld==;;<BD;<@C;:=BH\Udkg
lllkklllllllllllllllllllklllllllllllllllll]dSNdkllllllllllll
lllllllllkllkllllllllkkklkllllllllllllllllllkllllllkllllllll
llllllllllllllllllllllllllllllllllllllllllllllkkllllllllllll
lllllllllllklllllllllllllkgklllllllllkkTHHJJN=BHklllllllllll
lllllllllllllllllllllllllllllllllllllkllllllllllllllglllllll
lllllllgglllllllllllllllllllglllllllllllllllllllllllllllllll
lllllllllllllllllllllllll^lllllllieiiiiieiieie_ieiiiieii^Tii
e[iiiiiiiiiiiieiiieieii_eeeiiideiiiiiidQiiiedieieiieieeiiiie
ibieiiedieideeeedKeeVid\e`iiiYieiYi_ieeLeY_[>U_eeXeiEAENY_PR
cccQMVIOcVUHYR`MTTM^^T^\__^K[cS`MWU[MY^JFNMTWMNIIWAUBTIWPNQJ
MOTCYLccc[HN[LMJMM<?;
.
frg:130
clr:7,739
}
{RED
iid:1619
eid:1128922916
seq:
ACGATCTAGAGATTCGTACATTTTGAGTTGAGCCAATTATATAAGTTAAAGTATATTTAT
TTGGCACAAGAAAGATTGAGAAGGCTTAGTCAAAATAACTCAAATAAATTCCCAAATCAG
CCCTTGATCAATGAATCCTTAGGGAATTCAGATTTCTGAATTCCTGAATTTTCAGACCTC
TTCCCAAAGATCATCTGTGTTCTCTGTTTTTCAGGACTCAAAAGACCGAAGATCCAATAT
CAAAGTCGTGCCAAATTACATAGAACACAGTCTGGCCAAAGTTTGAACTCCAAACTAGGA
CCACCCCTACAAAGTA
.
qlt:
33234969744;:FNHJ5347H\MCNB:HEN?OM<POANTLTIGGE>I^N^MWN`YN964
4544774457<CUQ^LQSH:USeRdiURSV[>Se9<856<:56678D<687>=Rii__Ze
UUeei^eelPlllllllllllbleeebblX[llgggV@>:9;@UgllgllTLT59MCKSk
[kkkkGQNPkddTkkkkOlMU\TdTdBHMJ<<@B@;=LW====9<=:BSI9UHEJ7KDGK
D=5BP?P>6\RWB<B6<9<868=BPBA:7:?GQU<5:B<FA::KH;<B8?<=7=?:75;<
<=::=<:6<9<=8?:6
.
frg:130
clr:11,313
}
{RED
iid:1620
eid:1127298261
seq:
AGCTGTGTCTGATGTTCAGCTTGATTCGTATTCGGAAGCTCTCTTAAGATGGGGGCGGTT
TGACACTCTATGGTAATTAAACTTTCCGTCTGAGAGGCATTTTGAGAATTCTATCTGATA
CTCCTTTCATTACCCTTGAAATGAAACAAATGGGCATTAAAGAAAAAACATGTATCAAAT
TAAGACGACGGTTTTGCATATTAAGGAGGATCTAGGGATGTGCACACCTTTACGGAGGTG
GAAAACACCCCTAAGAAGCTGCGGTTGTGTGGTGCTAGCAGAAGTCGCCTTTCCGTGTGG
CAACCTTGCGGTTTTAAAAAGGGAGAGCGCGGAATAAGCCTCATGTCTGAGATTATATAA
TGAAGCGTGCGCCGGTGAGTTTTTCCCCCCAGTTTCAAAACACAAGCCCCCCCCTTAGTT
GTTGGGGGGGGGAAAAAAAAACCCCCCCCCCCATGGTGGATTTCGGTAAATGCGCGCTCT
ATGAGTTAATGATGTCATAGGGAGATGCCCATTACTTCCACCTGTTATGTTTGGCGGGAT
GTGAATATATACACTTTGAAGTGCTTCCGGGAGGATATTGTTTGATGAAAGATTCTTCTC
CGGGGTATGGGTCACGGTAATGTAACCG
.
qlt:
1213444677;B977;7767;B>RHDK8968RSAA79BZcZX[JOA<AK>^l_lIKeP86
64444477558;;86:dN6???YRI7<78:<:5944447744858;645=9;:;:F<<<=
=:;7;=:9==G@;=F9?=B<<<:548:8=:B6:<:=>:8;74496646:<;=CAEC?;K<
E>9?:9;:8<9?==?H<<<?B<<<=BL=;@<F=BC<9=;:::=?B===<9<9G=KG;<:<
CMD976<B=?;ABC=FH<F<<B=<<;;<;?=:=B<:<=8EB869:9<=H?=<=;9;9:=B
<SUB;LP5688RNK?FC;;=9BM:=<9:DG:JK=:<<7G;><:?B:::<N6B88<EB=>:
<BBE8BK<N?<C@BN9CG::==;846;;;69=5;;LHP>NDM?<7<CGUTUKC;CO4:TT
8BD<=BLHB=B<?CQPTTKRL?TOOOWLOMG=C>A=7@=J<>@;;9;L@<ECP=J<B<;?
>@=GB<=?C<G;<H<I;=@AB<;:<=L<=D;:9G:?:;?:;C:M:G?H=BA<<=C<B=\O
II@<=<55;@D;8=><DD@?;<LF>CELMHN;=MG<aBM[FDPLP;HB=D<I><>>?UKL
H@WG<=D;>Q:;LAGF==?L?CCH@;;;
.
frg:131
clr:20,626
}
{RED
iid:1621
eid:1128922917
seq:
AGATCTAGAGATTCGTCTGACATAGGTGGTATCAAAGCCATGCTGACTGTAGGACCGCTA
ACCTAGAATAGAATGGTCGTTCTAAGGACTATAGACCTCTGTCCCTGCCTTGACTTTGAT
ATCCCTTCAAAAGTTGGTCATACCGACCAAACCTATGTTCTACTATATATTATACCTTGC
TGAAAATTATGTTTTATTCTAATCCTTCATTTATTTATGGTTCATTACTTGCTGGTCATA
TTAATTCTGTTCTCACTCTTTCACTTGCGGTGTCTTTTGTAGATGGCTCGACTTAGACAC
ACTGCACGAAAGTCCGTCATCCCCTTCTTACCCTCCCGCCTTGCTGAGCGTCTGCTTCGT
CGTCCCGTGGTCGGACAGTCCAGTCACTTGGAGAGACTGCACCACCGCCTGCATGAGGAG
CAGGAACGTCGACGACAGGAGCAGGAGCAGCAGGGCTCTTCTTTCTCGCTCCAACAGGAG
ATAGAGTCTGTGAGGAGCTGCTCCCCTTTGCTTCCTCTGGAGGTGCCCCCTGCACCACCA
CTGGGCGCCCCAGCCTTTGGAGTAGCTGCTGGAGGAGACCCAGACGACGAATGTGGCGAC
GACAGCTCGAGCCACGACACCGACTTCTCTGCTGACCATGAGCCGGAAGGATGGGTTGTT
CGACCCATCACTCGCGACGCTGCTCGCGGGTGTCACTTCCACGATGCGCTCGACACCCTG
CTACGTCGGGCACTTAGCGCATACTTGTCATCGAGTATCGCTGTGTGGTCTACAGCACAG
TCGCGGGTCTACCGACGCTGGAGCGACTGCTGTGCGCGTCGGAGAACATCTCCAGGTGTA
AAGCCGCTCAGCCAATCCA
.
qlt:
456::;<:79;8XYMZbYYM:<VTeTKiTENNQKZlllPDllllll]lledllgOlll_<
><?F9DRRd_gllalglllllgNlllllllllkllllllllkk\glllllllllllllll
lllllllkallkkllllllllllllllkllllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllklllllkllllllllllllllllllllll
lllllllllllllllllllllllllllglllllllllllllllllllllllllllgllll
llllllllllglllllllllllbbllllllllllllllllllllllllllllllllllll
llllllllllllllllllllediiieiiii_ieiieiiiibiibiiee__iieiiieiid
ii_iieeiiidddeid]iid_iidiidieeidO^Y^iidiibi^eeideiedLedbWidQ
XOibiWeedd_ec@ieXeeeWe_RIVe^idZXVV^W\XJMeM^PeFiii]UiUUMNQUeT
_U[JI\WRc]ONP^_I^O]A]KNXHNO`MM]IW?W_A_E]_QL`KF`FD[D4GH[MDKYL
B[IGQLUIHMMHTJLM[LLHIJVRSTLMMIMIMLY@ODLMYGN@:DD;<:J?RcI=EY;F
TFVAVNGTLALQR@DAQDBAJGIMOCEJcJCMCQ@BJLDCEJ?VGQF>@MRGNA?9OC@P
=GJOBF?@\@;@AC=74543;B;;@77597J@5?H>><HAAL@8>86=3:<;M7:B55=C
CG65BJB7E:<;;47B7:<=9FE547K?E6B:2554A88956>5D74=;755D7@=9<68
57C943384334445B632
.
frg:131
clr:12,810
}
{RED
iid:1622
eid:1127298262
seq:
TGGGTCTGATGAATCAGCTTGATTCGTTTTGCTTTTGATTACTGGATCATAAGACAAGGC
AACACAATCGCTAAATGTTAAGGACCTTCGCCATTCGAAGCGGTGGGCGCCAATGTTGGT
CTCTTGCTTTTGATTACTGGATCATAAAACAAGGCAACACAACCGTTAACGTTAAGGACC
TTCGTCCTTCGAAGCATTATCTCCTTTTGGGCATAATGAACTTCGAACGAAGGTCATGAA
GAACAAGTCTTCGTCATTCAAAAAATATAGTTACAGATGTAACATTATGATGATTATTCA
TTTCATATCAAATGTTAAATAATATTAAAAATTCATCACATATCGACAAAGTTATACACA
ACGTATATTACATTGGTACCTTCGTCTTGCTTGAAGGCAAAAGCGAGGGTGCAATTCCAA
TCCCGCCTCCATAGTACAAGGGTATTATTCATCTATTATAGGCAAGAGACGCAGCCCAAG
CAAAAGTACATTTATGACCCTAACATATACACATAATCCTAATACAAAACATCAGGGATT
AAGTAGTCTTTTCTTCTTTGGTCAACATCATGTTTGACTTTCATAACCACCTTAAGCCGA
AATTGCATCCTTCAGCGCTTTACGCATGCTTGTTGTAGCTTCGACATTCAGTCTTGTTGT
TTATAGACAATTTCTCTGTCTTGAGGACCTTCGGCAGAGAAAGAGACCCCCAATAGGACA
CTCTTCCCCGGCCTATTCCTTTGACTACTATGCTGCCGCCCCTAATACAGTAGATCGAGA
TGGCAGGAATTCAACAACAAGG
.
qlt:
4444499BW:D;77:88:l:A:7;l_llll_VlllllaV[kkllkkkkklllllklllll
WR=;E:9B<<;PTT[klllllllllllllllkkllllllllllak[NTNLTTakllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
lllllllkklllllllllllllllllllllllllllllllllllllllllllllllllll
llllllllllllklllllllllllllllllllllllllllllllllllllllllllllll
lllllllllllllllllllllllllllllllllkkllllllllllllllkllllllllll
llllllllllllllllllllkgllllllllllllllllllllllllllllllllllllll
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llOObllllllllllllllllllllllllllllllllllllllll__llllllllOU^_i
iiiiiieiiiii_eiiiiiiZXe_iieidbiibiiiidiiiebeiiidZiiieeieiiei
iSXiiedeieeidV\iieiieeXeedeiei_iXeiSeXeieeOUXX\i\QY`e\ecK_cN
^N_QV\]OP^N^]__^`cU`L_^]M`[<UH]Y@[PYYcD^^[[^LTGc^WNMVMNB^TGN
M^^MWMccTM^GXHQATMSRcMONGLLMJ[LVNMVHRPSc\PFJQ>SOMJAVELAMBDFS
B?@A76659BRN?IIBGD9C87
.
frg:132
clr:7,799
}
{RED
iid:1623
eid:1128922918
seq:
TAACGATCTAGAGATTCGTATGAGGGTGGAATGGGATGCCCTTAGCTGAATAATTAGAGG
ATCCGGTGTGTAGTTTGCTTAGCCGTTGTGCCGTCAATGGGGCTCGGTGTATGCGGCTCG
CTCTGCCAAGTTTGGGTTCGCCCCTTGGGGAGGAGTGCGGTGCATTTAGGAAACCTAACG
GGTGGCTACAGCCCCAGGGATCTTTGTAAAGGCTACATAGTGATGCCCTGCTGGGTCACC
TTGGTAGTGATCAATGGAGAGTCATGATCTGCGGGCAGAAAGGGAATCACGACTTGTGGG
TAAAGTGCACAACCTCATAAATCAGAGACAACCTCATAAATCAGAGACACTTGTGGGTAA
AACTGATATATCAGCCGTGCTCGCGGTTATGAGCGTCCAAGGGAGCTTCAGTGATTAGTG
GTACTTGATCAGAGACACTTTGCTTTTCAGGTGGCAATGAGACTGATGGTTTTGGTTATG
ACTATGGTGCTGGTAAGTGGTATTCTTTTCGTTTGGAAAGGGTACATCGGGCTAATAACT
TGGGTTAATGCTAAAACCTGGCTTTCTATTAGTAAATAATAATCTGACCAACTAAAAGCA
ACTGCTTGACTTATCCCCACATAAAGCTAGTCCACTACACCCAAACAGGATACTTGCTGA
GTATGTTGATTTGTACTCACCCTTGCTCTACACACCAAACCCCCCCATCCCCAGGTTGTC
AGCATTGCAACCACTGCTCAGGAGAAGATGAAGCCGTGGAGAGACTTCCAGGAGTCCAGA
CTATGACGAGTTCTAGGCGTGGGTAGCGGCAACCCCAGTCGGCTGCCTGTGAAGGCCGCA
GTTATCTATTGTTTCTTTTTCCGCACCTAG
.
qlt:
75555867<BBB:88[_PPNH`eHi??l_I=AlllDE[[llgglgllllbblllaaNlgd
Q@B@FCFKkkbUkklllllkklllllllkglllllkllllllkkkkkdlkllllllllll
llllllkkllklllllllklllgllllllllllllllllllllllllllkglllllllll
lllllllllllkgklllllkllllllllkllllllllllllllllllllllllllllllk
llllllllllllllllllllllllllllllllllllllllllllllllllllllllllll
llglllllllllggllllllllllgllllglllllllllllllgllllllllllllllll
lllllllllllllelllllll